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Specialty: Genetics & Stem Cells

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Total 914 results found since Jan 2013.

Stroke-associated pattern of gene expression previously identified by machine-learning is diagnostically robust in an independent patient population
The objective of this study was to assess the diagnostic capacity and temporal stability of this stroke-associated transcriptional signature in an independent patient population. Publicly available whole blood microarray data generated from 23 ischemic stroke patients at 3, 5, and 24h post-symptom onset, as well from 23 cardiovascular disease controls, were obtained via the National Center for Biotechnology Information Gene Expression Omnibus. Expression levels of the ten candidate genes (ANTXR2, STK3, PDK4, CD163, MAL, GRAP, ID3, CTSZ, KIF1B, and PLXDC2) were extracted, compared between groups, and evaluated for their dis...
Source: Genomics Data - September 2, 2017 Category: Genetics & Stem Cells Source Type: research

GSE128623 The spinal transcriptome after cortical stroke – In search of molecular factors regulating spontaneous recovery in the spinal cord
In this study, we provide insights into the molecular changes in the spinal cord tissue after large ischemic cortical injury in adult female mice, with a focus on factors that might influence the re-innervation process by contralesional corticospinal neurons. We mapped the area of cervical grey matter re-innervation by sprouting contralesional corticospinal axons after unilateral photothrombotic stroke of the motor cortex in mice using anterograde tracing. The mRNA profile of this re-innervation area was analyzed using whole-genome sequencing to identify differentially expressed genes at selected time points during the rec...
Source: GEO: Gene Expression Omnibus - April 30, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Analysis of association between RAGE polymorphisms and stroke risk
Publication date: Available online 29 August 2019Source: Meta GeneAuthor(s): Mohammad Reza Safari, Rezvan Noroozi, Mir Davood Omrani, Mohammad Taheri, Soudeh Ghafouri-FardAbstractReceptor for advanced glycation end products (RAGE) is a kind of immunoglobulins that interacts with several ligands and participates in regulation of immune responses. Variants within RAGE gene have been associated with risk of stroke in different populations. In the present study, we have assessed associations between two single nucleotide polymorphisms (SNPs) in this gene and risk of ischemic stroke in Iranian persons by using tetra primer-ampl...
Source: Meta Gene - August 30, 2019 Category: Genetics & Stem Cells Source Type: research

Ctnnb1 transcriptional upregulation compensates for Mdm2/p53-mediated β-catenin degradation in neutrophils following cardioembolic stroke.
CONCLUSION: Compensatory Ctnnb1 transcriptional upregulation in neutrophils induced by ischemic neuron exposure may be involved in promoting neutrophil survival following cardioembolic stroke. PMID: 32758579 [PubMed - as supplied by publisher]
Source: Gene - August 2, 2020 Category: Genetics & Stem Cells Authors: Wang H, Zhou K, Li W, Du J, Xiao J Tags: Gene Source Type: research

Neuroprotective Effects of SOX5 against Ischemic Stroke by Regulating VEGF/PI3K/AKT pathway.
In conclusion, SOX5 transcription regulates the expression of VEGF to activate the PI3K/AKT pathway, which repaired nerve damage caused by ischemic stroke. Therefore, SOX5 could be a new targetto regulate VEGF which can repair nerve injury induced by ischemic stroke. PMID: 32949698 [PubMed - as supplied by publisher]
Source: Gene - September 15, 2020 Category: Genetics & Stem Cells Authors: Zhang W, Wu Y, Chen H, Yu D, Zhao J, Chen J Tags: Gene Source Type: research

GSE162072 Transcriptome profiling following focal ischemic stroke in female rats
Contributors : Mimmi Rehnstr öm ; Simona D Frederiksen ; Saema Ansar ; Lars EdvinssonSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusBackground. Women account for 60% of all stroke deaths and are more often permanently disabled than men, despite their higher observed stroke incidence. Considering the clinical population affected by stroke, an obvious drawback is that many pre-clinical and clinical studies only investigate young males. To improve therapeutic translation from bench to bedside, we believe that it is advantageous to include both sexes in experimental models of stroke. The aims of this s...
Source: GEO: Gene Expression Omnibus - November 25, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research

Exploring the bi-directional relationship and shared genes between depression and stroke via NHANES and bioinformatic analysis
Conclusion: We successfully identified the ten hub shared genes linking the IS and MDD and constructed the regulatory networks for them that could serve as novel targeted therapy for the comorbidities.
Source: Frontiers in Genetics - March 31, 2023 Category: Genetics & Stem Cells Source Type: research

Identification of the lncRNA –miRNA‒mRNA regulatory network for middle cerebral artery occlusion-induced ischemic stroke
Stroke known as a neurological disease has significant rates of disability and mortality. Middle cerebral artery occlusion (MCAO) models in rodents is crucial in stroke research to mimic human stroke. Building the mRNA and non-conding RNA network is essential for preventing MCAO-induced ischemic stroke occurrence. Herein, genome-wide mRNA, miRNA, and lncRNA expression profiles among the MCAO group at 3 h, 6 h, and 12 h after surgery and controls using high-throughput RNA sequencing. We detected differentially expressed mRNAs (DE-mRNAs), miRNAs (DE-miRNAs), and lncRNAs (DE-lncRNAs) between the MCAO and control groups. In...
Source: Frontiers in Genetics - May 9, 2023 Category: Genetics & Stem Cells Source Type: research

Methylenetetrahydrofolate Reductase (MTHFR) Gene polymorphisms and susceptibility to ischemic stroke:A meta-analysis.
Abstract Associations between 5, 10-methylenetetrahydrofolate reductase (MTHFR) Gene C677T polymorphism and ischemic stroke have been reported [1-3], but the results of these studies are inconsistent. To investigate the possible associations between the MTHFR gene polymorphism and ischemic stroke, we performed a meta-analysis. Nineteen case-control studies were included associated with MTHFR gene C667T involving 2223 cases and 2936 controls. Heterogeneity among studies was evaluated with I(2) and Egger's test and an inverted funnel plot was used to assess publication bias. Odds ratio (OR) was observed to identify ...
Source: Gene - October 16, 2013 Category: Genetics & Stem Cells Authors: Li P, Qin C Tags: Gene Source Type: research

An intronic haplotype in α galactosidase A is associated with reduced mRNA expression in males with cryptogenic stroke.
Abstract Persons with unexplained early-onset stroke have been targeted for screening surveys for Fabry disease, the most common of the three X-linked lysosomal disorders, because Fabry patients with stroke are more likely to have the life-threatening progressive cardiac and renal manifestations and would therefore most benefit from early diagnosis and intervention with enzyme replacement therapy (ERT). Among 175 Israeli patients with unexplained cryptogenic stroke screened for mutations in the Fabry α galactosidase A (GLA) gene, sequencing identified six with 2-4 GLA intronic variants, one of whose father and th...
Source: Gene - August 4, 2014 Category: Genetics & Stem Cells Authors: Zeevi DA, Hakam-Spector E, Herskovitz Y, Beeri R, Elstein D, Altarescu G Tags: Gene Source Type: research

PPARγ and IL-6 -174G>C gene variants in Croatian patients with ischemic stroke.
CONCLUSION: We can point to the IL-6 -174G>C polymorphisms as candidate gene marker and risk factor for the prediction of ischemic stroke. PMID: 25659766 [PubMed - as supplied by publisher]
Source: Gene - February 7, 2015 Category: Genetics & Stem Cells Authors: Bazina A, Sertić J, Mišmaš A, Lovrić T, Poljaković Z, Miličić D Tags: Gene Source Type: research

Susceptible and protective associations of HLA DRB1*/DQB1* alleles and haplotypes with ischaemic stroke
Summary Stroke has emerged as the second commonest cause of mortality worldwide and is a major public health problem. For the first time, we present here the association of human leucocyte antigen (HLA)‐DRB1*/DQB1* alleles and haplotypes with ischaemic stroke in South Indian patients. Ischaemic stroke (IS) cases and controls were genotyped for HLA‐DRB1*/DQB1* alleles by polymerase chain reaction sequence‐specific primers (PCR‐SSP) method. The frequencies of HLA class II alleles such as DRB1*04, DRB1*07, DRB1*11, DRB1*12, DRB1*13, DQB1*02 and DQB1*07 were high in IS patients than in the age‐ and gender‐matched c...
Source: International Journal of Immunogenetics - March 31, 2016 Category: Genetics & Stem Cells Authors: V. Murali, C. Rathika, S. Ramgopal, R. Padma Malini, M. J. Arun Kumar, V. Neethi Arasu, K. Jeyaram Illiayaraja, K. Balakrishnan Tags: Original Article Source Type: research

Genome-Wide Analysis of the Circulating miRNome After Cerebral Ischemia Reveals a Reperfusion-Induced MicroRNA Cluster.
CONCLUSIONS: Alteration of the miRNome in the circulation is associated with cerebral ischemia/reperfusion, but not hemorrhage, suggesting a potential to serve as biomarkers for reperfusion in the acute phase. The pathophysiological role of reperfusion-inducible miR-1264/1298/448 cluster, which is located on chromosome X within the introns of the serotonin receptor HTR2C, requires further investigation. PMID: 28193834 [PubMed - as supplied by publisher]
Source: Genomics Proteomics ... - February 12, 2017 Category: Genetics & Stem Cells Authors: Uhlmann S, Mracsko E, Javidi E, Lamble S, Teixeira A, Hotz-Wagenblatt A, Glatting KH, Veltkamp R Tags: Stroke Source Type: research

Genes, Vol. 8, Pages 89: Epigenetics in Stroke Recovery
Abstract: While the death rate from stroke has continually decreased due to interventions in the hyperacute stage of the disease, long-term disability and institutionalization have become common sequelae in the aftermath of stroke. Therefore, identification of new molecular pathways that could be targeted to improve neurological recovery among survivors of stroke is crucial. Epigenetic mechanisms such as post-translational modifications of histone proteins and microRNAs have recently emerged as key regulators of the enhanced plasticity observed during repair processes after stroke. In this review, we highlight the recent a...
Source: Genes - February 26, 2017 Category: Genetics & Stem Cells Authors: Haifa Kassis Amjad Shehadah Michael Chopp Zheng Zhang Tags: Review Source Type: research

GSE116878 Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke
Contributors : Joonki Kim ; Thiruma V ArumugamSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntermittent fasting is previously reported to exhibit neuroprotection against experimental ischemic stroke. However, the detailed understanding of protection mechanisms are lacking. By observing the overall transcriptomic changes in each timepoint of ischemic stroke would benefit the understanding of underlying active pathways and mechanisms. Here, we conduct experimental MCAO ischemic stroke on mice exposed to different daily intermittent fasting method to compare not only among the ischemi...
Source: GEO: Gene Expression Omnibus - July 11, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research