Obesity and ischemic stroke modulate the methylation levels of KCNQ1 in white blood cells

In conclusion, obesity induced changes in the KCNQ1 methylation pattern which were also dependent on stroke. Furthermore, the epigenetic marks differentially methylated in the stroke patients were dependent on the previous obese state. These DNA methylation patterns could be used as future potential stroke biomarkers.

Source: Human Molecular Genetics - February 9, 2015 Category: Genetics & Stem Cells Authors: Gomez-Uriz, A. M., Milagro, F. I., Mansego, M. L., Cordero, P., Abete, I., De Arce, A., Goyenechea, E., Blazquez, V., Martinez-Zabaleta, M., Martinez, J. A., Lopez De Munain, A., Campion, J. Tags: ARTICLES Source Type: research