Pathogenesis of Acute Stroke and the Role of Inflammasomes.

Pathogenesis of Acute Stroke and the Role of Inflammasomes. Ageing Res Rev. 2013 Oct 5; Authors: Fann DY, Lee SY, Manzanero S, Chunduri P, Sobey CG, Arumugam TV Abstract Inflammation is an innate immune response to infection or tissue damage that is designed to limit harm to the host, but contributes significantly to ischemic brain injury following stroke. The inflammatory response is initiated by the detection of acute damage via extracellular and intracellular pattern recognition receptors, which respond to conserved microbial structures, termed pathogen-associated molecular patterns or host-derived danger signals termed damage-associated molecular patterns. Multi-protein complexes known as inflammasomes (e.g. containing NLRP1, NLRP2, NLRP3, NLRP6, NLRP7, NLRP12, NLRC4, AIM2 and/or Pyrin), then process these signals to trigger an effector response. Briefly, signaling through NLRP1 and NLRP3 inflammasomes produces cleaved caspase-1, which cleaves both pro-IL-1β and pro- IL-18 into their biologically active mature pro-inflammatory cytokines that are released into the extracellular environment. This review will describe the molecular structure, cellular signaling pathways and current evidence for inflammasome activation following cerebral ischemia, and the potential for future treatments for stroke that may involve targeting inflammasome formation or its products in the ischemic brain. PMID: 24103368 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research

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ConclusionWe demonstrate that a microbial community with depleted Roseburia and enriched opportunistic pathogens is associated with increased risk of SAP among AIS patients. Gut microbiota screening might be useful for identifying patients at high risk for SAP and provide clues for stroke treatment.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Condition:   Ischemic Stroke Interventions:   Other: Intervention group;   Other: Control group Sponsor:   Lithuanian University of Health Sciences Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The self-controlled case series (n=86,742) and matched cohort study (additional 348,481 control individuals) found Covid-19 was associated with increased risk of acute MI, highest during the first week, suggesting they represent a part of the clinical picture of Covid-19.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
CONCLUSIONS: RDW-SD is a simple, inexpensive, rapid, and easily accessible parameter that can be used to predict PSD in patients with stroke.PMID:34335867 | PMC:PMC8315889 | DOI:10.1155/2021/8361504
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Authors: Source Type: research
This study is aimed at prospectively assessing the prognostic determinant value of IL-10 in patients with acute ischemic stroke in a cohort of Chinese people.METHODS: In a prospective cohort study, consecutive first-ever patients with acute ischemic stroke admitted to our hospital were included from October 2019 to October 2020. The serum level of IL-10 was measured at baseline. A structured follow-up telephone interview was performed on day 90 after admission. Logistic regression analyses were used to assess the prognostic value of IL-10 to predict the poor functional outcome (defined as a modified Rankin Scale score of 3...
Source: Disease Markers - Category: Laboratory Medicine Authors: Source Type: research
J Xray Sci Technol. 2021 Jul 24. doi: 10.3233/XST-210898. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVE: Estimates of parameters used to select patients for endovascular thrombectomy (EVT) for acute ischemic stroke differ among software packages for automated computed tomography (CT) perfusion analysis. To determine impact of these differences in decision making, we analyzed intra-observer and inter-observer agreement in recommendations about whether to perform EVT based on perfusion maps from 4 packages.METHODS: Perfusion CT datasets from 63 consecutive patients with suspected acute ischemic stroke were retrospec...
Source: Journal of X-Ray Science and Technology - Category: Radiology Authors: Source Type: research
CONCLUSIONS: Statin use was not associated with cardiovascular risk reduction in high-risk persons with normal or near normal coronary arteries. More individualised lipid-lowering therapy may benefit this population.PMID:34334544 | DOI:10.5551/jat.63004
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Authors: Source Type: research
Top Stroke Rehabil. 2021 Aug 1:1-8. doi: 10.1080/10749357.2021.1948155. Online ahead of print.ABSTRACTTheory of mind is the ability to understand, and infer thoughts or mental states to others. This is a central domain of social cognition that can be impaired after brain injury, resulting in changes in social skills and implications for rehabilitation.The aim of this investigation was to analyze the reliability of the Theory of Mind Task Battery (ToM TB) in post-stroke patients.This is a cross-sectional prospective study with psychometric characteristics, involving 38 patients diagnosed with ischemic or hemorrhagic stroke ...
Source: Topics in Stroke Rehabilitation - Category: Neurology Authors: Source Type: research
We have read with great interest of the article by Minhas et al. [1], in which indicates adjusted odds of myocardial injury, ischemic stroke and all-cause mortality are significantly higher in men compared to women with COVID-19.Higher inflammatory markers are present in men but associated similarly with risk in both men and women, suggesting that adverse cardiovascular outcomes in men vs. women are independent of cardiovascular comorbidities.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Letter to the Editor Source Type: research
Post-stroke dysphagia is a common symptom in stroke patients. It is known that 13% to 18% of patients have persistent symptoms of dysphagia until 6 months after onset.1, 2 Dysphagia increases the risks of aspiration, associated complications (e.g., aspiration pneumonia), malnutrition, poor prognostic outcomes,3 and increased mortality.4 Early detection and treatment of dysphagia in stroke patients are crucial to prevent adverse complications, decrease the length of hospital stay, and reduce the health-care costs.
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Source Type: research
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