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Specialty: Genetics & Stem Cells

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Total 914 results found since Jan 2013.

Genes, Vol. 13, Pages 415: Special Issue: & ldquo;Genomics of Stroke & rdquo;
Genes, Vol. 13, Pages 415: Special Issue: “Genomics of Stroke” Genes doi: 10.3390/genes13030415 Authors: Svetlana A. Limborska Ivan B. Filippenkov Stroke is a multifactorial disease and an extremely serious and socially important medical condition [...]
Source: Genes - February 25, 2022 Category: Genetics & Stem Cells Authors: Svetlana A. Limborska Ivan B. Filippenkov Tags: Editorial Source Type: research

Profile and Functional Prediction of Plasma Exosome-Derived CircRNAs From Acute Ischemic Stroke Patients
In conclusion, plasma exosome-derived circRNAs were significantly differentially quantified between AIS patients and controls and participated in the occurrence and progression of AIS by sponging miRNA/RBPs or translating into proteins, indicating that circRNAs from plasma exosomes could be crucial molecules in the pathogenesis of AIS and promising candidates as diagnostic biomarkers and therapeutic targets for the condition.
Source: Frontiers in Genetics - March 14, 2022 Category: Genetics & Stem Cells Source Type: research

GSE199435 Differential expression and correlation analysis of global transcriptome for hemorrhagic transformation after acute ischemic stroke
Contributors : Daojing Li ; Rongrong Han ; Peng Zhang ; Hongfang Li ; Yun Chen ; Yongnan Hao ; Qiang Guo ; Aimei ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn order to explore the epigenetic characteristics of hemorrhagic transformation(HT) after acute ischemic stroke, we used transcriptome sequencing technology to analyze the global transcriptome expression profile of patients with and without HT after acute ischemic stroke and to study the differential expression of messenger RNA (mRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) between HT group and non-HT group.
Source: GEO: Gene Expression Omnibus - March 30, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Association of Single-Nucleotide Polymorphisms of rs2383206, rs2383207, and rs10757278 With Stroke Risk in the Chinese Population: A Meta-analysis
Several studies have reported that chromosome 9p21 is significantly associated with ischemic stroke (IS) risk, with the G allele associated with increased risk. However, controversial results have been reported in the literature. We systematically assessed the relationship between stroke and three 9p21 loci (rs2303206, rs2383207, and rs10757278) in this meta-analysis. First, we searched the PubMed and Embase databases for relevant studies. We then calculated odds ratios using the chi-squared test. The evaluation of experimental data was performed using bias tests and sensitivity analyses. We analyzed data from 16 studies i...
Source: Frontiers in Genetics - June 28, 2022 Category: Genetics & Stem Cells Source Type: research

Genes, Vol. 13, Pages 1584: Hip Osteoarthritis and the Risk of Lacunar Stroke: A Two-Sample Mendelian Randomization Study
This study showed a causal effect of hip OA on the risk of LS, and more efforts should be made to explore the potential mechanisms in the future.
Source: Genes - September 3, 2022 Category: Genetics & Stem Cells Authors: Yi Shen Fuju Li Lina Cao Yunyun Wang Jing Xiao Xiaoyi Zhou Tian Tian Tags: Article Source Type: research

A cross-species approach using an in  vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes
Using a newly established in  vivo gene rescue platform in mice, we validated Rabep2, a candidate gene modulating infarct volume after ischemic stroke. We then determined the functional consequences of human RABEP2-coding variants. This cross-species approach will expand the number of physiologically relevant therapeutic targe ts for human ischemic stroke.
Source: The American Journal of Human Genetics - September 26, 2022 Category: Genetics & Stem Cells Authors: Han Kyu Lee, Do Hoon Kwon, David L. Aylor, Douglas A. Marchuk Tags: Article Source Type: research

Impact of frailty models on the prescription of oral anticoagulants and on the incidence of stroke, bleeding, and mortality in older patients with atrial fibrillation: a systematic review
CONCLUSIONS: Due to the great heterogeneity among different validated frailty measures, indiscriminately relying on "frailty" should not be regarded as the gold standard for clinical decision-making about stroke prevention in older AF patients. Present findings suggest that severe frailty according to the DAM is associated with less use of OAT and increased risk of all-cause mortality, thereby representing at the moment the most reasonable tool to efficiently recognize patients with limited life expectancy and for whom there is so far scant, if any, evidence of a clinical benefit of OAT.AVAILABILITY OF DATA AND MATERIAL: A...
Source: Ageing Research Reviews - October 21, 2022 Category: Genetics & Stem Cells Authors: Roberto Presta Enrico Brunetti Maria Cristina Polidori Mario Bo Source Type: research

GSE206945 Gene expression profile at single cell level of infiltrated macrophages from ischemic brain after stroke
Contributors : Wei Cai ; Zhengqi LuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMacrophages play an important role in the pathological process of stroke. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of infiltrated macrophages from ischemic brain after stroke.
Source: GEO: Gene Expression Omnibus - December 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Genes, Vol. 14, Pages 353: Common Genetic Factors and Pathways in Alzheimer & rsquo;s Disease and Ischemic Stroke: Evidences from GWAS
Genes, Vol. 14, Pages 353: Common Genetic Factors and Pathways in Alzheimer’s Disease and Ischemic Stroke: Evidences from GWAS Genes doi: 10.3390/genes14020353 Authors: Wei Dong Yue Huang Alzheimer’s disease (AD) and ischemic stroke (IS) are common neurological disorders, and the comorbidity of these two brain diseases is often seen. Although AD and IS were regarded as two distinct disease entities, in terms of different etiologies and clinical presentation, recent genome-wide association studies (GWASs) revealed that there were common risk genes between AD and IS, indicating common molecu...
Source: Genes - January 30, 2023 Category: Genetics & Stem Cells Authors: Wei Dong Yue Huang Tags: Review Source Type: research

GSE223628 Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate (bulk)
Contributors : Jie Ding ; Kanako Yuki ; Calvin KuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDerangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The Norrin/FZD4/TSPAN12 pathway activates WNT/ -catenin signaling, which is essential for BBB and BRB function. However, systemic pharmacologic FZD4 stimulation is hindered by obligate palmitoylation and insolubility of native WNTs and suboptimal properties of the FZD4-selective ligand Norrin. Here, we developed L6-F...
Source: GEO: Gene Expression Omnibus - January 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE223498 Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate
Contributors : Jie Ding ; Lukas Vlahos ; Vincent van Unen ; Kanako Yuki ; Calvin KuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDerangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The Norrin/FZD4/TSPAN12 pathway activates WNT/ -catenin signaling, which is essential for BBB and BRB function. However, systemic pharmacologic FZD4 stimulation is hindered by obligate palmitoylation and insolubility of native WNTs and suboptimal properties of the FZD4-selective liga...
Source: GEO: Gene Expression Omnibus - January 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Genes, Vol. 14, Pages 514: Special Issue & ldquo;Genomics of Stroke & rdquo; 2022
Genes, Vol. 14, Pages 514: Special Issue “Genomics of Stroke” 2022 Genes doi: 10.3390/genes14020514 Authors: Svetlana A. Limborska Ivan B. Filippenkov Stroke is one of the greatest medical threats to human health and quality of life in modern society [...]
Source: Genes - February 17, 2023 Category: Genetics & Stem Cells Authors: Svetlana A. Limborska Ivan B. Filippenkov Tags: Editorial Source Type: research

GSE199819 seq-RNA analysis of PBMC in stroke patients with severe atherosclerosis and healthy donors
Contributors : Xiaohong Cen ; Kui ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goals of this study are to evaluate the gene expression of PBMC in stroke patients with atherosclerosis compared with healthy donors. PBMC mRNA profiles of stroke patients and healthy donors were generated by sequencing using Illumina. We detected 60613 transcripts, and there are there are 470 significant genes expression upregulated (fold change> 2 and p value
Source: GEO: Gene Expression Omnibus - March 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Repetitive Transcranial Magnetic Stimulation Combined with Cognitive Training for Cognitive Function and Activities of Daily Living in Patients with Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis
CONCLUSIONS: The pooled data showed more positive effects of rTMS + cognitive training for global cognition, executive function, working memory and ADL in patients with PSCI. While, robust evidence of rTMS + cognitive training for global cognition, executive function, working memory and ADL from the Grade recommendations is lacking. Further, rTMS + cognitive training did not show no better effects on memory. Future definitive trials are needed to determine the benefits of rTMS + cognitive training for cognitive function and ADL in the field of PSCI.PMID:37004840 | DOI:10.1016/j.arr.2023.101919
Source: Ageing Research Reviews - April 2, 2023 Category: Genetics & Stem Cells Authors: Yong Gao Yue Qiu Qingyan Yang Shaowen Tang Jianqiu Gong Hong Fan Yuefeng Wu Xiao Lu Source Type: research