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Specialty: Genetics & Stem Cells

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Total 914 results found since Jan 2013.

Longitudinal Study Reveals Long-Term Proinflammatory Proteomic Signature After Ischemic Stroke Across Subtypes
CONCLUSIONS: We found inflammation-related proteins that were differentially regulated in ischemic stroke cases compared with controls only in the acute phase and others that remained elevated also at later time points. This latter group of proteins could reflect underlying pathophysiological processes of relevance. Future studies both in terms of disease risk and prognostication are warranted.PMID:35686557 | DOI:10.1161/STROKEAHA.121.038349
Source: Genomics Proteomics ... - June 10, 2022 Category: Genetics & Stem Cells Authors: Tara M Stanne Annelie Angerfors Bj örn Andersson Cecilia Br ännmark Lukas Holmegaard Christina Jern Source Type: research

Lack of association between a functional variant of the BRCA-1 related associated protein (BRAP) gene and ischemic stroke
Conclusions: The BRAP polymorphism may not play an important role in ischemic stroke in the studied population.
Source: BMC Medical Genetics - Latest articles - January 28, 2013 Category: Genetics & Stem Cells Authors: Yi-Chu LiaoHsiu-Fen LinYuh-Cherng GuoChung-Hung ChenZhi-Zhang HuangSuh-Hang JuoRuey-Tay Lin Source Type: research

Expression profile based gene clusters for ischemic stroke detection: Whole blood gene clusters for ischemic stroke detection.
Abstract In microarray studies alterations in gene expression in circulating leukocytes have shown utility for ischemic stroke diagnosis. We studied forty candidate markers identified in three gene expression profiles to (1) quantitate individual transcript expression, (2) identify transcript clusters and (3) assess the clinical diagnostic utility of the clusters identified for ischemic stroke detection. Using high throughput next generation qPCR 16 of the 40 transcripts were significantly up-regulated in stroke patients relative to control subjects (p<0.05). Six clusters of between 5 and 7 transcripts weredisc...
Source: Genomics - August 15, 2014 Category: Genetics & Stem Cells Authors: Adamski MG, Li Y, Wagner E, Yu H, Seales-Bailey C, Soper SA, Murphy M, Baird AE Tags: Genomics Source Type: research

Serum Proteome Alterations in Human Cystathionine β-Synthase Deficiency and Ischemic Stroke Subtypes.
Abstract Ischemic stroke induces brain injury via thrombotic or embolic mechanisms involving large or small vessels. Cystathionine β-synthase deficiency (CBS), an inborn error of metabolism, is associated with vascular thromboembolism, the major cause of morbidity and mortality in affected patients. Because thromboembolism involves the brain vasculature in these patients, we hypothesize that CBS deficiency and ischemic stroke have similar molecular phenotypes. We used label-free mass spectrometry for quantification of changes in serum proteomes in CBS-deficient patients (n = 10) and gender/age-matched unaffected ...
Source: Genomics Proteomics ... - June 24, 2019 Category: Genetics & Stem Cells Authors: Sikora M, Lewandowska I, Kupc M, Kubalska J, Graban A, Marczak Ł, Kaźmierski R, Jakubowski H Tags: Int J Mol Sci Source Type: research

Association of blood lipids, atherosclerosis and statin use with dementia and cognitive impairment after stroke: a systematic review and meta-analysis.
CONCLUSION: Atherosclerosis may be associated with an increased risk of post-stroke dementia. Post-stroke statin use was associated with decreased risk of cognitive impairment. To confirm whether or not statins confer advantages in the post-stroke population in terms of preventing cognitive decline over and above their known effectiveness in reducing risk of further vascular events, further stroke trials including cognitive assessment and observational analyses adjusted for key confounders, focusing on key subgroups or statin use patterns are required. PMID: 31505259 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - September 6, 2019 Category: Genetics & Stem Cells Authors: Yang Z, Wang H, Edwards D, Ding C, Yan L, Brayne C, Mant J Tags: Ageing Res Rev Source Type: research

Childhood Obesity and Risk of Stroke: A Mendelian Randomisation Analysis
Conclusion: Our study provides evidence that childhood obesity is associated with a higher risk of stroke, IS, and LAS. The prevention of stroke, especially IS and LAS, should be promoted in populations with childhood obesity.
Source: Frontiers in Genetics - November 17, 2021 Category: Genetics & Stem Cells Source Type: research

Genetic Contributors of Incident Stroke in 10,700 African Americans With Hypertension: A Meta-Analysis From the Genetics of Hypertension Associated Treatments and Reasons for Geographic and Racial Differences in Stroke Studies
Conclusion: This study highlights biologically plausible genetic determinants for incident stroke in hypertensive AAs. Ultimately, a better understanding of genetic risk factors for stroke in AAs may give new insight into stroke burden and potential clinical tools for those among the highest at risk.
Source: Frontiers in Genetics - December 21, 2021 Category: Genetics & Stem Cells Source Type: research

GSE203399 Study of the DNA methylation in the stroke outcome: an Epigenome-Wide Association Study
Contributors : Israel Fern ández-Cadenas ; Joan Montaner ; Natalia CullellSeries Type : Methylation profiling by arrayOrganism : Homo sapiensBackground and Purpose The neurological course after stroke is highly variable and is determined by demographic, clinical, and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. Methods We performed a three-stage epigenome-wide association study (EWAS) to evaluate DNA methylation associated with the difference between the National Institutes of Health Stroke Scale (NIHSS) at baseline and at disc...
Source: GEO: Gene Expression Omnibus - May 20, 2022 Category: Genetics & Stem Cells Tags: Methylation profiling by array Homo sapiens Source Type: research

Polymorphisms of TRIB1 Genes for Coronary Artery Disease and Stroke Risk: A Systematic Review and Meta-analysis
CONCLUSIONS: The rs2954029 A allele was significantly associated with an increased risk of CAD and stroke, according to the present meta-analysis. However, the association of rs17321515 polymorphism with susceptibility to CAD and stroke has not been found in this study.PMID:37414350 | DOI:10.1016/j.gene.2023.147613
Source: Gene - July 6, 2023 Category: Genetics & Stem Cells Authors: Jiangang Jiang Xinmin Chen Chengwei Li Xiaoma Du Huadong Zhou Source Type: research

Association of β-fibrinogen promoter gene polymorphism (−148C/T), hyperfibrinogenemia and ischemic stroke in young adult patients
Conclusion There was a significant association between SNP −148C/T and fibrinogen levels, SNP −148C/T and ischemic stroke, and fibrinogen levels and ischemic stroke.
Source: Egyptian Journal of Medical Human Genetics - December 18, 2014 Category: Genetics & Stem Cells Source Type: research

The association between three promoter polymorphisms of IL-1 and stroke: A meta-analysis.
CONCLUSION: In conclusion, our results suggested that IL-1α-889C/T polymorphism is associated with stroke risk, especially in Asians. However, no associations of IL-1β-511C/T and IL-RN polymorphisms on stroke risk in overall analysis or subgroup analysis. PMID: 25917615 [PubMed - as supplied by publisher]
Source: Gene - April 23, 2015 Category: Genetics & Stem Cells Authors: Zou L, Zhao H, Gong X, Jiang A, Guan S, Wang L, Zheng S Tags: Gene Source Type: research

ALA16VAL-MnSOD gene polymorphism and stroke: Association with dyslipidemia and glucose levels.
Abstract Stroke risk has been associated to the progression of carotid plaques due to high glucose levels and lipid accumulation, which are greatly associated to cerebral injury, brain oxidative stress, and apoptosis. The ALA16VAL-MnSOD gene single nucleotide polymorphism (SNP) has shown to modulate risk factors of several metabolic and vascular diseases, such as blood glucose (GLU) and lipid levels. However, the association of these factors in stroke patients has not been studied to date. Thus, we evaluated the influence of the Ala16Val-MnSOD SNP on lipid profile, GLU levels, oxidative and DNA damage of 44 patien...
Source: Gene - May 25, 2017 Category: Genetics & Stem Cells Authors: Flores AE, Pascotini ET, Kegler A, Gabbi P, Bochi GV, Barbisan F, Duarte T, Prado ALC, Duarte MMMF, da Cruz IBM, Moresco RN, Santos ARS, Bresciani G, Royes LFF, Fighera MR Tags: Gene Source Type: research

Chromosome 10q25 polymorphism is associated with susceptibility to large artery atherosclerotic stroke.
CONCLUSIONS: In the southeastern Chinese population, the rs11196288A > G polymorphism is associated with decreased risk of LAA stroke. PMID: 30580071 [PubMed - as supplied by publisher]
Source: Gene - December 20, 2018 Category: Genetics & Stem Cells Authors: Gu M, Wang M, Cai B, Cheng X, Li Z, Sun B, Wang F, Shi Y, Zhang Z, Liu X Tags: Gene Source Type: research