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Specialty: Genetics & Stem Cells

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Total 914 results found since Jan 2013.

Blood miR-1275 is associated with risk of ischemic stroke and inhibits macrophage foam cell formation by targeting ApoC2 gene.
In this study, we first explored potential ApoC2-targeting microRNAs (miRNAs) by bioinformatics tool and compared the miRNA expression profiles in the blood cells of 25 IS patients and 25 control subjects by miRNA microarray. miR-1275 was predicted to bind with the 3' untranslated region of ApoC2, and a significant reduction of blood miR-1275 levels was observed in IS patients. Dual-luciferase reporter assay and quantitative RT-PCR confirmed the regulation of ApoC2 by miR-1275 in THP-1 derived macrophages. miR-1275 also inhibited cellular uptake of ox-LDL and suppressed formation of macrophage foam cell. Furthermore, the w...
Source: Gene - January 10, 2020 Category: Genetics & Stem Cells Authors: Li L, Xu W, Fu X, Huang Y, Wen Y, Xu Q, He X, Wang K, Huang S, Lv Z Tags: Gene Source Type: research

GSE141972 TGF β-activated kinase 1-dependent microglial and macrophage responses aggravate long-term outcomes after ischemic stroke
Contributors : Yejie Shi ; Jun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroglia/macrophages (Mi/M Φ) can profoundly influence stroke outcomes by acquiring functionally dominant phenotypes (pro-inflammatory or anti-inflammatory; neurotoxic or neuroprotective). Identification of the molecular mechanisms that dictate the functional status of Mi/MΦ after brain ischemia/reperfusion may reveal novel therapeutic targets for stroke. We hypothesized that activation of TGFβ-activated kinase 1 (TAK1), a key MAP3K upstream of multiple inflammation-regulating pathways, drives Mi/M...
Source: GEO: Gene Expression Omnibus - March 10, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Haptoglobin genotype 2-2 associated with atherosclerosis in patients with ischemic stroke.
CONCLUSION: This study has shown an association of the Hp2-2 genotype and atherosclerosis in patients with IS, indicating Hp2-2 genotype as a genetic biomarker for precision medicine and personalized healthcare. PMID: 32439379 [PubMed - as supplied by publisher]
Source: Gene - May 17, 2020 Category: Genetics & Stem Cells Authors: Merkler A, Sertić J, Martinović AB, Križ T, Miličić I, Šimić M, Caban D, Ljubić H, Markeljević J, Šimičević L, Kaštelan S, Pećin I, Reiner Ž Tags: Gene Source Type: research

Atrial fibrillation in the elderly: A risk factor beyond stroke.
Abstract Atrial fibrillation (AF) represents the most common arrhythmia worldwide, and its prevalence exponentially increases with age. It is related to increased risk of ischemic stroke or systemic embolism, which determines a significant burden of morbidity and mortality, as widely documented in the literature. AF also constitutes a risk factor for other less investigated conditions, such as heart failure, pulmonary embolism, impairment in physical performance, reduced quality of life and development of disability, mood disorders, and cognitive impairment up to dementia. In the elderly population, the management...
Source: Ageing Research Reviews - May 28, 2020 Category: Genetics & Stem Cells Authors: Bencivenga L, Komici K, Nocella P, Grieco FV, Spezzano A, Puzone B, Cannavo A, Cittadini A, Corbi G, Ferrara N, Rengo G Tags: Ageing Res Rev Source Type: research

Association between polymorphisms in ABO gene and stroke patients with small artery occlusion in southern Chinese Han population.
CONCLUSION: The resultsindicate that rs532436 polymorphism in ABO gene may have association with SAO in southern Chinese Han population. PMID: 33053422 [PubMed - as supplied by publisher]
Source: Gene - October 11, 2020 Category: Genetics & Stem Cells Authors: Jiang YY, Li JL, Liu LY, Zhou GQ, Mo DC, Jiang DD, Luo M Tags: Gene Source Type: research

Deep vein thrombosis inhibitor may play a therapeutic role in post-stroke patients
Deep vein thrombosis (DVT) is associated with stroke. Here, we hypothesize that genes associated with DVT may also play roles in the development of stroke.
Source: BMC Medical Genetics - October 22, 2020 Category: Genetics & Stem Cells Authors: Xixi Xiang, Di Yuan, Peiyan Kong, Ting Chen, Han Yao, Shijia Lin, Xi Zhang and Hongbao Cao Tags: Research Source Type: research

GSE155480 RNA sequencing of CD8 T cells flow sorted from post-stroke brain
Contributors : Uma Maheswari Selvaraj ; Xiangmei Kong ; Thomas Ujas ; Ashwani Kumar ; Erik J Plautz ; Shanrong Zhang ; Chao Xing ; Jadwiga Turchan-Cholewo ; Mark P Goldberg ; Ann StoweSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD8 T cells functional profile was characterized by comparing the gene expression between the cells isolated from 3 days post-stroke, 30 days post-stroke and na ïve brains.
Source: GEO: Gene Expression Omnibus - November 1, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Association Between Circulating Linoleic Acid and Risk of Ischemic Stroke
ConclusionOur study supports a potential inverse association of genetically predicted circulating LA levels with risk of IS, particularly LAS.
Source: Frontiers in Genetics - January 8, 2021 Category: Genetics & Stem Cells Source Type: research

Association between Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphism with the risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of 53 Studies
CONCLUSION: This meta-analysis suggests that ACE I/D polymorphism may lead to risk of HS and can be a potential biomarker for HS susceptibility especially in Asian population.PMID:33964377 | DOI:10.1016/j.gene.2021.145696
Source: Gene - May 8, 2021 Category: Genetics & Stem Cells Authors: Manabesh Nath Shubham Misra Pumanshi Talwar Deepti Vibha Achal Kumar Srivastava Kameshwar Prasad Pradeep Kumar Source Type: research

Genes, Vol. 12, Pages 1938: Examination of Genetic Variants Revealed from a Rat Model of Brain Ischemia in Patients with Ischemic Stroke: A Pilot Study
A. Limborska Although there has been great progress in understanding the genetic bases of ischemic stroke (IS), many of its aspects remain underexplored. These include the genetics of outcomes, as well as problems with the identification of real causative loci and their functional annotations. Therefore, analysis of the results obtained from animal models of brain ischemia could be helpful. We have developed a bioinformatic approach exploring single nucleotide polymorphisms (SNPs) in human orthologues of rat genes expressed differentially under conditions of induced brain ischemia. Using this approach, we identified a...
Source: Genes - November 30, 2021 Category: Genetics & Stem Cells Authors: Andrey V. Khrunin Gennady V. Khvorykh Alexandra V. Rozhkova Evgeniya A. Koltsova Elizaveta A. Petrova Ekaterina I. Kimelfeld Svetlana A. Limborska Tags: Article Source Type: research

Genes, Vol. 12, Pages 1955: Novel In-Frame Deletion in HTRA1 Gene, Responsible for Stroke at a Young Age and Dementia & mdash;A Case Study
We present the case of a Lithuanian male patient who had a stroke at the age of 36, experienced several transient ischemic attacks, and developed an early onset, progressing dementia. These clinical symptoms were associated with extensive leukoencephalopathy, lacunar infarcts, and microbleeds based on brain magnetic resonance imaging (MRI). A novel heterozygous in-frame HTRA1 gene deletion (NM_002775.5:c.533_535del; NP_002766.1:p.(Lys178del)) was identified by next generation sequencing. The variant was consistent with the patient’s phenotype, which could not be explained by alternative causes, appeared highl...
Source: Genes - December 7, 2021 Category: Genetics & Stem Cells Authors: Julija Grigait ė Kamil ė Šiaurytė Egl ė Audronytė Egl ė Preikšaitienė Birut ė Burnytė Erinija Pranckevi čienė Aleksandra Ekkert Algirdas Utkus Dalius Jatu žis Tags: Article Source Type: research

GSE197104 Ferroptosis in oligodendrocyte progenitor cells mediates white matter injury after hemorrhagic stroke
Contributors : Qian Li ; Danmin ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOligodendrocyte progenitor cells (OPCs) differentiate to myelin-producing mature oligodendrocytes and enwrap growing or demyelinated axons during development and post central nervous diseases. Failure of remyelination due to cell death or undifferentiation of OPC contributes to severe neurologic deficits and motor dysfunction. However, how to prevent the cell death of OPCs is still poorly understood, especially in hemorrhagic diseases. In this current study, we injected autologous blood into the mouse ...
Source: GEO: Gene Expression Omnibus - February 24, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research