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Specialty: Genetics & Stem Cells

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Total 914 results found since Jan 2013.

Safety and efficacy of cell therapies administered in the acute and subacute stages after stroke: a meta-analysis.
CONCLUSION: Although a number of therapies appear effective, many studies did not control for normal recovery (standard-care). Long-term safety also needs to be established. PMID: 27580670 [PubMed - as supplied by publisher]
Source: Regenerative Medicine - August 31, 2016 Category: Genetics & Stem Cells Authors: Unsworth DJ, Mathias JL, Dorstyn DS Tags: Regen Med Source Type: research

Stem cell therapies in age-related neurodegenerative diseases and stroke.
Abstract Aging, a complex process associated with various structural, functional and metabolic changes in the brain, is an important risk factor for neurodegenerative diseases and stroke. These diseases share similar neuropathological changes, such as the formation of misfolded proteins, oxidative stress, loss of neurons and synapses, dysfunction of the neurovascular unit (NVU), reduction of self-repair capacity, and motor and/or cognitive deficiencies. In addition to gray matter dysfunction, the plasticity and repair capacity of white matter also decrease with aging and contribute to neurodegenerative diseases. A...
Source: Ageing Research Reviews - November 18, 2016 Category: Genetics & Stem Cells Authors: Wang Y, Ji X, Leak RK, Chen F, Cao G Tags: Ageing Res Rev Source Type: research

Cell therapies administered in the chronic phase after stroke: a meta-analysis examining safety and efficacy.
CONCLUSION: Preliminary findings suggest that some cell therapies may be relatively safe and effective, but larger double-blinded placebo-controlled studies are needed to establish the long-term risks and benefits. PMID: 27977331 [PubMed - as supplied by publisher]
Source: Regenerative Medicine - December 14, 2016 Category: Genetics & Stem Cells Authors: Unsworth DJ, Mathias JL, Dorstyn DS Tags: Regen Med Source Type: research

Mycophenolate mofetil prevents cerebrovascular injury in stroke-prone spontaneously hypertensive rats
Stroke-prone spontaneously hypertensive rats (SHR-A3) develop strokes and progressive kidney disease as a result of naturally occurring genetic variations. We recently identified genetic variants in immune signaling pathways that contribute to end-organ injury. The present study was designed to test the hypothesis that a dysregulated immune response promotes stroke susceptibility. We salt-loaded 20 wk old male SHR-A3 rats and treated them with the immunosuppressant mycophenolate mofetil (MMF, 25 mg/kg/day po) (n = 8) or vehicle (saline) (n = 9) for 8 wk. Blood pressure (BP) was measured weekly by telemetry. Compared with v...
Source: Physiological Genomics - February 28, 2017 Category: Genetics & Stem Cells Authors: Dhande, I. S., Zhu, Y., Braun, M. C., Hicks, M. J., Wenderfer, S. E., Doris, P. A. Tags: Research Articles Source Type: research

Relationship of apolipoprotein (APOE) ε4 gene polymorphism with the risk of ischemic stroke: A hospital based case-control study
Conclusion Our results suggest that APO-ε4 gene polymorphism may be an important risk factor for IS in North Indian population. Further prospective studies are needed to validate the present findings.
Source: Meta Gene - March 28, 2017 Category: Genetics & Stem Cells Source Type: research

Association between matrix metalloproteinase family gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis of 29 studies.
CONCLUSION: Our meta-analysis suggests that MMP-9 (-1562C/T) and MMP-12 (-1082 A/G) gene polymorphisms could be a risk factor for IS while MMP-1 (-1607 1G/2G), MMP-2 (-1306C/T) & (-735C/T) and MMP-3 (-1612 5A/6A) have no association with the risk of causing IS. However, large prospective studies with sufficient power are required to validate our findings. PMID: 29906531 [PubMed - as supplied by publisher]
Source: Gene - June 12, 2018 Category: Genetics & Stem Cells Authors: Misra S, Talwar P, Kumar A, Kumar P, Sagar R, Vibha D, Pandit AK, Gulati A, Kushwaha S, Prasad K Tags: Gene Source Type: research

A stroke gene panel for whole-exome sequencing
A stroke gene panel for whole-exome sequencing, Published online: 24 October 2018; doi:10.1038/s41431-018-0274-4A stroke gene panel for whole-exome sequencing
Source: European Journal of Human Genetics - October 24, 2018 Category: Genetics & Stem Cells Authors: Andreea Ilinca Sofie Samuelsson Paul Piccinelli Maria Soller Ulf Kristoffersson Arne G. Lindgren Source Type: research

Association and interaction of genetic variants with occurrence of ischemic stroke among Brazilian patients.
Abstract Ischemic Stroke (IS) is a severe and complex disorder of high morbidity and mortality rates associated with clinical, environmental, and genetic predisposing factors. Despite previous studies have associated genetic variants to stroke, inconsistent results from different populations pointed to the genetic heterogeneity for IS. Therefore, we may hypothesize that an interaction effect among genetic variants could contribute to IS occurrence rather than genetic variants independently. In this context, we investigated the association and interaction between genetic variants and large-artery atherosclerosis IS...
Source: Gene - February 7, 2019 Category: Genetics & Stem Cells Authors: Ferreira LE, Secolin R, Lopes-Cendes I, Cabral NL, de França PHC Tags: Gene Source Type: research

Early-onset stroke in two siblings with Neurofibromatosis type 1.
Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder, characterized by cafe-au-lait macules, benign neurofibromas as well as malignant peripheral nerve sheath tumours, freckling in the axillary or inguinal regions, optic glioma and Lisch nodules (iris hamartomas) and further manifestations like bone deformities etc. Additionally, NF1 patients are at increased risk of early-onset cerebrovascular diseases, the pathogenesis of which has not been clarified yet. Here we report the first case of two siblings with NF1 who suffered an acute ischemic stroke. Professionals treating NF1 pa...
Source: European Journal of Medical Genetics - July 3, 2019 Category: Genetics & Stem Cells Authors: Rukavina K, Töpper R, Kunze A, Hess A, Glatzel M, Valdueza JM, Farschtschi S, Hagel C Tags: Eur J Med Genet Source Type: research

Discovery of stroke-related blood biomarkers from gene expression network models
Identifying molecular biomarkers characteristic of ischemic stroke has the potential to aid in distinguishing stroke cases from stroke mimicking symptoms, as well as advancing the understanding of the physiolo...
Source: BMC Medical Genomics - August 7, 2019 Category: Genetics & Stem Cells Authors: Konstantinos Theofilatos, Aigli Korfiati, Seferina Mavroudi, Matthew C. Cowperthwaite and Max Shpak Tags: Research article Source Type: research

GSE131774 IL4 improves white matter repair after stroke
We report that interleukin-4 (IL-4) promotes oligodendrocyte regeneration and remyelination. IL-4 receptor expression was detected in a variety of glial cells after ischemic brain injury, including oligodendrocyte lineage cells. IL-4 deficiency in knockout mice resulted in greater deterioration of white matter over 14 days after stroke. Consistent with these findings, intranasal delivery of IL-4 nanoparticles after stroke improved white matter integrity and attenuated long-term sensorimotor and cognitive deficits in wild-type mice, as revealed by histological immunostaining, electron microscopy, diffusion tensor imaging, a...
Source: GEO: Gene Expression Omnibus - August 31, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research

LncRNAs related key pathways and genes in ischemic stroke by weighted gene co-expression network analysis (WGCNA).
CONCLUSION: To summarize, this study identified the key pathways and genes, which might serve as biomarkers and targets for precise diagnosis and treatment of IS in the future. PMID: 31923616 [PubMed - as supplied by publisher]
Source: Genomics - January 6, 2020 Category: Genetics & Stem Cells Authors: Wang M, Wang L, Pu L, Li K, Feng T, Zheng P, Li S, Sun M, Yao Y, Jin L Tags: Genomics Source Type: research

Genes, Vol. 11, Pages 89: Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms
ranza Rubattu Epigenetics is the branch of molecular biology that studies modifications able to change gene expression without altering the DNA sequence. Epigenetic modulations include DNA methylation, histone modifications, and noncoding RNAs. These gene modifications are heritable and modifiable and can be triggered by lifestyle and nutritional factors. In recent years, epigenetic changes have been associated with the pathogenesis of several diseases such as diabetes, obesity, renal pathology, and different types of cancer. They have also been related with the pathogenesis of cardiovascular diseases including ischemi...
Source: Genes - January 12, 2020 Category: Genetics & Stem Cells Authors: Rosita Stanzione Maria Cotugno Franca Bianchi Simona Marchitti Maurizio Forte Massimo Volpe Speranza Rubattu Tags: Review Source Type: research

Alternate approach to stroke phenotyping identifies a genetic risk locus for small vessel stroke
European Journal of Human Genetics, Published online: 11 February 2020; doi:10.1038/s41431-020-0580-5Alternate approach to stroke phenotyping identifies a genetic risk locus for small vessel stroke
Source: European Journal of Human Genetics - February 10, 2020 Category: Genetics & Stem Cells Authors: Joanna von Berg Sander W. van der Laan Patrick F. McArdle Rainer Malik Steven J. Kittner Braxton D. Mitchell Bradford B. Worrall Jeroen de Ridder Sara L. Pulit Source Type: research

GSE136405 Gene expression changes following Knock-down of eRNA_06347 in post-stroke mouse cortex
Contributors : Ashutosh Dharap ; Sunil Bhattarai ; Aparna AkellaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-sequencing was conducted to profile the transcriptome of the eRNA_06347 knockdown post-stroke mouse cortices ( knockdown achieved by intracerebroventricular injection of oligos against eRNA_06347). RNA was isolated from sham, Negative control oligo injected post-stroke cortices and eRNA_06347 knockown post-stroke cortices (three independent biological replicates per group),converted into cDNA libraries, and used for Illumina deep sequencing.The sequencing reads were alig...
Source: GEO: Gene Expression Omnibus - November 12, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research