Cellulitis and Its Mimickers: an Approach to Diagnosis and Management
This article reviews the pathophysiology, clinical presentation, clinical mimickers, and management strategies for cellulitis in hospitalized patients.Recent FindingsCellulitis is a common skin infection with increasing hospitalizations and healthcare costs. The clinical presentation of cellulitis is mimicked by a wide spectrum of diagnoses including other infectious, inflammatory, vascular, and neoplastic conditions. Evaluating for and optimizing modifiable risk factors is paramount to treating cellulitis and preventing recurrences. These include local factors such as edema, previous cellulitis, skin barrier disruption du...
Source: Current Dermatology Reports - August 15, 2022 Category: Dermatology Source Type: research
Inpatient Considerations in the Diagnosis and Management of the Cutaneous T-Cell Lymphoma Patient
AbstractPurpose of ReviewTo review when to consider a diagnosis of cutaneous T-cell lymphoma (CTCL) in the inpatient setting and the diagnostic approach, as well as complications of disease and treatment that could lead to hospitalization.Recent FindingsCutaneous T-cell lymphomas (CTCLs) are a diverse group of non-Hodgkin lymphomas that are difficult to diagnosis as the initial presentation can mimic other benign inflammatory or infectious conditions of the skin. While the clinical course is typically indolent, with most cases normally diagnosed and managed in the outpatient settings, some CTCL-associated clinical scenario...
Source: Current Dermatology Reports - August 5, 2022 Category: Dermatology Source Type: research
Contact Dermatitis in the Inpatient Hospital Setting –an Updated Review of the Literature
AbstractPurpose of ReviewContact dermatitis (CD) is a common reason for dermatology consultation in hospitalized patients. We provide an updated comprehensive review of CD in the inpatient setting that highlights relevant exposure sources stratified by medical and surgical specialties.Recent FindingsContemporary studies show that CD is diagnosed in approximately 2 –8% of inpatient dermatology consultations. CD is an important mimicker of cellulitis whose early recognition and treatment can improve patient and health system outcomes. Inpatients are at risk for CD due to exposure to a wide variety of irritants and allergen...
Source: Current Dermatology Reports - August 4, 2022 Category: Dermatology Source Type: research
Neutrophilic Dermatosis and Management Strategies for the Inpatient Dermatologist
AbstractPurpose of ReviewNeutrophilic dermatoses are a heterogeneous group of disorders with significant overlap in associated conditions, clinical presentation, and histopathologic features. This review provides a structural overview of neutrophilic dermatoses that may present in the inpatient setting along with diagnostic work-up and management strategies.Recent FindingsSweet ’s syndrome has been found in patients with coronavirus disease 2019 (COVID-19). Pyoderma gangrenosum (PG) has been shown to be equally associated with ulcerative colitis and Crohn’s disease. A clinical trial shows that cyclosporine is equally e...
Source: Current Dermatology Reports - July 16, 2022 Category: Dermatology Source Type: research
PI3K Inhibitor Eruptions: an Overview of Diagnostic and Management Strategies for the Inpatient Dermatologist
AbstractPurpose of ReviewOveractivation of the phosphoinositide 3-kinase (PI3K) pathway plays a significant role in the oncogenesis of a majority of malignancies and is therefore of significant interest as a target for cancer therapy. Within recent years, five PI3K inhibitors (PI3Ki) have been approved, with others currently undergoing evaluation in clinical trials. In clinical trials, dermatologic adverse events (dAE) were among the most frequent adverse events reported. The goal of this review is to provide dermatologists with an overview of the diagnosis and management of dAE due to PI3Ki.Recent FindingsIn clinical tria...
Source: Current Dermatology Reports - July 14, 2022 Category: Dermatology Source Type: research
Psychological Considerations in Patients Undergoing Patch Testing
AbstractPurpose of ReviewPatch testing is the gold standard evaluation for allergic contact dermatitis, but there are important psychological considerations to be aware of. This review provides a stepwise, holistic approach for addressing patients who present for patch testing.Recent FindingsIt is important to clarify expectations prior to patch testing to mitigate potential disappointment as well as counsel patients on other possible conditions that mimic allergic contact dermatitis. Often, clinical severity does not correlate with the degree to which patients are psychologically distressed by their condition. Common como...
Source: Current Dermatology Reports - July 9, 2022 Category: Dermatology Source Type: research
Human Skin Cancer: an Overview Of Animal, Ex Vivo, and In Vitro Models
AbstractPurpose of ReviewSkin cancer is the most prevalent human cancer and has presented a considerable world incidence rate increase over the last years. While animals offer highly complex systems to study skin cancer biology, ethical concerns and the differences found between the human and animal skin have promoted the development of alternative methods. In this review, we provide an overview of the most important skin cancer models and describe the advantages of in vitro substitutes over ex vivo and animal models. To facilitate understanding, an insight into the biology of skin cancer is also given.Recent FindingsCurre...
Source: Current Dermatology Reports - June 18, 2022 Category: Dermatology Source Type: research
