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Specialty: Genetics & Stem Cells

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Total 914 results found since Jan 2013.

GSE135480 Genome-wide identification of enhancer domains in the healthy and post-stroke mouse cortices
We report the identification of enhancer domains in sham and stroke mouse cerebral cortices by high-throughput profiling of H3K27Ac chromatin modification. A total of 35.4, 28.8 and 29.6 million reads were generated from chromatin immunoprecipitated DNA from sham, stroke and pooled input samples. This resulted in 55,571 peaks in sham and 56,110 peaks in stroke samples representing 50408 and 51,292 active regions, respectively. These active regions represent putative enhancer domains.
Source: GEO: Gene Expression Omnibus - November 12, 2020 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

Transcriptome profiling revealed early vascular smooth muscle cell gene activation following focal ischemic stroke in female rats – comparisons with males
Women account for 60% of all stroke deaths and are more often permanently disabled than men, despite their higher observed stroke incidence. Considering the clinical population affected by stroke, an obvious d...
Source: BMC Genomics - December 9, 2020 Category: Genetics & Stem Cells Authors: Mimmi Rehnstr öm, Simona Denise Frederiksen, Saema Ansar and Lars Edvinsson Tags: Research article Source Type: research

Genes, Vol. 12, Pages 328: A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes
a Limborska In this paper we propose a workflow for studying the genetic architecture of ischemic stroke outcomes. It develops further the candidate gene approach. The workflow is based on the animal model of brain ischemia, comparative genomics, human genomic variations, and algorithms of selection of tagging single nucleotide polymorphisms (tagSNPs) in genes which expression was changed after ischemic stroke. The workflow starts from a set of rat genes that changed their expression in response to brain ischemia and results in a set of tagSNPs, which represent other SNPs in the human genes analyzed and influenced on t...
Source: Genes - February 25, 2021 Category: Genetics & Stem Cells Authors: Gennady Khvorykh Andrey Khrunin Ivan Filippenkov Vasily Stavchansky Lyudmila Dergunova Svetlana Limborska Tags: Article Source Type: research

Genes, Vol. 12, Pages 1617: Isolation of RNA from Acute Ischemic Stroke Clots Retrieved by Mechanical Thrombectomy
Adnan H. Siddiqui Mechanical thrombectomy (MT) for large vessel acute ischemic stroke (AIS) has enabled biologic analyses of resected clots. While clot histology has been well-studied, little is known about gene expression within the tissue, which could shed light on stroke pathophysiology. In this methodological study, we develop a pipeline for obtaining useful RNA from AIS clots. A total of 73 clot samples retrieved by MT were collected and stored in RNALater and in 10% phosphate-buffered formalin. RNA was extracted from all samples using a modified Chemagen magnetic bead extraction protocol on the PerkinElmer Chem...
Source: Genes - October 14, 2021 Category: Genetics & Stem Cells Authors: Vincent M. Tutino Sarah Fricano Kirsten Frauens Tatsat R. Patel Andre Monteiro Hamid H. Rai Muhammad Waqas Lee Chaves Kerry E. Poppenberg Adnan H. Siddiqui Tags: Article Source Type: research

GSE161913 CircRNA expression profiles in peripheral blood mononuclear cells of patients with large-artery atherosclerotic stroke
Contributors : Shengnan Li ; Weidong Hu ; Fu Deng ; Shaofeng Chen ; Peiyi Zhu ; Mengxu Wang ; Xinglan Chen ; Ying Wang ; Xingjuan Hu ; Bin Zhao ; Wangtao Zhong ; Guoda Ma ; You LiSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensCircular RNAs (circRNAs) are a recently discovered non-coding RNA isoform capable of regulating neurological disease incidence. The present study was designed to characterize the circRNA expression profiles present in large-artery atherosclerosis (LAA)-type acute ischemic stroke patients. Using a RNA-seq a...
Source: GEO: Gene Expression Omnibus - December 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research

Educational Attainment and Ischemic Stroke: A Mendelian Randomization Study
The objective of our study was to evaluate the potential causal association between higher education and the risk of stroke. Here, we performed a Mendelian randomization analysis to evaluate the potential association of educational attainment with ischemic stroke (IS) using large-scale GWAS datasets from the Social Science Genetic Association Consortium (SSGAC, 293,723 individuals), UK Biobank (111,349 individuals), and METASTROKE consortium (74,393 individuals). We selected three Mendelian randomization methods including inverse-variance-weighted meta-analysis (IVW), weighted median regression, and MR–Egger regression. ...
Source: Frontiers in Genetics - February 11, 2022 Category: Genetics & Stem Cells Source Type: research

A Bidirectional Mendelian Randomization Study of Selenium Levels and Ischemic Stroke
Conclusion: The MR study indicated no evidence to support the causal links between genetically predicted selenium levels and IS. Our results also did not support the use of selenium supplementation for IS prevention at the genetic level.
Source: Frontiers in Genetics - April 13, 2022 Category: Genetics & Stem Cells Source Type: research

Genes, Vol. 13, Pages 1179: Genotype-Phenotype Correlation and Functional Insights for Two Monoallelic TREX1 Missense Variants Affecting the Catalytic Core
In conclusion, functional analysis allowed us to interpret the impact of TREX1 variants on patients’ phenotypes. While the p.A136V variant is unlikely to be causative for AGS in Patient A, Patient B’s phenotype is potentially related to the p.R174G variant. Therefore, further functional investigations of TREX1 variants found in CADASIL-like patients are warranted to determine any causal link and interrogate the molecular disease mechanism(s).
Source: Genes - June 30, 2022 Category: Genetics & Stem Cells Authors: Giulia Amico Wayne O. Hemphill Mariasavina Severino Claudio Moratti Rosario Pascarella Marta Bertamino Flavia Napoli Stefano Volpi Francesca Rosamilia Sara Signa Fred Perrino Marialuisa Zedde Isabella Ceccherini on behalf of the Gaslini Stroke Study Group Tags: Article Source Type: research

GSE214644 Regeneration of the cerebral cortex by direct chemical reprogramming of macrophages into neuronal cells in acute ischemic stroke
Contributors : Itaru Ninomiya ; Akihide Koyama ; Yutaka Otsu ; Masato Kanazawa ; Osamu OnoderaSeries Type : Expression profiling by arrayOrganism : Homo sapiensIschemic stroke causes extensive neuronal cell death. Antithrombotic agents and rehabilitation are the primary treatment options but have limited efficacy. Therefore, to achieve radical neurological improvement, practical neuroregenerative technologies must be developed. Recently, direct chemical reprogramming using small molecules to transdifferentiate somatic cells into neurons has garnered much attention. We investigated the possibility of applying this technolog...
Source: GEO: Gene Expression Omnibus - October 5, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Updated Stroke Gene Panels: Rapid evolution of knowledge on monogenic causes of stroke
European Journal of Human Genetics, Published online: 17 October 2022; doi:10.1038/s41431-022-01207-6Updated Stroke Gene Panels: Rapid evolution of knowledge on monogenic causes of stroke
Source: European Journal of Human Genetics - October 17, 2022 Category: Genetics & Stem Cells Authors: Andreea Ilinca Andreas Puschmann Jukka Putaala Frank Erik de Leeuw John Cole Stephen Kittner Ulf Kristoffersson Arne G. Lindgren Source Type: research

GAS6-AS1, a long noncoding RNA, functions as a key candidate gene in atrial fibrillation related stroke determined by ceRNA network analysis and WGCNA
Stroke attributable to atrial fibrillation (AF related stroke, AFST) accounts for 13  ~ 26% of ischemic stroke. It has been found that AFST patients have a higher risk of disability and mortality than those wit...
Source: BMC Medical Genomics - March 9, 2023 Category: Genetics & Stem Cells Authors: Rui-bin Li, Xiao-hong Yang, Ji-dong Zhang and Wei Cui Tags: Research Source Type: research

Genes, Vol. 14, Pages 1171: Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis
Olga Y. Bushueva HSPA8 is involved in many stroke-associated cellular processes, playing a pivotal role in the protein quality control system. Here we report the results of the pilot study aimed at determining whether HSPA8 SNPs are linked to the risk of ischemic stroke (IS). DNA samples from 2139 Russians (888 IS patients and 1251 healthy controls) were genotyped for tagSNPs (rs1461496, rs10892958, and rs1136141) in the HSPA8 gene using probe-based PCR. SNP rs10892958 of HSPA8 was associated with an increased risk (risk allele G) of IS in smokers (OR = 1.37; 95% CI = 1.07–1.77; p = 0.01) and patients ...
Source: Genes - May 27, 2023 Category: Genetics & Stem Cells Authors: Ksenia A. Kobzeva Maria O. Soldatova Tatiana A. Stetskaya Vladislav O. Soldatov Alexey V. Deykin Maxim B. Freidin Marina A. Bykanova Mikhail I. Churnosov Alexey V. Polonikov Olga Y. Bushueva Tags: Article Source Type: research

The Association Between Thymidylate Synthase Gene Polymorphisms and the Risk of Ischemic Stroke in Chinese Han Population
In conclusion: This study has shown that TS rs699517 and rs2790 were significantly related to ischemic stroke patients.PMID:37378701 | DOI:10.1007/s10528-023-10431-8
Source: Biochemical Genetics - June 28, 2023 Category: Genetics & Stem Cells Authors: Fuhua Yu Lei Shi Qianru Wang Xiaohui Xing Zhongchen Li Lei Hou Zhengshan Zhou Zengguang Wang Yilei Xiao Source Type: research

An updated meta-analysis of endothelial nitric oxide synthase gene: Three well-characterized polymorphisms with ischemic stroke.
Abstract Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of ischemic stroke (IS), but the results are still debatable. A meta-analysis was performed to investigate the association between the eNOS gene polymorphisms in IS risk. Case-control studies on the association between the G894T, T-786C, and 4b/a polymorphisms and IS were searched up to July 2012, and the genotype frequencies in the control group were found to be consistent with the Hardy-Weinberg equilibrium (HWE). The effect summary odds ratio (OR) and 95% confidence intervals (CIs) were obtained. Meta-regression w...
Source: Gene - July 8, 2013 Category: Genetics & Stem Cells Authors: Yao YS, Chang WW, Jin YL, He LP Tags: Gene Source Type: research