A cross-species approach using an in  vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes

Using a newly established in  vivo gene rescue platform in mice, we validated Rabep2, a candidate gene modulating infarct volume after ischemic stroke. We then determined the functional consequences of human RABEP2-coding variants. This cross-species approach will expand the number of physiologically relevant therapeutic targe ts for human ischemic stroke.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research