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Specialty: Genetics & Stem Cells

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Total 914 results found since Jan 2013.

Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies.
CONCLUSION: In-silico molecular docking and virtual screening studies and in-vivo studies in MCAo induced stroke, animal model outcomes support the strong anti-stroke signature for possible neuroprotective therapeutics. PMID: 33054705 [PubMed - in process]
Source: Current Gene Therapy - October 20, 2020 Category: Genetics & Stem Cells Authors: Shah P, Chavda V, Patel S, Bhadada S, Ashraf GM Tags: Curr Gene Ther Source Type: research

Association of Fibroblast Growth Factor 23 With Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
In this study, we aimed to assess the association of FGF23 with ischemic stroke and its subtypes by applying a Mendelian randomization (MR) framework. Five genetic variants obtained from a genome-wide association study involving 16,624 European subjects were used as valid instruments of circulating FGF23 levels. MR was applied to infer the causality of FGF23 levels and the risk of ischemic stroke using data from the MEGASTROKE consortium. Subsequently, several MR analyses, including inverse-variance weighted meta-analysis, MR-Egger, weighted median estimate (WME), MR Pleiotropy Residual Sum and Outlier were performed. The ...
Source: Frontiers in Genetics - December 23, 2020 Category: Genetics & Stem Cells Source Type: research

GSE167593 Single-Cell RNA-Seq reveals cellualr heterogeneity and gene expression difference between ischemic and hemorrhagic stroke brain
Contributors : Xiaojing Shi ; Jixian Wang ; Yaohui TangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCluster analysis using nonlinear dimensionality reduction ([tSNE]) revealed the differences in global gene expression profiles of healthy and injured striatum, and identified clusters of cells with unique genetic signatures in both ischemic brain and hemorrhagic brain. Genes with p-value
Source: GEO: Gene Expression Omnibus - February 27, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Coding and non-coding nucleotides': The future of stroke gene therapeutics
Genomics. 2021 Mar 4:S0888-7543(21)00084-7. doi: 10.1016/j.ygeno.2021.03.003. Online ahead of print.ABSTRACTStroke is the foremost cause of death ranked after heart disease and cancer. It is the fatal life-threatening event that requires immediate medical admissions to overcome following morbidity and mortality. The therapeutic advances in stroke therapy have been manipulated with diverse paths for last 5 years. Recent research and clinical trials have investigated a variety of anti-stroke agents including anti-coagulants, cerebro-protective agents, antiplatelet therapy, stem-cell therapy, and specified gene therapy. In re...
Source: Genomics - March 7, 2021 Category: Genetics & Stem Cells Authors: Vishal Chavda Kajal Madhwani Source Type: research

GSE168934 The critical role of chondroitin sulfate proteoglycan interactions with receptor PTP σ in the inhibition of neural repair after stroke
Contributors : Yu Luo ; Jerry Silver ; Frank Huang ; Zhen YouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe used RNAseq to compare transcriptome of peri-infarct cortex in stroke mice that received vehicle or ISP treatment (which blocks the PTPsigma receptor signaling) at 14 days post stroke. The purpose of this project is to identify genes that are differentially expressed in control stroke mice and ISP treated stroke mice that might mediated the behavioral improvement in ISP treated stroke mice.
Source: GEO: Gene Expression Omnibus - March 16, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE173544 RNA Sequencing of WT Chronic Stroke Infarcts vs. Contralateral Cortices
Contributors : Danielle A Becktel ; Kristian P DoyleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe conducted bulk RNA sequencing on infarcts collected from young adult (3-month-old) mice at 7 weeks after the distal middle cerebral artery occlusion + hypoxia stroke model and compared them to contralateral cortices. As expected, differential expression (DE) analysis revealed marked differences between infarcts and contralateral cortices: 3,930 upregulated and 2,869 downregulated genes. The most significantly upregulated genes, including Lpl, Spp1, Cd36, Mmp2, and Mmp19, and the most...
Source: GEO: Gene Expression Omnibus - April 30, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE178764 Screening for differentially expressed circRNAs in ischemic stroke by RNA sequencing
Conclusion: The results of our study may help to elucidate the specific mechanism underlying ischemic stroke.
Source: GEO: Gene Expression Omnibus - June 24, 2021 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research

EDNRA Gene rs1878406 Polymorphism is Associated With Susceptibility to Large Artery Atherosclerotic Stroke
Conclusion: The rs1878406 C > T polymorphism is associated with increased risk of LAA stroke in the Chinese Han population.
Source: Frontiers in Genetics - January 3, 2022 Category: Genetics & Stem Cells Source Type: research

Genes, Vol. 13, Pages 144: Influence of Haptoglobin Polymorphism on Stroke in Sickle Cell Disease Patients
vain Doré This review outlines the current clinical research investigating how the haptoglobin (Hp) genetic polymorphism and stroke occurrence are implicated in sickle cell disease (SCD) pathophysiology. Hp is a blood serum glycoprotein responsible for binding and removing toxic free hemoglobin from the vasculature. The role of Hp in patients with SCD is critical in combating blood toxicity, inflammation, oxidative stress, and even stroke. Ischemic stroke occurs when a blocked vessel decreases oxygen delivery in the blood to cerebral tissue and is commonly associated with SCD. Due to the malformed red blood cells of s...
Source: Genes - January 14, 2022 Category: Genetics & Stem Cells Authors: Olivia Edwards Alicia Burris Josh Lua Diana J. Wilkie Miriam O. Ezenwa Sylvain Dor é Tags: Review Source Type: research

Circulating N-Terminal Probrain Natriuretic Peptide Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
Mendelian randomization was used to evaluate the potential causal association between N-terminal probrain natriuretic peptide (NT-proBNP) and ischemic stroke based on summary statistics data from large-scale genome-wide association studies. Three single-nucleotide polymorphisms (SNPs) rs198389, rs13107325, and rs11105306 associated with NT-proBNP levels found in large general populations and in patients with acute heart disease were used as instrumental variables. The results of genetic association analysis of each single SNP show that there is no significant association between NT-proBNP levels and ischemic stroke or its ...
Source: Frontiers in Genetics - February 22, 2022 Category: Genetics & Stem Cells Source Type: research

Evaluating the Causal Effects of TIMP-3 on Ischaemic Stroke and Intracerebral Haemorrhage: A Mendelian Randomization Study
Conclusion: Our results revealed that high levels of circulating TIMP-3 causally increased the risk of developing IS and SVS, but not CES, LAS, ICH, and all ICH subtypes. Further investigation is required to elucidate the underlying mechanism.
Source: Frontiers in Genetics - April 4, 2022 Category: Genetics & Stem Cells Source Type: research

Genes, Vol. 14, Pages 953: Neuroprotective Peptides and New Strategies for Ischemic Stroke Drug Discoveries
asoedov Ischemic stroke continues to be one of the leading causes of death and disability in the adult population worldwide. The currently used pharmacological methods for the treatment of ischemic stroke are not effective enough and require the search for new tools and approaches to identify therapeutic targets and potential neuroprotectors. Today, in the development of neuroprotective drugs for the treatment of stroke, special attention is paid to peptides. Namely, peptide action is aimed at blocking the cascade of pathological processes caused by a decrease in blood flow to the brain tissues. Different groups of pep...
Source: Genes - April 22, 2023 Category: Genetics & Stem Cells Authors: Lyudmila V. Dergunova Ivan B. Filippenkov Svetlana A. Limborska Nikolay F. Myasoedov Tags: Review Source Type: research

GSE231431 Specific stroke-induced miRNAs could mediate and interaction between peripheral blood and the brain
Contributors : Yusra Azar ; Colin M Wilson ; Reed G Selwyn ; Marc C Mabray ; Sharina P Desai ; Jeffrey F Thompson ; Sasha M Hobson ; Orrin B Myers ; Jacquelyn S Morales ; Surojit Paul ; Michel Torbey ; Tamara RoitbakSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIschemic stroke is a major public health problem that is currently among the top leading causes of serious, long-term disability worldwide. The lack of effective treatment strategies prompted a search for new molecular targets for stroke prognosis and therapy. One of the epigenetic mechanisms controlling stroke progression an...
Source: GEO: Gene Expression Omnibus - May 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research