Genes, Vol. 12, Pages 328: A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes

Genes, Vol. 12, Pages 328: A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes Genes doi: 10.3390/genes12030328 Authors: Gennady Khvorykh Andrey Khrunin Ivan Filippenkov Vasily Stavchansky Lyudmila Dergunova Svetlana Limborska In this paper we propose a workflow for studying the genetic architecture of ischemic stroke outcomes. It develops further the candidate gene approach. The workflow is based on the animal model of brain ischemia, comparative genomics, human genomic variations, and algorithms of selection of tagging single nucleotide polymorphisms (tagSNPs) in genes which expression was changed after ischemic stroke. The workflow starts from a set of rat genes that changed their expression in response to brain ischemia and results in a set of tagSNPs, which represent other SNPs in the human genes analyzed and influenced on their expression as well.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research