The management of risk and investment in cell therapy process development: a case study for neurodegenerative disease.
This study addresses process development issues using the exemplar of a human pluripotent stem cell-based dopaminergic neuron cell therapy product. Early identification and correction of risks to product safety and the manufacturing process reduces the expensive and time-consuming bridging studies later in development. A New Product Introduction map was used to determine the developmental requirements specific to the product. Systematic Risk Analysis is exemplified here. Expected current value-based prioritization guides decisions about the sequence of process studies and whether and if an early abandonment of further rese...
Source: Regenerative Medicine - June 18, 2019 Category: Genetics & Stem Cells Authors: Sebastian S, Hourd P, Chandra A, Williams DJ, Medcalf N Tags: Regen Med Source Type: research

Investigation mechanisms between normal, developing and regenerating livers for regenerative liver drug design.
Abstract Aim: A systematic multimolecule drug design procedure is proposed for promoting hepatogenesis and liver regeneration. Materials & methods: Genome-wide microarray data including three hepatic conditions are obtained from the GEO database (GSE15238). System modeling and big data mining methods are used to construct real genome-wide genetic-and-epigenetic networks (GWGENs). Then, we extracted the core GWGENs by applying principal network projection on real GWGENs of normal, developing and regenerating livers, respectively. After that, we investigated the significant signal pathways and epigenetic modific...
Source: Regenerative Medicine - June 17, 2019 Category: Genetics & Stem Cells Authors: Wong SW, Yeh SJ, Li CW, Wang LH, Chen BS Tags: Regen Med Source Type: research

Utilizing platelet-rich fibrin bioscaffold at the graft site improves the structure and function of mice ovarian grafts.
Conclusion: PRF bioscaffold improves the structure and function of mice-autografted ovary. PMID: 31187701 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 12, 2019 Category: Genetics & Stem Cells Authors: Shojafar E, Mehranjani MS, Shariatzadeh SM Tags: Regen Med Source Type: research

Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model.
Conclusion: Mural thrombi remodel into neotissue that persistently occludes the lumen of vascular grafts. PMID: 31180275 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 10, 2019 Category: Genetics & Stem Cells Authors: Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK Tags: Regen Med Source Type: research

Poly- ε-caprolactone and polyvinyl alcohol electrospun wound dressings: adhesion properties and wound management of skin defects in rabbits.
Conclusion: The results demonstrate the importance of proper dressing exchange. PMID: 31180294 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 10, 2019 Category: Genetics & Stem Cells Authors: Buzgo M, Plencner M, Rampichova M, Litvinec A, Prosecka E, Staffa A, Kralovic M, Filova E, Doupnik M, Lukasova V, Vocetkova K, Anderova J, Kubikova T, Zajicek R, Lopot F, Jelen K, Tonar Z, Amler E, Divin R, Fiori F Tags: Regen Med Source Type: research

Industry updates from the field of stem cell research and regenerative medicine in April 2019.
Abstract Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in April 2019. PMID: 31170883 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 7, 2019 Category: Genetics & Stem Cells Authors: Ilic D Tags: Regen Med Source Type: research

Circulatory support and stem cell therapy in the management of advanced heart failure: a concise review of available evidence.
We describe a rationale for concurrent BMC and left ventricular assist device therapy in selected heart failure patients. This combination therapy has demonstrated improved myocardial perfusion and cardiac function in patients with advanced ischemic cardiomyopathy. Moreover, preclinical data support improved cell retention with left ventricular unloading. The beneficial effects of BMC's are likely through a paracrine mechanism initiating a 'cardiac-repair' process. Combination therapy of BMC's and a left ventricular assist device may exhibit a synergistic effect with improved engraftment of BMC's through left ventricular u...
Source: Regenerative Medicine - May 22, 2019 Category: Genetics & Stem Cells Authors: Hussain MA, Colicchia M, Veerapen J, Weeraman D, Podaru MN, Jones D, Suzuki K, Mathur A Tags: Regen Med Source Type: research

G-CSF enhances the therapeutic potency of stem cells transplantation in spinal cord-injured rats.
Conclusion: This study demonstrated that G-CSF enhances neurotrophins secretion of tNSCs, and might help improving functional recovery from spinal cord injury in rats if they were given together. PMID: 31115255 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 22, 2019 Category: Genetics & Stem Cells Authors: Pang CY, Yang KL, Fu CH, Sun LY, Chen SY, Liao CH Tags: Regen Med Source Type: research

Cardiac nonmyocyte subpopulations: a secular congregation.
PMID: 31115258 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 22, 2019 Category: Genetics & Stem Cells Authors: Sussman MA Tags: Regen Med Source Type: research

Freeze-dried versus fresh platelet-rich plasma in acute wound healing of an animal model.
Conclusion: These results encourage randomized clinical trials to evaluate the effectiveness of freeze-dried PRP for skin ulcer treatment. PMID: 31115259 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 22, 2019 Category: Genetics & Stem Cells Authors: Huber SC, Junior JLRC, Silva LQ, Montalvão SAL, Annichino-Bizzacchi JM Tags: Regen Med Source Type: research

Generation and comprehensive characterization of induced pluripotent stem cells for translational research.
Abstract Induced pluripotent stem cells (iPSCs) hold immense potential in disease modeling, drug discovery and regenerative medicine. Despite advances in reprogramming methods, generation of clinical-grade iPSCs remains a challenge. Reported here is the first off-the-shelf reprogramming kit, CTS CytoTune-iPS 2.1, specifically designed for clinical and translational research. Workflow gaps were identified, and methods developed were used to consistently generate iPSC from multiple cell types. Resulting clones were subjected to characterization that included confirmation of pluripotency, preservation of genomic inte...
Source: Regenerative Medicine - May 22, 2019 Category: Genetics & Stem Cells Authors: MacArthur CC, Pradhan S, Wetton N, Zarrabi A, Dargitz C, Sridharan M, Jackson S, Pickle L, Lakshmipathy U Tags: Regen Med Source Type: research

Chimeric feeders of mesenchymal stromal cells and stromal cells modified with constitutively active AKT expand hematopoietic stem cells.
Conclusion: Chimeric feeders expand HSCs. PMID: 31115264 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 22, 2019 Category: Genetics & Stem Cells Authors: Vaidya A, Singh S, Limaye L, Kale V Tags: Regen Med Source Type: research

Nomenclature and heterogeneity: consequences for the use of mesenchymal stem cells in regenerative medicine.
Abstract Mesenchymal stem cells (MSCs) are in development for many clinical indications, based both on 'stem' properties (tissue repair or regeneration) and on signaling repertoire (immunomodulatory and anti-inflammatory effects). Potential conflation of MSC properties with those of tissue-derived stromal cells presents difficulties in comparing study outcomes and represents a source of confusion in cell therapy development. Cultured MSCs demonstrate significant heterogeneity in clonogenicity and multi-lineage differentiation potential. However in vivo biology of MSCs includes native functions unrelated to regener...
Source: Regenerative Medicine - May 22, 2019 Category: Genetics & Stem Cells Authors: Wilson A, Webster A, Genever P Tags: Regen Med Source Type: research

Screen-enrich-combine circulating system to prepare MSC/ β-TCP for bone repair in fractures with depressed tibial plateau.
Conclusion: MSC/β-TCP prepared by SECCS were effective in the treatment of bone defects in patients with depressed tibial plateau fractures, promoted bone regeneration and improved joint function recovery. PMID: 31115268 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 22, 2019 Category: Genetics & Stem Cells Authors: Chu W, Wang X, Gan Y, Zhuang Y, Shi D, Liu F, Sun Y, Zhao J, Tang T, Dai K Tags: Regen Med Source Type: research

Human umbilical cord blood cells restore vascular integrity in injured rat brain and modulate inflammation in vitro.
Conclusion: We observed that cells delivered 72 h postinjury significantly restored blood-brain barrier integrity. HUCB cells reduced the amount of TNF-α and IFN-γ released by activated primary rat splenocytes, which correlated with the expression of COX2 and IDO1. PMID: 31074319 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 10, 2019 Category: Genetics & Stem Cells Authors: Srivastava AK, Prabhakara KS, Kota DJ, Bedi SS, Triolo F, Brown KS, Skiles ML, Brown HL, Cox CS, Olson SD Tags: Regen Med Source Type: research

First decade of clinical trials and published studies with mesenchymal stromal cells from umbilical cord tissue.
Conclusion: Analyses that link trials with publications can elucidate factors that promote study completion and publication. More full disclosure of cell manufacturing is needed to evaluate the efficacy of mesenchymal stromal cell isolated from umbilical cord tissue (UC-MSC) products. PMID: 31070115 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 9, 2019 Category: Genetics & Stem Cells Authors: Couto PS, Shatirishvili G, Bersenev A, Verter F Tags: Regen Med Source Type: research

Immunogenicity analysis of decellularized cardiac scaffolds after transplantation into rats.
Conclusion: We found that scaffolds from all sources did not induce vascular or cellular rejection and exhibited low immunogenicity. PMID: 31070505 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 9, 2019 Category: Genetics & Stem Cells Authors: Tong C, Xia J, Xie B, Li M, Du F, Li C, Li Y, Shan Z, Qi Z Tags: Regen Med Source Type: research

Current strategies for human corneal endothelial regeneration.
PMID: 31070511 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 9, 2019 Category: Genetics & Stem Cells Authors: White IA, Sabater AL Tags: Regen Med Source Type: research

Chronic ischial tuberosity avulsion nonunion fracture treated with a platelet-rich plasma injection as a bone graft.
We present a case of an 18-year-old with a 2-year history of buttock pain who failed extensive treatment for a perceived hamstring strain. Upon evaluation, he was diagnosed with an ischial tuberosity nonunion avulsion fracture. The patient underwent bone grafting via an ultrasound guided leukocyte rich platelet-rich plasma injection followed by the use of a bone stimulator to enhance the bone healing. At 3 months, he was asymptomatic and had radiographic evidence of excellent bone healing. He remained asymptomatic at 1 year and had resumed full activities. This case report is the first in the literature to describe the tre...
Source: Regenerative Medicine - May 9, 2019 Category: Genetics & Stem Cells Authors: Stafford CD, Colberg RE, Nourse AL Tags: Regen Med Source Type: research

Bench-to-bedside optimization of mesenchymal stem cell isolation, processing, and expansion for in vivo administration.
Conclusion: This work provides guidance for preparation of robust MSCs for future clinical trials. PMID: 31070521 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 9, 2019 Category: Genetics & Stem Cells Authors: Antebi B, Walker KP, Mohammadipoor A, Rodriguez LA, Moore RK, Cancio LC, Batchinsky AI Tags: Regen Med Source Type: research

Industry updates from the field of stem cell research and regenerative medicine in March 2019.
Abstract Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in March 2019. PMID: 31046623 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 3, 2019 Category: Genetics & Stem Cells Authors: Ilic D Tags: Regen Med Source Type: research

Therapeutic targeting of gastrointestinal cancer stem cells.
Abstract Gastrointestinal cancers remain a tremendous burden on society. Despite advances in therapy options, including chemotherapy and radiation, cancer mortality from recurrences and metastases occur frequently. Cancer stem cells (CSCs) drive disease recurrence and metastasis, as these cells are uniquely equipped to self-renew and evade therapy. Therefore, cancer eradication requires treatment strategies that target CSCs in addition to differentiated cancer cells. This review highlights current literature on therapies targeting CSCs in gastrointestinal cancer. PMID: 31025613 [PubMed - as supplied by publis...
Source: Regenerative Medicine - April 26, 2019 Category: Genetics & Stem Cells Authors: Stem J, Flickinger JC, Merlino D, Caparosa EM, Snook AE, Waldman SA Tags: Regen Med Source Type: research

Modulation of inflammation in wounds of diabetic patients treated with porcine urinary bladder matrix.
Conclusions: UBM may assist in diabetic wound healing by restoring an inflammatory state similar to that of nondiabetic patients. PMID: 31020913 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - April 25, 2019 Category: Genetics & Stem Cells Authors: Paige JT, Kremer M, Landry J, Hatfield SA, Wathieu D, Brug A, Lightell DJ, Spiller KL, Woods TC Tags: Regen Med Source Type: research

Industry updates from the field of stem cell research and regenerative medicine in February 2019.
Abstract Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in February 2019. PMID: 30990373 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - April 16, 2019 Category: Genetics & Stem Cells Authors: Ilic D Tags: Regen Med Source Type: research

The use of mesenchymal stem cells for the treatment of progressive retinal diseases: a review.
Abstract Some ocular diseases, such as dystrophies, retinal and macular degeneration, optic nerve atrophy, and Stargardt disease, are progressive and irreversible. In this review, we focus on the use of mesenchymal stem cells (MSCs) in the treatment of these diseases. In animal studies, MSC transplantation significantly delayed retinal degeneration, led to the regeneration of cone cells, and supported the survival of retinal ganglion cells and axon regeneration. In clinical practice, patients with Behcet's disease with retinal vasculitis who received MSC injections experienced a decrease in retinal vascu...
Source: Regenerative Medicine - April 12, 2019 Category: Genetics & Stem Cells Authors: Borkowska-Kuczkowska A, Sługocka D, Świątkowska-Flis B, Boruczkowski D Tags: Regen Med Source Type: research

Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform.
This report summarizes the key issues discussed and records consensus reached by delegates and emphasizes the need for accurate language and nomenclature in the scientific discourse around stem cells. PMID: 30938271 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - April 2, 2019 Category: Genetics & Stem Cells Authors: Stacey GN, Andrews PW, Barbaric I, Boiers C, Chandra A, Cossu G, Csontos L, Frith TJ, Halliwell JA, Hewitt Z, McCall M, Moore HD, Parmar M, Panico MB, Pisupati V, Shichkin VP, Stacey AR, Tedesco FS, Thompson O, Wagey R Tags: Regen Med Source Type: research

Industry updates from the field of stem cell research and regenerative medicine in January 2019.
Abstract Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in January 2019. PMID: 30938577 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - April 2, 2019 Category: Genetics & Stem Cells Authors: Ilic D Tags: Regen Med Source Type: research

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in November 2018.
PMID: 30912684 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 26, 2019 Category: Genetics & Stem Cells Authors: Ilic D, Ang SY Tags: Regen Med Source Type: research

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in December 2018.
PMID: 30887891 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 19, 2019 Category: Genetics & Stem Cells Authors: Dusko I Tags: Regen Med Source Type: research

Ask the experts: current obstacles and future developments in cell culture.
ult B PMID: 30887896 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 19, 2019 Category: Genetics & Stem Cells Authors: Ben-Yosef O, Burns JS, Colacino JA, Kota DJ, Péault B Tags: Regen Med Source Type: research

Engineering, differentiation and harvesting of human adipose-derived stem cell multilayer cell sheets.
CONCLUSION: This simple protocol opens possibilities to engineer scaffold-free hADSCm cell sheet to transplant them on damaged organs. PMID: 30829557 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 4, 2019 Category: Genetics & Stem Cells Authors: Oliva J, Florentino A, Bardag-Gorce F, Niihara Y Tags: Regen Med Source Type: research

Autologous nanofat transplantation accelerates foot wound healing in diabetic rats.
CONCLUSION: This research shows that autologous nanofat transplantation can promote diabetic foot wound healing in rats. PMID: 30810491 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 27, 2019 Category: Genetics & Stem Cells Authors: Chen L, Wang ZC, Ma JJ, Sun WJ, Wang SW, Gu ZC, Yang X Tags: Regen Med Source Type: research

Exploration of 2-deoxy-D-ribose and 17 β-Estradiol as alternatives to exogenous VEGF to promote angiogenesis in tissue-engineered constructs.
CONCLUSION: We conclude that both 2dDR and E2 provide attractive alternatives to VEGF for the functionalization of tissue engineering scaffolds to promote angiogenesis in vivo. PMID: 30793662 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 22, 2019 Category: Genetics & Stem Cells Authors: Dikici S, Mangır N, Claeyssens F, Yar M, MacNeil S Tags: Regen Med Source Type: research

Bone tissue engineering in the greater omentum is enhanced by a periosteal transplant in a miniature pig model.
CONCLUSION: The greater omentum is a suitable bioreactor for bone tissue engineering. Endocultivation is both an innovative and promising approach in regenerative medicine. PMID: 30764722 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 15, 2019 Category: Genetics & Stem Cells Authors: Naujokat H, Lipp M, Açil Y, Wieker H, Birkenfeld F, Sengebusch A, Böhrnsen F, Wiltfang J Tags: Regen Med Source Type: research

Autologous plasma rich in growth factors technology for isolation and ex vivo expansion of human dental pulp stem cells for clinical translation.
CONCLUSION: The autologous PRGF technology could be a suitable and safer substitute for FBS as a culture medium supplement for clinical translation of cell therapy. PMID: 30767653 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 15, 2019 Category: Genetics & Stem Cells Authors: Anitua E, Zalduendo M, Troya M Tags: Regen Med Source Type: research

Intravenous administration of multipotent stromal cells and bone allograft modification to enhance allograft healing.
This study investigated a coordinated strategy of revitalizing bone allograft with circulating multipotent stromal cells (MSCs). MATERIALS & METHODS: After chemotactic and releasing assessments, stromal cell-derived factor 1 and platelet-derived growth factor BB in copolymers were coated on the bone allograft (AlloS-P). Allograft coated with copolymers alone (Allo), as controls, or AlloS-P was implanted into the femur of athymic mice, which received intravenous injections of human MSCs or saline at weeks 1, 2 and 3. RESULTS: At week 8, the total callus volume (both cartilaginous and bony callus) aro...
Source: Regenerative Medicine - February 14, 2019 Category: Genetics & Stem Cells Authors: Paudel S, Lee WH, Lee M, Zahoor T, Mitchell R, Yang SY, Zhao H, Schon L, Zhang Z Tags: Regen Med Source Type: research

Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial.
CONCLUSION: Autologous ADMSC therapy appears to be a safe and effective therapy for knee osteoarthritis and may have the potential to prevent disease progression. TRIAL REGISTRATION NUMBER: ACTRN12614000814673. PMID: 30762487 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 14, 2019 Category: Genetics & Stem Cells Authors: Freitag J, Bates D, Wickham J, Shah K, Huguenin L, Tenen A, Paterson K, Boyd R Tags: Regen Med Source Type: research

Evaluating the efficacy of tissue-engineered human amniotic membrane in the treatment of myocardial infarction.
CONCLUSION: Histological and immunohistochemical evaluations indicated the regeneration of cardiomyocytes and reduction of inflammation and fibrosis in the patch-implanted group compared with a control group, 14 days after the surgery. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate biotin nick-end labeling assay was suggestive for apoptosis reduction in the patch-implanted specimens. This study suggested that human AM can be developed into a novel treatment for treating postmyocardial infarction. PMID: 30741604 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 11, 2019 Category: Genetics & Stem Cells Authors: Khorramirouz R, Kameli SM, Fendereski K, Daryabari SS, Kajbafzadeh AM Tags: Regen Med Source Type: research

An insight into the whole transcriptome profile of four tissue-specific human mesenchymal stem cells.
This study is a milestone for evidence-based choice of the type of MSCs used in the treatment of diseases. PMID: 30702025 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - January 31, 2019 Category: Genetics & Stem Cells Authors: Alhattab D, Jamali F, Ali D, Hammad H, Adwan S, Rahmeh R, Samarah O, Salah B, Hamdan M, Awidi A Tags: Regen Med Source Type: research

Preparing regenerative therapies for clinical application: proposals for responsible translation.
PMID: 30651044 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - January 17, 2019 Category: Genetics & Stem Cells Authors: Shapiro SA, Smith CG, Arthurs JR, Master Z Tags: Regen Med Source Type: research

Preparing for first human trial of induced pluripotent stem cell-derived cells for Parkinson's disease: an interview with Jun Takahashi.
Abstract Professor Jun Takahashi received his MD from Kyoto University in 1986 and his PhD in neurosurgery and neurobiology from Kyoto University Graduate School of Medicine in 1993 (both Kyoto, Japan). He then did a postdoctoral fellowship at the Salk Institute (Dr Fred Gage's Laboratory, CA, USA) where he started research work on neural stem cells. Since returning to Kyoto University Hospital in 1997, he has been investigating functional neurosurgery including deep brain stimulation and cell-based therapies for Parkinson's disease. He has been at the Center for iPS Cell Research and Application at Kyoto Universi...
Source: Regenerative Medicine - January 15, 2019 Category: Genetics & Stem Cells Authors: Takahasi J Tags: Regen Med Source Type: research

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in October 2018.
PMID: 30618354 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - January 8, 2019 Category: Genetics & Stem Cells Authors: Ilic D Tags: Regen Med Source Type: research

Limbal niche cells: a novel feeder cell for autologous cultivated oral mucosal epithelial transplantation.
CONCLUSION: The culture system containing conspecific LNC feeders could substitute for the 3T3 cell system and decrease the risk of neovascularization after COMET. PMID: 30572808 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - December 21, 2018 Category: Genetics & Stem Cells Authors: Duan CY, Xie HT, Zhao XY, Zhang MC Tags: Regen Med Source Type: research

Introducing Volume 14 of Regenerative Medicine.
PMID: 30570390 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - December 20, 2018 Category: Genetics & Stem Cells Authors: Price-Evans A Tags: Regen Med Source Type: research

The effect of  mesenchymal stem cell-secreted factors on airway epithelial repair.
CONCLUSION: MSC-secreted factors accelerated airway epithelial repair by stimulating the endogenous reparative and regenerative ability of lung cells. PMID: 30566028 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - December 19, 2018 Category: Genetics & Stem Cells Authors: Halim NS, Aizat WM, Yahaya BH Tags: Regen Med Source Type: research

Efficiency of mesenchymal stem cells in treatment of urinary incontinence: a systematic review on animal models.
CONCLUSION: The obtained data suggested that further trials are needed to be focused on clinical phase of MSC therapy on the patients affected by UI. PMID: 30560712 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - December 18, 2018 Category: Genetics & Stem Cells Authors: Fazeli Z, Faramarzi S, Ahadi A, Omrani MD, Ghaderian SM Tags: Regen Med Source Type: research

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions September 1-30, 2018.
PMID: 30560719 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - December 18, 2018 Category: Genetics & Stem Cells Authors: Ilic D Tags: Regen Med Source Type: research

Intravascular cell therapy in stroke: predicting the future trends.
Abstract This short review examines the trends that have taken place during the last two decades in selecting delivery route and cell product in confirmatory preclinical stroke research. If there had been a major change, this might indicate a strategy with a high potential to enter early-phase clinical studies. The retrospective data show that intravenous cell delivery of mesenchymal stem cells remains the most popular approach in experimental research, clearly dominating early phase clinical studies. The advantages and risks of current practices are discussed in the hope that these will improve translational succ...
Source: Regenerative Medicine - December 18, 2018 Category: Genetics & Stem Cells Authors: Cui L, Moisan A, Jolkkonen J Tags: Regen Med Source Type: research

Mapping theme trends and knowledge structure on adipose-derived stem cells: a bibliometric analysis from 2003 to 2017.
CONCLUSION: The undeveloped themes and emerging hot spots could be considered as new research topics. PMID: 30547725 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - December 14, 2018 Category: Genetics & Stem Cells Authors: Shi B, Wei W, Qin X, Zhao F, Duan Y, Sun W, Li D, Cao Y Tags: Regen Med Source Type: research

Modeling biological and economic uncertainty on cell therapy manufacturing: the choice of culture media supplementation.
CONCLUSION: Passage numbers in the expansion step are strongly associated with isolation cell yield and drive cost increases per donor of $1970 and 2802 for fetal bovine serum and human platelet lysate. Human platelet lysate decreases passage numbers and process costs in 94.5 and 97% of donors through lower facility and labor costs. Cost savings are maintained with full equipment depreciation and higher numbers of cells per dose, highlighting the number of cells per passage step as the key cost driver. PMID: 30488770 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - November 29, 2018 Category: Genetics & Stem Cells Authors: Bandeiras C, Cabral JM, Finkelstein SN, Ferreira FC Tags: Regen Med Source Type: research