Occupational Contact Dermatitis: An Individualized Approach to the Worker with Dermatitis
AbstractPurpose of ReviewTo provide an up-to-date, customizable approach to the worker presenting with dermatitis.Recent FindingsOccupational contact dermatitis (OCD) is often a result of combined allergic, irritant, and endogenous factors. Potential causes of OCD can be categorized in 3 main groupings: workplace materials, personal protective equipment, and skin care. Although patterns of dermatitis may provide some indication of the etiological factor(s), patch testing remains essential in the diagnosis of allergic OCD. Management of OCD may require changes in workplace practices to reduce worker exposure to the causativ...
Source: Current Dermatology Reports - September 14, 2021 Category: Dermatology Source Type: research

Social Media and Ethical Challenges for the Dermatologist
AbstractPurpose of ReviewThe purpose of review is to provide guidance on the use of social media within the context of dermatology and discuss its ethical, professional, and legal implications in education, mentorship, networking, business, and clinical settings.Recent FindingsDespite its fundamental value as a means of communication and knowledge sharing, social media carries legal, ethical, and professional challenges. Healthcare providers have run into issues such as misinformation, conflicts of interest, and overstepping patient-physician boundaries when using social media. An interesting finding is that dermatologists...
Source: Current Dermatology Reports - September 13, 2021 Category: Dermatology Source Type: research

Social Media for Marketing and Business Promotion in Dermatology
AbstractPurpose of ReviewWe explore the utility of social media platforms as marketing tools in dermatology, providing a summary of how these sites are used by the public and dermatologists alike and demonstrating ways these findings may be applied for professional and business development.Recent FindingsRecent studies reveal that 80% of patients use the Internet to acquire medical information, yet only 15% of dermatologists employ social media for professional purposes. Use of social media by patients seeking dermatologic care is overlooked among clinicians who are marketing their practices.SummaryUnique advertising niche...
Source: Current Dermatology Reports - September 8, 2021 Category: Dermatology Source Type: research

Contact Dermatitis to Essential Oils
This article provides a comprehensive overview regarding allergenicity, prevalence of positive patch test reactions, and sources of exposure associated with EOs.Recent FindingsApproximately 80 different EOs have been implicated in contact allergy. Patch testing EOs is important for identifying sensitivity not detected by screening fragrance allergens. Clinical presentation depends on the specific EO and method of use.SummaryEOs are complex substances of highly variable composition which may cause ACD. Due to popularity and widespread use, clinicians should ask patients about EO use. Patch testing is an important tool in th...
Source: Current Dermatology Reports - September 7, 2021 Category: Dermatology Source Type: research

International Teledermatology Review
AbstractPurpose of ReviewThe use of teledermatology has been evolving slowly for the delivery of health care to remote and underserved populations. Improving technology and the recent COVID-19 pandemic have hastened its use internationally.Recent FindingsSome barriers to the use of teledermatology have fallen considerably in the last year.SummaryTeledermatology use has increased significantly in recent years in both government-sponsored and private health care systems and individual practices. There are no recognized international practice guidelines and variable use within countries. Many barriers remain to increasing the...
Source: Current Dermatology Reports - July 28, 2021 Category: Dermatology Source Type: research

Allergic Contact Dermatitis in Patients with Atopic Dermatitis
AbstractPurpose of ReviewIt is still debated whether the risk of allergic contact dermatitis (ACD) is altered in patients with atopic dermatitis (AD). In this article, the recent literature on the risk of ACD in AD patients is reviewed and put into a clinical context.Recent FindingsACD is common in AD patients, but a literature review showed conflicting results on the exact risk compared to non-AD individuals. The development of ACD in AD patients is affected by the dysfunctional skin barrier in particular due to filaggrin deficiency, the Th2 inflammatory immune dysregulation, and microbial dysbiosis. While the increased e...
Source: Current Dermatology Reports - July 12, 2021 Category: Dermatology Source Type: research

Bedside Diagnostic Techniques in Dermatology
AbstractPurpose of ReviewTo review bedside diagnostic techniques in the modern dermatologic landscape.Recent FindingsMicroscopy has been a commonly used bedside technique for the diagnosis of various fungal, parasitic, and bacterial infections. Tzanck smears are another useful technique often used for diagnosing herpesvirus lesions, but evidence shows that its use could be expanded to include other conditions as well. Wood ’s light fluorescence is a simple non-invasive technique that has often been utilized to diagnose various bacterial, fungal, and pigmentation disorders, although its list of uses has not been exhau...
Source: Current Dermatology Reports - July 11, 2021 Category: Dermatology Source Type: research

Management of atopic dermatitis in the inpatient setting
AbstractPurpose of ReviewDespite the significant burden of inpatient hospitalization for AD, there are few reviews of inpatient management of AD. In this review, we address common indications for hospitalization in AD patients, the role of dermatology consultation, treatment considerations, and discharge planning.Recent FindingsThere are significant socioeconomic and racial/ethnic disparities that lead to increased risk of hospitalization and readmission for AD. A significant burden of mental health disorders in patients with AD can result in psychiatric emergencies and hospitalization in AD patients.SummaryThe mainstay of...
Source: Current Dermatology Reports - May 28, 2021 Category: Dermatology Source Type: research

A Scoping Review of Pharmacotherapy, Complementary, and Alternative Medicine (CAM), and Surgical Therapies for Androgenic Alopecia
AbstractPurpose of ReviewAndrogenic alopecia(AGA) is the most common form of non-scarring alopecia, affecting millions of men and women in the United States (U.S.). This review highlights alternative and complementary treatment options for AGA.Recent FindingsThe treatment regimens for AGA have increased in pharmacotherapeutics, surgical, and complementary (CAM) categories. Each of the different treatment approaches can now be utilized by dermatologists to combat patient hair loss.SummaryThe U.S. Food and Drug Administration (FDA) has approved only two agents to treat AGA: prescription-only, oral finasteride and over-the-co...
Source: Current Dermatology Reports - March 29, 2021 Category: Dermatology Source Type: research

Teledermatology in Military Settings
AbstractPurpose of ReviewThis review summarizes the history and usage of teledermatology in the US Military and potential directions in the future.Recent FindingsGiven the remote and austere environment that operational settings present, it is hard to provide specialized medical care for soldiers who are deployed. Telemedicine has been shown to improve health care in the military. It is well documented that non-life-threatening skin disease comprises the majority of specialty care requests in the deployed setting. Thus, teledermatology is a critical resource in military operational medical settings.SummaryTeledermatology c...
Source: Current Dermatology Reports - March 15, 2021 Category: Dermatology Source Type: research

Teledermatology Addressing Disparities in Health Care Access: a Review
AbstractPurpose of ReviewDermatologists have been at the forefront of researching telemedicine to expand access to care. The current COVID-19 pandemic has prompted even greater expansion and implementation of teledermatology. This review discusses the research examining the potential impact of teledermatology addressing disparities in care.Recent FindingsTeledermatology appears to increase access to dermatology given expanded means to deliver care. Specifically, recent studies have found increased access among Medicaid-insured, resource-poor urban and rural, and elderly populations. Teledermatology implementation also faci...
Source: Current Dermatology Reports - March 12, 2021 Category: Dermatology Source Type: research

Molecular Methods for Detection of Beta and Gammapapillomaviruses for Non-melanoma Skin Cancer
AbstractPurpose of reviewHuman Papillomaviruses (HPV) have some associations with that of the beta and gamma genera with non melanoma skin cancers (NMSC). The detection of HPV in clinical specimens is molecular-based since the isolation of the virus in in vitro cell lines has not been achieved. In this contest, we provide information about the choices of molecular methods applicable in epidemiological surveys.Recent findingsA limited number of assays have been developed to detect and genotype cutaneous HPVs (associated with NMSC). Consensus PCR followed by hybridization, consensus PCR followed by sequencing, multiplex PCR,...
Source: Current Dermatology Reports - January 19, 2021 Category: Dermatology Source Type: research

Deucravacitinib for Psoriasis
This article reviews the mechanism and significance of TYK2 inhibition, as well as the current data on the safety and efficacy of deucravacitinib.Recent FindingsPhase II results for deucravacitinib have shown that four out of six treatment groups resulted in statistically significant increases in PASI75 improvement over the placebo group. The most common adverse effects were headache, nasopharyngitis, upper respiratory tract infection, nausea, acne, and diarrhea. Three serious adverse events were noted in the treatment group, and they were gastroenteritis due to rotavirus, accidental eye injury, and dizziness.SummaryDeucra...
Source: Current Dermatology Reports - January 7, 2021 Category: Dermatology Source Type: research

Halobetasol Propionate and Tazarotene Combination Lotion 0.01%/0.045% for Psoriasis
This article reviews in detail the merits and unique nature of this combination lotion and also discusses a new type of strategy for treating psoriasis topically.Recent FindingsThe combination lotion proved much more efficacious than the vehicle. Moreover, when the combination lotion was compared head-to-head with each of the components alone (halobetasol, tazarotene) and vehicle lotion, the combination was clearly more efficacious after 8  weeks. In terms of safety, the combination lotion was well tolerated by the patients. The combination lotion is also unique in that it is the only superpotent topical steroid with ...
Source: Current Dermatology Reports - January 6, 2021 Category: Dermatology Source Type: research

Advancements in Biologic Therapy for Psoriasis: the IL-23 Inhibitors
AbstractPurpose of ReviewThe purpose of this article is to review clinical trials evaluating the efficacy and safety of IL-23 inhibitors in the treatment of moderate-to-severe plaque psoriasis and psoriatic arthritis.Recent FindingsGuselkumab, tildrakizumab, and risankizumab have been approved for the treatment of psoriasis. Mirikizumab is still under investigation in phase 3 studies. IL-23 inhibitors show excellent efficacy and outperform other biologic therapies in multiple head-to-head trials. Network meta-analyses have demonstrated that IL-23 inhibitors have superior long-term efficacy, while IL-17 inhibitors have supe...
Source: Current Dermatology Reports - January 4, 2021 Category: Dermatology Source Type: research

Phototherapy for Psoriasis: New Research and Insights
AbstractPurpose of ReviewThe purpose of the review is to highlight some of the new findings on phototherapy treatment for psoriasis and present clinical pearls for the practitioner.Recent FindingsRecent research has helped to further elucidate the molecular mechanisms of UV light in the treatment of psoriasis. New evidence regarding the combination of phototherapy with biologic agents and phototherapy ’s effect on quality of life is also highlighted.SummaryPhototherapy remains an effective and viable option for patients seeking non-invasive and safe treatment of psoriasis. Further research is still needed to understa...
Source: Current Dermatology Reports - January 4, 2021 Category: Dermatology Source Type: research

A Framework-Driven Systematic Review of the Barriers and Facilitators to Teledermatology Implementation
AbstractPurpose of ReviewTelemedicine use in dermatology, termed “teledermatology”, offers a cost-effective model to improve healthcare efficiency and access. Only a minority of dermatology practices has integrated teledermatology into their practice prior to COVID-19. A thorough understanding of the barriers and facilitators may promote teledermatology adopt ion. Implementation science frameworks offer theoretically driven ways to assess factors affecting teledermatology implementation. This review uses a comprehensive implementation science framework to summarize barriers and facilitators of teledermatology i...
Source: Current Dermatology Reports - November 12, 2020 Category: Dermatology Source Type: research

Update on IL-17 Inhibitors for Psoriasis
AbstractPurpose of ReviewPsoriasis is a common chronic, inflammatory skin condition. The pathogenesis of psoriasis involves many cytokines in the IL-17 family and their subsequent signaling cascade; therefore, IL-17 inhibitors may have utility in the treatment of psoriasis. This review aims to evaluate the efficacy and safety of IL-17 inhibitors and their emerging role as a therapeutic option for patients with psoriasis.Recent FindingsIn multiple phase III clinical trials, IL-17 inhibitors were more efficacious than placebo or slightly more efficacious in comparisons to many other systemic and biologic treatments. Overall,...
Source: Current Dermatology Reports - November 11, 2020 Category: Dermatology Source Type: research

Venous Procedures to Treat Venous Leg Ulcers
ConclusionMinimally invasive procedures have replaced open surgical techniques as a means of treating VLUs. EVLA and UGFS appear to be safe and effective treatment options for most patients. (Source: Current Dermatology Reports)
Source: Current Dermatology Reports - November 10, 2020 Category: Dermatology Source Type: research

Clinical Implications of Cellular Senescence on Wound Healing
AbstractPurpose of ReviewCellular senescence, a process where cells reach maximum proliferative capacity ceasing division without cell death, is involved in numerous processes, including organismal aging, tissue repair, and wound healing. Here, we review mechanisms underlying cellular senescence and discuss the role of different forms of senescence in physiologic cutaneous wound healing and in the pathology of non-healing wounds.Recent FindingsIn terms of wound healing, studies have shown that the cellular senescence exhibits a paradoxical effects where on one hand it promotes activity and differentiation of fibroblasts ne...
Source: Current Dermatology Reports - November 7, 2020 Category: Dermatology Source Type: research

Wound Dressings – A Practical Review
AbstractPurpose of ReviewThere are currently thousands of wound dressing products and materials available on the market. Despite the wide selection, there is no universally superior dressing, which prompts healthcare providers to choose materials that are most suitable to each particular case. This review provides an overview of various types of wound dressings, suggested uses, and recent advancements.Recent FindingsModern dressings have evolved to encompass an expansive array of semipermeable films and foams, hydrofibers, hydrogels, hydrocolloids, and alginates. Recent studies have investigated new technologies such as el...
Source: Current Dermatology Reports - November 5, 2020 Category: Dermatology Source Type: research

Topical Therapies for Psoriasis in Phase 3 Trials
AbstractPurpose of ReviewThis review will discuss new topical therapeutics for psoriasis that have undergone or published phase III trials in the last 5  years, as well as promising therapeutics in development.Recent FindingsNew corticosteroid-only additions to the marketplace include formulations that improve absorption and ease-of-use, including betamethasone dipropionate (BD) 0.05% spray, halobetasol propionate (HP) 0.05% foam and 0.01% lotion, and clobetasol propionate 0.025% cream. Combination therapies include BD 0.064% plus calcipotriene 0.005% (Cal/BD) foam, Cal/BD cream, and HP 0.01% plus tazarotene 0.045% lo...
Source: Current Dermatology Reports - November 5, 2020 Category: Dermatology Source Type: research

Inpatient Dermatology Best Practice Strategies for Educating and Relaying Findings to Colleagues
AbstractPurpose of ReviewThis review examines the role of education and relaying findings to non-dermatologist colleagues when performing inpatient dermatology consults. We highlight best practices for communication and education.Recent FindingsNon-dermatologists receive minimal training on the diagnosis and the management of skin conditions. Efforts to teach dermatology in the inpatient setting via traditional didactics have been met with limited success, and hospitalists have indicated a desire to learn from specialists. Incorporating education into standard consultation practices including the note, one-on-one communica...
Source: Current Dermatology Reports - October 27, 2020 Category: Dermatology Source Type: research

Calciphylaxis: Diagnostic and Treatment Advances for the Inpatient Dermatologist
This article provides a comprehensive overview of the risk factors, classification, and pathogenesis of calciphylaxis, and summarizes current evidence for diagnostic testing and multi-disciplinary therapeutic management.Recent FindingsThe two major subtypes of calciphylaxis tend to present in different anatomic locations, with non-uremic lesions favoring the distal extremities. Skin biopsies obtained on the distal extremities are more sensitive in detecting calciphylaxis-related vascular calcifications, compared to other sites. Underlying hypercoagulable disorders are common among calciphylaxis patients, implicating thromb...
Source: Current Dermatology Reports - October 18, 2020 Category: Dermatology Source Type: research

Vitamin D Update
AbstractPurposeThe goal of this review is to provide an update in the field of vitamin D, in particular, the role of vitamin D in non-skeletal health, the complexity of providing patient guidance regarding obtaining sufficient vitamin D, and the possible involvement of vitamin D in morbidity and mortality due to SARS-CoV-2 (COVID-19).Recent FindingsIn addition to bone health, vitamin D may play a role in innate immunity, cardiovascular disease, and asthma. Although rickets is often regarded as an historical disease of the early twentieth century, it appears to be making a comeback worldwide, including “first-world&rd...
Source: Current Dermatology Reports - October 14, 2020 Category: Dermatology Source Type: research

Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist
AbstractPurpose of ReviewProgrammed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous adverse events (irCAEs) to PD-1 and PD-L1 inhibitors, with emphasis on disease processes practitioners may encounter in hospitalized patients.Recent FindingsA systematic approach for suspected irCAEs has been well-detailed in recent clinical guidelines. However, the breadth of irCAE manifestations and treatment options co...
Source: Current Dermatology Reports - September 28, 2020 Category: Dermatology Source Type: research

Systemic Lupus Erythematosus: Considerations in Diagnosis and Management for the Inpatient Dermatologist
AbstractPurpose of ReviewHospitalization of systemic lupus erythematosus (SLE) patients is frequent and most often due to disease flares and infection. Herein, we describe the clinical features and therapy for specific and nonspecific cutaneous manifestations of hospitalized lupus patients.Recent FindingsNew insights of the pathogenic mechanisms of SLE allow consideration of novel therapeutic targets and strategies. The precise role of these treatments for hospitalized SLE patients requires further study.SummarySevere lupus-specific cutaneous eruptions important for the inpatient dermatologist include acute cutaneous lupus...
Source: Current Dermatology Reports - September 23, 2020 Category: Dermatology Source Type: research

Epidemiologic Burden of Skin Cancer in the US and Worldwide
AbstractPurpose of ReviewSkin cancer is one of the leading causes of skin disease burden worldwide. This systematic review provides an overview of the United States (US) and global melanoma and non-melanoma skin cancer (NMSC) epidemiologic studies published in the last 5  years.Recent FindingsThe incidence of melanoma and NMSC continues to rise both in the US and worldwide. The highest global age-standardized incidence rates (ASIRs) for melanoma were Australasia, North America, Eastern Europe, Western Europe, and Central Europe. Various results were reported for the mortality of skin cancer; however, overall, the mort...
Source: Current Dermatology Reports - September 17, 2020 Category: Dermatology Source Type: research

Correction to: Systemic Photoprotection
The original version of this article did not include the results from articles showing a more favorable side effect profile with a controlled-release subcutaneous implant of afamelanotide. (Source: Current Dermatology Reports)
Source: Current Dermatology Reports - September 16, 2020 Category: Dermatology Source Type: research

Approaching Target and Targetoid Eruptions in Inpatient Dermatology
AbstractPurpose of ReviewTo summarize the differential diagnosis and describe a clinical approach for the evaluation of target and targetoid lesions in hospitalized patients.Recent FindingsImportant diagnostic considerations for target and targetoid lesions in an inpatient setting include erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis, mycoplasma-associated rash and mucositis, fixed drug eruption, urticaria multiforme, subacute cutaneous lupus erythematosus, and Rowell syndrome. Less frequent diagnoses may include erythema migrans, arthropod bite, erythema gyratum repens, erythema annulare centrif...
Source: Current Dermatology Reports - August 25, 2020 Category: Dermatology Source Type: research

Climate Change and Inpatient Dermatology
AbstractPurpose of ReviewClimate change represents a major existential threat facing the global community, and it has already begun to affect human health in a multitude of ways. This review highlights and discusses the implications that climate change has already had and is expected to have for inpatient dermatologists.Recent FindingsThere are a variety of conditions affected by climate changes. The distribution and frequencies of infectious diseases and their vectors are changing in line with variations in climate conditions. Increased temperatures have already been associated with exacerbation of existing skin condition...
Source: Current Dermatology Reports - August 21, 2020 Category: Dermatology Source Type: research

Light-Based Devices for Wound Healing
AbstractPurpose of ReviewThe goal of this review is to provide a broad overview of light-based treatments that have shown effectiveness in enhancing various aspects of wound healing, examine the drawbacks that have impeded the translation of some light-based therapies into clinical use, and highlight scenarios where these treatments may confer benefits over current standards in wound care.Recent FindingsSeveral categories of light-based treatments, in particular laser debridement, fractional photothermolysis, and photodynamic therapy, have seen exciting recent clinical results that may justify expanding the use of these mo...
Source: Current Dermatology Reports - August 21, 2020 Category: Dermatology Source Type: research

Photocarcinogenesis
AbstractPurpose of ReviewSkin cancers account for more than 40% of all cancers in the USA and continue to rise in incidence. It is prudent to understand the current burden and pathogenesis of photocarcinogenesis and preventive measures.Recent FindingsInsights into recently discovered mechanisms have paved way for potential targets for prevention and therapeutics. Nicotinamide has shown promising results as an oral chemopreventive agent. UVB affects the DHODH pathway of pyrimidine synthesis via STAT 3. DHODH inhibition by leflunomide may be a potential targeted chemoprevention strategy. A photolyase containing sunscreen, wh...
Source: Current Dermatology Reports - July 12, 2020 Category: Dermatology Source Type: research

Systemic Photoprotection
AbstractPurpose of ReviewSystemic photoprotection is an attractive concept; however, its use has been limited by a lack of robust evidence. We performed a review to evaluate the evidence for systemic photoprotection and skin cancer prevention in humans by vitamins C, D and E, carotenoids, nicotinamide, retinoids, polyphenols,Polypodium leucotomos extract, NSAIDs and afamelanotide.Recent FindingsIn a randomized controlled trial, compared with placebo, a 13% reduction in actinic keratoses and a 23% reduction in keratinocyte carcinoma were found with continued nicotinamide use over 12  months, although the result should ...
Source: Current Dermatology Reports - June 26, 2020 Category: Dermatology Source Type: research

Current Economic Evidence for Teledermoscopy
AbstractPurpose of ReviewStore-and-forward teledermoscopy involves capturing dermoscopic images and sending them with relevant clinical information for review by a dermatologist. Teledermoscopy increases access to timely dermatology surveillance and diagnosis, which is important given the low ratio of dermatologists to the general population in many countries. Here we summarise the current economic evidence available for teledermoscopy, focusing on three stakeholders: the health system, consumers, and practitioners.Recent FindingsCompared with in-person consultations store-and-forward teledermoscopy has been found to have ...
Source: Current Dermatology Reports - April 6, 2020 Category: Dermatology Source Type: research

The Skin Microbiome in Inflammatory Skin Diseases
AbstractPurpose of ReviewOngoing investigations of the human skin microbiome strongly suggest a connection to skin diseases and skin health. This review provides an overview of recent literature on the skin microbiome in relation to skin diseases, with a specific focus on common inflammatory skin conditions, such as atopic dermatitis, psoriasis, hidradenitis suppurativa, acne, and rosacea.Recent FindingsIn healthy subjects, the skin microbiome mediates fundamental processes involving the immune response and epidermal development and differentiation. Microbiome characteristics in inflammatory skin diseases differ depending ...
Source: Current Dermatology Reports - March 16, 2020 Category: Dermatology Source Type: research

Photosensitivity in Lupus Erythematosus and Dermatomyositis
AbstractPurpose of ReviewPhotosensitivity is a common symptom in the autoimmune diseases lupus erythematosus (LE) and dermatomyositis (DM). This review provides a framework for dermatologists, rheumatologists, and general practitioners to aid in recognizing and understanding photosensitivity reactions within the scope of these conditions.Recent FindingsPhotosensitivity reactions encompass not only cutaneous symptoms but also include systemic manifestations. Prevalence of photosensitivity is high in both LE and DM and tends to vary based on race and geographical location. Pathophysiology implicates the various effects of ul...
Source: Current Dermatology Reports - March 15, 2020 Category: Dermatology Source Type: research

Phenotypes of Canine Atopic Dermatitis
AbstractPurpose of ReviewCanine atopic dermatitis is a model of human atopic dermatitis. This review provides an outline and discussion of clinical and other phenotypes of atopic dermatitis in dogs to better understand this disease in both dogs and humans.Recent FindingsAlthough phenotypes of canine atopic dermatitis can vary widely, there is little research in dogs that has identified reliable phenotypic markers to be able to predict disease progression or response to therapy.SummaryCurrently, canine atopic dermatitis patients need individually tailored therapy without the practitioner understanding why a certain treatmen...
Source: Current Dermatology Reports - March 13, 2020 Category: Dermatology Source Type: research

JAK Inhibitors for Psoriasis and Psoriatic Arthritis
This article reviews the utility and clinical significance of JAK inhibitors for the treatment of psoriatic disease —both psoriatic arthritis and plaque psoriasis—as demonstrated in clinical trials.Recent FindingsTofacitinib, the most widely studied of the JAK inhibitors in psoriatic disease, has demonstrated significant efficacy for the treatment of both psoriatic arthritis and plaque psoriasis. However, while it received approval from the US Food and Drug Association for the former indication, it was denied for the latter. This has not deterred the development of newer JAK inhibitors which hope to provide a b...
Source: Current Dermatology Reports - March 9, 2020 Category: Dermatology Source Type: research

Teledermatology in Medical and Continuing Education
AbstractPurpose of ReviewTeledermatology improves access to dermatologic care and has the potential to lower health care costs. Although teledermatology use is increasing in practice, a minority of dermatology programs incorporate teledermatology into resident training. This review summarizes the current state of teledermatology education for both dermatologists and non-dermatologists.Recent FindingsLess than half of dermatology residency programs include teledermatology in their curriculum. Teledermatology offers educational opportunities for dermatology and non-dermatology trainees and practitioners through both remote a...
Source: Current Dermatology Reports - March 8, 2020 Category: Dermatology Source Type: research

“Teledermatopathology: A Review”
AbstractPurpose of ReviewIn this review, we will cover definitions of relevant terms, present need, technologic requirements, regulation, validation, and current and emerging applications of teledermatopathology.Recent FindingsNumerous studies have found no significant diagnostic discordance between teledermatopathology and glass microscopy in evaluation of melanocytic, non-melanocytic, and inflammatory diagnoses. Teledermatopathology has led to a significant difference in patient management in low-resource settings. Furthermore, studies using static images acquired using smartphones and microscope adapters have high diagn...
Source: Current Dermatology Reports - March 8, 2020 Category: Dermatology Source Type: research

Recognition and Management of Angioinvasive Fungal Infections
AbstractPurpose of ReviewTo describe the clinical features, diagnosis, and treatment of angioinvasive fungal infections.Recent FindingsCandida auris is a recently discovered species with multi- to pan-drug resistance to azoles, amphotericin B, and echinocandins. The SECURE trial showed that isavuconazole was non-inferior to voriconazole for treatment ofAspergillus. Additionally, the VITAL study showed that there was no difference in mortality between those treated with either isavuconazole or amphotericin B. Isavuconazole is now approved by the FDA for the treatment ofAspergillus andMucor.SummaryInvasive fungal infections ...
Source: Current Dermatology Reports - March 6, 2020 Category: Dermatology Source Type: research

New Developments in Bacterial, Viral, and Fungal Cutaneous Infections
AbstractPurpose of ReviewThis review highlights clinically relevant updates to common and significant bacterial, viral, and fungal cutaneous infection within the past 5  years. Recent developments are presented so that the clinician may provide evidence-based, high-quality patient care.Recent FindingsNew resistance patterns in cutaneous pathogens have recently emerged as a result of inappropriate antimicrobial use. Several new FDA-approved antimicrobials have been approved to treat such infections, including multi-drug resistant pathogens. Several organizational guidelines for cutaneous infection management have been ...
Source: Current Dermatology Reports - March 4, 2020 Category: Dermatology Source Type: research

Teledermatology for Skin Cancer: The Australian Experience
AbstractPurpose of ReviewThis review aims to understand how Australia compares internationally in the practice of teledermatology for the diagnosis and management of skin cancer, and in the process, ascertain the robustness of the evidence for teledermatology, as well as identify its limitations and current difficulties for its adoption in Australia.Recent FindingsDiagnostic and treatment concordance, time to detection and action, as well as expected cost in Australia were comparable with international studies. Earlier detection of skin cancer and convenience such as reduced travel are main reasons supportive of teledermat...
Source: Current Dermatology Reports - March 2, 2020 Category: Dermatology Source Type: research

Certolizumab Pegol for Psoriasis and Psoriatic Arthritis
AbstractPurpose of ReviewThe purpose of this review is to provide an overview of the use of certolizumab pegol (Cimzia ®, UCB S.A.) for psoriasis and psoriatic arthritis and summarize important findings.Recent FindingsThree pivotal phase three clinical trials CIMPASI-1, CIMPASI-2, and CIMPACT have demonstrated efficacy and safety of certolizumab pegol (CZP) in patients with plaque psoriasis. In addition, another multicenter phase three clinical trial, RAPID-PsA, has shown long-term efficacy and safety data of CZP in psoriatic arthritis.SummaryWhen compared with other TNF-alpha blockers, CZP has demonstrated increased e...
Source: Current Dermatology Reports - March 2, 2020 Category: Dermatology Source Type: research

Pediatric Teledermatology: a Review
This article reviews teledermatology terminology and summarizes the recent literature supporting pediatric teledermatology ’s diagnostic accuracy, efficacy, usability and cost-effectiveness.Recent FindingsDiagnoses rendered using pediatric teledermatology share high concordance rates with in-person diagnoses. While most dermatologists prefer store and forward compared to real-time interactive teledermatology, a hybrid model may be advantageous for complex cases. Physician-to-physician teledermatology is ideal for pediatric inpatient and outpatient consultations, while direct-to-patient teledermatology may be more eff...
Source: Current Dermatology Reports - February 28, 2020 Category: Dermatology Source Type: research

Molluscum Contagiosum: Review and Update on Clinical Presentation, Diagnosis, Risk, Prevention, and Treatment
AbstractPurpose of ReviewMolluscum contagiosum (MC) is a self-limited cutaneous viral infection that most commonly affects children and immunocompromised populations. This review provides an update on the clinical manifestations, risk, diagnosis, treatment, and prevention of this frequently encountered infection.Recent FindingsA recent Cochrane review concluded that there is insufficient evidence to establish the superiority of any specific treatment modality or to confirm that active intervention is superior to benign neglect (van der Wouden JC et al., Cochrane Database Syst Rev 5:CD004767, 2017). Interim pilot study data...
Source: Current Dermatology Reports - February 19, 2020 Category: Dermatology Source Type: research

Wound Management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
AbstractPurpose of ReviewStevens-Johnson syndrome and toxic epidermal necrolysis are severe mucocutaneous drug reactions associated with a potentially high mortality rate. They are characterized by epidermal necrosis and extensive detachment. For these reasons, wound care is a fundamental component of patient management. However, there is a lack of evidence-based data, and treatment approaches can vary drastically between institutions. Our aim was to analyze the available studies on this topic as an attempt to review various management strategies.Recent FindingsConsidering the rarity, variable presentations, and difficulty...
Source: Current Dermatology Reports - January 29, 2020 Category: Dermatology Source Type: research

What Can We Learn from Canine Atopic Dermatitis History?
AbstractPurpose of ReviewUnderstanding the origin and shaping the current knowledge of canine atopic dermatitis (cAD) with an emphasis on its similarities and differences with its human counterpart, human atopic dermatitis (hAD), has been the purpose of this study.Recent FindingFundamental research on the ethiopathogenesis and recent specific therapeutic findings have gradually reclassified cAD from a single disease to a multifactorial syndrome.SummaryFrom first being referred to as “red mange” or “canine eczema” in a dog reacting to ragweed pollen, cAD has then been considered to be the canine coun...
Source: Current Dermatology Reports - January 27, 2020 Category: Dermatology Source Type: research

Bimekizumab
AbstractPurpose of ReviewBimekizumab, a novel monoclonal antibody directed against both interleukin (IL)-17A and IL-17F, is in clinical development as a treatment for psoriasis and psoriatic arthritis. The purpose of this review is to highlight the roles of IL-17A and IL-17F in psoriatic inflammation as well as the clinical data on bimekizumab that has been reported to date.Recent FindingsPhase 2 efficacy results with bimekizumab have demonstrated high levels of rapid skin clearance in psoriasis patients, and high levels of joint disease improvement in psoriatic arthritis patients. Thus far, safety concerns have been limit...
Source: Current Dermatology Reports - January 20, 2020 Category: Dermatology Source Type: research