GSE161913 CircRNA expression profiles in peripheral blood mononuclear cells of patients with large-artery atherosclerotic stroke

Contributors : Shengnan Li ; Weidong Hu ; Fu Deng ; Shaofeng Chen ; Peiyi Zhu ; Mengxu Wang ; Xinglan Chen ; Ying Wang ; Xingjuan Hu ; Bin Zhao ; Wangtao Zhong ; Guoda Ma ; You LiSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensCircular RNAs (circRNAs) are a recently discovered non-coding RNA isoform capable of regulating neurological disease incidence. The present study was designed to characterize the circRNA expression profiles present in large-artery atherosclerosis (LAA)-type acute ischemic stroke patients. Using a RNA-seq approach, we characterized circRNA expression profiles in 5 LAA-stroke patients and 4 controls. We identified 182 and 176 circRNAs that were up- and down-regulated, respectively, in LAA-stroke patients relative to controls. Enrichment analyses suggested these differentially expressed circRNAs to primarily be associated with chromatin modification, autophagy, platelet activation, and neural precursor cell proliferation.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research