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Specialty: Genetics & Stem Cells
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Total 914 results found since Jan 2013.
Genetic variants in ALDH2 predict risk of ischemic stroke in a Chinese population.
CONCLUSIONS: Genetic polymorphisms in ALDH2 modified ischemic stroke risk and outcome in Chinese males, but not in females.
PMID: 30077765 [PubMed - as supplied by publisher]
Source: Gene - August 2, 2018 Category: Genetics & Stem Cells Authors: Cheng X, Xu J, Gu M, Wang M, Sun B, Li Z, Ni G, Wang G, Weng Z, Shi Y, Zhang Z, Liu X Tags: Gene Source Type: research
Gene polymorphisms of angiotensin-converting enzyme and angiotensinogen and risk of idiopathic ischemic stroke.
CONCLUSIONS: The M235T and T174M polymorphisms represented an increased risk for stroke in young Mexican individuals. In contrast, the I/D was not associated with in the same group of patients. The AGT levels were higher in the acute phase of stroke, but it was not determined by the polymorphisms.
PMID: 30521887 [PubMed - as supplied by publisher]
Source: Gene - December 3, 2018 Category: Genetics & Stem Cells Authors: Isordia-Salas I, Santiago-Germán D, Cerda-Mancillas MC, Hernández-Juárez J, Bernabé-García M, Leaños-Miranda A, Alvarado-Moreno JA, Majluf-Cruz A Tags: Gene Source Type: research
TNFRSF11B polymorphisms predict poor outcome after large artery atherosclerosis stroke.
This study aimed to determine whether TNFRSF11B polymorphisms are associated with prognosis of large artery atherosclerosis (LAA) stroke. Three TNFRSF11B polymorphisms (rs2073617, rs2073618 and rs3134069) were genotyped in 1,010 patients with LAA stroke. Short-term outcome was evaluated using the modified Rankin Scale score at 3-month after stroke onset. Long-term outcome was assessed using the stroke recurrence. We found that rs2073617G was associated with an increased risk of poor outcome of LAA stroke (additive model: odds ratio (OR) = 1.35, 95% confidence interval (CI) = 1.06-1.73). This association was also observed i...
Source: Gene - March 24, 2020 Category: Genetics & Stem Cells Authors: Wang M, Gu M, Li Z, Lian X, Shen H, Dai Z, Zhang Z, Liu X Tags: Gene Source Type: research
Stroke and Alzheimer ’s Disease: A Mendelian Randomization Study
In conclusion, different types of stroke, including AS, AIS, LAS, and CES, would not be causally associated with AD risk.
Source: Frontiers in Genetics - July 13, 2020 Category: Genetics & Stem Cells Source Type: research
Genes, Vol. 12, Pages 1825: Genetic and Genomic Epidemiology of Stroke in People of African Ancestry
cinth
Stroke is one of the leading causes of disability and death worldwide and places a significant burden on healthcare systems. There are significant racial/ethnic differences in the incidence, subtype, and prognosis of stroke, between people of European and African ancestry, of which only about 50% can be explained by traditional stroke risk facts. However, only a small number of genetic studies include individuals of African descent, leaving many gaps in our understanding of stroke genetics among this population. This review article highlights the need for and significance of including African-ancestry individuals...
Source: Genes - November 19, 2021 Category: Genetics & Stem Cells Authors: Savvina Prapiadou Stacie L. Demel Hyacinth I. Hyacinth Tags: Review Source Type: research
Worst spasticity in patients post-stroke associated with mnsod ala16val polymorphism and interleukin-1 β
Gene. 2022 Sep 10:146880. doi: 10.1016/j.gene.2022.146880. Online ahead of print.ABSTRACTThe MnSOD Ala16Val single nucleotide polymorphism (SNP) has shown to be associated to risk factors of several metabolic and vascular diseases. However, little is known about interaction between MnSOD Ala16Val SNP in stroke, a frequent neurologic disease that involves clinic manifestations such as motor deficits and spasticity. In this sense, we decided to investigate the relationship between MnSOD Ala16Val SNP with spasticity in stroke and also its influence on interleukin levels, BDNF, and glycolipid parameters. Eighty post-stroke sub...
Source: Gene - September 13, 2022 Category: Genetics & Stem Cells Authors: Ariane Ethur Flores Eduardo Tanuri Pascotini Aline Kegler N úbia Broetto Patricia Gabbi Thiago Duarte Ana Lucia Cervi Prado Marta M M F Duarte Ivana B M da Cruz Adair Roberto Soares Dos Santos Luiz Fernando Freire Royes Michele Rechia Fighera Source Type: research
Genes, Vol. 14, Pages 61: Exome Array Analysis of 9721 Ischemic Stroke Cases from the SiGN Consortium
James Perry
Charles Hong
John Cole
Elizabeth Pugh
Kimberly Doheny
Sharon Kardia
David Weir
Steven Kittner
Braxton Consortium
Recent genome wide association studies have identified 89 common genetic variants robustly associated with ischemic stroke and primarily located in non-coding regions. To evaluate the contribution of coding variants, which are mostly rare, we performed an exome array analysis on 106,101 SNPs for 9721 ischemic stroke cases from the SiGN Consortium, and 12,345 subjects with no history of stroke from the Health Retirement Study and SiGN consortium. We identified 15 coding variants si...
Source: Genes - December 24, 2022 Category: Genetics & Stem Cells Authors: Huichun Xu Kevin Nguyen Brady Gaynor Hua Ling Wei Zhao Patrick McArdle Timothy O ’Connor O. Stine Kathleen Ryan Megan Lynch Jennifer Smith Jessica Faul Yao Hu Jeffrey Haessler Myriam Fornage Charles Kooperberg On Group James Perry Charles Hong John Cole Tags: Article Source Type: research
GSE234052 The transcriptional landscape of pericytes in acute ischemic stroke
This study identifies temporal transcriptional changes in the acute phase of ischemic stroke that reflect the early response of pericytes to the ischemic insult and its secondary consequences and may constitute potential future therapeutic targets.
Source: GEO: Gene Expression Omnibus - June 29, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Serotonin receptor 2C gene polymorphism associated with post-stroke depression in Chinese patients.
We examined the association between post-stroke depression (PSD) and polymorphism in HTR2C. A cohort of 223 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months after the onset of the index stroke, a research assistant administered the locally validated 15-item Geriatric Depression Scale. PSD was defined as a geriatric depression scale score of 7 or above. Possible confounding factors, including previous history of stroke, severity of stroke, level of social support, and recent life events, were investigated. All patients were g...
Source: Genetics and Molecular Research - October 30, 2013 Category: Genetics & Stem Cells Authors: Tang WK, Tang N, Liao CD, Liang HJ, Mok VC, Ungvari GS, Wong KS Tags: Genet Mol Res Source Type: research
Genetic determinants in ischaemic stroke subtypes: Seven year findings and a review.
Abstract
Stroke is a global health problem and a leading cause of disability worldwide. There have been numerable studies undertaking research on different aspects of ischaemic stroke employing various epidemiological, clinical and molecular parameters. Nevertheless ischaemic stroke being a complex disorder with different subtypes demands equal attention towards its subtypes too. Since there has been enough evidence that disposition to certain subtype is genetically determined and there is a distinct mechanism that influences its development, association studies should focus on subtypes simultaneously while studyi...
Source: Gene - November 12, 2014 Category: Genetics & Stem Cells Authors: Munshi A, Das S, Kaul S Tags: Gene Source Type: research
Genetic polymorphisms of T-1131C APOA5 and ALOX5AP SG13S114 with the susceptibility of ischaemic stroke in Morocco.
Abstract
Ischaemic stroke is a multifactorial disease. Genetic polymorphisms involved in lipid, inflammatory and thrombotic metabolisms play an important role in the development of ischaemic stroke. The present study aimed to assess the relationship between T1131C APOA5 and SG13S114 ALOX5AP polymorphisms and the risk of ischemic stroke in 175 cases and 201 controls. Genotyping was performed by high resolution melting and polymerase chain reaction restriction fragment length polymorphism methods. In the case of T-1131C APOA5, a modest risk of ischaemic stroke was noticed with CC (OR: 2.86; 95% CI = 1.24-6.58; Pc = ...
Source: Journal of Genetics - May 31, 2016 Category: Genetics & Stem Cells Authors: Diakite B, Hamzi K, Hmimech W, Nadifi S, GMRAVC Tags: J Genet Source Type: research
ZNF208 polymorphisms associate with ischemic stroke in southern Chinese Han population
ConclusionThe results indicate a potential association between ZNF208 variants and ischemic stroke risk in southern Chinese Han population.
Source: The Journal of Gene Medicine - December 8, 2016 Category: Genetics & Stem Cells Authors: Jianzhong Yu, Feng Zhou, Dong Luo, Nianzhen Wang, Chong Zhang, Tianbo Jin, Xiongfei Liang, Dan Yu Tags: RESEARCH ARTICLE Source Type: research
Transcriptome Sequencing Unravels Potential Biomarkers at Different Stages of Cerebral Ischemic Stroke
This study assessed the characteristics of transcriptome changes at different stages of ischemic stroke using a mouse model of transient middle cerebral artery occlusion (tMCAO) and bioinformatics analyses. Cerebral cortex tissues from tMCAO mice at days 1, 3, 7, 14, and 28 were removed for RNA-Seq and small RNA-Seq library construction, sequencing, and bioinformatics analysis. We identified differentially expressed (DE) genes and miRNAs and revealed an association of the up-regulated or down-regulated DEmiRNAs with the correspondingly altered DEgene targets at each time point. In addition, different biological pathways we...
Source: Frontiers in Genetics - September 23, 2019 Category: Genetics & Stem Cells Source Type: research
Association between microRNA binding site polymorphisms in immunoinflammatory genes and recurrence risk of ischemic stroke.
Abstract
MicroRNA binding site polymorphisms in immunoinflammatory genes have been implicated as candidate biomarkers for prediction of complex human diseases. However, the roles of microRNA binding site polymorphisms in stroke onset and prognosis remain unclear. Thus, for the first time, five potential functional polymorphisms in immunoinflammatory genes (CXCR2 rs1126579, TLR4 rs11536889, ADIPOR2 rs12342, MMP-2 rs7201 and MMP-9 rs1056628) were genotyped in 657 patients with ischemic stroke. These five polymorphisms were not related with age onset of ischemic stroke. However, we found that ADIPOR2 rs12342 was sign...
Source: Genomics - December 24, 2019 Category: Genetics & Stem Cells Authors: Zhu R, Zhao Y, Xiao T, Wang Q, Liu X Tags: Genomics Source Type: research
Nanoparticle-Based Gene Therapy Intervention for Stroke Treatment: a Systematic Review.
In conclusion, due to the inability of brain regeneration and the importance of genes in stroke-related complications, gene therapy seems to be a suitable treatment strategy. The use of suitable nanoparticles for transportation ensures the efficiency and usefulness of this method.
PMID: 33045966 [PubMed - as supplied by publisher]
Source: Current Gene Therapy - October 12, 2020 Category: Genetics & Stem Cells Authors: Ghasemi S, Alavian K, Alavian F Tags: Curr Gene Ther Source Type: research
