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Specialty: Genetics & Stem Cells
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Total 914 results found since Jan 2013.
Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients.
CONCLUSION: BMMNC labeling with technetium-99m allowed imaging for up to 24 h after intra-arterial or intravenous injection in stroke patients.
PMID: 23477395 [PubMed - in process]
Source: Regenerative Medicine - March 1, 2013 Category: Genetics & Stem Cells Authors: Rosado-de-Castro PH, Schmidt Fda R, Battistella V, Lopes de Souza SA, Gutfilen B, Goldenberg RC, Kasai-Brunswick TH, Vairo L, Silva RM, Wajnberg E, Alvarenga Americano do Brasil PE, Gasparetto EL, Maiolino A, Alves-Leon SV, Andre C, Mendez-Otero R, Rodrig Tags: Regen Med Source Type: research
Association of AHSG Gene Polymorphisms with Ischemic Stroke in a Han Chinese Population.
In this study, genotype and allele frequencies of the rs4918 SNP in the AHSG gene were examined in 380 patients with ischemic stroke and 350 healthy controls from a Northern Han Chinese population via the PCR-RFLP technique. Frequencies of the GG genotype and the G allele in AHSG (rs4918) were significantly higher in patients with ischemic stroke or atherosclerotic cerebral infarction than those in the control group (P < 0.05). Logistic regression analysis demonstrated the significance of rs4918 in these patients, after adjustment for confounding factors (P < 0.05). These findings suggest that rs4918 SNPs of the ...
Source: Biochemical Genetics - August 2, 2013 Category: Genetics & Stem Cells Authors: Ma S, He Z, Zhao J, Li L, Yuan L, Dai Y, Qiu J Tags: Biochem Genet Source Type: research
The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene SG13S114 polymorphism and ischemic stroke in Chinese population: A meta-analysis.
Abstract
Previous studies has indicated that the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene SG13S114 polymorphism is associated with risk of ischemic stroke (IS), but the results remain inconclusive even in Chinese population. A meta-analysis of 10 case-control studies was conducted on the relationship between ALOX5AP SG13S114 polymorphism and susceptibility to IS in Chinese population published domestically and abroad from September 2007 to December 2012. Data were extracted by two authors and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Meta-analysis results sho...
Source: Gene - October 19, 2013 Category: Genetics & Stem Cells Authors: Wang G, Liu R, Zhang J Tags: Gene Source Type: research
Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke
by Stephen R. Williams, Qiong Yang, Fang Chen, Xuan Liu, Keith L. Keene, Paul Jacques, Wei-Min Chen, Galit Weinstein, Fang-Chi Hsu, Alexa Beiser, Liewei Wang, Ebony Bookman, Kimberly F. Doheny, Philip A. Wolf, Michelle Zilka, Jacob Selhub, Sarah Nelson, Stephanie M. Gogarten, Bradford B. Worrall, Sudha Seshadri, Michèle M. Sale, the Genomics and Randomized Trials Network , the Framingham Heart Study
Circulating homocysteine levels (tHcy), a product of the folate one carbon metabolism pathway (FOCM) through the demethylation of methionine, are heritable and are associated with an increased risk of common diseases such as...
Source: PLoS Genetics - March 20, 2014 Category: Genetics & Stem Cells Authors: Stephen R. Williams et al. Source Type: research
G894T endothelial nitric oxide synthase polymorphism and ischemic stroke in Morocco
In this study, genotyping with PCR-RFLP and HRM (high resolution melting) methods were conducted on 165 ischemic stroke patients as well as 182 controls. The goal here was to compare genotyping with PCR-RLFP primer sequences of eNOS gene (size<300bp) to HRM. Our data suggests a statistically significant association between G894T eNOS polymorphism and ischemic stroke in recessive, dominant and additive models with P<0.05 and odds ratio of 2.68 (1.08–6.70), 1.78 (1.16–2.73), and 1.71 (1.21–2.43) respectively. In sum, although the sample size is relatively small, it suggests that G894T eNOS polymorphism co...
Source: Meta Gene - November 4, 2014 Category: Genetics & Stem Cells Source Type: research
Association of GWAS-supported loci rs2107595 in HDAC9 gene with ischemic stroke in Southern Han Chinese.
CONCLUSIONS: Our results indicate that HDAC9 variant rs2107595 may be not associated with IS risk in southern Han Chinese. However, the rs2107595 polymorphism may be associated with serum TC and TG level of IS patients.
PMID: 26093197 [PubMed - as supplied by publisher]
Source: Gene - June 17, 2015 Category: Genetics & Stem Cells Authors: Su L, Shen T, Liang B, Xie J, Tan J, Chen Q, Wei Q, Jiang H, Gu L Tags: Gene Source Type: research
Case report: 5year follow-up of adult late-onset mitochondrial encephalomyopathy with lactic acid and stroke-like episodes (MELAS)
We describe the follow-up of a patient who was diagnosed with late-onset MELAS at the age of 49. Her clinical course includes sensorineural hearing loss, seizures, and multiple episodes of stroke-like metabolic crises. Molecular genetic testing on whole blood revealed 31% heteroplasmy of a m.3243A>G variant in the mtDNA, the causative variant in approximately 80% of MELAS cases. The original diagnostic criteria for MELAS required the onset of stroke-like episodes prior to 40years of age but this case and others demonstrate that onset may be delayed in certain individuals. Therefore, MELAS should be included in the d...
Source: Molecular Genetics and Metabolism Reports - November 18, 2016 Category: Genetics & Stem Cells Source Type: research
GSE110993 RNA-seq identifies circulating miR-125a-5p, miR-125b-5p and miR-143-3p as potential biomarkers for acute ischemic stroke
Conclusions: A set of circulating miRNAs (miR-125a-5p, miR-125b-5p, miR-143-3p) associates with acute IS and might have clinical utility as an early diagnostic marker.
Source: GEO: Gene Expression Omnibus - February 22, 2018 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Genetic underpinnings of recovery after stroke: an opportunity for gene discovery, risk stratification, and precision medicine
AbstractAs the number of stroke survivors continues to increase, identification of therapeutic targets for stroke recovery has become a priority in stroke genomics research. The introduction of high-throughput genotyping technologies and novel analytical tools has significantly advanced our understanding of the genetic underpinnings of stroke recovery.
Source: Genome Medicine - September 12, 2019 Category: Genetics & Stem Cells Source Type: research
GSE138849 Identification of Blood Circular RNAs as the Potential Biomarkers for Acute Ischemic Stroke
In this study, we examined whether the blood-borne circRNAs can be promising candidates as adjunctive diagnostic biomarkers and their pathophysiological roles after stroke. We profiled the blood circRNA expression in mice subjected to experimental focal cerebral ischemia, and validated the selected circRNAs in AIS patients. We demonstrated that 128, 198 and 789 circRNAs were significantly altered at 5 min, 3 h and 24 h after ischemic stroke, respectively.
Source: GEO: Gene Expression Omnibus - January 23, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Mus musculus Source Type: research
GSE137482 RNA-Seq of ischemic stroke in young and aged mice
Contributors : Peter Androvi č ; Pavel Abaffy ; Lukáš ValihrachSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIschemic stroke is one of the leading causes of mortality and major healthcare and economic burden. It is a well recognized disease of aging, yet it is unclear how the age-dependent vulnerability occurs and what are the underlying mechanisms. To address these issues, we performed a comprehensive RNA-Seq analysis of aging, ischemic stroke and their interaction using a model of permanent middle cerebral artery occlusion (MCAO) in 3 and 18 month old female mice. We assessed d...
Source: GEO: Gene Expression Omnibus - June 17, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
MiR-29a Knockout Aggravates Neurological Damage by Pre-polarizing M1 Microglia in Experimental Rat Models of Acute Stroke
ConclusionKnockout of miR-29a in rats promoted M1 microglial polarization and increased glutamate release, thereby aggravating neurological damage in experimental stroke rat models.
Source: Frontiers in Genetics - March 15, 2021 Category: Genetics & Stem Cells Source Type: research
Genes, Vol. 12, Pages 579: Association Study of SLC6A4 (5-HTTLPR) Polymorphism and Its Promoter Methylation with Rehabilitation Outcome in Patients with Subacute Stroke
rene Aprile
Recently it has been suggested that serotonin transporter (SLC6A4) and its 5HTTLPR polymorphism could be involved in post stroke recovery. Here, we characterized the methylation profile of two different CpG islands within the SLC6A4 promoter region in the whole blood of 50 patients with subacute stroke before and after a six-week rehabilitation treatment. These patients were genotyped for 5HTTLPR polymorphism identifying patients on the basis of short (S) and L (L) alleles: 17 patients LL, 22 patients LS and 11 patients SS. At baseline, all CpG sites for both CpG islands displayed a heterogeneous methylatio...
Source: Genes - April 16, 2021 Category: Genetics & Stem Cells Authors: Massimo Santoro Mariacristina Siotto Marco Germanotta Alessia Mastrorosa Dionysia Papadopoulou Irene Aprile Tags: Article Source Type: research
Genes, Vol. 12, Pages 787: Network Protein Interaction in the link between Stroke and Periodontitis Interplay: A Pilot Bioinformatic Analysis
ado
Botelho
The clinical interaction between stroke and periodontitis has been consistently studied and confirmed. Hence, exploring potentially new protein interactions in this association using bioinformatic strategies presents potential interest. In this exploratory study, we conducted a protein–protein network interaction (PPI) search with documented encoded proteins for both stroke and periodontitis. Genes of interest were collected via GWAS database. The STRING database was used to predict the PPI networks, first in a sensitivity purpose (confidence cut-off of 0.7), and then with a highest confidence cut-off ...
Source: Genes - May 20, 2021 Category: Genetics & Stem Cells Authors: Leira Mascarenhas Blanco Sobrino Mendes Machado Botelho Tags: Article Source Type: research
Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation
Stroke is a leading cause of death and disability worldwide. However, our understanding of its underlying biology and the number of available treatment options remain limited. Mendelian randomization (MR) offers a powerful approach to identify novel biological pathways and therapeutic targets for this disease. Around ~100 MR studies have been conducted so far to explore, confirm, and quantify causal relationships between several exposures and risk of stroke. In this review, we summarize the current evidence arising from these studies, including those investigating ischemic stroke, hemorrhagic stroke, or both. We highlight ...
Source: Frontiers in Genetics - August 12, 2021 Category: Genetics & Stem Cells Source Type: research
