Mucocutaneous Candida Infections in Immunocompromised Patients
AbstractPurpose of ReviewCandida species are considered opportunistic infections, and can cause a large variety of mucocutaneous and systemic diseases in immunocompromised individuals. In total, 95% of Candida infections in the USA are caused byC. albicans,C. glabrata,C. parapsilosis,C. tropicalis, andC. krusei, with proportions varying based on geographic region and patient population (Cleveland et al. in PLos One 10(3),2015; Lockhart et al. in Clin Microbiol Newsl 36(17):131–136,2014). Knowledge of these risk factors, and differences in disease processes, is extremely important when diagnosing and managing Candida i...
Source: Current Dermatology Reports - March 12, 2022 Category: Dermatology Source Type: research
Microbiome in Hidradenitis Suppurativa: Current Evidence and Practice
AbstractPurposeThe role of the host microbiome in hidradenitis suppurativa (HS) is heavily debated. Previous culture-based methods have not led to strong conclusions. Despite antibiotics being a mainstay of HS treatment, microbiome research in other cutaneous inflammatory diseases such as atopic dermatitis and psoriasis is more robust. This review evaluates the current evidence regarding the influence of skin and gut dysbiosis on HS pathogenesis. Current and potential future microbiome modulating therapeutic modalities are also discussed.Recent FindingsNewer studies using 16S genome sequencing have furthered our understand...
Source: Current Dermatology Reports - March 11, 2022 Category: Dermatology Source Type: research
Medical Device Contact Allergy: Glucose Monitors and Insulin Pumps
AbstractPurpose of ReviewTo describe contact allergy to diabetes devices and recommend steps for evaluation and management of these complex cutaneous complications.Recent FindingsAllergens reported in glucose monitors include isobornyl acrylate (IBOA), colophony,N,N-dimethylacrylamide, 2,2 ’-methylenebis(6-tert-butyl-4-methylphenol) monoacrylate and ethyl cyanoacrylate. Recently described insulin pump allergens include IBOA, colophony, and ethyl cyanoacrylate.SummaryContact allergy to diabetes devices has become more prevalent in recent years, particularly given their increasing use in patients with type I and type II di...
Source: Current Dermatology Reports - March 11, 2022 Category: Dermatology Source Type: research
Microbiome in Hidradenitis Suppurativa: Current Evidence and Practice
AbstractPurposeThe role of the host microbiome in hidradenitis suppurativa (HS) is heavily debated. Previous culture-based methods have not led to strong conclusions. Despite antibiotics being a mainstay of HS treatment, microbiome research in other cutaneous inflammatory diseases such as atopic dermatitis and psoriasis is more robust. This review evaluates the current evidence regarding the influence of skin and gut dysbiosis on HS pathogenesis. Current and potential future microbiome modulating therapeutic modalities are also discussed.Recent FindingsNewer studies using 16S genome sequencing have furthered our understand...
Source: Current Dermatology Reports - March 11, 2022 Category: Dermatology Source Type: research
Medical Device Contact Allergy: Glucose Monitors and Insulin Pumps
AbstractPurpose of ReviewTo describe contact allergy to diabetes devices and recommend steps for evaluation and management of these complex cutaneous complications.Recent FindingsAllergens reported in glucose monitors include isobornyl acrylate (IBOA), colophony,N,N-dimethylacrylamide, 2,2 ’-methylenebis(6-tert-butyl-4-methylphenol) monoacrylate and ethyl cyanoacrylate. Recently described insulin pump allergens include IBOA, colophony, and ethyl cyanoacrylate.SummaryContact allergy to diabetes devices has become more prevalent in recent years, particularly given their increasing use in patients with type I and type II di...
Source: Current Dermatology Reports - March 11, 2022 Category: Dermatology Source Type: research
Allergic Contact Dermatitis to Corticosteroids
AbstractPurpose of ReviewThis review summarizes current state of knowledge of allergic contact dermatitis to corticosteroids and highlights recent findings in this field.Recent FindingsTixocortol-21-pivalate and budesonide are the most commonly reported corticosteroid allergens. Up to 50% of those who patch-tested positive to corticosteroids were allergic to more than one compound using European baseline series, though there has been significant variation in rates of positive reactions to multiple corticosteroids in previous studies. Steroid classification, while helpful in predicting steroid allergen cross-reactivity, is ...
Source: Current Dermatology Reports - November 24, 2021 Category: Dermatology Source Type: research
Social Media and Clinical Research in Dermatology
AbstractPurpose of ReviewThe immense growth of social media has afforded new opportunities in dermatology clinical research. This review serves to outline how social media has impacted clinical research and to explore future avenues for which social media can make a significant impact in dermatology clinical research.Recent FindingsRecent clinical trials augmented by social media have demonstrated increased participant enrollment, shortened recruitment timelines, and decreased recruitment cost. The incorporation of social media into clinical research has also afforded greater access to teledermatology and the initiation of...
Source: Current Dermatology Reports - November 19, 2021 Category: Dermatology Source Type: research
Updates and Insights in the Diagnosis and Management of DRESS Syndrome
AbstractPurpose of ReviewTo provide updates on recent advances in the diagnosis and management of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.Recent FindingsThe number of identified HLA allele associations with DRESS continues to grow. There is increasing evidence indicating viral infection, reactivation, and cross-reactivity may play key roles in disease. Translational work illuminated JAK/STAT activation in recalcitrant disease. There is expanding recognition of rapid-onset DRESS resulting from specific drugs.SummaryDRESS is a severe form of adverse drug reaction with potential for significan...
Source: Current Dermatology Reports - November 9, 2021 Category: Dermatology Source Type: research
Emerging Treatment Options for Rosacea
AbstractPurpose of ReviewRosacea is a ubiquitous chronic inflammatory dermatosis that affects approximately 10% of the population worldwide. Skin manifestations can appear in diverse amalgamations and several degrees of intensity, with frequent spells of aggravation and regression. According to the National Rosacea Society (NRS), about 16 million Americans were affected by rosacea in 2021.Recent FindingsRosacea has been linked to immune system dysregulation and alterations in the neurological and vascular systems. The primary treatment paradigm for rosacea encompasses local and systemic therapies, as well as lasers. Howeve...
Source: Current Dermatology Reports - November 2, 2021 Category: Dermatology Source Type: research
