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Specialty: Genetics & Stem Cells
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Total 914 results found since Jan 2013.
Targeted re-sequencing in pediatric and perinatal stroke.
Abstract
Pediatric and perinatal stroke can present as an early symptom in undiagnosed syndromes characterized by simple Mendelian inheritance. In order to diagnose those patients affected with a monogenic disorder in which an arterial cerebrovascular event or arteriopathy may have preceded any other specific symptom, we aimed to establish and validate a targeted gene panel, and to determine its diagnostic yield and clinical utility. To this end, thirty-eight patients were selected with heterogeneous cryptogenic stroke phenotypes, mostly including multiple and recurrent ischemic or hemorrhagic arterial strokes and...
Source: European Journal of Medical Genetics - August 16, 2020 Category: Genetics & Stem Cells Authors: Grossi A, Severino M, Rusmini M, Tortora D, Ramenghi LA, Cama A, Rossi A, Di Rocco M, Ceccherini I, Bertamino M, Gaslini Stroke Study Group Tags: Eur J Med Genet Source Type: research
Post stroke depression and risk of stroke recurrence and mortality: A systematic review and meta-analysis.
CONCLUSION AND RELEVANCE: Post stroke depression is associated with a significantly increased risk of mortality in stroke survivors. More researches are required on the association with stroke recurrence.
PMID: 30711712 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - January 31, 2019 Category: Genetics & Stem Cells Authors: Cai W, Mueller C, Li YJ, Shen WD, Stewart R Tags: Ageing Res Rev Source Type: research
Genes, Vol. 13, Pages 48: Ischemic Stroke Genetics: What Is New and How to Apply It in Clinical Practice?
Jatužis
The etiology of ischemic stroke is multifactorial. Although receiving less emphasis, genetic causes make a significant contribution to ischemic stroke genesis, especially in early-onset stroke. Several stroke classification systems based on genetic information corresponding to various stroke phenotypes were proposed. Twin and family history studies, as well as candidate gene approach, are common methods to discover genetic causes of stroke, however, both have their own limitations. Genome-wide association studies and next generation sequencing are more efficient, promising and increasingly used for daily diagn...
Source: Genes - December 24, 2021 Category: Genetics & Stem Cells Authors: Aleksandra Ekkert Aleksandra Šliachtenko Julija Grigait ė Birut ė Burnytė Algirdas Utkus Dalius Jatu žis Tags: Review Source Type: research
GSE155257 Analysis of human stroke brain tissue resected during decompressive craniectomy or stroke-ectomy surgery
Conclusions: Dysregulated miRNAs detected in our study could be regarded as potential candidates for biomarkers and/or targets for therapeutic intervention. The obtained data will serve for better understanding of the molecular basis of stroke and provide valuable information for the future functional studies in the experimental models of stroke.
Source: GEO: Gene Expression Omnibus - July 29, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Investigating the association of atopic dermatitis with ischemic stroke and coronary heart disease: A mendelian randomization study
Conclusion: Our MR study does not support a causal association of genetically predicted AD with ischemic stroke, large artery stroke, cardioembolic stroke, small vessel stroke, coronary heart disease, and myocardial infarction.
Source: Frontiers in Genetics - August 30, 2022 Category: Genetics & Stem Cells Source Type: research
Association between paraoxonase gene and stroke in the Han Chinese population
Conclusions:
These findings indicate that polymorphisms of PON1 gene may be a risk factor of stroke.
Source: BMC Medical Genetics - Latest articles - January 28, 2013 Category: Genetics & Stem Cells Authors: Guojun ZhangWenjin LiZhiqiang LiHong LvYonghong RenRuimin MaXiaohong LiXixiong KangYongyong ShiYimin Sun Source Type: research
Effect of gene –gene and gene–environment interaction on the risk of first‐ever stroke and poststroke death
ConclusionsOur findings identified two novel genetic interactions ofVKORC1 andChr.9p21.3 and ofVEGFA andKDR for risk of stroke and subtypes as well as future stroke prognosis.
Source: Molecular Genetics & Genomic Medicine - July 9, 2019 Category: Genetics & Stem Cells Authors: Congrui Feng,
Yunyun Yang,
Shujun Yang,
Xin Tu,
Yibo Wang,
Yiqing Song,
Rutai Hui,
Weili Zhang Tags: ORIGINAL ARTICLE Source Type: research
Genes, Vol. 12, Pages 1860: MicroRNA Analysis of Human Stroke Brain Tissue Resected during Decompressive Craniectomy/Stroke-Ectomy Surgery
Conclusions: Dysregulated miRNAs detected in our study could be regarded as potential candidates for biomarkers and/or targets for therapeutic intervention. The results described herein further our understanding of the molecular basis of stroke and provide valuable information for the future functional studies in the experimental models of stroke.
Source: Genes - November 23, 2021 Category: Genetics & Stem Cells Authors: Andrew P. Carlson William McKay Jeremy S. Edwards Radha Swaminathan Karen S. SantaCruz Ron L. Mims Howard Yonas Tamara Roitbak Tags: Article Source Type: research
Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke.
Abstract
Stem cell-based treatments have been suggested as promising candidates for stroke. Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for a wide range of diseases. In particular, clinical trial studies have suggested MSCs for stroke therapy. The focus of MSC treatments has been directed towards cell replacement. However, recent research has lately highlighted their paracrine actions. The secretion of extracellular vesicles (EVs) is offered to be the main therapeutic mechanism of MSC therapy. However, EV-based treatments may provide a wider therapeutic window compared to t...
Source: Ageing Research Reviews - June 17, 2020 Category: Genetics & Stem Cells Authors: Rahmani A, Saleki K, Javanmehr N, Khodaparast J, Saadat P, Nouri HR Tags: Ageing Res Rev Source Type: research
Genes, Vol. 11, Pages 726: Transcriptome Analysis of Skeletal Muscle Reveals Altered Proteolytic and Neuromuscular Junction Associated Gene Expressions in a Mouse Model of Cerebral Ischemic Stroke
S. Mohamed
Stroke is a leading cause of mortality and long-term disability in patients worldwide. Skeletal muscle is the primary systemic target organ of stroke that induces muscle wasting and weakness, which predominantly contribute to functional disability in stroke patients. Currently, no pharmacological drug is available to treat post-stroke muscle morbidities as the mechanisms underlying post-stroke muscle wasting remain poorly understood. To understand the stroke-mediated molecular changes occurring at the transcriptional level in skeletal muscle, the gene expression profiles and enrichment pathways were explore...
Source: Genes - June 29, 2020 Category: Genetics & Stem Cells Authors: Peter J. Ferrandi Mohammad Moshahid Khan Hector G. Paez Christopher R. Pitzer Stephen E. Alway Junaith S. Mohamed Tags: Article Source Type: research
Effect of PITX2 genetic variants on the susceptibility to stroke in the Chinese Han population
CONCLUSIONS: This study indicated that there was a significant association between the PITX2 gene and stroke risk, and provided some data as far as possible to support the prevention of stroke.PMID:34990849 | DOI:10.1016/j.meegid.2021.105201
Source: Infection, Genetics and Evolution - January 6, 2022 Category: Genetics & Stem Cells Authors: Weiwei Zhao Xiuxia Hu Jie Hao Le Guo Wenjie Zhang Jianfeng Liu Tianbo Jin Dakuan Gao Jin Zhi Source Type: research
Genes, Vol. 13, Pages 978: Stroke and Etiopathogenesis: What Is Known?
Conclusion: We summarize the latest evidence and perspectives of ischemic stroke genetics that may be of interest to the physician and useful for day-to-day clinical work in terms of both prevention and treatment of ischemic stroke.
Source: Genes - May 30, 2022 Category: Genetics & Stem Cells Authors: Tiziana Ciarambino Pietro Crispino Erika Mastrolorenzo Antonello Viceconti Mauro Giordano Tags: Review Source Type: research
Single nucleotide polymorphism of CD40 in the 5'-untranslated region is associated with ischemic stroke.
CONCLUSIONS: The findings suggested that the CD40 -1C/T polymorphism might contribute to the susceptibility to ischemic stroke in the Chinese population, and might be associated with history of previous stroke.
PMID: 23954880 [PubMed - as supplied by publisher]
Source: Gene - August 14, 2013 Category: Genetics & Stem Cells Authors: Ma Y, Wang SX, Liu Y, Peng GG, Wang XM, Zhang B, Wu BH, Yu JM Tags: Gene Source Type: research
Obesity and ischemic stroke modulate the methylation levels of KCNQ1 in white blood cells
In conclusion, obesity induced changes in the KCNQ1 methylation pattern which were also dependent on stroke. Furthermore, the epigenetic marks differentially methylated in the stroke patients were dependent on the previous obese state. These DNA methylation patterns could be used as future potential stroke biomarkers.
Source: Human Molecular Genetics - February 9, 2015 Category: Genetics & Stem Cells Authors: Gomez-Uriz, A. M., Milagro, F. I., Mansego, M. L., Cordero, P., Abete, I., De Arce, A., Goyenechea, E., Blazquez, V., Martinez-Zabaleta, M., Martinez, J. A., Lopez De Munain, A., Campion, J. Tags: ARTICLES Source Type: research
Longitudinal Study Reveals Long-Term Proinflammatory Proteomic Signature After Ischemic Stroke Across Subtypes
CONCLUSIONS: We found inflammation-related proteins that were differentially regulated in ischemic stroke cases compared with controls only in the acute phase and others that remained elevated also at later time points. This latter group of proteins could reflect underlying pathophysiological processes of relevance. Future studies both in terms of disease risk and prognostication are warranted.PMID:35686557 | DOI:10.1161/STROKEAHA.121.038349
Source: Genomics Proteomics ... - June 10, 2022 Category: Genetics & Stem Cells Authors: Tara M Stanne Annelie Angerfors Bj örn Andersson Cecilia Br ännmark Lukas Holmegaard Christina Jern Source Type: research
