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Specialty: Genetics & Stem Cells

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Total 914 results found since Jan 2013.

Daily Life Behaviors and Depression Risk Following Stroke: A Preliminary Study Using Ecological Momentary Assessment
Approximately one-third of stroke survivors have symptoms of depression. A better understanding of the early risk factors implicated in this form of comorbidity may contribute to the development of early prevention strategies and to improving outcomes for this population. The current study uses ecological momentary assessment techniques to identify behavioral risk factors for depression 3 months after stroke. Thirty-six participants completed ambulatory monitoring of daily life circumstances (location, social environment, and activity) 5 times per day during a 1-week period after hospital discharge. Clinician-administered ...
Source: Journal of Geriatric Psychiatry and Neurology - August 23, 2013 Category: Genetics & Stem Cells Authors: Jean, F. A. M., Swendsen, J. D., Sibon, I., Feher, K., Husky, M. Tags: Articles Source Type: research

Natural Genetic Variation of Integrin Alpha L (Itgal) Modulates Ischemic Brain Injury in Stroke
In this study, genome-wide association mapping using 32 inbred mouse strains and an additional linkage scan for infarct volume confirmed that the size of the infarct is determined by ancestral alleles of the causative gene(s). The genetically isolated Civq1 locus in reciprocal recombinant congenic mice refined the critical interval and demonstrated that infarct size is determined by both vascular (collateral vessel anatomy) and non-vascular (neuroprotection) effects. Through the use of interval-specific SNP haplotype analysis, we further refined the Civq1 locus and identified integrin alpha L (Itgal) as one of the causativ...
Source: PLoS Genetics - October 10, 2013 Category: Genetics & Stem Cells Authors: Sehoon Keum et al. Source Type: research

Researchers discover underlying genetics, marker for stroke, cardiovascular disease
Scientists studying the genomes of nearly 5,000 people have pinpointed a genetic variant tied to an increased risk for stroke, and have also uncovered new details about an important metabolic pathway that plays a major role in several common diseases. Together, their findings may provide new clues to underlying genetic and biochemical influences in the development of stroke and cardiovascular disease, and may also help lead to new treatment strategies.
Source: NHGRI Press Releases - March 20, 2014 Category: Genetics & Stem Cells Source Type: news

Validity and Reliability of the Neuropsychiatric Inventory Questionnaire Version in Patients With Stroke or Transient Ischemic Attack Having Cognitive Impairment
This study examined the validity and reliability of the Neuropsychiatric Inventory Questionnaire version (NPI-Q), a proxy-reported format of the interview-based NPI, in assessing neuropsychiatric symptoms in 173 patients with stroke or transient ischemic attack (TIA) having cognitive impairment. The NPI-Q was validated against the NPI as a gold standard. Informants took approximately 7 minutes to complete the NPI-Q. Bland-Altman analysis revealed a bias of 0.7 points, with 95% limits of agreement between –8.6 and 10.0 between the total symptom scores of the NPI and NPI-Q. The NPI-Q correlated significantly with the N...
Source: Journal of Geriatric Psychiatry and Neurology - October 30, 2014 Category: Genetics & Stem Cells Authors: Wong, A., Cheng, S.-T., Lo, E. S. K., Kwan, P. W. L., Law, L. S. N., Chan, A. Y. Y., Wong, L. K.-S., Mok, V. Tags: Articles Source Type: research

Methodologic Comparison of Left Ventricular Stroke Volumes in the Early Neonatal Period by Echocardiography
Abstract Several methods for evaluating left ventricular stroke volume (SV) in neonates using echocardiography have been reported. However, no studies on methodologic comparison of SV with three-dimensional (3D) echocardiography are available. This is the first detailed report on a methodologic comparison of SV in the early neonatal period. The study group included 70 normal neonates (35 boys and 35 girls). An iE33 echocardiograph and Q-LAB supplied by Philips Electronics were used to examine and calculate volumes. Comparisons of SV were performed using Teichholz (T), the velocity time integral (VTI), Pombo (P), ...
Source: Mammalian Genome - November 18, 2014 Category: Genetics & Stem Cells Source Type: research

ARL6IP6 , a susceptibility locus for ischemic stroke, is mutated in a patient with syndromic Cutis Marmorata Telangiectatica Congenita
Abstract Cutis Marmorata Telangiectatica Congenita (CMTC) is a congenital localized or generalized vascular anomaly, usually sporadic in occurrence. It can be associated with other cutaneous or systemic manifestations. About 300 cases have been reported. The molecular etiology remains largely unknown. The main purpose of this study is to delineate the molecular basis for a syndromic CMTC phenotype in a consanguineous Saudi family. Clinical phenotyping including detailed neurological imaging, followed by autozygosity mapping and trio whole exome sequencing (WES) are also studied. We have identified a homozygous tru...
Source: Human Genetics - May 10, 2015 Category: Genetics & Stem Cells Source Type: research

GSE69138 Epigenome analysis of ischemic stroke patients
Contributors : Jaume Roquer ; Carolina Soriano-Tarraga ; Jordi Jimenez-CondeSeries Type : Methylation profiling by arrayOrganism : Homo sapiensWe performed a genome-wide methylation study in whole-blood DNA from 404 ischemic stroke patient cohort, distributed across 3 ischemic stroke subtypes: Large-artery atherosclerosis (n=132), Small-artery disease (n=141) and Cardio embolic (n=127) . Illumina HumanMethylation450 BeadChip array was used to measure DNA methylation in CpG sites.
Source: GEO: Gene Expression Omnibus - August 19, 2015 Category: Genetics & Stem Cells Tags: Methylation profiling by array Homo sapiens Source Type: research

Tumor necrosis factor-alpha (−308G/A, +488G/A, −857C/T and -1031T/C) gene polymorphisms and risk of ischemic stroke in north Indian population: A hospital based case–control study
Conclusions Two SNPs (+488G/A and -857C/T) of TNF-α gene and their haplotypes are significantly associated with the risk of IS in the population enrolled from North India. Our findings indicate that polymorphisms and haplotypes of TNF-α gene may be used as a genetic marker for identifying individuals at increased risk for developing IS.
Source: Meta Gene - November 19, 2015 Category: Genetics & Stem Cells Source Type: research

Genes, Vol. 6, Pages 1283-1299: A Meta-Analysis of the Association between Polymorphisms in MicroRNAs and Risk of Ischemic Stroke
Ischemic stroke (IS) is responsible for a high death rate and for adult disability worldwide. MiR-146a (rs2910164), miR-149 (rs2292832), miR-196a2 (rs11614913) and miR-499 (rs3746444) are found to be associated with ischemic stroke. However, the results were inconsistent and inconclusive. The present study performed a meta-analysis to get a more precise and comprehensive estimation of the association between the four polymorphisms and IS risk. The databases Pubmed, Embase, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, and Chinese Biomedical Literature Database were searched for ...
Source: Genes - December 7, 2015 Category: Genetics & Stem Cells Authors: Yan XiaoMei-Hua BaoHuai-Qing LuoJu XiangJian-Ming Li Tags: Article Source Type: research

Genetic association between inflammatory genes (IL-1α,CD14, LGALS2, PSMA6)and risk of ischemic stroke: A meta-analysis
Conclusion Our meta-analysis shows that IL-1α (−C889T and −C511T), CD14 (−C159T), LGALS2 (−C3279T) and gene polymorphisms are not significantly associated with the risk of IS while PSMA6 (−C8G) gene polymorphism may play a protective role with the susceptibility of IS. Further prospective large epidemiological studies are needed to confirm these findings in different populations.
Source: Meta Gene - January 20, 2016 Category: Genetics & Stem Cells Source Type: research

Genetic association between inflammatory genes (IL-1α, CD14, LGALS2, PSMA6) and risk of ischemic stroke: A meta-analysis
Conclusion Our meta-analysis shows that IL-1α (-C889T and -C511T), CD14 (-C159T), LGALS2 (-C3279T) and gene polymorphisms are not significantly associated with the risk of IS while PSMA6 (-C8G) gene polymorphism may play a protective role with the susceptibility of IS. Further prospective large epidemiological studies are needed to confirm these findings in different populations.
Source: Meta Gene - February 7, 2016 Category: Genetics & Stem Cells Source Type: research

Association between methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and risk of ischemic stroke in North Indian population: A hospital based case–control study
Conclusion Findings of the present study suggest that MTHFR C677T gene polymorphism might be a risk factor of IS mainly for SVD subtypes of IS in North Indian population. Further large prospective studies are required to confirm these findings.
Source: Egyptian Journal of Medical Human Genetics - March 7, 2016 Category: Genetics & Stem Cells Source Type: research

Genetic association between inflammatory genes (IL-1 α, CD14, LGALS2, PSMA6) and risk of ischemic stroke: A meta-analysis
Conclusion Our meta-analysis shows that IL-1α (-C889T and -C511T), CD14 (-C159T), LGALS2 (-C3279T) and gene polymorphisms are not significantly associated with the risk of IS while PSMA6 (-C8G) gene polymorphism may play a protective role with the susceptibility of IS. Further prospective large epidemiological studies are needed to confirm these findings in different populations.
Source: Meta Gene - July 20, 2016 Category: Genetics & Stem Cells Source Type: research

Tumor necrosis factor-alpha ( −308G/A, +488G/A, −857C/T and -1031T/C) gene polymorphisms and risk of ischemic stroke in north Indian population: A hospital based case–control study
Conclusions Two SNPs (+488G/A and -857C/T) of TNF-α gene and their haplotypes are significantly associated with the risk of IS in the population enrolled from North India. Our findings indicate that polymorphisms and haplotypes of TNF-α gene may be used as a genetic marker for identifying individuals at increased risk for developing IS.
Source: Meta Gene - July 20, 2016 Category: Genetics & Stem Cells Source Type: research

GSE45703 Tau exacerbates excitotoxic brain damage in an animal model of stroke
Contributors : Amadeus Gladbach ; Janet V Eersel ; Mian Bi ; Julius M üller ; Ernesto Guccione ; Yazi D Ke ; Lars M IttnerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeuronal excitotoxicity induced by aberrant excitation of glutamatergic receptors contributes to brain damage in stroke. Here, we show that tau-deficient (tau-/-) mice are profoundly protected from excitotoxic brain damage and neurological deficits following experimental stroke, using a middle cerebral artery occlusion (MCAO) with reperfusion model. Mechanistically, we show that this protection is due to site-specifi...
Source: GEO: Gene Expression Omnibus - September 1, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research