Journal of Geriatric Psychiatry and Neurology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Convergent Validity, Concurrent Validity, and Diagnostic Accuracy of the interRAI Depression Rating Scale
Conclusion: This study and the existing literature raise concerns that the DRS is not an adequate measure of depression. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Penny, K., Barron, A., Higgins, A.-M., Gee, S., Croucher, M., Cheung, G. Tags: Articles Source Type: research

Office-Based Assessment of At-Risk Driving in Older Adults With and Without Cognitive Impairment
Conclusions: Future research on larger and more clinically representative neurological samples will improve understanding of the utility of the UFOV Divided Attention and NAB Driving Scenes in detecting at-risk older adult drivers in the clinic. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Stern, R. A., Abularach, L. M., Seichepine, D. R., Alosco, M. L., Gavett, B. E., Tripodis, Y. Tags: Articles Source Type: research

Person-Based Versus Generalized Impulsivity Disinhibition in Frontotemporal Dementia and Alzheimer Disease
Conclusions: Person-based disinhibition was predominant in bvFTD and correlated with the left STS. In both dementia, violations of social propriety and personal boundaries involved fronto-parieto-temporal network of Theory of Mind, whereas nonspecific disinhibition involved the OFC and aTL. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Paholpak, P., Carr, A. R., Barsuglia, J. P., Barrows, R. J., Jimenez, E., Lee, G. J., Mendez, M. F. Tags: Articles Source Type: research

The Frontal Assessment Battery: Normative Performance in a Large Sample of Older Community-Dwelling Hospital Outpatient or General Practitioner Attenders
Conclusion: This is the largest study to date to create normative data for the FAB. Age and education had the most significant impact on FAB performance, which was largely independent of global cognition (MMSE). These data may be of benefit in interpreting FAB performance in individuals with similar demographic/health status characteristics in hospital outpatient or GP settings. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Coen, R. F., McCarroll, K., Casey, M., McNulty, H., Laird, E., Molloy, A. M., Ward, M., Strain, J. J., Hoey, L., Hughes, C., Cunningham, C. J. Tags: Articles Source Type: research

Risk Factors for Cognitive Impairment in Fragile X-Associated Tremor/Ataxia Syndrome
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disease with motor, psychiatric, and cognitive manifestations that occurs in carriers of the fragile X mental retardation 1 (FMR1) gene premutations. This was a retrospective chart review of 196 individuals (127 men and 69 women) with FXTAS. Forty-six (23%) participants were cognitively impaired, of whom 19 (10%) had dementia. Risk factors for dementia were examined (CGG repeat size; alcohol, benzodiazepine, and opioid use; diabetes; hyperlipidemia; hypertension; hypothyroidism; obesity; sleep apnea; surgeries with general anesthesia; dep...
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Seritan, A. L., Kim, K., Benjamin, I., Seritan, I., Hagerman, R. J. Tags: Articles Source Type: research

Preoperative Cognitive Performance Dominates Risk for Delirium Among Older Adults
Conclusion: Risk of delirium is linearly and strongly related to presurgical cognitive performance level even at levels above the population median, which would be considered unimpaired. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Jones, R. N., Marcantonio, E. R., Saczynski, J. S., Tommet, D., Gross, A. L., Travison, T. G., Alsop, D. C., Schmitt, E. M., Fong, T. G., Cizginer, S., Shafi, M. M., Pascual-Leone, A., Inouye, S. K. Tags: Articles Source Type: research

Functional Status Predicts Awareness in Late-Onset but not in Early-Onset Alzheimer Disease
This study aims to assess whether there are differences between the level of awareness in early-onset Alzheimer disease (EOAD) and late-onset Alzheimer disease (LOAD) and to test its association with quality of life (QOL). A consecutive series of 207 people with Alzheimer disease and their caregivers were selected from an outpatient unit. There were no significant differences in awareness. In LOAD, impairment on awareness was predicted by functional level (β = .37, P < .001), self (P = .006), and informant report of QOL (P = .010). The predictors of unawareness in EOAD were self (P = .002) and informant report of Q...
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Dourado, M. C. N., Laks, J., Mograbi, D. Tags: Articles Source Type: research

Update on Vascular Dementia
Vascular dementia (VaD) is a major contributor to the dementia syndrome and is described as having problems with reasoning, planning, judgment, and memory caused by impaired blood flow to the brain and damage to the blood vessels resulting from events such as stroke. There are a variety of etiologies that contribute to the development of vascular cognitive impairment and VaD, and these are often associated with other dementia-related pathologies such as Alzheimer disease. The diagnosis of VaD is difficult due to the number and types of lesions and their locations in the brain. Factors that increase the risk of vascular dis...
Source: Journal of Geriatric Psychiatry and Neurology - August 7, 2016 Category: Genetics & Stem Cells Authors: Khan, A., Kalaria, R. N., Corbett, A., Ballard, C. Tags: Articles Source Type: research

Frontotemporal Dementia: An Updated Clinicians Guide
Today, frontotemporal dementia (FTD) remains one of the most common forms of early-onset dementia, that is, before the age of 65, thus posing several diagnostic challenges to clinicians since symptoms are often mistaken for psychiatric or neurological diseases causing a delay in correct diagnosis, and the majority of patients with FTD present with symptoms at ages between 50 and 60. Genetic components are established risk factors for FTD, but the influence of lifestyle, comorbidity, and environmental factors on the risk of FTD is still unclear. Approximately 40% of individuals with FTD have a family history of dementia but...
Source: Journal of Geriatric Psychiatry and Neurology - August 7, 2016 Category: Genetics & Stem Cells Authors: Rosness, T. A., Engedal, K., Chemali, Z. Tags: Articles Source Type: research

Parkinson Disease and Dementia
Dementia is a frequent complication of Parkinson disease (PD) with a yearly incidence of around 10% of patients with PD. Lewy body pathology is the most important factor in the development of Parkinson disease dementia (PDD) and there is evidence for a synergistic effect with β-amyloid. The clinical phenotype in PDD extends beyond the dysexecutive syndrome that is often present in early PD and encompasses deficits in recognition memory, attention, and visual perception. Sleep disturbances, hallucinations, neuroleptic sensitivity, and fluctuations are often present. This review provides an update on current knowledge o...
Source: Journal of Geriatric Psychiatry and Neurology - August 7, 2016 Category: Genetics & Stem Cells Authors: Garcia-Ptacek, S., Kramberger, M. G. Tags: Articles Source Type: research

Imaging in Dementia With Lewy Bodies: An Overview
This article will provide an overview of the main imaging findings in DLB. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - August 7, 2016 Category: Genetics & Stem Cells Authors: Watson, R., Colloby, S. J. Tags: Articles Source Type: research

Revisiting DLB Diagnosis: A Consideration of Prodromal DLB and of the Diagnostic Overlap With Alzheimer Disease
This article argues that further efforts should now be made to characterize this atypical group that constitutes cases previously identified postmortem as the Lewy body variant of Alzheimer disease (AD) or as AD with Lewy bodies. Since such fine distinction is unlikely to be achieved on clinical grounds alone, this new diagnostic category will require robust biomarker validation. Turning to a consideration of early/prodromal diagnosis of both typical and atypical DLB cases, it is suggested that there will be at least 3 prototypical forms—a mild cognitive impairment variant, associated with early visuoperceptual and a...
Source: Journal of Geriatric Psychiatry and Neurology - August 7, 2016 Category: Genetics & Stem Cells Authors: McKeith, I., Taylor, J.-P., Thomas, A., Donaghy, P., Kane, J. Tags: Articles Source Type: research

Non-Alzheimer Dementias
(Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - August 7, 2016 Category: Genetics & Stem Cells Authors: Rongve, A., Ballard, C., Aarsland, D. Tags: Guest Editorial Source Type: research

Corrigendum
(Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Tags: Corrigendum Source Type: research

Quetiapine for Psychosis in Parkinson Disease and Neurodegenerative Parkinsonian Disorders: A Systematic Review
We performed a systematic review of randomized controlled trials to assess the high-level evidence regarding the role of quetiapine in the treatment of psychosis in patients with neurodegenerative parkinsonian disorders. Studies were included in the qualitative review if they (1) enrolled participants with diagnosis of Parkinson disease, Lewy body dementia, or any other neurodegenerative parkinsonian disorders; (2) assessed the efficacy of quetiapine; and (3) evaluated psychotic and motor outcomes using validated tools. Of the 341 manuscripts identified, 7 studies fulfilled our inclusion criteria. The studies’ risk o...
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Desmarais, P., Massoud, F., Filion, J., Nguyen, Q. D., Bajsarowicz, P. Tags: Articles Source Type: research