Convergent Validity, Concurrent Validity, and Diagnostic Accuracy of the interRAI Depression Rating Scale
Conclusion: This study and the existing literature raise concerns that the DRS is not an adequate measure of depression. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Penny, K., Barron, A., Higgins, A.-M., Gee, S., Croucher, M., Cheung, G. Tags: Articles Source Type: research

Office-Based Assessment of At-Risk Driving in Older Adults With and Without Cognitive Impairment
Conclusions: Future research on larger and more clinically representative neurological samples will improve understanding of the utility of the UFOV Divided Attention and NAB Driving Scenes in detecting at-risk older adult drivers in the clinic. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Stern, R. A., Abularach, L. M., Seichepine, D. R., Alosco, M. L., Gavett, B. E., Tripodis, Y. Tags: Articles Source Type: research

Person-Based Versus Generalized Impulsivity Disinhibition in Frontotemporal Dementia and Alzheimer Disease
Background: While much disinhibition in dementia results from generalized impulsivity, in behavioral variant frontotemporal dementia (bvFTD) disinhibition may also result from impaired social cognition. Objective: To deconstruct disinhibition and its neural correlates in bvFTD vs. early-onset Alzheimer’s disease (eAD). Methods: Caregivers of 16 bvFTD and 21 matched-eAD patients completed the Frontal Systems Behavior Scale disinhibition items. The disinhibition items were further categorized into (1) "person-based" subscale which predominantly associated with violating social propriety and personal boundar...
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Paholpak, P., Carr, A. R., Barsuglia, J. P., Barrows, R. J., Jimenez, E., Lee, G. J., Mendez, M. F. Tags: Articles Source Type: research

The Frontal Assessment Battery: Normative Performance in a Large Sample of Older Community-Dwelling Hospital Outpatient or General Practitioner Attenders
Background: The Frontal Assessment Battery (FAB) is a short battery designed to assess frontal executive functioning, but data for interpretation of performance are limited. Objectives: The Trinity, Ulster, Department of Agriculture (TUDA) study provided the opportunity to derive performance data from a large sample of community-dwelling hospital outpatient or general practitioner (GP) attenders. Methods: Normative analysis based on 2508 TUDA participants meeting these criteria: Mini-Mental State Examination (MMSE)>26/30, not depressed (Center for Epidemiologic Studies Depression
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Coen, R. F., McCarroll, K., Casey, M., McNulty, H., Laird, E., Molloy, A. M., Ward, M., Strain, J. J., Hoey, L., Hughes, C., Cunningham, C. J. Tags: Articles Source Type: research

Risk Factors for Cognitive Impairment in Fragile X-Associated Tremor/Ataxia Syndrome
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disease with motor, psychiatric, and cognitive manifestations that occurs in carriers of the fragile X mental retardation 1 (FMR1) gene premutations. This was a retrospective chart review of 196 individuals (127 men and 69 women) with FXTAS. Forty-six (23%) participants were cognitively impaired, of whom 19 (10%) had dementia. Risk factors for dementia were examined (CGG repeat size; alcohol, benzodiazepine, and opioid use; diabetes; hyperlipidemia; hypertension; hypothyroidism; obesity; sleep apnea; surgeries with general anesthesia; dep...
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Seritan, A. L., Kim, K., Benjamin, I., Seritan, I., Hagerman, R. J. Tags: Articles Source Type: research

Preoperative Cognitive Performance Dominates Risk for Delirium Among Older Adults
Conclusion: Risk of delirium is linearly and strongly related to presurgical cognitive performance level even at levels above the population median, which would be considered unimpaired. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Jones, R. N., Marcantonio, E. R., Saczynski, J. S., Tommet, D., Gross, A. L., Travison, T. G., Alsop, D. C., Schmitt, E. M., Fong, T. G., Cizginer, S., Shafi, M. M., Pascual-Leone, A., Inouye, S. K. Tags: Articles Source Type: research

Functional Status Predicts Awareness in Late-Onset but not in Early-Onset Alzheimer Disease
This study aims to assess whether there are differences between the level of awareness in early-onset Alzheimer disease (EOAD) and late-onset Alzheimer disease (LOAD) and to test its association with quality of life (QOL). A consecutive series of 207 people with Alzheimer disease and their caregivers were selected from an outpatient unit. There were no significant differences in awareness. In LOAD, impairment on awareness was predicted by functional level (β = .37, P
Source: Journal of Geriatric Psychiatry and Neurology - October 6, 2016 Category: Genetics & Stem Cells Authors: Dourado, M. C. N., Laks, J., Mograbi, D. Tags: Articles Source Type: research

Update on Vascular Dementia
Vascular dementia (VaD) is a major contributor to the dementia syndrome and is described as having problems with reasoning, planning, judgment, and memory caused by impaired blood flow to the brain and damage to the blood vessels resulting from events such as stroke. There are a variety of etiologies that contribute to the development of vascular cognitive impairment and VaD, and these are often associated with other dementia-related pathologies such as Alzheimer disease. The diagnosis of VaD is difficult due to the number and types of lesions and their locations in the brain. Factors that increase the risk of vascular dis...
Source: Journal of Geriatric Psychiatry and Neurology - August 7, 2016 Category: Genetics & Stem Cells Authors: Khan, A., Kalaria, R. N., Corbett, A., Ballard, C. Tags: Articles Source Type: research

Frontotemporal Dementia: An Updated Clinicians Guide
Today, frontotemporal dementia (FTD) remains one of the most common forms of early-onset dementia, that is, before the age of 65, thus posing several diagnostic challenges to clinicians since symptoms are often mistaken for psychiatric or neurological diseases causing a delay in correct diagnosis, and the majority of patients with FTD present with symptoms at ages between 50 and 60. Genetic components are established risk factors for FTD, but the influence of lifestyle, comorbidity, and environmental factors on the risk of FTD is still unclear. Approximately 40% of individuals with FTD have a family history of dementia but...
Source: Journal of Geriatric Psychiatry and Neurology - August 7, 2016 Category: Genetics & Stem Cells Authors: Rosness, T. A., Engedal, K., Chemali, Z. Tags: Articles Source Type: research

Parkinson Disease and Dementia
Dementia is a frequent complication of Parkinson disease (PD) with a yearly incidence of around 10% of patients with PD. Lewy body pathology is the most important factor in the development of Parkinson disease dementia (PDD) and there is evidence for a synergistic effect with β-amyloid. The clinical phenotype in PDD extends beyond the dysexecutive syndrome that is often present in early PD and encompasses deficits in recognition memory, attention, and visual perception. Sleep disturbances, hallucinations, neuroleptic sensitivity, and fluctuations are often present. This review provides an update on current knowledge o...
Source: Journal of Geriatric Psychiatry and Neurology - August 7, 2016 Category: Genetics & Stem Cells Authors: Garcia-Ptacek, S., Kramberger, M. G. Tags: Articles Source Type: research

Imaging in Dementia With Lewy Bodies: An Overview
This article will provide an overview of the main imaging findings in DLB. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - August 7, 2016 Category: Genetics & Stem Cells Authors: Watson, R., Colloby, S. J. Tags: Articles Source Type: research

Revisiting DLB Diagnosis: A Consideration of Prodromal DLB and of the Diagnostic Overlap With Alzheimer Disease
This article argues that further efforts should now be made to characterize this atypical group that constitutes cases previously identified postmortem as the Lewy body variant of Alzheimer disease (AD) or as AD with Lewy bodies. Since such fine distinction is unlikely to be achieved on clinical grounds alone, this new diagnostic category will require robust biomarker validation. Turning to a consideration of early/prodromal diagnosis of both typical and atypical DLB cases, it is suggested that there will be at least 3 prototypical forms—a mild cognitive impairment variant, associated with early visuoperceptual and a...
Source: Journal of Geriatric Psychiatry and Neurology - August 7, 2016 Category: Genetics & Stem Cells Authors: McKeith, I., Taylor, J.-P., Thomas, A., Donaghy, P., Kane, J. Tags: Articles Source Type: research

Non-Alzheimer Dementias
(Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - August 7, 2016 Category: Genetics & Stem Cells Authors: Rongve, A., Ballard, C., Aarsland, D. Tags: Guest Editorial Source Type: research

Corrigendum
(Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Tags: Corrigendum Source Type: research

Quetiapine for Psychosis in Parkinson Disease and Neurodegenerative Parkinsonian Disorders: A Systematic Review
We performed a systematic review of randomized controlled trials to assess the high-level evidence regarding the role of quetiapine in the treatment of psychosis in patients with neurodegenerative parkinsonian disorders. Studies were included in the qualitative review if they (1) enrolled participants with diagnosis of Parkinson disease, Lewy body dementia, or any other neurodegenerative parkinsonian disorders; (2) assessed the efficacy of quetiapine; and (3) evaluated psychotic and motor outcomes using validated tools. Of the 341 manuscripts identified, 7 studies fulfilled our inclusion criteria. The studies’ risk o...
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Desmarais, P., Massoud, F., Filion, J., Nguyen, Q. D., Bajsarowicz, P. Tags: Articles Source Type: research

The Association Between Clusterin and APOE Polymorphisms and Late-Onset Alzheimer Disease in a Turkish Cohort
In this study, we investigated the association between rs2279590, rs11136000, and rs9331888 single-nucleotide polymorphisms (SNPs) in CLU and apolipoprotein E (APOE) genotypes in a cohort of Turkish patients with late-onset AD (LOAD). There were 183 patients with LOAD and 154 healthy controls included in the study. The CLU and APOE polymorphisms were genotyped using the LightSNiP assay. The "GG" genotype of rs9331888 was significantly more frequent in patients with LOAD. The "CC" genotype of the SNP was significantly more frequent in controls. The rs9331888 "GG" genotype in patients and the &q...
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Alaylıoglu, M., Gezen-Ak, D., Dursun, E., Bilgic, B., Hanagası, H., Ertan, T., Gürvit, H., Emre, M., Eker, E., Uysal, O., Yılmazer, S. Tags: Articles Source Type: research

Association Between Metacognition and Mood Symptoms Poststroke
Introduction: The link between metacognition and mood has been well established, particularly in other conditions with psychological comorbidity, however, there is no evidence regarding this association in the area of stroke. Aim: The aim of this study was to examine the association between metacognition, based on the Self-Regulatory Executive Function model, and mood symptoms in the acute phase after stroke. Methods: One hundred thirty patients were recruited to a prospective stroke study in Bahrain, and n = 64 were assessed for mood and cognition. A neuropsychological battery of cognitive assessments included the follo...
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Donnellan, C., Al Banna, M., Redha, N., Al Sharoqi, I., Al-Jishi, A., Bakhiet, M., Taha, S., Abdulla, F. Tags: Articles Source Type: research

Meta-Analysis of Facial Emotion Recognition in Behavioral Variant Frontotemporal Dementia: Comparison With Alzheimer Disease and Healthy Controls
Behavioral disturbances and lack of empathy are distinctive clinical features of behavioral variant frontotemporal dementia (bvFTD) in comparison to Alzheimer disease (AD). The aim of this meta-analytic review was to compare facial emotion recognition performances of bvFTD with healthy controls and AD. The current meta-analysis included a total of 19 studies and involved comparisons of 288 individuals with bvFTD and 329 healthy controls and 162 bvFTD and 147 patients with AD. Facial emotion recognition was significantly impaired in bvFTD in comparison to the healthy controls (d = 1.81) and AD (d = 1.23). In bvFTD, recognit...
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Bora, E., Velakoulis, D., Walterfang, M. Tags: Articles Source Type: research

Comorbidity of Cognitive Impairment and Late-Life Depression Increase Mortality: Results From a Cohort of Community-Dwelling Elderly Individuals in Rural Greece
Conclusion: COGI and depression, 2 entities often coexisting among elderly individuals, appear to increase all-cause mortality and cardiovascular mortality. Gender-specific modes may prevail but their comorbidity should be carefully assessed, as it seems to represent an independent index of increased frailty, which eventually shortens life expectancy. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Georgakis, M. K., Papadopoulos, F. C., Protogerou, A. D., Pagonari, I., Sarigianni, F., Biniaris-Georgallis, S.-I., Kalogirou, E. I., Thomopoulos, T. P., Kapaki, E., Papageorgiou, C., Papageorgiou, S. G., Tousoulis, D., Petridou, E. T. Tags: Articles Source Type: research

Excessive Iron and {alpha}-Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease
Objectives: To investigate the demographic features, clinical features, and potential mechanism in patients with Parkinson disease (PD) with pure apathy. Method: A total of 145 patients with PD without depression and dementia and 30 age-matched controls were consecutively recruited. Patients with PD were evaluated by Apathy Scale (AS), scales for motor symptoms and quality of life. The levels of iron, oxidative and neuroinflammatory factors, α-synuclein oligomer, and dopamine in cerebrospinal fluid (CSF) from patients with PD and controls were detected by enzyme-linked immunosorbent assay, chemical colorimetric meth...
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Wang, F., Yu, S.-Y., Zuo, L.-J., Cao, C.-J., Hu, Y., Chen, Z.-J., Piao, Y.-s., Wang, Y.-J., Wang, X.-M., Chen, S.-D., Chan, P., Zhang, W. Tags: Articles Source Type: research

Apathy in Older Persons With Depression: Course and Predictors: The NESDO Study
Conclusion: Severity of apathy at baseline, but not depression, predicted apathy at follow-up. Incident apathy was predicted by poorer cognitive function, whereas severe apathy at baseline predicted its persistence. Remarkably, new apathy was not associated with worse outcome of depression whereas persistent apathy was. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Groeneweg-Koolhoven, I., Comijs, H. C., Naarding, P., de Waal, M. W. M., van der Mast, R. C. Tags: Articles Source Type: research

Frontal Cortical Atrophy as a Predictor of Poststroke Apathy
The aim of the study was to identify associations between the symptoms of poststroke apathy and sociodemographic, stroke-related (severity of stroke, degree of disability, and performance in activities of daily living), and radiological correlates. We determined the degree of cortical and subcortical brain atrophy, the severity of white matter and basal ganglia lesions on baseline computed tomography (CT) scans, and the localization of acute ischemia on control CT or magnetic resonance imaging scans in subacute stages of stroke. During follow-up examinations, in addition to the assessment of apathy symptoms using the Apath...
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Mihalov, J., Mikula, P., Budis, J., Valkovic, P. Tags: Articles Source Type: research

Development and Validation of the Rappel Indice-24: Behavioral and Brain Morphological Evidence
The primary goals of the present study were to develop and validate the Rappel Indicé 24 (RI-24), a shorter version of the original Rappel Indicé, which includes 48 items (RI-48), and to identify the specific brain regions that were correlated with scores on the RI-24. Using these clinical scales, the present study evaluated 91 elderly Korean participants who were classified into 3 groups: normal control (NC; n = 34), patients with mild cognitive impairment (MCI; n = 29), and patients with Alzheimer disease (AD; n = 28). Of the 91 participants, 77 also underwent magnetic resonance imaging scans. The RI-24 del...
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Park, S., Kim, I., Park, H. G., Shin, S. A., Cho, Y., Youn, J.-H., Kim, Y. K., Lee, J.-Y. Tags: Articles Source Type: research

Cortical Amyloid {beta} Deposition and Current Depressive Symptoms in Alzheimer Disease and Mild Cognitive Impairment
Depressive symptoms are frequently seen in patients with dementia and mild cognitive impairment (MCI). Evidence suggests that there may be a link between current depressive symptoms and Alzheimer disease (AD)-associated pathological changes, such as an increase in cortical amyloid-β (Aβ). However, limited in vivo studies have explored the relationship between current depressive symptoms and cortical Aβ in patients with MCI and AD. Our study, using a large sample of 455 patients with MCI and 153 patients with AD from the Alzheimer’s disease Neuroimaging Initiatives, investigated whether current depressi...
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Chung, J. K., Plitman, E., Nakajima, S., Chakravarty, M. M., Caravaggio, F., Gerretsen, P., Iwata, Y., Graff-Guerrero, A., for the Alzheimers Disease Neuroimaging Initiative Tags: Articles Source Type: research

Stroke Symptoms With Absence of Recognized Stroke Are Associated With Cognitive Impairment and Depressive Symptoms in Older Adults With Diabetes
We examined relationships between stroke symptoms, cognitive impairment, and depressive symptoms in a high-risk sample: 247 adults aged ≥65 with diabetes. Stroke symptoms were assessed using the Questionnaire for Verifying Stroke-free Status, cognitive impairment was measured with the modified Telephone Interview for Cognitive Status, and depressive symptoms were measured using the 15-item Geriatric Depression Scale. In 206 participants without history of stroke/transient ischemic attack, 27.7% reported stroke symptoms, with sudden loss of comprehension most frequently reported (11.7%). Having>1 versus 0 stroke sympt...
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Passler, J. S., Clay, O. J., Wadley, V. G., Ovalle, F., Crowe, M. Tags: Articles Source Type: research

Cognitive Function in Older Suicide Attempters and a Population-Based Comparison Group
Conclusion: Older suicide attempters may have cognitive deficits, which may in part be related to the attempt itself. This needs to be taken into account when designing intervention strategies. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Olsson, P., Wiktorsson, S., Sacuiu, S., Marlow, T., Östling, S., Fässberg, M. M., Skoog, I., Waern, M. Tags: Articles Source Type: research

Cognitive Deficits in Healthy Elderly Population With "Normal" Scores on the Mini-Mental State Examination
This study investigated whether healthy older adults with Mini-Mental State Examination (MMSE) scores above 23 exhibit cognitive impairment on neuropsychological tests. Participants completed the MMSE and a neuropsychological battery including tests of 10 domains. Results were compared to published normative data. On neuropsychological testing, participants performed well on measures of naming and recall but showed mild to moderate impairment in working memory and processing speed and marked impairment in inhibition, sustained attention, and executive functioning. Almost everyone (91%) scored at least 1 standard deviation ...
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Votruba, K. L., Persad, C., Giordani, B. Tags: Articles Source Type: research

The Association Between Diabetes and Dementia Among Elderly Individuals: A Nationwide Inpatient Sample Analysis
The objective was to better delineate this relationship and influence of multiple comorbidities using a nationwide sample. Methods: Data were obtained from the Nationwide Inpatient Sample 1998 to 2011 using appropriate International Classification of Diseases, Ninth Version codes. Descriptive and bivariate analysis was performed. Multivariate nominal logistic regression models adjusted for age, sex, race, and comorbidities explored the independent relationship between Alzheimer dementia (AD), non-Alzheimer dementia (VaD), and diabetes. Results: 21% of the participants were diabetic patients, 3.7% had AD, and 2.2% had VaD...
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Sherzai, D., Sherzai, A., Lui, K., Pan, D., Chiou, D., Bazargan, M., Shaheen, M. Tags: Articles Source Type: research

Diagnostic Validity and Factor Analysis of Montgomery-Asberg Depression Rating Scale in Parkinson Disease Population
Conclusion: The MADRS has diagnostic utility in major depression in PD. The 3-factor structure of MADRS may help to understand the different dimensions of major depression and identify distinct symptom subgroups in this population. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Ketharanathan, T., Hanwella, R., Weerasundera, R., de Silva, V. A. Tags: Articles Source Type: research

Emotional Decoding Abilities Do Not Influence Neuropsychiatric Disturbances in Patients With Frontotemporal Dementia
The ability to accurately recognize emotional information belongs to very important interpersonal communication skills in humans. Disturbance of emotional processing is present in behavioral variant of frontotemporal dementia (bvFTD), and the severity of pathological behavior may be linked to misunderstanding of other people’s emotions. In our study, we examined hypothesis that patients with worse ability to decode emotions have more behavioral and psychopathological disturbances—the most challenging manifestations of dementia—than those who decode emotions better. We were not able to prove this hypothesi...
Source: Journal of Geriatric Psychiatry and Neurology - February 8, 2016 Category: Genetics & Stem Cells Authors: Klimkowicz-Mrowiec, A., Krzywoszanski, L., Szyper-Maciejewska, A., Dziedzic, T., Pera, J., Slowik, A. Tags: Articles Source Type: research

Symptom Dimensions of Depression and 3-Year Incidence of Dementia: Results From the Amsterdam Study of the Elderly
Conclusion: Our findings suggest that the increased risk of dementia associated with depressive symptoms in many previous studies appears to be heterogeneous, that is, it is likely due to different underlying pathways, including a pathway involving depression itself and a pathway in which cognitive and motivational symptoms reflect subjective cognitive complaints, particularly in the absence of depressed mood. These different pathways might warrant a different treatment approach. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - February 8, 2016 Category: Genetics & Stem Cells Authors: Lugtenburg, A., Zuidersma, M., Voshaar, R. C. O., Schoevers, R. A. Tags: Articles Source Type: research

Clinical Significance of Individual GAD Symptoms in Later Life
Conclusions: These findings suggest that individual GAD symptoms are differentially associated with aspects of clinical significance relevant to daily life, such as social, occupational, and functional ability. The differential impact of individual symptoms on functional status may be diluted when using symptom sum scores. A nuanced approach to assessing the clinical significance of individual GAD symptoms in older adults may be fruitful for efforts aimed at early detection and treatment. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - February 8, 2016 Category: Genetics & Stem Cells Authors: Miloyan, B., Pachana, N. A. Tags: Articles Source Type: research

Psychiatric Conditions in Parkinson Disease: A Comparison With Classical Psychiatric Disorders
Psychiatric conditions often complicate the outcome of patients affected by Parkinson disease (PD), but they differ from classical psychiatric disorders in terms of underlying biological mechanisms, clinical presentation, and treatment response. The purpose of the present review is to illustrate the biological and clinical aspects of psychiatric conditions associated with PD, with particular reference to the differences with respect to classical psychiatric disorders. A careful search of articles on main databases was performed in order to obtain a comprehensive review about the main psychiatric conditions associated with ...
Source: Journal of Geriatric Psychiatry and Neurology - February 8, 2016 Category: Genetics & Stem Cells Authors: Buoli, M., Caldiroli, A., Altamura, A. C. Tags: Articles Source Type: research

Neuropsychiatric Symptoms in Posterior Cortical Atrophy and Alzheimer Disease
Conclusion: Prevalence of the 12 NPS examined was similar between patients with PCA and AD. Hallucinations in PCA may be helpful in the differential diagnosis between PCA-AD and PCA-DLB. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - February 8, 2016 Category: Genetics & Stem Cells Authors: Suarez-Gonzalez, A., Crutch, S. J., Franco-Macias, E., Gil-Neciga, E. Tags: Articles Source Type: research

Citalopram for the Treatment of Agitation in Alzheimer Dementia: Genetic Influences
Discussion: Treatment outcomes in CitAD showed modest, although statistically significant, influence of genetic variation at HTR2A and HTR2C loci. Future studies should continue to examine the interaction of known genetic variants with antidepressant treatment in patients with AD having agitation. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - February 8, 2016 Category: Genetics & Stem Cells Authors: Peters, M. E., Vaidya, V., Drye, L. T., Devanand, D. P., Mintzer, J. E., Pollock, B. G., Porsteinsson, A. P., Rosenberg, P. B., Schneider, L. S., Shade, D. M., Weintraub, D., Yesavage, J., Lyketsos, C. G., Avramopoulos, D., For the CitAD Research Group Tags: Articles Source Type: research

Updating the Cognitive Performance Scale
This study presents the first update of the Cognitive Performance Scale (CPS) in 20 years. Its goals are 3-fold: extend category options; characterize how the new scale variant tracks with the Mini-Mental State Examination; and present a series of associative findings. Secondary analysis of data from 3733 older adults from 8 countries was completed. Examination of scale dimensions using older and new items was completed using a forward-entry stepwise regression. The revised scale was validated by examining the scale’s distribution with a self-reported dementia diagnosis, functional problems, living status, and distre...
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Morris, J. N., Howard, E. P., Steel, K., Perlman, C., Fries, B. E., Garms-Homolova, V., Henrard, J.-C., Hirdes, J. P., Ljunggren, G., Gray, L., Szczerbinska, K. Tags: Articles Source Type: research

Study of Spirituality in Elderly With Subjective Memory Complaints
This study was done to find out whether any relation exists between these 2 variables in elderly. A total of 120 elderly individuals, presenting with subjective memory complaints, were divided into 3 groups — controls, elderly with depression, and elderly with mild cognitive impairment (MCI). Spirituality in them was studied by dividing it into the subdomains of self-transcendence, presence of meaning in life, search for meaning in life, and locus of control. Spirituality was the highest in controls, followed by MCI group, and then depression group. Spirituality had a direct negative relationship with severity of dep...
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Trivedi, S. C., Subramanyam, A. A., Kamath, R. M., Pinto, C. Tags: Articles Source Type: research

The Effect of Reminiscence Therapy on Cognition, Depression, and Activities of Daily Living for Patients With Alzheimer Disease
The purpose of this study was, conducted with experimental design, to investigate the effect of reminiscence therapy on cognition, depression, activities of daily living of institutionalized mild and moderate Alzheimer patients. The study was conducted with a total of 62 patients (31 intervention group and 31 control group) in four home care in Ankara, Turkey. Study was done between the July 1, 2013 and December 20, 2014. Reminiscence therapy sessions were held with groups consists of 4-5 patients, once a week with 30-35 minute duration for 12 weeks. Standardized Mini Mental Test was used in sample selection. Patients were...
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Duru Asiret, G., Kapucu, S. Tags: Articles Source Type: research

Visual Priming and Visual Hallucinations in Parkinsons Disease. Evidence for Normal Top-Down Processes
Conclusions: The study showed that VH in PD are not associated with relatively greater top-down activation, and that the interaction between top-down and bottom-up processes is intact. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Straughan, S., Collerton, D., Bruce, V. Tags: Articles Source Type: research

Strengths and Limitations of the MoCA for Assessing Cognitive Functioning: Findings From a Large Representative Sample of Irish Older Adults
Conclusion: Lack of concordance between the CFA and EFA findings demonstrates that the correspondence between individual tests and their assumed cognitive domains is not robust, reflecting at least in part a current lack of consensus on how core cognitive constructs are defined and on what subcomponents can be subsumed under different cognitive domains. The MoCA should not be viewed as a substitute for more in-depth neuropsychological assessment when domain-specific information is required. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Coen, R. F., Robertson, D. A., Kenny, R. A., King-Kallimanis, B. L. Tags: Articles Source Type: research

Autonomic Nervous System Dysfunction in Patients With Parkinson Disease Having Depression
Conclusion: Depression is associated with neurocirculatory abnormalities—especially orthostatic hypotension—in early PD. Although the association does not imply causation, this result suggests that depression in PD might be associated with functional impairment of the autonomic nervous system and its pathologic substrate. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Park, H.-E., Kim, J.-S., Oh, Y.-S., Park, I.-S., Park, J.-W., Song, I.-U., Lee, K.-S. Tags: Articles Source Type: research

Cognitive and Behavioral Symptoms in ALSFTD: Detection, Differentiation, and Progression
Brief screening tools that detect and differentiate patients with amyotrophic lateral sclerosis and frontotemporal dementia (ALSFTD) from those more subtle cognitive or behavioral symptoms (ALS plus) and motor symptoms only (ALS pure) is pertinent in a clinical setting. The utility of 2 validated and data-driven tests (Mini-Addenbrooke’s Cognitive Examination [M-ACE] and Motor Neuron Disease Behavioral Scale [MiND-B]) was investigated in 70 ALS patients (24 ALSFTD, 19 ALS plus, and 27 ALS pure). More than 90% of patients with ALSFTD scored at or below the cutoff on the M-ACE, whereas this was seen in only about 20% o...
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Hsieh, S., Caga, J., Leslie, F. V. C., Shibata, M., Daveson, N., Foxe, D., Ramsey, E., Lillo, P., Ahmed, R. M., Devenney, E., Burrell, J. R., Hodges, J. R., Kiernan, M. C., Mioshi, E. Tags: Articles Source Type: research

The Association Between Benzodiazepine Use and Depression Outcomes in Older Veterans
Benzodiazepines (BZDs) are commonly prescribed to older adults with depression, but it is unknown whether they improve antidepressant (AD) adherence or depressive symptoms. We followed 297 older veterans diagnosed with depression and provided a new AD medication prospectively for 4 months. Data include validated self-report measures and VA pharmacy records. At initial assessment, 20.5% of participants were prescribed a BZD. Those with a BZD prescription at baseline were significantly more likely than those without to have a personality disorder, schizophrenia spectrum disorder, or other anxiety disorder, and higher depress...
Source: Journal of Geriatric Psychiatry and Neurology - October 26, 2015 Category: Genetics & Stem Cells Authors: Leggett, A., Kavanagh, J., Zivin, K., Chiang, C., Kim, H. M., Kales, H. C. Tags: Articles Source Type: research

Depressed Spousal Caregivers Have Psychological Stress Unrelated to the Progression of Alzheimer Disease: A 3-Year Follow-Up Report, Kuopio ALSOVA Study
Objective: To explore family caregiver (FC) long-term psychological distress after Alzheimer disease (AD) diagnosis in a family member. Methods: FC (n = 236) and patients with AD were prospectively followed up to 36 months after AD diagnosis. FC psychological distress was evaluated using the General Health Questionnaire (GHQ). Furthermore, caregiver depressive symptoms and sense of coherence, along with AD patient measurements, were measured at baseline and annually. Generalized estimating equation models were applied to study associations of these baseline factors to caregiver GHQ. Results: After 36 months of follow-up,...
Source: Journal of Geriatric Psychiatry and Neurology - October 26, 2015 Category: Genetics & Stem Cells Authors: Välimäki, T. H., Martikainen, J. A., Hallikainen, I. T., Väätäinen, S. T., Koivisto, A. M. Tags: Articles Source Type: research

Risk of Cognitive and Functional Impairment in Spouses of People With Dementia: Evidence From the Health and Retirement Study
We examined whether having (i) a spouse with dementia and (ii) a spouse who requires assistance with activities of daily living predicted cognitive and functional impairments in respondents to the Health and Retirement Study (n = 7965). Respondents who had a spouse who requires care had poorer cognitive functioning, whereby this relationship was significantly stronger for male respondents. Having a spouse with dementia moderated the relationship between income and cognition and predicted caregiver functional impairment, though not when depression was controlled. Although we found no significant differences on any individua...
Source: Journal of Geriatric Psychiatry and Neurology - October 26, 2015 Category: Genetics & Stem Cells Authors: Pertl, M. M., Lawlor, B. A., Robertson, I. H., Walsh, C., Brennan, S. Tags: Articles Source Type: research

Symptom Assessment for a Palliative Care Approach in People With Dementia Admitted to Acute Hospitals: Results From a National Audit
Conclusion: This study suggests a picture of poor symptom assessment and possible inappropriate prescription of antipsychotic medication, including at EOL, hindering the planning and delivery of effective dementia palliative care in acute hospitals. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - October 26, 2015 Category: Genetics & Stem Cells Authors: O'Shea, E., Timmons, S., Kennelly, S., Siun, A. d., Gallagher, P., O'Neill, D. Tags: Articles Source Type: research

The Relationship Between Medial Temporal Lobe Atrophy and Cognitive Impairment in Patients With Dementia With Lewy Bodies
Conclusions: These results suggest that MTA is related to cognitive impairment in patients with DLB, particularly the regions of orientation, immediate and delayed recall, and word fluency. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - October 26, 2015 Category: Genetics & Stem Cells Authors: Tagawa, R., Hashimoto, H., Nakanishi, A., Kawarada, Y., Muramatsu, T., Matsuda, Y., Kataoka, K., Shimada, A., Uchida, K., Yoshida, A., Higashiyama, S., Kawabe, J., Kai, T., Shiomi, S., Mori, H., Inoue, K. Tags: Articles Source Type: research

Executive Abilities as Reflected by Clock Hand Placement: Frontotemporal Dementia Versus Early-Onset Alzheimer Disease
The clock-drawing test (CDT) is widely used in clinical practice to diagnose and distinguish patients with dementia. It remains unclear, however, whether the CDT can distinguish among the early-onset dementias. Accordingly, we examined the ability of both quantitative and qualitative CDT analyses to distinguish behavioral variant frontotemporal dementia (bvFTD) and early-onset Alzheimer disease (eAD), the 2 most common neurodegenerative dementias with onset
Source: Journal of Geriatric Psychiatry and Neurology - October 26, 2015 Category: Genetics & Stem Cells Authors: Barrows, R. J., Barsuglia, J., Paholpak, P., Eknoyan, D., Sabodash, V., Lee, G. J., Mendez, M. F. Tags: Articles Source Type: research

Comparison of Clock Test Deficits Between Elderly Patients With Early and Late Onset Depression
To compare clock test deficits in elderly patients with early onset depression (EOD) and late onset depression (LOD), we assessed 32 elderly healthy controls (HCs), 26 patients with EOD, and 27 patients with LOD with the clock drawing test (CDT), clock setting test, clock reading test, and the Tùˆbingen Clock Questionnaire testing semantic memory about clock times. There was no significant difference in depression severity between patients with EOD and LOD. Patients with LOD had significantly lower scores on the CDT than patients with EOD and HCs. Semantic memory impairment concerning minute hand functionality was highly ...
Source: Journal of Geriatric Psychiatry and Neurology - October 26, 2015 Category: Genetics & Stem Cells Authors: Klein, L., Saur, R., Müller, S., Leyhe, T. Tags: Articles Source Type: research

The Role of Coping Strategies in Psychological Outcomes for Frontotemporal Dementia Caregivers
This study identifies variables amenable to clinical interventions that can improve caregivers’ well-being: specifically, caregiver strain and coping strategies. For a disease without cure yet increasing prevalence and cost, ameliorating the caregiver experience through targeted interventions is essential. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - August 20, 2015 Category: Genetics & Stem Cells Authors: Roche, DClinPsy, L., Croot, K., MacCann, C., Cramer, B., Diehl-Schmid, J. Tags: Articles Source Type: research