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Specialty: Neurology
Condition: Multiple Sclerosis

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Total 440 results found since Jan 2013.

Neurofilament Light Chain Levels in Multiple Sclerosis Correlate With Lesions Containing Foamy Macrophages and With Acute Axonal Damage
Discussion Our results demonstrated that active and mixed white matter MS lesions with foamy microglia show high acute axonal damage and correlate with elevated CSF NfL levels. Our data support the use of this biomarker to monitor inflammatory demyelinating lesion activity with axonal damage in MS.
Source: Neurology Neuroimmunology and Neuroinflammation - March 3, 2022 Category: Neurology Authors: van den Bosch, A., Fransen, N., Mason, M., Rozemuller, A. J., Teunissen, C., Smolders, J., Huitinga, I. Tags: Multiple sclerosis Research Article Source Type: research

Effect of home-based virtual reality training and telerehabilitation on balance in individuals with Parkinson disease, multiple sclerosis, and stroke: a systematic review and meta-analysis
ConclusionHome-based VR and TR can be used as prolongation to conventional therapy.
Source: Neurological Sciences - February 17, 2022 Category: Neurology Source Type: research

Blood GFAP as an emerging biomarker in brain and spinal cord disorders
Nature Reviews Neurology, Published online: 03 February 2022; doi:10.1038/s41582-021-00616-3In this Review, the authors provide an overview of the evidence regarding the use of blood levels of glial fibrillary acidic protein as a biomarker in a range of neurological diseases, including traumatic brain injury, stroke, multiple sclerosis and Alzheimer disease.
Source: Nature Reviews Neurology - February 3, 2022 Category: Neurology Authors: Ahmed Abdelhak Matteo Foschi Samir Abu-Rumeileh John K. Yue Lucio D ’Anna Andre Huss Patrick Oeckl Albert C. Ludolph Jens Kuhle Axel Petzold Geoffrey T. Manley Ari J. Green Markus Otto Hayrettin Tumani Source Type: research

Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement
AbstractRetinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with particularly high evolutionary conservation of ligand binding domain. The receptor exists in α, β, and γ isotypes that form homo-/heterodimeric complexes with other permissive and non-permissive receptors. While research has identified the biochemical roles of several nuclear receptor family members, the roles of RXRs in various neurological disorders remain relatively under-investigated . RXR acts as ligand-regulated transcription factor, modulating the expression of genes that plays a critical role in mediating several deve...
Source: Molecular Neurobiology - January 11, 2022 Category: Neurology Source Type: research

Social Determinants of Health in Neurology
Neurologic health disparities are created and perpetuated by structural and social determinants of health. These factors include, but are not limited to, interpersonal bias, institutional factors that lead to disparate access to care, and neighborhood-level factors, such as socioeconomic status, segregation, and access to healthy food. Effects of these determinants of health can be seen throughout neurology, including in stroke, epilepsy, headache, amyotrophic lateral sclerosis, multiple sclerosis, and dementia. Interventions to improve neurologic health equity require multilayered approaches to address these interdependen...
Source: Neurologic Clinics - November 17, 2021 Category: Neurology Authors: Nicole Rosendale Source Type: research

Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease
Exp Neurol. 2021 Oct 9:113891. doi: 10.1016/j.expneurol.2021.113891. Online ahead of print.ABSTRACTWe review progress towards greater mechanistic understanding and clinical translation of a strategy to improve respiratory and non-respiratory motor function in people with neuromuscular disorders, therapeutic acute intermittent hypoxia (tAIH). In 2016 and 2020, workshops to create and update a "road map to clinical translation" were held to help guide future research and development of tAIH to restore movement in people living with chronic, incomplete spinal cord injuries. After briefly discussing the pioneering, non-targete...
Source: Experimental Neurology - October 12, 2021 Category: Neurology Authors: Alicia K Vose Joseph F Welch Jayakrishnan Nair Erica A Dale Emily J Fox Gillian D Muir Randy D Trumbower Gordon S Mitchell Source Type: research

Dietary Insights in Neurological Diseases
This article describes the most common and impactful dietary regimens for commonly encountered neurological disorders.RECENT FINDINGS: Plant-based, low-fat, high-fiber diets, rich in antioxidants and other lifestyle interventions may reduce the burden and disability of common neurological disorders. The ketogenic diet, the diet of choice for the treatment of refractory epilepsy, is such an example. Diverse neurological disorders demonstrate several common pathophysiological mechanisms including increased oxidative stress, neuroinflammation, and disrupted metabolism. Dietary interventions can potentially influence these pat...
Source: Epilepsy Curr - September 29, 2021 Category: Neurology Authors: Sergio A Ram írez-Salazar Cherie Herren Jessica McCartney Jorge G Ortiz Garc ía Source Type: research

Effectiveness of interventions to prevent falls for people with multiple sclerosis, Parkinson ’s disease and stroke: an umbrella review
The implementation of condition-specific falls prevention interventions is proving challenging due to lack of critical mass and resources. Given the similarities in falls risk factors across stroke, Parkinson ’...
Source: BMC Neurology - September 29, 2021 Category: Neurology Authors: Nicola O ’Malley, Amanda M. Clifford, Mairéad Conneely, Bláthín Casey and Susan Coote Tags: Research Source Type: research

Is the unstable ataxic hand of Alajouanine and Akerman a distinct contribution?
Rev Neurol (Paris). 2021 Jun 21:S0035-3787(21)00552-X. doi: 10.1016/j.neurol.2020.12.004. Online ahead of print.ABSTRACTWe discuss from a historical perspective whether the 1931 description of the "unstable ataxic hand" by Théophile Alajouanine, the fifth successor of Charcot at la Salpêtrière, and the Brazilian neurologist Abraham Akerman, then studying in France, merits being considered a distinct contribution vis-à-vis the earlier description by Oppenheim of the "useless hand syndrome". The specific object of the article by Alajouanine and Akerman was a semiologic sign, namely a pseudoathetosis localized in the hand...
Source: Revue Neurologique - June 25, 2021 Category: Neurology Authors: G Levy E Engelhardt Source Type: research

Cognitive–motor Interference in Individuals With a Neurologic Disorder: A Systematic Review of Neural Correlates
Conclusion: Despite large heterogeneity in study methodologies, some recurrent patterns were noted. Particularly, in neurologic patients, an already higher brain activation during single tasks was seen compared with healthy controls, perhaps compromising the patients’ ability to further adapt brain activation with increasing load during dual tasking and resulting in reduced behavioral dual task performance.
Source: Cognitive and Behavioral Neurology - June 1, 2021 Category: Neurology Tags: Review Source Type: research

The emerging role of FTY720 as a sphingosine 1 ‐phosphate analog for the treatment of ischemic stroke: The cellular and molecular mechanisms
Three important mechanisms for neuroprotective effects of FTY720 have been described. Functional antagonistic, functional agonistic and receptor-independent mechanisms. Here, we review these mechanisms in more details and describe animal model and in clinical trial studies AbstractFinding novel and effective drugs for the treatment of ischemic stroke is warranted because there is not a definitive treatment for this prevalent disease. Due to the relevance between the sphingosine 1-phosphate (S1P) receptor and several neurological diseases including ischemic stroke, it seems that fingolimod (FTY720), as an agonist of S1P rec...
Source: Brain and Behavior - May 10, 2021 Category: Neurology Authors: Maryam Naseh, Jafar Vatanparast, Ali Rafati, Mahnaz Bayat, Masoud Haghani Tags: REVIEW Source Type: research