Gene-edited cells: novel allogeneic gene/cell therapy for epidermolysis bullosa
This article attempts to summarize the current situation, potential development prospects, and some of the challenges related to the cell therapy approach for EB treatment.PMID:38459407 | DOI:10.1007/s13353-024-00839-2 (Source: J Appl Genet)
Source: J Appl Genet - March 8, 2024 Category: Genetics & Stem Cells Authors: Fatemeh Gila Vahab Alamdari-Palangi Maedeh Rafiee Arezoo Jokar Sajad Ehtiaty Aria Dianatinasab Seyyed Hossein Khatami Mortaza Taheri-Anganeh Ahmad Movahedpour Jafar Fallahi Source Type: research
Multifunctional Hydrogel Enhances Inflammatory Control, Antimicrobial Activity, and Oxygenation to Promote Healing in Infectious Wounds
Biomacromolecules. 2024 Mar 8. doi: 10.1021/acs.biomac.3c01386. Online ahead of print.ABSTRACTChronic infected wounds often fail to heal through normal repair mechanisms, and the persistent response of reactive oxygen species (ROS) and inflammation is a major contributing factor to the difficulty in their healing. In this context, we developed an ROS-responsive injectable hydrogel. This hydrogel is composed of ε-polylysine grafted (EPL) with caffeic acid (CA) and hyaluronic acid (HA) grafted with phenylboronic acid (PBA). Before the gelation process, a mixture CaO2@Cur-PDA (CCP) consisting of calcium peroxide (CaO2) coate...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Yunfeng Tang Renliang Zhao Min Yi Zilu Ge Dong Wang Guanglin Wang Xiangtian Deng Source Type: research
Multifunctional Hydrogel Enhances Inflammatory Control, Antimicrobial Activity, and Oxygenation to Promote Healing in Infectious Wounds
Biomacromolecules. 2024 Mar 8. doi: 10.1021/acs.biomac.3c01386. Online ahead of print.ABSTRACTChronic infected wounds often fail to heal through normal repair mechanisms, and the persistent response of reactive oxygen species (ROS) and inflammation is a major contributing factor to the difficulty in their healing. In this context, we developed an ROS-responsive injectable hydrogel. This hydrogel is composed of ε-polylysine grafted (EPL) with caffeic acid (CA) and hyaluronic acid (HA) grafted with phenylboronic acid (PBA). Before the gelation process, a mixture CaO2@Cur-PDA (CCP) consisting of calcium peroxide (CaO2) coate...
Source: Cancer Control - March 8, 2024 Category: Cancer & Oncology Authors: Yunfeng Tang Renliang Zhao Min Yi Zilu Ge Dong Wang Guanglin Wang Xiangtian Deng Source Type: research
Gene-edited cells: novel allogeneic gene/cell therapy for epidermolysis bullosa
This article attempts to summarize the current situation, potential development prospects, and some of the challenges related to the cell therapy approach for EB treatment.PMID:38459407 | DOI:10.1007/s13353-024-00839-2 (Source: J Appl Genet)
Source: J Appl Genet - March 8, 2024 Category: Genetics & Stem Cells Authors: Fatemeh Gila Vahab Alamdari-Palangi Maedeh Rafiee Arezoo Jokar Sajad Ehtiaty Aria Dianatinasab Seyyed Hossein Khatami Mortaza Taheri-Anganeh Ahmad Movahedpour Jafar Fallahi Source Type: research
Multifunctional Hydrogel Enhances Inflammatory Control, Antimicrobial Activity, and Oxygenation to Promote Healing in Infectious Wounds
Biomacromolecules. 2024 Mar 8. doi: 10.1021/acs.biomac.3c01386. Online ahead of print.ABSTRACTChronic infected wounds often fail to heal through normal repair mechanisms, and the persistent response of reactive oxygen species (ROS) and inflammation is a major contributing factor to the difficulty in their healing. In this context, we developed an ROS-responsive injectable hydrogel. This hydrogel is composed of ε-polylysine grafted (EPL) with caffeic acid (CA) and hyaluronic acid (HA) grafted with phenylboronic acid (PBA). Before the gelation process, a mixture CaO2@Cur-PDA (CCP) consisting of calcium peroxide (CaO2) coate...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Yunfeng Tang Renliang Zhao Min Yi Zilu Ge Dong Wang Guanglin Wang Xiangtian Deng Source Type: research
Gene-edited cells: novel allogeneic gene/cell therapy for epidermolysis bullosa
This article attempts to summarize the current situation, potential development prospects, and some of the challenges related to the cell therapy approach for EB treatment.PMID:38459407 | DOI:10.1007/s13353-024-00839-2 (Source: J Appl Genet)
Source: J Appl Genet - March 8, 2024 Category: Genetics & Stem Cells Authors: Fatemeh Gila Vahab Alamdari-Palangi Maedeh Rafiee Arezoo Jokar Sajad Ehtiaty Aria Dianatinasab Seyyed Hossein Khatami Mortaza Taheri-Anganeh Ahmad Movahedpour Jafar Fallahi Source Type: research
Multifunctional Hydrogel Enhances Inflammatory Control, Antimicrobial Activity, and Oxygenation to Promote Healing in Infectious Wounds
Biomacromolecules. 2024 Mar 8. doi: 10.1021/acs.biomac.3c01386. Online ahead of print.ABSTRACTChronic infected wounds often fail to heal through normal repair mechanisms, and the persistent response of reactive oxygen species (ROS) and inflammation is a major contributing factor to the difficulty in their healing. In this context, we developed an ROS-responsive injectable hydrogel. This hydrogel is composed of ε-polylysine grafted (EPL) with caffeic acid (CA) and hyaluronic acid (HA) grafted with phenylboronic acid (PBA). Before the gelation process, a mixture CaO2@Cur-PDA (CCP) consisting of calcium peroxide (CaO2) coate...
Source: Biomacromolecules - March 8, 2024 Category: Biochemistry Authors: Yunfeng Tang Renliang Zhao Min Yi Zilu Ge Dong Wang Guanglin Wang Xiangtian Deng Source Type: research
Gene-edited cells: novel allogeneic gene/cell therapy for epidermolysis bullosa
This article attempts to summarize the current situation, potential development prospects, and some of the challenges related to the cell therapy approach for EB treatment.PMID:38459407 | DOI:10.1007/s13353-024-00839-2 (Source: J Appl Genet)
Source: J Appl Genet - March 8, 2024 Category: Genetics & Stem Cells Authors: Fatemeh Gila Vahab Alamdari-Palangi Maedeh Rafiee Arezoo Jokar Sajad Ehtiaty Aria Dianatinasab Seyyed Hossein Khatami Mortaza Taheri-Anganeh Ahmad Movahedpour Jafar Fallahi Source Type: research
Supraclavicular Artery Perforator Based Flap in Reconstruction of Neck Soft Tissue Defects: Our Experience
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):739-747. doi: 10.1007/s12070-023-04265-4. Epub 2023 Dec 23.ABSTRACTNeck reconstruction is challenging task as it requires achievement of both function and aesthetic form as it is exposed and visible part of body. Various reconstruction modalities like Skin graft to free flap has been described in literature (Achauer and Sood's Burns Surgery, edition 2006). We used Supraclavicular artery perforator based island Flap for resurfacing defect in Five patients. After localization of Supraclavicular artery perforator with hand held Doppler; flap was raised in subfascial plane an...
Source: Hand Surgery - March 5, 2024 Category: Surgery Authors: Ganesh Sadashiv Chaudhari Sanjay Gordhanbhai Vaghani Raghuvir Solanki Source Type: research
Usage of Dermal Regeneration Templates (Pelnac) for Coverage of Exposed Hand Tendons in Acute Setting
CONCLUSIONS: Using Pelnac to cover the exposed hand tendons in an acute setting is a convenient and efficient procedure with minimal morbidity. It can offer a good option for their coverage with preservation of hand function and acceptable aesthetic outcome.PMID:38440369 | PMC:PMC10911527 | DOI:10.1097/GOX.0000000000005673 (Source: Hand Surgery)
Source: Hand Surgery - March 5, 2024 Category: Surgery Authors: Rama Ahmed Ali Ahmed Gamal Hemidan Hamed Mohamed Kadry Ahmed Samy Saad Source Type: research
Usage of Dermal Regeneration Templates (Pelnac) for Coverage of Exposed Hand Tendons in Acute Setting
CONCLUSIONS: Using Pelnac to cover the exposed hand tendons in an acute setting is a convenient and efficient procedure with minimal morbidity. It can offer a good option for their coverage with preservation of hand function and acceptable aesthetic outcome.PMID:38440369 | PMC:PMC10911527 | DOI:10.1097/GOX.0000000000005673 (Source: Hand Surgery)
Source: Hand Surgery - March 5, 2024 Category: Surgery Authors: Rama Ahmed Ali Ahmed Gamal Hemidan Hamed Mohamed Kadry Ahmed Samy Saad Source Type: research
Supraclavicular Artery Perforator Based Flap in Reconstruction of Neck Soft Tissue Defects: Our Experience
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):739-747. doi: 10.1007/s12070-023-04265-4. Epub 2023 Dec 23.ABSTRACTNeck reconstruction is challenging task as it requires achievement of both function and aesthetic form as it is exposed and visible part of body. Various reconstruction modalities like Skin graft to free flap has been described in literature (Achauer and Sood's Burns Surgery, edition 2006). We used Supraclavicular artery perforator based island Flap for resurfacing defect in Five patients. After localization of Supraclavicular artery perforator with hand held Doppler; flap was raised in subfascial plane an...
Source: Hand Surgery - March 5, 2024 Category: Surgery Authors: Ganesh Sadashiv Chaudhari Sanjay Gordhanbhai Vaghani Raghuvir Solanki Source Type: research
Survey of EBMT nurses to explore the current topical skin management of chronic cutaneous graft versus host disease in the real-world clinical environment
To understand the current practice in relation to the management of topical therapy for ccGvHD and access to ECP within European allo-HCT centres by a survey of nurses. (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - March 5, 2024 Category: Cancer & Oncology Authors: John Murray, Sarah Liptrott, Marta Canesi, Jarl Mooyaart, Annika Kisch, Brian Piepenbroek, Jacqui Stringer Source Type: research
Survey of European Blood and Marrow Transplant (EBMT) nurses to explore the current topical skin management of chronic cutaneous graft versus host disease in the real-world clinical environment
To understand the current practice in relation to the management of topical therapy for cutaneous chronic Graft versus Host Disease (ccGvHD) and access to extracorporeal photopheresis (ECP) within European allogeneic haematopoietic cell transplantation centres by a survey of nurses. (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - March 5, 2024 Category: Cancer & Oncology Authors: John Murray, Sarah Liptrott, Marta Canesi, Jarl Mooyaart, Annika Kisch, Brian Piepenbroek, Jacqui Stringer Source Type: research
Carboxymethyl cellulose-agarose hydrogel in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofibers: A novel tissue engineered skin graft
In this study, a biocompatible hybrid scaffold was developed for wound healing applications using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers embedded with hydrogel made of 2 % carboxymethyl cellulose (CMC) blended with 1 % agarose. Hybrid scaffolds, characterized for surface morphology, swellability, porosity, and degradation, were found to be suitable for wound healing. Furthermore, the incorporation of CMC-agarose hydrogel into nanofibers significantly enhanced their mechanical strength compared to PHBV nanofibers alone (p < 0.05). Extract cytotoxicity and direct cytotoxicity tests showed that the ...
Source: International Journal of Biological Macromolecules - March 3, 2024 Category: Biochemistry Authors: Harshavardhan Budharaju Shambhavi Bagewadi Priyadharshini Devanathan Davidraj Chellappan Prabu Chinnaswamy Swaminathan Sethuraman Dhakshinamoorthy Sundaramurthi Source Type: research
