Umbilical cord-derived mesenchymal stem cells in neurodegenerative disorders: from literature to clinical practice.
Abstract Mesenchymal stem cells (MSCs) have provided a promising tool for cell therapy. Umbilical cord (UC) is one of the best sources of MSCs since its collection is noninvasive, and effortless, and the cells from this source are more capable and prolific. It has been proven that the differentiation, migration and protective properties of UC-MSCs are superior compared with other kinds of stem cells. Moreover, incurable neurodegenerative diseases, such as Alzheimer's disease, multiple sclerosis, Parkinson's disease and Huntington, encourage scientists to apply UC-MSCs transplantation in order to find a definite tr...
Source: Regenerative Medicine - June 1, 2020 Category: Genetics & Stem Cells Authors: Reyhani S, Abbaspanah B, Mousavi SH Tags: Regen Med Source Type: research

Bone regeneration in rabbit calvarial defects using PRGF and adipose-derived stem cells: histomorphometrical analysis.
Conclusion: Combining PRGF and ADSCs boosts the bone graft regenerative potential at the earliest period of healing. PMID: 32452715 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 26, 2020 Category: Genetics & Stem Cells Authors: Stumbras A, Kuliesius P, Darinskas A, Kubilius R, Zigmantaite V, Juodzbalys G Tags: Regen Med Source Type: research

Industry updates from the field of stem cell research and regenerative medicine in March 2020.
Abstract Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in March 2020. PMID: 32452720 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 26, 2020 Category: Genetics & Stem Cells Authors: Ilic D, Liovic M Tags: Regen Med Source Type: research

Development of a decellularized porcine bone matrix for potential applications in bone tissue regeneration.
Conclusion: DBM has similar function on cell behavior to β-TCP scaffolds that have promising potential in bone tissue regeneration. PMID: 32441554 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 22, 2020 Category: Genetics & Stem Cells Authors: Nie Z, Wang X, Ren L, Kang Y Tags: Regen Med Source Type: research

More than 500  million years of evolution in a fibrin-based therapeutic scaffold.
More than 500 million years of evolution in a fibrin-based therapeutic scaffold. Regen Med. 2020 May 22;: Authors: Anitua E, Nurden P, Nurden AT, Padilla S PMID: 32441555 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 22, 2020 Category: Genetics & Stem Cells Authors: Anitua E, Nurden P, Nurden AT, Padilla S Tags: Regen Med Source Type: research

Platelet-rich plasma for treatment of chronic proximal hamstring tendinopathy.
Abstract Aim: To determine whether platelet-rich plasma (PRP) can successfully treat symptoms associated with proximal hamstring tendinopathy. Materials & methods: Charts were retrospectively reviewed of patients with a diagnosis of chronic proximal hamstring tendinopathy who underwent an ultrasound-guided leukocyte-rich PRP injection to assess reported outcomes at baseline and final follow-up post-intervention. Results: In 22 patients with a mean age of 48.7 years and mean symptom duration of 26.5 months, mean Numeric Pain Rating Scale and Victorian Institute of Sport Assessment Scale for Proximal H...
Source: Regenerative Medicine - May 18, 2020 Category: Genetics & Stem Cells Authors: Auriemma MJ, Tenforde AS, Harris A, McInnis KC Tags: Regen Med Source Type: research

Reimbursement and pricing of regenerative medicine in South Korea: key factors for achieving reimbursement.
Abstract In the South Korean health technology assessment system, prices of alternative medicines, incremental cost-effectiveness ratios in pharmaco-economic evaluations and patient access improvement systems such as risk-sharing agreements are the most important factors concerning the reimbursement of regenerative medicine (RM). Research and development companies in RM should review the key features of these medicines throughout the product development cycle to increase the probability of successful reimbursement. In addition, the South Korean government should take steps to improve the system to reflect the uniq...
Source: Regenerative Medicine - May 1, 2020 Category: Genetics & Stem Cells Authors: Cho E, Yoo SL, Kang Y, Lee JH Tags: Regen Med Source Type: research

In vitro potential of human mesenchymal stem cells for corneal epithelial regeneration.
Conclusion: BM-MSC has potential for corneal epithelial induction in a protocol compatible with human application. PMID: 32352350 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - April 30, 2020 Category: Genetics & Stem Cells Authors: Nieto-Nicolau N, Martín-Antonio B, Müller-Sánchez C, Casaroli-Marano RP Tags: Regen Med Source Type: research

Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?
Abstract Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bone marrow and blood cells until needed for transfusion. Nevertheless, its effects on cell biology and apparent toxicity in patients have been an ongoing topic of debate, driving the search for less cytotoxic cryoprotectants. This review seeks to place the toxicity of DMSO in context of its ef...
Source: Regenerative Medicine - April 28, 2020 Category: Genetics & Stem Cells Authors: Awan M, Buriak I, Fleck R, Fuller B, Goltsev A, Kerby J, Lowdell M, Mericka P, Petrenko A, Petrenko Y, Stolzing A, Rogulska O, Stacey GN Tags: Regen Med Source Type: research

Antioxidant pretreatment enhances umbilical cord derived stem cells survival in response to thermal stress in vitro.
Conclusion: Our data suggest that antioxidant pretreatment of WJMSCs strengthens the endurance of the cells, within stress conditions. PMID: 32339058 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - April 27, 2020 Category: Genetics & Stem Cells Authors: Ashfaq R, Mehmood A, Ramzan A, Hussain I, Tarar MN, Riazuddin S Tags: Regen Med Source Type: research

Challenging misinformation and engaging patients: characterizing a regenerative medicine consult service.
Conclusion: An institutional RMCS can meet patients' informational needs and support the responsible translation of regenerative medicine. PMID: 32319855 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - April 22, 2020 Category: Genetics & Stem Cells Authors: Smith C, Martin-Lillie C, Higano JD, Turner L, Phu S, Arthurs J, Nelson TJ, Shapiro S, Master Z Tags: Regen Med Source Type: research

Human platelet lysate stimulated adipose stem cells exhibit strong neurotrophic potency for nerve tissue engineering applications.
Conclusion: HPL supplementation significantly improved the neurotrophic potency of ASC as evidenced by the robust axonal outgrowth; these findings hold significance for nerve tissue engineering applications. PMID: 32308109 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - April 20, 2020 Category: Genetics & Stem Cells Authors: Lischer M, di Summa PG, Oranges CM, Schaefer DJ, Kalbermatten DF, Guzman R, Madduri S Tags: Regen Med Source Type: research

Mesenchymal stem cells modifications for enhanced bone targeting and bone regeneration.
Abstract In pathological bone conditions (e.g., osteoporotic fractures or critical size bone defects), increasing the pool of osteoblast progenitor cells is a promising therapeutic approach to facilitate bone healing. Since mesenchymal stem cells (MSCs) give rise to the osteogenic lineage, a number of clinical trials investigated the potential of MSCs transplantation for bone regeneration. However, the engraftment of transplanted cells is often hindered by insufficient oxygen and nutrients supply and the tendency of MSCs to home to different sites of the body. In this review, we discuss various approaches of MSCs ...
Source: Regenerative Medicine - April 16, 2020 Category: Genetics & Stem Cells Authors: Safarova Y, Umbayev B, Hortelano G, Askarova S Tags: Regen Med Source Type: research

Industry updates from the field of stem cell research and regenerative medicine in February 2020.
Abstract The latest developments in the field of stem-cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in February 2020. PMID: 32290767 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - April 15, 2020 Category: Genetics & Stem Cells Authors: Ilic D, Liovic M Tags: Regen Med Source Type: research

Human umbilical cord-mesenchymal stem cells: a promising strategy for corneal epithelial regeneration.
Conclusion: hUC-MSC promote corneal epithelial growth and functions after treatment with hUC-MSC. PMID: 32253974 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - April 7, 2020 Category: Genetics & Stem Cells Authors: Azmi SM, Salih M, Abdelrazeg S, Roslan FF, Mohamed R, Jie TJ, Shaharuddin B Tags: Regen Med Source Type: research

Salivary gland tissue engineering to attain clinical benefits: a special report.
This report concludes that in the literature, numerous strategies have been suggested and discussed pertaining to the engineering of salivary gland, however, challenges remain in terms of its production and accurate function. Dedicated efforts are required from researchers all over the world to obtain the maximum benefits from salivary gland engineering techniques. PMID: 32253995 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - April 7, 2020 Category: Genetics & Stem Cells Authors: Khan E, Farooq I, Khabeer A, Ali S, Zafar MS, Khurshid Z Tags: Regen Med Source Type: research

Design and biofabrication of dermal regeneration scaffolds: role of oligomeric collagen fibril density and architecture.
Conclusion: Fibril content, spatial gradient and orientation are important collagen scaffold design considerations for promoting vascularization and dermal regeneration while reducing wound contraction. PMID: 32228274 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 31, 2020 Category: Genetics & Stem Cells Authors: Sohutskay DO, Buno KP, Tholpady SS, Nier SJ, Voytik-Harbin SL Tags: Regen Med Source Type: research

Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing.
Conclusion: hiPSC-SMC promote angiogenesis and accelerate diabetic wound healing, making them a promising new candidate for treatment of diabetic wounds. PMID: 32228292 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 31, 2020 Category: Genetics & Stem Cells Authors: Gorecka J, Gao X, Fereydooni A, Dash BC, Luo J, Lee SR, Taniguchi R, Hsia HC, Qyang Y, Dardik A Tags: Regen Med Source Type: research

Microvascular tissue as a platform technology to modify the local microenvironment and influence the healing cascade.
Conclusion: Microvascular tissue contains elements relevant to tissue repair and can be clinically applied to enable or accelerate the closure of challenging wounds. PMID: 32228366 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 31, 2020 Category: Genetics & Stem Cells Authors: Dobke M, Peterson DR, Mattern RH, Arm DM Tags: Regen Med Source Type: research

Australian regulation of autologous human cell and tissue products: implications for commercial stem cell clinics.
Abstract In 2018, Australia's Therapeutic Goods Administration introduced regulatory reforms that set stricter criteria around the regulation of products derived from a patient's own cells and tissues, posing significant implications for clinics offering stem cell treatments. We review the regulatory framework and discuss its potential commercial implications, including the ambiguities that may arise from it in practice, as well as the likely impact it will have on product development and advertising practices in the future. PMID: 32228372 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 31, 2020 Category: Genetics & Stem Cells Authors: Ghinea N, Munsie M, Rudge C, Stewart C Tags: Regen Med Source Type: research

Pharmacological PTEN inhibition: potential clinical applications and effects in tissue regeneration.
Abstract Although the human body can heal, it takes time, and slow healing and chronic wounds often occur. Thus, identifying novel therapies to aid regeneration is needed. Here, we conducted a systematic review following the Preferred Reporting Items for Systematic Reviews guidelines and assessed preclinical studies on phosphatase and tensin homolog (PTEN) inhibitors and their effects on tissue repair and regeneration. In conditions associated with neurodegeneration, tissue injury and ischemia, the PTEN-regulated PI3K/AKT signaling pathway is activated. The use of PTEN inhibitors resulted in better tissue response...
Source: Regenerative Medicine - March 30, 2020 Category: Genetics & Stem Cells Authors: Borges GA, Webber LP, M Marques AE, Guerra EN, Castilho RM, Squarize CH Tags: Regen Med Source Type: research

Looking back at 2019 in Regenerative Medicine.
PMID: 32157951 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 11, 2020 Category: Genetics & Stem Cells Authors: Price-Evans A Tags: Regen Med Source Type: research

Industry updates from the field of stem cell research and regenerative medicine in January 2020: Industry News.
Abstract Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in January 2020. PMID: 32157958 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 11, 2020 Category: Genetics & Stem Cells Authors: Ilic D, Liovic M Tags: Regen Med Source Type: research

Allogeneic mesenchymal stem cells and growth factors in gel scaffold repair osteochondral defect in rabbit.
Conclusion: Combined use of MSCs and growth factors could accelerate osteochondral healing. PMID: 32154762 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 10, 2020 Category: Genetics & Stem Cells Authors: Gugjoo MB, Amarpal, Abdelbaset-Ismail A, Aithal HP, Kinjavdekar P, Kumar GS, Sharma GT Tags: Regen Med Source Type: research

Current evidence of tissue engineering for dentine regeneration in animal models: a systematic review.
Conclusion: Up to date scientific evidence shows a positive trend to dentine regeneration when considering tissue engineering in animal models, regardless the type of scaffolds used. PMID: 32148166 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 9, 2020 Category: Genetics & Stem Cells Authors: da Silva GS, Moreira MS, Fukushima KA, Raggio DP, V Mello-Moura AC, Lara JS, Gimenez T, Junior SA, Morimoto S, Tedesco TK Tags: Regen Med Source Type: research

Publication rates and reported results in a cohort of gene- and cell-based therapy trials.
Conclusion: Publication rates are currently suboptimal indicating a need for enhanced knowledge sharing to stimulate gene- and cell-based therapy development. PMID: 32103712 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 27, 2020 Category: Genetics & Stem Cells Authors: Coppens DG, Gardarsdottir H, van den Bogert CA, De Bruin ML, Leufkens HG, Hoekman J Tags: Regen Med Source Type: research

In vivo tissue engineering of a trilayered leaflet-shaped tissue construct.
Conclusion: Trilayered, oriented fibrous scaffolds brought the orientations of the infiltrated cells and their produced extracellular matrix proteins into the constructs. PMID: 32100626 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 26, 2020 Category: Genetics & Stem Cells Authors: Jana S, Lerman A Tags: Regen Med Source Type: research

Portrayal of umbilical cord blood research in the North American popular press: promise or hype?
Conclusion: Findings demonstrate the need for continual monitoring of the media portrayals of UCB as stem cell and transplantation research develops and as clinics continue to operate. PMID: 32101099 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 26, 2020 Category: Genetics & Stem Cells Authors: Marcon AR, Allan D, Barber M, Murdoch B, Caulfield T Tags: Regen Med Source Type: research

Industry updates from the field of stem cell research and regenerative medicine in November 2019.
Abstract Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in November 2019. PMID: 32056512 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 14, 2020 Category: Genetics & Stem Cells Authors: Ilic D, Mohd Amran De Costa AB Tags: Regen Med Source Type: research

First endocavitary treatment with cord blood platelet gel for perianal fistula.
We report the successful use of this procedure to heal a recurrent perianal fistula. PMID: 32046600 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 12, 2020 Category: Genetics & Stem Cells Authors: Bisceglia G, Santodirocco M, Faienza A, Mastrodonato N, Urbano F, Totaro A, Bazzocchi F, Mauro LD Tags: Regen Med Source Type: research

Human adipose-derived mesenchymal progenitor cells plus microfracture and hyaluronic acid for cartilage repair: a Phase IIa trial.
This study aimed to preliminarily evaluate the safety and efficacy of human adipose-derived mesenchymal progenitor cells (haMPCs) in combination with microfracture and hyaluronic acid (HA) for treating cartilage defects. Materials & methods: A total of 30 patients with medial femoro-tibial condylar cartilage defects were randomized into three groups: arthroscopic microfracture group and normal saline injection, arthroscopic microfracture and intra-articular injection of HA, or arthroscopic microfracture in combination with intra-articular injection of HA and haMPCs. Results & conclusions: The data demonst...
Source: Regenerative Medicine - February 11, 2020 Category: Genetics & Stem Cells Authors: Qiao Z, Tang J, Yue B, Wang J, Zhang J, Xuan L, Dai C, Li S, Li M, Xu C, Dai K, Wang Y Tags: Regen Med Source Type: research

Industry updates from the field of stem cell research and regenerative medicine in December 2019.
Abstract Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in December 2019. PMID: 32026751 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 6, 2020 Category: Genetics & Stem Cells Authors: Ilic D, Liovic M Tags: Regen Med Source Type: research

The direct-to-consumer market for stem cell-based interventions in Australia: exploring the experiences of patients.
Abstract The prevalence of businesses selling autologous stem cell-based interventions to patients in Australia has raised serious concerns about how weaknesses in regulation have enabled the emergence of an industry that engages in aggressive marketing of unproven treatments to patients. Little is known about how patients experience this marketing and their subsequent interactions with practitioners. This paper reports results from 15 semistructured interviews with patients and carers, and also draws upon discussion conducted with patients, carers and family members (22 participants) in a workshop setting. We exp...
Source: Regenerative Medicine - February 3, 2020 Category: Genetics & Stem Cells Authors: Waldby C, Hendl T, Kerridge I, Lipworth W, Lysaght T, Munsie M, Stewart C Tags: Regen Med Source Type: research

Industry updates from the field of stem cell research and regenerative medicine in October 2019.
Abstract Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in October 2019. PMID: 32009543 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 3, 2020 Category: Genetics & Stem Cells Authors: Ilic D, Liovic M, Noli L Tags: Regen Med Source Type: research

Effect of cell therapy with osteoblasts differentiated from bone marrow or adipose tissue stromal cells on bone repair.
Conclusion: Results of this study demonstrated that cell therapy with osteoblasts induced significant bone formation that exhibited the same quality as that of pre-existent bone. PMID: 31960753 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - January 21, 2020 Category: Genetics & Stem Cells Authors: Freitas GP, Lopes HB, P Souza AT, F P Oliveira PG, G Almeida AL, Coelho PG, Ferreira FU, Covas DT, Beloti MM, Rosa AL Tags: Regen Med Source Type: research

Platelet rich plasma for the treatment of coccydynia: a case report and review of regenerative medicine for coccydynia.
Conclusion: Platelet rich plasma may be considered as a treatment option in patients with refractory coccydynia. PMID: 31960759 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - January 21, 2020 Category: Genetics & Stem Cells Authors: Sussman WI, Jerome MA, Foster L Tags: Regen Med Source Type: research

Contact us for more information: an analysis of public enquiries about stem cells.
Conclusion: Sustained and in-depth tailored guidance is needed to effectively meet the diverse stem cell-related information-based needs of communities internationally. Such efforts should be prioritized by regenerative medicine research initiatives and organizations, given the trust and hope diverse publics appear to place in these groups. PMID: 31960784 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - January 21, 2020 Category: Genetics & Stem Cells Authors: Zarzeczny A, Tanner C, Barfoot J, Blackburn C, Couturier A, Munsie M Tags: Regen Med Source Type: research

Periodontal regeneration: a bibliometric analysis of the most influential studies.
Conclusion: The present bibliometric analysis provides comprehensive information regarding the contributions made in the advancement of regenerative periodontal research. The authors from developed countries and affiliated with interdisciplinary/multicenter institutions have predominantly contributed. PMID: 31957597 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - January 20, 2020 Category: Genetics & Stem Cells Authors: Shaikh MS, Ullah R, Lone MA, Matabdin H, Khan F, Zafar MS Tags: Regen Med Source Type: research

Transplantation efficacy of autologous bone marrow mesenchymal stem cells combined with atorvastatin for acute myocardial infarction (TEAM-AMI): rationale and design of a randomized, double-blind, placebo-controlled, multi-center, Phase II TEAM-AMI trial.
ao RL, Yang YJ Abstract Aim: To determine the efficacy and safety of intracoronary infusion of autologous bone marrow mesenchymal stem cells (MSCINJ) in combination with intensive atorvastatin (ATV) treatment for patients with anterior ST-segment elevation myocardial infarction-elevation myocardial infarction. Patients & methods: The trial enrolls a total of 100 patients with anterior ST-elevation myocardial infarction. The subjects are randomly assigned (1:1:1:1) to receive routine ATV (20 mg/d) with placebo or MSCsINJ and intensive ATV (80 mg/d) with placebo or MSCsINJ. The primary end point is the absolute ...
Source: Regenerative Medicine - December 12, 2019 Category: Genetics & Stem Cells Authors: Xu JY, Qian HY, Huang PS, Xu J, Xiong YY, Jiang WY, Xu Y, Leng WX, Li XD, Chen GH, Tang RJ, Huang CR, Hu MJ, Jin C, Wu Y, Zhang J, Qian J, Xu B, Zhao SH, Lu MJ, Shen R, Fang W, Wu WC, Chen X, Wang Y, Li W, Lu XF, Jiang XF, Ma CC, Li JW, Geng YJ, Qiao SB, Tags: Regen Med Source Type: research

Polycaprolactone/gelatin degradable vascular grafts simulating endothelium functions modified by nitric oxide generation.
Conclusion: Modification of biodegradable scaffolds, proposed in this work, could enhance biological functions of vascular grafts and provides new strategies for the construction of small diameter vascular grafts. PMID: 31829097 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - December 12, 2019 Category: Genetics & Stem Cells Authors: Zhang X, Shi J, Chen S, Dong Y, Zhang L, Midgley AC, Kong D, Wang S Tags: Regen Med Source Type: research

Industry updates from the field of stem cell research and regenerative medicine in September 2019.
Abstract Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in September 2019. PMID: 31755357 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - November 22, 2019 Category: Genetics & Stem Cells Authors: Ilic D, Liovic M, Noli L Tags: Regen Med Source Type: research

Enhancing medial layer recellularization of tissue-engineered blood vessels using radial microchannels.
hy BP Abstract Aim: Cell repopulation of tissue-engineered vascular grafts (TEVGs) from decellularized arterial scaffolds is limited by dense concentric tunica media layers which impede cells migrating radially between the layers. We aimed to develop and validate a new microneedle device to modify decellularized carotid arteries with radial microchannels to enhance medial layer repopulation. Material & methods: Modified decellularized porcine arteries were seeded with rat mesenchymal stem cells using either standard longitudinal injection, or a dual vacuum-perfusion bioreactor. Mechanical tests were used to as...
Source: Regenerative Medicine - November 20, 2019 Category: Genetics & Stem Cells Authors: Eufrásio-da-Silva T, Ruiz-Hernandez E, O'Dwyer J, Picazo-Frutos D, Duffy GP, Murphy BP Tags: Regen Med Source Type: research

Regenerative effects of mesenchymal stem cells by dosage in a chronic rotator cuff tendon tear in a rabbit model.
Conclusion: The benefits of UCB-MSCs are not dose-dependent in a rabbit model. PMID: 31726959 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - November 15, 2019 Category: Genetics & Stem Cells Authors: Kwon DR, Park GY, Lee SC Tags: Regen Med Source Type: research

From protocol to product: ventral midbrain dopaminergic neuron differentiation for the treatment of Parkinson's disease.
This report summaries key milestones in specifically for ventral midbrain dopaminergic neuroprogenitor differentiation and key translational considerations and recommendations to enable successful, robust and reproducible current cell therapy product-manufacturing. PMID: 31718456 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - November 13, 2019 Category: Genetics & Stem Cells Authors: Kusena JW, Thomas RJ, McCall MJ, Wilson SL Tags: Regen Med Source Type: research

Skin regenerative medicine advancements in the Islamic Republic of Iran: a concise review.
Abstract In the last decade, the Islamic Republic of Iran has witnessed significant improvement and growth in the field of interdisciplinary medicine and in its translation to patients, including the field of cell and stem cell therapy. The main aim of this report is to highlight various advances in regenerative medicine for skin and dermatology using stem cell technology, and its translation to clinic in the past two decades, in Iranian academic centers, clinical institutes and hospitals. While there have been numerous positive advances in clinical outcomes reported in Iran, there is no comparative analytical inf...
Source: Regenerative Medicine - November 13, 2019 Category: Genetics & Stem Cells Authors: Nilforoushzadeh MA, Amirkhani MA, Hamidieh AA, Seifalian AM, Sisakht MM Tags: Regen Med Source Type: research

Establishing the variation of blood metrics within UK Biobank to inform cell therapy manufacturing processes.
Conclusion: This variation and range of process input signals a requirement for new strategies for manufacturing process design and control. PMID: 31718498 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - November 13, 2019 Category: Genetics & Stem Cells Authors: Thurman-Newell J, Petzing J, Williams DJ Tags: Regen Med Source Type: research

Industry updates from the field of stem cell research and regenerative medicine in August 2019.
Abstract Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in August 2019. PMID: 31701803 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - November 8, 2019 Category: Genetics & Stem Cells Authors: Ilic D, Liovic M, Noli L Tags: Regen Med Source Type: research

Manufacturing MSCs for commercial application: an interview with Ross Macdonald.
Abstract Ross Macdonald is the CEO and Managing Director of Cynata Therapeutics Limited (Australia). He has over 30 years of experience and a track record of success in pharmaceuticals and biotechnology businesses. His career history includes positions as Vice President of Business Development for Sinclair Pharmaceuticals Ltd (now Sinclair IS Pharma), a UK-based specialty pharmaceuticals company, and Vice President of Corporate Development for Stiefel Laboratories, Inc., then the largest independent dermatology company in the world and acquired by GlaxoSmithKline in 2009 for £2.25 billion. He has also s...
Source: Regenerative Medicine - November 7, 2019 Category: Genetics & Stem Cells Authors: Macdonald R Tags: Regen Med Source Type: research

Engineering strategies for generating hypoimmunogenic cells with high clinical and commercial value.
PMID: 31663432 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - October 30, 2019 Category: Genetics & Stem Cells Authors: Malik NN, Jenkins AM, Mellon J, Bailey G Tags: Regen Med Source Type: research

Conditioned medium from 3D culture system of stromal vascular fraction cells accelerates wound healing in diabetic rats.
Conclusion: Gel-CM is a promising therapeutic option for treating diabetic wounds. PMID: 31599183 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - October 10, 2019 Category: Genetics & Stem Cells Authors: Deng C, He Y, Feng J, Dong Z, Yao Y, Lu F Tags: Regen Med Source Type: research