Carboxymethyl cellulose-agarose hydrogel in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofibers: A novel tissue engineered skin graft
In this study, a biocompatible hybrid scaffold was developed for wound healing applications using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers embedded with hydrogel made of 2 % carboxymethyl cellulose (CMC) blended with 1 % agarose. Hybrid scaffolds, characterized for surface morphology, swellability, porosity, and degradation, were found to be suitable for wound healing. Furthermore, the incorporation of CMC-agarose hydrogel into nanofibers significantly enhanced their mechanical strength compared to PHBV nanofibers alone (p < 0.05). Extract cytotoxicity and direct cytotoxicity tests showed that the ...
Source: International Journal of Biological Macromolecules - March 3, 2024 Category: Biochemistry Authors: Harshavardhan Budharaju Shambhavi Bagewadi Priyadharshini Devanathan Davidraj Chellappan Prabu Chinnaswamy Swaminathan Sethuraman Dhakshinamoorthy Sundaramurthi Source Type: research
Sensory and Pain Outcomes of Neurotized Skin-grafted Free Gracilis Muscle Flaps for Lower Extremity Reconstruction
This study prospectively analyzes the sensory and neuropathic pain outcomes of neurotized skin-grafted free gracilis muscle flaps for reconstruction of lower extremity defects. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - March 3, 2024 Category: Cosmetic Surgery Authors: Ebai A. Eseme, Katya Remy, Blandine Le Men é, Solange N. Walz, Srinivas Madduri, Carlo M. Oranges, Daniel F. Kalbermatten Source Type: research
Tipping the balance toward transplantation tolerance: in vivo therapy using a mutated IL-2
Immune tolerance to allogenic transplanted tissues remains elusive, and therapeutics promoting CD4+FOXP3+ Tregs are required to achieve this ultimate goal. In this issue of the JCI, Efe and colleagues engineered an Fc domain fused to a human mutein IL-2 (mIL-2–Fc) bearing mutations that confer preferential binding to the high-affinity IL-2 receptor expressed on Tregs. In vivo mIL-2–Fc therapy effectively heightened mouse, monkey, and human Treg numbers, promoted tolerance to minor antigen mismatched skin grafts in mice, and synergized with immunosuppressive drugs used in the clinic. These findings warrant clinical tria...
Source: Journal of Clinical Investigation - March 1, 2024 Category: Biomedical Science Authors: Geoffrey Camirand, Fadi G. Lakkis Source Type: research
Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models
Tissue-intrinsic mechanisms that regulate severity of systemic pathogenic immune-mediated diseases, such as acute graft-versus-host disease (GVHD), remain poorly understood. Following allogeneic hematopoietic stem cell transplantation, autophagy, a cellular stress protective response, is induced in host nonhematopoietic cells. To systematically address the role of autophagy in various host nonhematopoietic tissues, both specific classical target organs of acute GVHD (intestines, liver, and skin) and organs conventionally not known to be targets of GVHD (kidneys and heart), we generated mice with organ-specific knockout of ...
Source: Journal of Clinical Investigation - March 1, 2024 Category: Biomedical Science Authors: Katherine Oravecz-Wilson, Emma Lauder, Austin Taylor, Laure Maneix, Jeanine L. Van Nostrand, Yaping Sun, Lu Li, Dongchang Zhao, Chen Liu, Pavan Reddy Source Type: research
A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models
Long-term organ transplant survival remains suboptimal, and life-long immunosuppression predisposes transplant recipients to an increased risk of infection, malignancy, and kidney toxicity. Promoting the regulatory arm of the immune system by expanding Tregs may allow immunosuppression minimization and improve long-term graft outcomes. While low-dose IL-2 treatment can expand Tregs, it has a short half-life and off-target expansion of NK and effector T cells, limiting its clinical applicability. Here, we designed a humanized mutein IL-2 with high Treg selectivity and a prolonged half-life due to the fusion of an Fc domain,...
Source: Journal of Clinical Investigation - March 1, 2024 Category: Biomedical Science Authors: Orhan Efe, Rodrigo B. Gassen, Leela Morena, Yoshikazu Ganchiku, Ayman Al Jurdi, Isadora T. Lape, Pedro Ventura-Aguiar, Christian LeGuern, Joren C. Madsen, Zachary Shriver, Gregory J. Babcock, Thiago J. Borges, Leonardo V. Riella Source Type: research
Reconstruction of the human nipple-areolar complex: a tissue engineering approach
Conclusion: Tissue engineering allowed us to create an acellular and biocompatible NAC with a preserved morphology, microarchitecture, and matrix proteins while maintaining their cell growth potential and ability to regenerate the skin epidermis. Thus, tissue engineering could provide a novel alternative to personalized and natural NAC reconstruction.PMID:38425730 | PMC:PMC10902434 | DOI:10.3389/fbioe.2023.1295075 (Source: Cancer Control)
Source: Cancer Control - March 1, 2024 Category: Cancer & Oncology Authors: Louis Maistriaux Vincent Foulon Lies Fiev é Daela Xhema Robin Evrard Julie Manon Maude Coyette Caroline Bouzin Yves Poumay Pierre Gianello Catherine Behets Beno ît Lengelé Source Type: research
The "Swing-Door" Regrafting of Donor Site: An Alternative Method for Split-Thickness Skin Graft in the Hand
Conclusion The "Swing-door" STSG is a useful alternative for treating hand skin defects.PMID:38425865 | PMC:PMC10901598 | DOI:10.1055/a-2166-8995 (Source: Hand Surgery)
Source: Hand Surgery - March 1, 2024 Category: Surgery Authors: Jin Soo Kim Chan Ju Park Sung Hoon Koh Dong Chul Lee Si Young Roh Kyung Jin Lee Source Type: research
Improvement of Shoulder Motion in Two-Stage Dual-Plane Implant-Based Breast Reconstruction followed by Radiation Therapy through Delayed Prepectoral Conversion
Conclusion Shoulder exercises in irradiated patients who underwent subpectoral reconstruction were improved by delayed prepectoral conversion using an ADM inlay graft. It is recommended that subpectoral reconstruction not be ruled out due to concerns regarding muscle contracture and shoulder morbidity in radiation-planned patients with poor mastectomy skin flaps.PMID:38425848 | PMC:PMC10901588 | DOI:10.1055/s-0043-1775591 (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - March 1, 2024 Category: Cosmetic Surgery Authors: Jin Sol Park Ung Sik Jin Source Type: research
The "Swing-Door" Regrafting of Donor Site: An Alternative Method for Split-Thickness Skin Graft in the Hand
Conclusion The "Swing-door" STSG is a useful alternative for treating hand skin defects.PMID:38425865 | PMC:PMC10901598 | DOI:10.1055/a-2166-8995 (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - March 1, 2024 Category: Cosmetic Surgery Authors: Jin Soo Kim Chan Ju Park Sung Hoon Koh Dong Chul Lee Si Young Roh Kyung Jin Lee Source Type: research
Improvement of Shoulder Motion in Two-Stage Dual-Plane Implant-Based Breast Reconstruction followed by Radiation Therapy through Delayed Prepectoral Conversion
Conclusion Shoulder exercises in irradiated patients who underwent subpectoral reconstruction were improved by delayed prepectoral conversion using an ADM inlay graft. It is recommended that subpectoral reconstruction not be ruled out due to concerns regarding muscle contracture and shoulder morbidity in radiation-planned patients with poor mastectomy skin flaps.PMID:38425848 | PMC:PMC10901588 | DOI:10.1055/s-0043-1775591 (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - March 1, 2024 Category: Cosmetic Surgery Authors: Jin Sol Park Ung Sik Jin Source Type: research
The "Swing-Door" Regrafting of Donor Site: An Alternative Method for Split-Thickness Skin Graft in the Hand
Conclusion The "Swing-door" STSG is a useful alternative for treating hand skin defects.PMID:38425865 | PMC:PMC10901598 | DOI:10.1055/a-2166-8995 (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - March 1, 2024 Category: Cosmetic Surgery Authors: Jin Soo Kim Chan Ju Park Sung Hoon Koh Dong Chul Lee Si Young Roh Kyung Jin Lee Source Type: research
Improvement of Shoulder Motion in Two-Stage Dual-Plane Implant-Based Breast Reconstruction followed by Radiation Therapy through Delayed Prepectoral Conversion
Conclusion Shoulder exercises in irradiated patients who underwent subpectoral reconstruction were improved by delayed prepectoral conversion using an ADM inlay graft. It is recommended that subpectoral reconstruction not be ruled out due to concerns regarding muscle contracture and shoulder morbidity in radiation-planned patients with poor mastectomy skin flaps.PMID:38425848 | PMC:PMC10901588 | DOI:10.1055/s-0043-1775591 (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - March 1, 2024 Category: Cosmetic Surgery Authors: Jin Sol Park Ung Sik Jin Source Type: research
The "Swing-Door" Regrafting of Donor Site: An Alternative Method for Split-Thickness Skin Graft in the Hand
Conclusion The "Swing-door" STSG is a useful alternative for treating hand skin defects.PMID:38425865 | PMC:PMC10901598 | DOI:10.1055/a-2166-8995 (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - March 1, 2024 Category: Cosmetic Surgery Authors: Jin Soo Kim Chan Ju Park Sung Hoon Koh Dong Chul Lee Si Young Roh Kyung Jin Lee Source Type: research
Antiproliferative and Antimigratory Activity of Poly-gallic Acid in Cancer Cell Lines
CONCLUSION: PGAL and PGAL-grafted amino acids are potential adjuvants for prostate cancer treatment, with improved physicochemical characteristics compared to GA.PMID:38423672 | DOI:10.21873/anticanres.16915 (Source: Cell Research)
Source: Cell Research - February 29, 2024 Category: Cytology Authors: Carmen G Hernandez-Valencia Griselda Rodriguez-Martinez Andres M Carriles-Perez Daniel Gonzalez-Perez Carmina Ortega-Sanchez Marco A Andonegui-Elguera Yessica Zamudio-Cuevas Javier Fernandez-Torres Miguel A Hernandez-Valdepena Miquel Gimeno Roberto Sanche Source Type: research
Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy
CONCLUSIONS: The findings indicated that naringenin treatment could promote flap survival by inhibiting pyroptosis, apoptosis, necroptosis, and alleviating oxidative stress, caused by the activation of autophagy.PMID:38423240 | DOI:10.1016/j.ejphar.2024.176455 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - February 29, 2024 Category: Drugs & Pharmacology Authors: Shuai Jiang Feixia Ma Junsheng Lou Jiafeng Li Xiushuai Shang Yifan Li Junsong Wu Sanzhong Xu Source Type: research
