A Framework-Driven Systematic Review of the Barriers and Facilitators to Teledermatology Implementation
AbstractPurpose of ReviewTelemedicine use in dermatology, termed “teledermatology”, offers a cost-effective model to improve healthcare efficiency and access. Only a minority of dermatology practices has integrated teledermatology into their practice prior to COVID-19. A thorough understanding of the barriers and facilitators may promote teledermatology adopt ion. Implementation science frameworks offer theoretically driven ways to assess factors affecting teledermatology implementation. This review uses a comprehensive implementation science framework to summarize barriers and facilitators of teledermatology implement...
Source: Current Dermatology Reports - November 12, 2020 Category: Dermatology Source Type: research
Update on IL-17 Inhibitors for Psoriasis
AbstractPurpose of ReviewPsoriasis is a common chronic, inflammatory skin condition. The pathogenesis of psoriasis involves many cytokines in the IL-17 family and their subsequent signaling cascade; therefore, IL-17 inhibitors may have utility in the treatment of psoriasis. This review aims to evaluate the efficacy and safety of IL-17 inhibitors and their emerging role as a therapeutic option for patients with psoriasis.Recent FindingsIn multiple phase III clinical trials, IL-17 inhibitors were more efficacious than placebo or slightly more efficacious in comparisons to many other systemic and biologic treatments. Overall,...
Source: Current Dermatology Reports - November 11, 2020 Category: Dermatology Source Type: research
Venous Procedures to Treat Venous Leg Ulcers
ConclusionMinimally invasive procedures have replaced open surgical techniques as a means of treating VLUs. EVLA and UGFS appear to be safe and effective treatment options for most patients. (Source: Current Dermatology Reports)
Source: Current Dermatology Reports - November 10, 2020 Category: Dermatology Source Type: research
Clinical Implications of Cellular Senescence on Wound Healing
AbstractPurpose of ReviewCellular senescence, a process where cells reach maximum proliferative capacity ceasing division without cell death, is involved in numerous processes, including organismal aging, tissue repair, and wound healing. Here, we review mechanisms underlying cellular senescence and discuss the role of different forms of senescence in physiologic cutaneous wound healing and in the pathology of non-healing wounds.Recent FindingsIn terms of wound healing, studies have shown that the cellular senescence exhibits a paradoxical effects where on one hand it promotes activity and differentiation of fibroblasts ne...
Source: Current Dermatology Reports - November 7, 2020 Category: Dermatology Source Type: research
Wound Dressings – A Practical Review
AbstractPurpose of ReviewThere are currently thousands of wound dressing products and materials available on the market. Despite the wide selection, there is no universally superior dressing, which prompts healthcare providers to choose materials that are most suitable to each particular case. This review provides an overview of various types of wound dressings, suggested uses, and recent advancements.Recent FindingsModern dressings have evolved to encompass an expansive array of semipermeable films and foams, hydrofibers, hydrogels, hydrocolloids, and alginates. Recent studies have investigated new technologies such as el...
Source: Current Dermatology Reports - November 5, 2020 Category: Dermatology Source Type: research
Topical Therapies for Psoriasis in Phase 3 Trials
AbstractPurpose of ReviewThis review will discuss new topical therapeutics for psoriasis that have undergone or published phase III trials in the last 5 years, as well as promising therapeutics in development.Recent FindingsNew corticosteroid-only additions to the marketplace include formulations that improve absorption and ease-of-use, including betamethasone dipropionate (BD) 0.05% spray, halobetasol propionate (HP) 0.05% foam and 0.01% lotion, and clobetasol propionate 0.025% cream. Combination therapies include BD 0.064% plus calcipotriene 0.005% (Cal/BD) foam, Cal/BD cream, and HP 0.01% plus tazarotene 0.045% lotion...
Source: Current Dermatology Reports - November 5, 2020 Category: Dermatology Source Type: research
Inpatient Dermatology Best Practice Strategies for Educating and Relaying Findings to Colleagues
AbstractPurpose of ReviewThis review examines the role of education and relaying findings to non-dermatologist colleagues when performing inpatient dermatology consults. We highlight best practices for communication and education.Recent FindingsNon-dermatologists receive minimal training on the diagnosis and the management of skin conditions. Efforts to teach dermatology in the inpatient setting via traditional didactics have been met with limited success, and hospitalists have indicated a desire to learn from specialists. Incorporating education into standard consultation practices including the note, one-on-one communica...
Source: Current Dermatology Reports - October 27, 2020 Category: Dermatology Source Type: research
Calciphylaxis: Diagnostic and Treatment Advances for the Inpatient Dermatologist
This article provides a comprehensive overview of the risk factors, classification, and pathogenesis of calciphylaxis, and summarizes current evidence for diagnostic testing and multi-disciplinary therapeutic management.Recent FindingsThe two major subtypes of calciphylaxis tend to present in different anatomic locations, with non-uremic lesions favoring the distal extremities. Skin biopsies obtained on the distal extremities are more sensitive in detecting calciphylaxis-related vascular calcifications, compared to other sites. Underlying hypercoagulable disorders are common among calciphylaxis patients, implicating thromb...
Source: Current Dermatology Reports - October 18, 2020 Category: Dermatology Source Type: research
Vitamin D Update
AbstractPurposeThe goal of this review is to provide an update in the field of vitamin D, in particular, the role of vitamin D in non-skeletal health, the complexity of providing patient guidance regarding obtaining sufficient vitamin D, and the possible involvement of vitamin D in morbidity and mortality due to SARS-CoV-2 (COVID-19).Recent FindingsIn addition to bone health, vitamin D may play a role in innate immunity, cardiovascular disease, and asthma. Although rickets is often regarded as an historical disease of the early twentieth century, it appears to be making a comeback worldwide, including “first-world” cou...
Source: Current Dermatology Reports - October 14, 2020 Category: Dermatology Source Type: research
Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist
AbstractPurpose of ReviewProgrammed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous adverse events (irCAEs) to PD-1 and PD-L1 inhibitors, with emphasis on disease processes practitioners may encounter in hospitalized patients.Recent FindingsA systematic approach for suspected irCAEs has been well-detailed in recent clinical guidelines. However, the breadth of irCAE manifestations and treatment options co...
Source: Current Dermatology Reports - September 28, 2020 Category: Dermatology Source Type: research
Systemic Lupus Erythematosus: Considerations in Diagnosis and Management for the Inpatient Dermatologist
AbstractPurpose of ReviewHospitalization of systemic lupus erythematosus (SLE) patients is frequent and most often due to disease flares and infection. Herein, we describe the clinical features and therapy for specific and nonspecific cutaneous manifestations of hospitalized lupus patients.Recent FindingsNew insights of the pathogenic mechanisms of SLE allow consideration of novel therapeutic targets and strategies. The precise role of these treatments for hospitalized SLE patients requires further study.SummarySevere lupus-specific cutaneous eruptions important for the inpatient dermatologist include acute cutaneous lupus...
Source: Current Dermatology Reports - September 23, 2020 Category: Dermatology Source Type: research
Epidemiologic Burden of Skin Cancer in the US and Worldwide
AbstractPurpose of ReviewSkin cancer is one of the leading causes of skin disease burden worldwide. This systematic review provides an overview of the United States (US) and global melanoma and non-melanoma skin cancer (NMSC) epidemiologic studies published in the last 5 years.Recent FindingsThe incidence of melanoma and NMSC continues to rise both in the US and worldwide. The highest global age-standardized incidence rates (ASIRs) for melanoma were Australasia, North America, Eastern Europe, Western Europe, and Central Europe. Various results were reported for the mortality of skin cancer; however, overall, the mortalit...
Source: Current Dermatology Reports - September 17, 2020 Category: Dermatology Source Type: research
Correction to: Systemic Photoprotection
The original version of this article did not include the results from articles showing a more favorable side effect profile with a controlled-release subcutaneous implant of afamelanotide. (Source: Current Dermatology Reports)
Source: Current Dermatology Reports - September 16, 2020 Category: Dermatology Source Type: research
Approaching Target and Targetoid Eruptions in Inpatient Dermatology
AbstractPurpose of ReviewTo summarize the differential diagnosis and describe a clinical approach for the evaluation of target and targetoid lesions in hospitalized patients.Recent FindingsImportant diagnostic considerations for target and targetoid lesions in an inpatient setting include erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis, mycoplasma-associated rash and mucositis, fixed drug eruption, urticaria multiforme, subacute cutaneous lupus erythematosus, and Rowell syndrome. Less frequent diagnoses may include erythema migrans, arthropod bite, erythema gyratum repens, erythema annulare centrif...
Source: Current Dermatology Reports - August 25, 2020 Category: Dermatology Source Type: research
Climate Change and Inpatient Dermatology
AbstractPurpose of ReviewClimate change represents a major existential threat facing the global community, and it has already begun to affect human health in a multitude of ways. This review highlights and discusses the implications that climate change has already had and is expected to have for inpatient dermatologists.Recent FindingsThere are a variety of conditions affected by climate changes. The distribution and frequencies of infectious diseases and their vectors are changing in line with variations in climate conditions. Increased temperatures have already been associated with exacerbation of existing skin condition...
Source: Current Dermatology Reports - August 21, 2020 Category: Dermatology Source Type: research
