Impact of frailty models on the prescription of oral anticoagulants and on the incidence of stroke, bleeding, and mortality in older patients with atrial fibrillation: a systematic review

CONCLUSIONS: Due to the great heterogeneity among different validated frailty measures, indiscriminately relying on "frailty" should not be regarded as the gold standard for clinical decision-making about stroke prevention in older AF patients. Present findings suggest that severe frailty according to the DAM is associated with less use of OAT and increased risk of all-cause mortality, thereby representing at the moment the most reasonable tool to efficiently recognize patients with limited life expectancy and for whom there is so far scant, if any, evidence of a clinical benefit of OAT.AVAILABILITY OF DATA AND MATERIAL: All Authors had all access to the data in this work and approved the submission of the present manuscript. All material in this assignment is Authors' own work and does not involve plagiarism. The data that support the findings of this study are available from the corresponding author upon reasonable request.PMID:36270605 | DOI:10.1016/j.arr.2022.101761
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Source Type: research