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Specialty: Genetics & Stem Cells
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Total 914 results found since Jan 2013.
New | phs002386.v1.p1 | Optimizing Primary Stroke Prevention in Children with Sickle Cell Anemia (STOP II)
Optimizing Primary Stroke Prevention in Children with Sickle Cell Anemia (STOP II) (study page |release notes)
Source: dbGaP, the database of Genotypes and Phenotypes - March 26, 2021 Category: Genetics & Stem Cells Tags: StudyRelease Source Type: research
Discovering Cerebral Ischemic Stroke Associated Genes Based on Network Representation Learning
Cerebral ischemic stroke (IS) is a complex disease caused by multiple factors including vascular risk factors, genetic factors, and environment factors, which accentuates the difficulty in discovering corresponding disease-related genes. Identifying the genes associated with IS is critical for understanding the biological mechanism of IS, which would be significantly beneficial to the diagnosis and clinical treatment of cerebral IS. However, existing methods to predict IS-related genes are mainly based on the hypothesis of guilt-by-association (GBA). These methods cannot capture the global structure information of the whol...
Source: Frontiers in Genetics - September 1, 2021 Category: Genetics & Stem Cells Source Type: research
Ischemic stroke induces cardiac dysfunction and alters transcriptome profile in mice
Stroke can induce cardiac dysfunction in the absence of primary cardiac disease; however, the mechanisms underlying the interaction between the neurological deficits and the heart are poorly understood. The ob...
Source: BMC Genomics - September 4, 2021 Category: Genetics & Stem Cells Authors: Jie Chen, Jiahong Gong, Haili Chen, Xuqing Li, Li Wang, Xiaoli Qian, Kecheng Zhou, Ting Wang, Songhe Jiang, Lei Li and Shengcun Li Tags: Research Source Type: research
New | phs000966.v2.p2 | National Institute of Neurological Disorders and Stroke (NINDS), Family Study of Essential Tremor (FASET), Identification of Susceptibility Genes for Essential Tremor
National Institute of Neurological Disorders and Stroke (NINDS), Family Study of Essential Tremor (FASET), Identification of Susceptibility Genes for Essential Tremor (study page |release notes)
Source: dbGaP, the database of Genotypes and Phenotypes - September 2, 2021 Category: Genetics & Stem Cells Tags: StudyRelease Source Type: research
GSE180470 Dysregulated lncRNA and mRNA may promote the progression of ischemic stroke via immune and inflammatory pathways: results from RNA sequencing and bioinformatics analysis
Contributors : Yingshuang Wang ; Feifei Feng ; Pingping Zheng ; Lijuan Wang ; Yanjun Wang ; Yaogai Lv ; Li Shen ; Kexin Li ; Tianyu Feng ; Yang Chen ; Zhigang Liu ; Yan YaoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensLong non-coding RNAs (lncRNAs) are widely involved in gene transcription regulation and which act as epigenetic modifiers. To determine whether lncRNAs are involved in ischemic stroke (IS), we analyzed the expression profile of lncRNAs and mRNAs in IS. RNA sequencing was performed on the blood of three pairs of IS patients and heathy controls. Differential expressi...
Source: GEO: Gene Expression Omnibus - October 20, 2021 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Moderating effect of ppar- γ on the association of c-reactive protein and ischemic stroke in patients younger than 60
CONCLUSION: In patients with PPAR CC genotype the association of serum CRP level and IS was significant.PMID:34673211 | DOI:10.1016/j.gene.2021.146029
Source: Gene - October 21, 2021 Category: Genetics & Stem Cells Authors: A Bazina Martinovi ć A Merkler I Ćelić K Star čević M Šimić I Karmeli ć Z Poljakovi ć D Kalini ć J Serti ć Source Type: research
New | phs002406.v1.p1 | The Northern Manhattan Family Study - a Sub-Study of the Epidemiologic Study of Stroke Outcome in 3 Ethnic Groups: The Northern Manhattan Study
The Northern Manhattan Family Study - a Sub-Study of the Epidemiologic Study of Stroke Outcome in 3 Ethnic Groups: The Northern Manhattan Study (study page |release notes
Source: dbGaP, the database of Genotypes and Phenotypes - December 16, 2021 Category: Genetics & Stem Cells Tags: StudyRelease Source Type: research
GSE162955 Expression data from stroke patients brain samples
Contributors : Teresa Garc ía-Berrocoso ; Joan MontanerSeries Type : Expression profiling by arrayOrganism : Homo sapiensStroke is still a major cause of death and disability worldwide. A better comprehension of stroke pathophysiology is fundamental to reduce its dramatic outcome.Our aim was to identify and verify gene expression changes that occur in the human brain after ischemia.
Source: GEO: Gene Expression Omnibus - December 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Identification of a ferroptosis-related gene pair biomarker with immune infiltration landscapes in ischemic stroke: a bioinformatics-based comprehensive study
Ischemic stroke (IS) is a principal contributor to long-term disability in adults. A new cell death mediated by iron is ferroptosis, characterized by lethal aggregation of lipid peroxidation. However, a paucit...
Source: BMC Genomics - January 16, 2022 Category: Genetics & Stem Cells Authors: Jiaxin Fan, Mengying Chen, Shuai Cao, Qingling Yao, Xiaodong Zhang, Shuang Du, Huiyang Qu, Yuxuan Cheng, Shuyin Ma, Meijuan Zhang, Yizhou Huang, Nan Zhang, Kaili Shi and Shuqin Zhan Tags: Research Source Type: research
GSE190869 High-throughput Sequencing of exosomal circRNAs in large artery atherosclerotic stroke
Contributors : Xudong Pan ; Xiaoyan ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExosomal circRNA sequencing was used to identify differentially expressed circRNAs between LAA stroke and normal controls. From a further validation stage, the results were validated using RT-qPCR.
Source: GEO: Gene Expression Omnibus - February 2, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Genetic variations in ABCA1/G1 associated with plasma lipid levels and risk of ischemic stroke
CONCLUSIONS: Polymorphism of ABCA1/G1 associated with varieties of plasma lipid levels and risk of IS.PMID:35219812 | DOI:10.1016/j.gene.2022.146343
Source: Gene - February 27, 2022 Category: Genetics & Stem Cells Authors: Shangdong Yang Jing Jia Yang Liu Zheng Li Zhihao Li Zhaojing Zhang Baixue Zhou Yingying Luan Yanyang Huang Yue Peng Tianyi Han Yan Xu Ying He Hong Zheng Source Type: research
Integrated Analysis of Competitive Endogenous RNA Networks in Acute Ischemic Stroke
Conclusion: These findings may contribute to a better understanding of the molecular mechanisms of AIS and provide the basis for the development of novel treatment targets in AIS.
Source: Frontiers in Genetics - March 25, 2022 Category: Genetics & Stem Cells Source Type: research
Construction Immune Related Feed-Forward Loop Network Reveals Angiotensin II Receptor Blocker as Potential Neuroprotective Drug for Ischemic Stroke
Ischemic stroke (IS) accounts for the leading cause of disability and mortality in China. Increasing researchers are studying the effects of neuroprotective agents on IS. However, the molecular mechanisms of feed-forward loops (FFLs) associated with neuroprotection in the pathogenesis of IS need to be further studied. A protein-protein interaction (PPI) network of IS immune genes was constructed to decipher the characters and excavate 3 hub genes (PI3K, IL6, and TNF) of immunity. Then, we identified two hub clusters of IS immune genes, and the cytokine-cytokine receptor interaction pathway was discovered on the pathway enr...
Source: Frontiers in Genetics - March 28, 2022 Category: Genetics & Stem Cells Source Type: research
EHBP1, TUBB, and WWOX SNPs, Gene-Gene and Gene-Environment Interactions on Coronary Artery Disease and Ischemic Stroke
This study aimed to detect the associations of these SNPs, gene-gene and gene-environment interactions and CAD and IS in the Guangxi Han population. A total of 1853 unrelated subjects were recruited into normal control (n = 638), CAD (n = 622), and IS (n = 593) groups. Related genotypes were determined by high-throughput sequencing. The genotypic and minor allelic frequencies of rs2278075 were different between the CAD and control groups, and those of rs2710642, rs3130685, and rs2278075 were also different between the IS and control groups. The rs2278075T allele, rs3130685-rs2222896-rs2278075, rs3130685-rs2222896-diabetes,...
Source: Frontiers in Genetics - April 26, 2022 Category: Genetics & Stem Cells Source Type: research
