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Specialty: Genetics & Stem Cells

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Total 914 results found since Jan 2013.

Heart Failure and Ischemic Stroke: A Bidirectional and Multivariable Mendelian Randomization Study
Conclusion: This MR analysis provided evidence of the causal links between genetically predicted HF and IS. Subgroup analysis highlighted the causal or suggestive relationship between genetically predicted HF and LAS or CES. The potential causal links need further investigation with genetic information about other ancestries or etiologies of HF.
Source: Frontiers in Genetics - November 29, 2021 Category: Genetics & Stem Cells Source Type: research

Multi-omics research strategies in ischemic stroke: A multidimensional perspective
Ageing Res Rev. 2022 Sep 7:101730. doi: 10.1016/j.arr.2022.101730. Online ahead of print.ABSTRACTIschemic stroke (IS) is a multifactorial and heterogeneous neurological disorder with high rate of death and long-term impairment. Despite years of studies, there are still no stroke biomarkers for clinical practice, and the molecular mechanisms of stroke remain largely unclear. The high-throughput omics approach provides new avenues for discovering biomarkers of IS and explaining its pathological mechanisms. However, single-omics approaches only provide a limited understanding of the biological pathways of diseases. The integr...
Source: Ageing Research Reviews - September 10, 2022 Category: Genetics & Stem Cells Authors: Wentao Li Chongyu Shao Huifen Zhou Haixia Du Haiyang Chen Haitong Wan Yu He Source Type: research

Genes, Vol. 13, Pages 2204: Proteomic Markers in the Muscles and Brain of Pigs Recovered from Hemorrhagic Stroke
Conclusions: A network of gene interactions has been constructed for proteins involved in the regulation of synaptic transmission, in particular presynaptic vesicular and endocytic processes. The presence of transmitters and transporters associated with stimulation of NMDA receptors at neuromuscular junctions shows the relationship between upper motor neurons and neuromuscular junctions.
Source: Genes - November 24, 2022 Category: Genetics & Stem Cells Authors: Fedulova Vasilevskaya Tikhonova Kazieva Tolmacheva Makarenko Tags: Article Source Type: research

Genes, Vol. 14, Pages 454: Temporal and Spatial Gene Expression Profile of Stroke Recovery Genes in Mice
kus Aswendt Stroke patients show some degree of spontaneous functional recovery, but this is not sufficient to prevent long-term disability. One promising approach is to characterize the dynamics of stroke recovery genes in the lesion and distant areas. We induced sensorimotor cortex lesions in adult C57BL/6J mice using photothrombosis and performed qPCR on selected brain areas at 14, 28, and 56 days post-stroke (P14-56). Based on the grid walk and rotating beam test, the mice were classified into two groups. The expression of cAMP pathway genes Adora2a, Pde10a, and Drd2, was higher in poor- compared to well-recovered ...
Source: Genes - February 9, 2023 Category: Genetics & Stem Cells Authors: Jan G ötz Frederique Wieters Veronika J. Fritz Olivia K äsgen Aref Kalantari Gereon R. Fink Markus Aswendt Tags: Article Source Type: research

Polymorphism in genes encoding two fatty acid binding proteins increases risk of ischemic stroke in a Chinese Han population
Conclusion: The GA genotype of FABP2 rs1799883, interactions between rs1799883, rs2241883 and smoking and alcohol consumption were associated with IS risk in Chinese Han populations.
Source: Frontiers in Genetics - April 6, 2023 Category: Genetics & Stem Cells Source Type: research

Genes, Vol. 14, Pages 1382: Synthetic Adrenocorticotropic Peptides Modulate the Expression Pattern of Immune Genes in Rat Brain following the Early Post-Stroke Period
This study gives insight into how the transcriptome depends on the variation in the structure of the related peptides, and it is valuable from the standpoint of the development of measures for early post-stroke therapy.
Source: Genes - June 30, 2023 Category: Genetics & Stem Cells Authors: Ivan B. Filippenkov Julia A. Remizova Vasily V. Stavchansky Alina E. Denisova Leonid V. Gubsky Nikolay F. Myasoedov Svetlana A. Limborska Lyudmila V. Dergunova Tags: Article Source Type: research

Genes, Vol. 14, Pages 1448: Isoflurane Anesthesia & rsquo;s Impact on Gene Expression Patterns of Rat Brains in an Ischemic Stroke Model
Conclusions: We were able to determine the effects of the duration of anesthesia using isoflurane on the transcriptomes in the brains of rats at 24 h after tMCAO. Thus, specific genome responses may be useful in developing potential approaches to reduce damaged areas after cerebral ischemia and neuroprotection.
Source: Genes - July 14, 2023 Category: Genetics & Stem Cells Authors: Yana Y. Shpetko Ivan B. Filippenkov Alina E. Denisova Vasily V. Stavchansky Leonid V. Gubsky Svetlana A. Limborska Lyudmila V. Dergunova Tags: Article Source Type: research

GSE216349 TMAO promotes NLRP3 inflammasome activation of microglia aggravating neurological injury in stroke through FTO/IGF2BP2
In conclusion, these results demonstrated that TMAO promotes NLRP3 inflammasome activation of microglia aggravating neurological injury in stroke through FTO/IGF2BP2.
Source: GEO: Gene Expression Omnibus - September 6, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Pathogenesis of Acute Stroke and the Role of Inflammasomes.
Abstract Inflammation is an innate immune response to infection or tissue damage that is designed to limit harm to the host, but contributes significantly to ischemic brain injury following stroke. The inflammatory response is initiated by the detection of acute damage via extracellular and intracellular pattern recognition receptors, which respond to conserved microbial structures, termed pathogen-associated molecular patterns or host-derived danger signals termed damage-associated molecular patterns. Multi-protein complexes known as inflammasomes (e.g. containing NLRP1, NLRP2, NLRP3, NLRP6, NLRP7, NLRP12, NLRC4,...
Source: Ageing Research Reviews - October 5, 2013 Category: Genetics & Stem Cells Authors: Fann DY, Lee SY, Manzanero S, Chunduri P, Sobey CG, Arumugam TV Tags: Ageing Res Rev Source Type: research

Association of IL-6-174G>C and -572C>G polymorphisms with risk of young ischemic stroke patients.
CONCLUSION: Our results suggest that polymorphisms in IL-6-174G>C and -572C>G are associated with IS risk in young patients, and that these polymorphisms interact with hypertension, obesity and etiologic subtypes. These findings could be helpful in identifying individuals at increased risk for developing IS. PMID: 24486505 [PubMed - as supplied by publisher]
Source: Gene - January 29, 2014 Category: Genetics & Stem Cells Authors: Yang X, Feng L, Li C, Li Y Tags: Gene Source Type: research

A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach
by Matthew Traylor, Kari-Matti Mäkelä, Laura L. Kilarski, Elizabeth G. Holliday, William J. Devan, Mike A. Nalls, Kerri L. Wiggins, Wei Zhao, Yu-Ching Cheng, Sefanja Achterberg, Rainer Malik, Cathie Sudlow, Steve Bevan, Emma Raitoharju, METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2) , Niku Oksala, Vincent Thijs, Robin Lemmens, Arne Lindgren, Agnieszka Slowik, Jane M. Maguire, Matthew Walters, Ale Algra, Pankaj Sharma, John R. Attia, Giorgio B. Boncoraglio, Peter M. Rothwell, Paul I. W. de Bakker, Joshua C. Bis, Danish Saleheen, Steven J. Kittner, Braxton D. Mitchell, Jonat...
Source: PLoS Genetics - July 31, 2014 Category: Genetics & Stem Cells Authors: Matthew Traylor et al. Source Type: research

Pontine Microbleeds and Depression in Stroke
Conclusion: The results suggest that pontine CMBs are associated with a higher risk of developing PSD.
Source: Journal of Geriatric Psychiatry and Neurology - August 14, 2014 Category: Genetics & Stem Cells Authors: Tang, W. K., Liu, X. X., Chen, Y. K., Abrigo, J., Chu, W. C. W., Mok, V. C. T., Ungvari, G. S., Wong, K. S. Tags: Articles Source Type: research

Pharmacogenetic effects of ‘candidate gene complexes’ on stroke in the GenHAT study
ObjectiveThe aim of this study was to investigate whether there is a genotype-by-treatment interaction in patients experiencing stroke and treated with one of three antihypertensive drugs, that is chlorthalidone, amlodipine, or lisinopril. Participants and methodsA population of 436 African Americans and 539 whites who had experienced stroke in the GenHAT study were genotyped for 768 single nucleotide polymorphisms (SNPs) in 280 candidate genes. To detect a genotype-by-treatment interaction, we used the Pearson’s χ2-test to assess whether the genotype frequencies differed at the single SNP level for the three drug treat...
Source: Pharmacogenetics and Genomics - October 9, 2014 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Correlation of plasma soluble cluster of differentiation 40 ligand, alpha fetoprotein A, and pregnancy-associated plasma protein A with carotid plaque in patients with ischemic stroke.
This study investigated the correlation of plama levels of inflammatory biomarkers [soluble cluster of differentiation 40 ligand (sCD40L), alpha fetoprotein A (fetuin-A), and pregnancy-associated protein A (PAPP-A)] with carotid plaque in patients with acute ischemic stroke. After undergoing color Doppler ultrasonography of the bilateral carotid arteries, 200 patients with acute ischemic stroke were grouped into plaque and non-plaque groups. The plaque group was further divided into stable and unstable plaque sub-groups by carotid plaque stability. Inter-group and -subgroup comparisons included demographic characteristics,...
Source: Genetics and Molecular Research - July 29, 2015 Category: Genetics & Stem Cells Authors: Wang YJ, Gong ZQ, Bi XM, Li YL Tags: Genet Mol Res Source Type: research