Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy
CONCLUSIONS: The findings indicated that naringenin treatment could promote flap survival by inhibiting pyroptosis, apoptosis, necroptosis, and alleviating oxidative stress, caused by the activation of autophagy.PMID:38423240 | DOI:10.1016/j.ejphar.2024.176455 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - February 29, 2024 Category: Drugs & Pharmacology Authors: Shuai Jiang Feixia Ma Junsheng Lou Jiafeng Li Xiushuai Shang Yifan Li Junsong Wu Sanzhong Xu Source Type: research

Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy
CONCLUSIONS: The findings indicated that naringenin treatment could promote flap survival by inhibiting pyroptosis, apoptosis, necroptosis, and alleviating oxidative stress, caused by the activation of autophagy.PMID:38423240 | DOI:10.1016/j.ejphar.2024.176455 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - February 29, 2024 Category: Drugs & Pharmacology Authors: Shuai Jiang Feixia Ma Junsheng Lou Jiafeng Li Xiushuai Shang Yifan Li Junsong Wu Sanzhong Xu Source Type: research

Management of the Sequelae of Skin Grafting
Scars commonly give rise to unpredictable, potentially irritating, cutaneous complications including pruritis, folliculitis, and pigment changes. These problems can be self-limiting and are prevalent in many burn cases, although their expression varies among individuals. A better understanding of the presentation, risk factors, and pathophysiology of these long-term sequelae allows for more comprehensive care of burn survivors. (Source: Clinics in Plastic Surgery)
Source: Clinics in Plastic Surgery - February 29, 2024 Category: Cosmetic Surgery Authors: Anna White, Debra Ann Reilly Source Type: research

Paediatric fibrosarcoma treatment
CONCLUSION: The involvement of the vascular surgeon in performing the tumour resection permitted the preservation of the best circulation to the extremity, thereby, avoiding amputation. The difficult decision made by the reconstructive surgeon to place a partial thickness graft over the surgical site, and to start radiotherapy/chemotherapy by paediatric oncology, were key to the success in achieving the patient's satisfactory progress.PMID:38414962 | PMC:PMC10898908 | DOI:10.3332/ecancer.2023.1608 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - February 28, 2024 Category: Cancer & Oncology Authors: Adri án Cano-Padilla Augusto Ram írez Paola Cervantes-Rivera Rosalba Bellido-Maga ña Gilberto Flores-Vargas Nicol ás Padilla-Raygoza Source Type: research

Improving Outcomes in Chronic Graft-vs-Host Disease
Chronic graft-vs-host disease (cGVHD) is a frequent, heterogeneous, and often life-threatening complication of allogeneic hematopoietic stem cell transplantation. A total of 25% to 50% of all transplant survivors develop cGVHD, and cutaneous manifestations are seen in approximately 75% of these patients. Cutaneous manifestations of cGVHD include skin fibrosis (sclerotic cGVHD), epidermal involvement resembling lichen planus, or a combination of both findings. Alopecia, genital inflammation/scarring, nail dystrophy, pigmentary changes, ulceration, and poor wound healing are additional features. Associated skin changes range...
Source: JAMA Dermatology - February 28, 2024 Category: Dermatology Source Type: research

Hand-held electron spin resonance scanner for subcutaneous oximetry using OxyChip
CONCLUSION: The compact ESR scanner can report pO2 data in ATE phantom from an external position relative to the scanner. Implementing this scanner in preclinical and clinical applications for subcutaneous pO2 measurements is a feasible next phase for this development. This innovative design also has the potential to operate in conjunction with artificial skin graft for wound healing, combining therapeutic and pO2 diagnostic features.PMID:38411265 | DOI:10.1002/mrm.30066 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - February 27, 2024 Category: Radiology Authors: Nir Almog Oleg Zgadzai Periannan Kuppusamy Yehonatan Zur Limor Baruch Marcelle Machluf Aharon Blank Source Type: research

Hand-held electron spin resonance scanner for subcutaneous oximetry using OxyChip
CONCLUSION: The compact ESR scanner can report pO2 data in ATE phantom from an external position relative to the scanner. Implementing this scanner in preclinical and clinical applications for subcutaneous pO2 measurements is a feasible next phase for this development. This innovative design also has the potential to operate in conjunction with artificial skin graft for wound healing, combining therapeutic and pO2 diagnostic features.PMID:38411265 | DOI:10.1002/mrm.30066 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - February 27, 2024 Category: Radiology Authors: Nir Almog Oleg Zgadzai Periannan Kuppusamy Yehonatan Zur Limor Baruch Marcelle Machluf Aharon Blank Source Type: research

Hand-held electron spin resonance scanner for subcutaneous oximetry using OxyChip
CONCLUSION: The compact ESR scanner can report pO2 data in ATE phantom from an external position relative to the scanner. Implementing this scanner in preclinical and clinical applications for subcutaneous pO2 measurements is a feasible next phase for this development. This innovative design also has the potential to operate in conjunction with artificial skin graft for wound healing, combining therapeutic and pO2 diagnostic features.PMID:38411265 | DOI:10.1002/mrm.30066 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - February 27, 2024 Category: Radiology Authors: Nir Almog Oleg Zgadzai Periannan Kuppusamy Yehonatan Zur Limor Baruch Marcelle Machluf Aharon Blank Source Type: research

Hand-held electron spin resonance scanner for subcutaneous oximetry using OxyChip
CONCLUSION: The compact ESR scanner can report pO2 data in ATE phantom from an external position relative to the scanner. Implementing this scanner in preclinical and clinical applications for subcutaneous pO2 measurements is a feasible next phase for this development. This innovative design also has the potential to operate in conjunction with artificial skin graft for wound healing, combining therapeutic and pO2 diagnostic features.PMID:38411265 | DOI:10.1002/mrm.30066 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - February 27, 2024 Category: Radiology Authors: Nir Almog Oleg Zgadzai Periannan Kuppusamy Yehonatan Zur Limor Baruch Marcelle Machluf Aharon Blank Source Type: research

Hand-held electron spin resonance scanner for subcutaneous oximetry using OxyChip
CONCLUSION: The compact ESR scanner can report pO2 data in ATE phantom from an external position relative to the scanner. Implementing this scanner in preclinical and clinical applications for subcutaneous pO2 measurements is a feasible next phase for this development. This innovative design also has the potential to operate in conjunction with artificial skin graft for wound healing, combining therapeutic and pO2 diagnostic features.PMID:38411265 | DOI:10.1002/mrm.30066 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - February 27, 2024 Category: Radiology Authors: Nir Almog Oleg Zgadzai Periannan Kuppusamy Yehonatan Zur Limor Baruch Marcelle Machluf Aharon Blank Source Type: research

Effectiveness of a Regenerative Epithelial Suspension (RES), on the pigmentation of split-thickness skin graft donor sites in children: the dRESsing pilot randomised controlled trial protocol
This study was prospectively registered on the Australian New Zealand Clinical Trials Registry (available at https://anzctr.org.au/ACTRN12620000227998.aspx). Trial registration number Australian New Zealand Clinical Trials Registry [Available at https://anzctr.org.au/ACTRN12620000227998.aspx] (Source: BMJ Open)
Source: BMJ Open - February 27, 2024 Category: General Medicine Authors: Bairagi, A., Tyack, Z., Kimble, R. M., McPhail, S. M., McBride, C. A., Patel, B., Vagenas, D., Dettrick, Z., Griffin, B. Tags: Open access, Surgery Source Type: research

Full-thickness skin graft versus split-thickness skin graft for radial forearm free flap donor site closure: protocol for a systematic review and meta-analysis
This study's findings may help us understand both closure techniques' complication rates and may have important implications for developing future guidelines for RFFF donor site management. If available data is limited and several questions remain unanswered, additional comparative studies will be needed.Systematic review registrationThe protocol was developed in line with the PRISMA-P extension for protocols and was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 17 September 2023 (registration number CRD42023351903). (Source: Systematic Reviews)
Source: Systematic Reviews - February 26, 2024 Category: International Medicine & Public Health Source Type: research

Open Distal Femur Fractures Treated with Bone Cement Intramedullary Support Combined with Locked Plate Fixation
CONCLUSIONS: Bone cement intramedullary support combined with locked plate fixation was an effective treatment modality of open distal femur fractures with high union rate, low complication, adequate alignment and satisfactory functional outcomes.PMID:38401096 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 24, 2024 Category: Complementary Medicine Authors: Dapeng Zhou Hong Yuan Tianyu Han Xiangyu Ma Zhengang Ji Bing Xie Source Type: research

Open Distal Femur Fractures Treated with Bone Cement Intramedullary Support Combined with Locked Plate Fixation
CONCLUSIONS: Bone cement intramedullary support combined with locked plate fixation was an effective treatment modality of open distal femur fractures with high union rate, low complication, adequate alignment and satisfactory functional outcomes.PMID:38401096 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 24, 2024 Category: Complementary Medicine Authors: Dapeng Zhou Hong Yuan Tianyu Han Xiangyu Ma Zhengang Ji Bing Xie Source Type: research