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Specialty: Genetics & Stem Cells

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Total 914 results found since Jan 2013.

Involvement of polymorphisms of the nerve growth factor and its receptor encoding genes in the etiopathogenesis of ischemic stroke
Despite the important role of the nerve growth factor in the survival and maintenance of neurons in ischemic stroke, data regarding the relationships between variations in the encoding gene and stroke are lack...
Source: BMC Medical Genetics - March 2, 2018 Category: Genetics & Stem Cells Authors: Ani Stepanyan, Roksana Zakharyan, Arsen Simonyan, Gohar Tsakanova and Arsen Arakelyan Tags: Research article Source Type: research

Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats
Publication date: Available online 15 June 2018 Source:Genes & Diseases Author(s): Yongying Hou, Ke Wang, Weijun Wan, Yue Cheng, Xia Pu, Xiufeng Ye Ischemic stroke is a common disease with high mortality and morbidity worldwide. One of the important pathophysiological effects of ischemic stroke is apoptosis. A neuroprotective effect is defined as the inhibition of neuronal apoptosis to rescue or delay the infarction in the surviving ischemic penumbra. Resveratrol is a natural polyphenol that reportedly prevents cerebral ischemia injury by regulating the expression of PI3K/AKT/mTOR. Therefore, this study aimed to e...
Source: Genes and Diseases - June 15, 2018 Category: Genetics & Stem Cells Source Type: research

GSE102558 Expression data from heart tissue after induction of ischemic stroke (occlusion of the middle cerebral artery)
Contributors : Lorenz H Lehmann ; Roland VeltkampSeries Type : Expression profiling by arrayOrganism : Mus musculusStroke is frequently associated with cardiac troponin increase and cardiac complications. 24h and 72h after experimental ischemic stroke of the brain, we harvested the heart to investigate pathways and target genes, involved in cardiac dysfunction after acute ischemic stroke
Source: GEO: Gene Expression Omnibus - July 19, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

GSE114897 Real-time quantitative PCR analysis of human stroke patients recovering from upper extremity hemiparesis
Contributor : Matthew A EdwardsonSeries Type : Expression profiling by RT-PCROrganism : Homo sapiensFasting blood samples were collected from 27 stroke patients in EDTA tubes mean 19 days post-stroke, plasma was extracted and frozen at -80C, then 200uL of plasma sent for qPCR.
Source: GEO: Gene Expression Omnibus - August 31, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by RT-PCR Homo sapiens Source Type: research

Intravascular cell therapy in stroke: predicting the future trends.
Abstract This short review examines the trends that have taken place during the last two decades in selecting delivery route and cell product in confirmatory preclinical stroke research. If there had been a major change, this might indicate a strategy with a high potential to enter early-phase clinical studies. The retrospective data show that intravenous cell delivery of mesenchymal stem cells remains the most popular approach in experimental research, clearly dominating early phase clinical studies. The advantages and risks of current practices are discussed in the hope that these will improve translational succ...
Source: Regenerative Medicine - December 18, 2018 Category: Genetics & Stem Cells Authors: Cui L, Moisan A, Jolkkonen J Tags: Regen Med Source Type: research

GSE103782 Stroke target identification guided by astrocyte transcriptome analysis single animal
Contributors : Cordula Rakers ; Melvin Schleif ; Thomas Ulas ; Kristian H ändler ; Santiago ValleTorres ; Toni Schumacher ; Khalid Tai ; Caroline Dalmoro ; Joachim L Schultze ; Walker Jackson ; Gabor C PetzoldSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe aimed to investigate the influence of ischemic stroke in mice on their ribosomal mRNA in astrocytes. Therefore, we make use of the conditional Cre/LoxP System in the RiboTag mouse line in order to isolate the ribosomal mRNA of astrocytes. CreERT2 expression under the astrocyte-specific Cx43 promoter is induced by Tamoxif...
Source: GEO: Gene Expression Omnibus - February 22, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research

GSE103781 Stroke target identification guided by astrocyte transcriptome analysis pool
Contributors : Cordula Rakers ; Melvin Schleif ; Thomas Ulas ; Kristian H ändler ; Santiago ValleTorres ; Toni Schumacher ; Khalid Tai ; Caroline Dalmoro ; Joachim L Schultze ; Walker Jackson ; Gabor C PetzoldSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe aimed to investigate the influence of ischemic stroke in mice on their ribosomal mRNA in astrocytes. Therefore, we make use of the conditional Cre/LoxP System in the RiboTag mouse line in order to isolate the ribosomal mRNA of astrocytes. CreERT2 expression under the astrocyte-specific Cx43 promoter is induced by Tamoxif...
Source: GEO: Gene Expression Omnibus - February 22, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research

Associations of intercellular adhesion molecule ‐1 rs5498 polymorphism with ischemic stroke: A meta‐analysis
ConclusionsOur findings indicated that rs5498 polymorphism was significantly associated with individual susceptibility to IS in Caucasians, but not in Asians.
Source: Molecular Genetics & Genomic Medicine - April 16, 2019 Category: Genetics & Stem Cells Authors: Hua Gao, Xinhua Zhang Tags: ORIGINAL ARTICLE Source Type: research

A Systems Analysis of the Relationships Between Anemia and Ischemic Stroke Rehabilitation Based on RNA-Seq Data
In this study, we choose 28 IS patients, of which 12 were suffering from anemia. Statistical analyses results showed that the outcome of the patients were different when dividing them into two groups characterized by Hb concentration. 2 sex and age matched patients were first chosen to perform RNA-seq analyses twice on different time points, after which the Hb counts were tested at least 24 hours after sequencing. Results showed that the outcome of anemia patients was poor compared with non-anemia patients. Two other patients were then chosen for analyses which excluded the coincidence of other factors. The results showed ...
Source: Frontiers in Genetics - May 23, 2019 Category: Genetics & Stem Cells Source Type: research

PDE3A variant associated with hypertension and brachydactyly syndrome in a patient with ischemic stroke caused by spontaneous intracranial artery dissection: A review of the clinical and molecular genetic features.
Abstract Hypertension and brachydactyly syndrome (HTNB; MIM 112410) is a rare, recently described, autosomal dominant syndromic disease characterized by the triad of brachydactyly type E (BDE), short stature, and hypertension. HTNB is caused by a heterozygous mutation in the PDE3A (MIM 123805) gene on chromosome 12p12; this gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase family. PED3A plays a role in many signal transduction pathways, including those involved in vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, and hormone secretion. ...
Source: European Journal of Medical Genetics - October 3, 2019 Category: Genetics & Stem Cells Authors: Lee CG, Kang K, Yoon RG, Seo JY, Park JM Tags: Eur J Med Genet Source Type: research

GSE140275 Expression profile and potential functions of circulating long noncoding RNAs in acute ischemic stroke in the Southern Chinese Han population
Conclusion: This study provides evidence of altered expression of lncRNAs and their potential functions in AIS. Our findings may facilitate pathological mechanistic studies of lncRNAs in AIS and provide potential diagnostic biomarkers and therapeutic targets for AIS.
Source: GEO: Gene Expression Omnibus - November 13, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE142152 RNA sequencing analysis revealed a distinct motor cortex transcriptome in spontaneously-recovered mice after stroke
Contributors : Michelle Cheng ; Alex G Lee ; Gary SteinbergSeries Type : Expression profiling by high throughput sequencingOrganism :The goal of this study is to elucidate the intrinsic changes in spontaneous recovery after stroke, by directly investigating the transcriptome of primary motor cortex in mice that naturally recovered after stroke.
Source: GEO: Gene Expression Omnibus - December 17, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

GSE120701 Developmentally controlled expression of Cxcr4 by hematopoietic progenitors allows tracing of monocyte function in stroke
Contributors : Yves Werner ; Elvira MassSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMonocyte-derived and tissue-resident macrophages, such as microglia, belong to independent lineages with distinct functions in steady state. During inflammation, however, changes in phenotypes and transcriptional profiles make it difficult to assess their respective roles in pathology. Here, we report that developmentally controlled expression of Cxcr4 by hematopoietic progenitors allows highly specific inducible lineage tracing of hematopoietic stem cell-derived monocytes during inflammation. In t...
Source: GEO: Gene Expression Omnibus - December 31, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research