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Specialty: Neurology
Condition: Multiple Sclerosis

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Total 440 results found since Jan 2013.

Letter re: Evaluating the safety of {beta}-interferons in MS: A series of nested case-control studies
In a series of case-control studies of patients with multiple sclerosis (MS), de Jong et al.1 found that exposure to β-interferons was associated with a 1.8-fold increased risk of stroke. The authors rightfully state that stroke is not well-recognized as a potential adverse event of β-interferons, referring to cases reported in 2006 and 2008.2,3
Source: Neurology - November 6, 2017 Category: Neurology Authors: Jongen, P. J. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research

Novel candidate genes of the PARK7 interactome as mediators of apoptosis and acetylation in multiple sclerosis: an in silico analysis
Conclusions Based on our results, novel potential target genes are revealed; these differentially expressed genes regulate epigenetic and apoptotic pathways that may further elucidate underlying mechanisms of autorreactivity in MS.
Source: Multiple Sclerosis and Related Disorders - October 24, 2017 Category: Neurology Source Type: research

Global, regional, and national burden of neurological disorders during 1990 –2015: a systematic analysis for the Global Burden of Disease Study 2015
Publication date: Available online 17 September 2017 Source:The Lancet Neurology Author(s): GBD 2015 Neurological Disorders Collaborator GroupValery LFeiginAmanuel AlemuAbajobirKalkidan HassenAbateFoadAbd-AllahAbdishakur MAbdulleSemaw FeredeAberaGebre YitayihAbyuMuktar BeshirAhmedAmani NidhalAichourIbtihelAichourMiloud Taki EddineAichourRufus OlusolaAkinyemiSamerAlabedRajaaAl-RaddadiNelsonAlvis-GuzmanAzmeraw T.AmareHosseinAnsariPalwashaAnwariJohanÄrnlövHamidAsayeshSolomon WeldegebrealAsgedomTesfay MehariAteyLeticiaAvila-BurgosEuripideFrinelG. ArthurAvokpahoAleksandraBaracMiguelBarbozaSuzanne LBarker-ColloTillBärnighaus...
Source: The Lancet Neurology - September 19, 2017 Category: Neurology Source Type: research

Comment A new era of multiple sclerosis rehabilitation: lessons from stroke
Just over 20 years ago, no treatments were available for multiple sclerosis, a disease characterised by two overlapping processes of nervous system injury: inflammatory destruction of myelin and neurodegeneration of grey and white matter.1 Disease-modifying drugs, particularly the new oral medications, have changed the prognosis of multiple sclerosis, contributing to increased periods of disease stability and greater potential for rehabilitative therapies to reduce impairment.2 In The Lancet Neurology, Robert Motl and colleagues3 argue that exercise can be a beneficial rehabilitation strategy for people with multiple scler...
Source: Lancet Neurology - September 13, 2017 Category: Neurology Authors: Michelle Ploughman Tags: Comment Source Type: research

A new era of multiple sclerosis rehabilitation: lessons from stroke
Publication date: October 2017 Source:The Lancet Neurology, Volume 16, Issue 10 Author(s): Michelle Ploughman
Source: The Lancet Neurology - September 13, 2017 Category: Neurology Source Type: research

DR α1-MOG-35-55 treatment reduces lesion volumes and improves neurological deficits after traumatic brain injury
AbstractTraumatic brain injury (TBI) results in severe neurological impairments without effective treatments. Inflammation appears to be an important contributor to key pathogenic events such as secondary brain injury following TBI and therefore serves as a promising target for novel therapies. We have recently demonstrated the ability of a molecular construct comprised of the human leukocyte antigen (HLA)-DR α1 domain linked covalently to mouse (m)MOG-35-55 peptide (DRα1-MOG-35-55 construct) to reduce CNS inflammation and tissue injury in animal models of multiple sclerosis and ischemic stroke. The aim of the current st...
Source: Metabolic Brain Disease - September 12, 2017 Category: Neurology Source Type: research

Is spasticity always the same? An observational study comparing the features of spastic equinus foot in patients with chronic stroke and multiple sclerosis
Spasticity is common in stroke and multiple sclerosis. To treat spasticity we have a wide range of interventions, whose application may depend not only on the severity of spasticity but also on its etiology. Consequently, a better understanding of muscle spasticity in different neurological diseases may inform clinicians as to the more appropriate therapeutic approach. Our aim was to compare the clinical and ultrasonographic features of spastic equinus in patients with chronic stroke and multiple sclerosis.
Source: Journal of the Neurological Sciences - July 19, 2017 Category: Neurology Authors: Alessandro Picelli, Gabriella Vallies, Elena Chemello, Paola Castellazzi, Annalisa Brugnera, Marialuisa Gandolfi, Alessio Baricich, Carlo Cisari, Andrea Santamato, Leopold Saltuari, Andreas Waldner, Nicola Smania Source Type: research

Hospital safety among neurologic patients: A population-based cohort study of adverse events
Conclusions: This study demonstrates that neurologic patients have a high proportion of AEs in hospital. The findings provide information on the quality and safety of care for people with neurologic conditions in hospital, which can help inform future quality improvement initiatives.
Source: Neurology - July 17, 2017 Category: Neurology Authors: Sauro, K. M., Quan, H., Sikdar, K. C., Faris, P., Jette, N. Tags: All Health Services Research, Medical care, All Clinical Neurology, Patient safety ARTICLE Source Type: research

Music-based interventions in neurological rehabilitation
Publication date: Available online 26 June 2017 Source:The Lancet Neurology Author(s): Aleksi J Sihvonen, Teppo Särkämö, Vera Leo, Mari Tervaniemi, Eckart Altenmüller, Seppo Soinila During the past ten years, an increasing number of controlled studies have assessed the potential rehabilitative effects of music-based interventions, such as music listening, singing, or playing an instrument, in several neurological diseases. Although the number of studies and extent of available evidence is greatest in stroke and dementia, there is also evidence for the effects of music-based interventions on supporting cognition, motor...
Source: The Lancet Neurology - June 28, 2017 Category: Neurology Source Type: research

Review Music-based interventions in neurological rehabilitation
During the past ten years, an increasing number of controlled studies have assessed the potential rehabilitative effects of music-based interventions, such as music listening, singing, or playing an instrument, in several neurological diseases. Although the number of studies and extent of available evidence is greatest in stroke and dementia, there is also evidence for the effects of music-based interventions on supporting cognition, motor function, or emotional wellbeing in people with Parkinson's disease, epilepsy, or multiple sclerosis.
Source: Lancet Neurology - June 26, 2017 Category: Neurology Authors: Aleksi J Sihvonen, Teppo S ärkämö, Vera Leo, Mari Tervaniemi, Eckart Altenmüller, Seppo Soinila Tags: Review Source Type: research

Evaluating the safety of {beta}-interferons in MS: A series of nested case-control studies
Conclusions: Among patients with RRMS, IFN-β was associated with a 1.8- and 1.6-fold increase in the risk of stroke and migraine and 1.3-fold increases in depression and hematologic abnormalities.
Source: Neurology - June 12, 2017 Category: Neurology Authors: de Jong, H. J. I., Kingwell, E., Shirani, A., Cohen Tervaert, J. W., Hupperts, R., Zhao, Y., Zhu, F., Evans, C., van der Kop, M. L., Traboulsee, A., Gustafson, P., Petkau, J., Marrie, R. A., Tremlett, H., On behalf of the British Columbia Multiple Scleros Tags: Patient safety, Multiple sclerosis, All epidemiology, Case control studies ARTICLE Source Type: research

The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration
AbstractStatins, cholesterol lowering drugs, have been demonstrated to exert beneficial effects in other conditions such as primary and progressing neurodegenerative diseases beyond their original role. Observation that statins ameliorate the neurodegenerative diseases such as Parkinson ’s disease (PD), Alzheimer’s disease (AD), multiple sclerosis (MS) and cerebral ischemic stroke, the neuroprotective effects of these drugs are thought to be linked to their anti-inflammatory, anti-oxidative, and anti-excitotoxic properties. Despite the voluminous literature on the clinical adva ntages of 3-hydroxy-3-methylglutaryl Co-e...
Source: Metabolic Brain Disease - June 3, 2017 Category: Neurology Source Type: research

Do patients with thalamic pain have a specific somatosensory phenotype? (P1.222)
Conclusions:The somatosensory phenotype of the CPSP patients was characterized by reduced sensation for vibration and light touch on the affected side. These patients showed mechanical hyperalgesia and more pronounced hypoesthesia, but no temperature perception abnormalities, compared to the control patients. Our results do not support the view that a specific dysfunction of the spinothalamic tract is involved in the pathogenesis of thalamic CPSP.Disclosure: Dr. Papadopoulou has nothing to disclose. Dr. Magon has nothing to disclose. Dr. Gaetano has received personal compensation for activities with Novartis Pharmaceutical...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Papadopoulou, A., Magon, S., Gaetano, L., Jaeger, Y., Kappos, L., Sprenger, T. Tags: Pain and Palliative Care Source Type: research

Misdiagnosis of CADASIL: A single Medical Center experience (P1.251)
Conclusions:CADASIL is the most prevalent monogenic cerebral small-vessel arteriopathy. Despite wide availability of genetic testing, misdiagnosis and delay diagnosis are common. We encourage for enhanced awareness of CADASIL among patients with migraines with aura, recurrent TIAs or subcortical ischemic strokes, and mood disorder, in order to provide appropriate multidisciplinary treatment, psychological support and genetic counselingStudy Supported by: n/aDisclosure: Dr. Ortiz-Garcia has nothing to disclose. Dr. Orjuela has nothing to disclose. Dr. Sweis has nothing to disclose. Dr. Biller has received personal compensat...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ortiz-Garcia, J., Orjuela, K., Sweis, R., Biller, J. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Severe recurrent neuroinflammation associated with cytotoxic T-lymphocyte antigen-4 (CTLA4) haploinsufficiency (P1.330)
Conclusions:CTLA4 mutations are associated with a distinct pattern of neuroinflammation. Supported by available pathology, the clinical-radiological discordance suggests that even large, enhancing lesions need not be destructive, even when behaving as space-occupying masses. Further characterization and modeling of this genetic disorder may provide insight into the mechanisms underlying other neuroimmunological disorders.Study Supported by: Fellowship funding from the National Multiple Sclerosis Society-American Brain Foundation. Intramural funds from the National Institute of Neurological Disorders and Stroke.Disclosure: ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Schindler, M., Pittaluga, S., Uzel, G., Reich, D., Cortese, I. Tags: CNS Inflammatory Diseases and Differential Diagnosis I Source Type: research