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Specialty: Neurology
Condition: Multiple Sclerosis

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Total 440 results found since Jan 2013.

Patient-Reported Outcome Measurement in Manual Ability for Multiple Sclerosis: Addressing the Targeting Issues of the ABILHAND (P3.364)
Conclusions:Our study suggests that complementing the ABILHAND with bolt-on items appears to provide additional clinically relevant and targeted measurement of manual ability and related impact in early stage patients. To confirm this, ABILHAND along with new bolt-on items should be tested in a larger clinically-defined sample to evaluate its measurement properties (including measurement coverage and precision) in RRMS.Study Supported by: This study was funded by Biogen.Disclosure: Dr. Chen has received personal compensation for activities with Biogen as an employee. Dr. Chen holds stock and/or stock options in Biogen. Dr....
Source: Neurology - April 17, 2017 Category: Neurology Authors: Chen, S.-Y., Pompilus, F., Strzok, S., Cleanthous, S., Cano, S., Marquis, P., Cohan, S., Goldman, M., Kresa-Reahl, K., Petrillo, J., Castrillo-Viguera, C., Cadavid, D., Mellion, M. Tags: Quality of Life, Symptoms and Symptomatic Therapy, Comorbidity, and Patient Reported Outcomes in Multiple Sclerosis Source Type: research

The Adult Spasticity International Registry (ASPIRE) Study: 1-Year Results (P4.034)
Conclusions:Findings demonstrate the real-world safety and effectiveness for onabotulinumtoxinA treatment in spasticity. Further analyses will explore clinical and burden outcomes and differences across etiology and presentation.Study Supported by: Allergan plcDisclosure: Dr. Francisco has received personal compensation for activities with Allergan, Ipsen, Mallinckrodt, and Merz. Dr. Francisco has received personal compensation in an editorial capacity for Journal of Rehabilitation Medicine. Dr. Francisco has received research support from Allergan, Ipsen, Mallinckrodt, Medtronic, Merz, Microtransponder, and Nexstim. Dr. B...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Francisco, G. E., Bandari, D. S., Bavikatte, G., Jost, W. H., Adams, A. M., Largent, J., Esquenazi, A. Tags: Neuro-rehabilitation: Motor Recovery and Spasticity Treatment Source Type: research

Characteristics of Code Stroke Cases in a Level 1 Trauma U.S. Military Treatment Facility: Comparison with a Civilian Stroke Center (P3.265)
Conclusions:The proportion of code strokes ultimately diagnosed with AISor TIA in our facility is lower than that reported in a civilian stroke center, and the proportion of functional diagnoses is higher. Further studies are needed to describe the reasons for these differences, which may be unique to military populations.Disclosure: Dr. Koehn has nothing to disclose. Dr. Williams has nothing to disclose. Dr. Chao has nothing to disclose. Dr. Frattalone has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Koehn, T., Williams, J., Chao, W., Frattalone, A. Tags: Cerebrovascular Disease Epidemiology Source Type: research

Sexuality and disability, a poorly studied relationship in neurology (P2.199)
Conclusions:Sexual dysfunction was more frequent in patients with chronic neurological diseases. We found a statistically significant relationship between sexual dysfunction and disability. For overall sexual function, the results indicate that women had lower rates of sexual performance for the same degree of disability than menDisclosure: Dr. Nasimbera has nothing to disclose. Dr. Rosales has nothing to disclose. Dr. Quarrachino has nothing to disclose. Dr. Rodriquez has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Nasimbera, A., Rosales, J., Silva, B., Alonso, R., Bohorquez, N., Lepera, S., Garreto, N., Tomoko, A., Garcea, O., Raul, R., Quarrachino, C., Rodriquez, G. Tags: General Neurology: Practice Improvement and Novel Approaches to Care Source Type: research

Constraint-Induced Movement Therapy for Chronic Hemiparesis: Neuroscience Evidence from Basic Laboratory Research and Quantitative Structural Brain MRI in Patients with Diverse Disabling Neurological Disorders (S43.003)
Conclusions:CIMT is increasing worldwide practice to improve reduced real-world limb use in chronic hemiparesis in diverse neurological diseases and ages of patients. Structural CNS changes following CIMT may support improved and extended functional use of the paretic limb.Study Supported by: NIH, National MS SocietyDisclosure: Dr. Mark has nothing to disclose. Dr. Taub has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mark, V., Taub, E. Tags: Exciting New Results in Neuro-rehabilitation Source Type: research

Maternal levels of Epstein-Barr virus IgG antibodies and risk of multiple sclerosis in offspring in the Finnish Maternity Cohort (S44.006)
Conclusions:Elevated maternal levels of VCA IgG are associated with an increased risk of MS in the offspring. Further studies are needed to elucidate potential biological mechanisms.Study Supported by: This study was funded by the National Institute of Neurological Disorders and Stroke (NIH R01 NS073633, PI: Ascherio).Disclosure: Dr. Munger has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Aivo has nothing to disclose. Dr. Hongell has nothing to disclose. Dr. Soilu-Hanninen has nothing to disclose. Dr. Surcel has nothing to disclose. Dr. Ascherio has received personal compensation for activities with Almirall...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Munger, K., Zhang, Z., Aivo, J., Hongell, K., Soilu-Hanninen, M., Surcel, H.-M., Ascherio, A. Tags: MS Risk Factors and Modifications Source Type: research

The role of aquaporin-4 in synaptic plasticity, memory and disease.
Abstract Since the discovery of aquaporins, it has become clear that the various mammalian aquaporins play critical physiological roles in water and ion balance in multiple tissues. Aquaporin-4 (AQP4), the principal aquaporin expressed in the central nervous system (CNS, brain and spinal cord), has been shown to mediate CNS water homeostasis. In this review, we summarize new and exciting studies indicating that AQP4 also plays critical and unanticipated roles in synaptic plasticity and memory formation. Next, we consider the role of AQP4 in Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's...
Source: Brain Research Bulletin - March 4, 2017 Category: Neurology Authors: Hubbard JA, Szu JI, Binder DK Tags: Brain Res Bull Source Type: research

The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus
This article is protected by copyright. All rights reserved. Utilizing fEPSP recording in hippocampal slices the authors showed that adiponectin receptors activation led to a dose‐dependent dampening of LTP. Adiporon (ADPO) had no effect on basal evoked synaptic transmission but it decreased the paired pulse facilitation and the responses during High frequency Stimulation (HFS). A reduction of AMPA receptor‐mediated current is probably involved in the latter effect.
Source: Synapse - February 11, 2017 Category: Neurology Authors: Filippo Weisz, Sonia Piccinin, Dalila Mango, Richard Teke Ngomba, Nicola B. Mercuri, Ferdinando Nicoletti, Robert Nistic ò Tags: Research Article Source Type: research

Tauopathies - focus on changes at the neurovascular unit.
Abstract In the past, the blood-brain barrier (BBB) had been characterized mainly as a layer of endothelial cells forming the vessel/capillary wall of the brain. More recently, the BBB is considered to be a part of a highly dynamic and interactive system called the neurovascular unit (NVU), consisting of vascular cells, glial cells, and neurons. The list of central nervous system (CNS) pathologies involving BBB dysfunction is rapidly growing. The opening of the BBB and subsequent infiltration of serum components to the brain can lead to host of processes resulting in progressive synaptic and neuronal dysfunction a...
Source: Current Alzheimer Research - February 2, 2017 Category: Neurology Authors: Michalicova A, Banks WA, Legath J, Kovac A Tags: Curr Alzheimer Res Source Type: research

MMP-12, a Promising Therapeutic Target for Neurological Diseases
AbstractThe role of matrix metalloproteinase-12 (MMP-12) in the pathogenesis of several inflammatory diseases such as chronic obstructive pulmonary disease, emphysema, and asthma is well established. Several new studies and recent reports from our laboratory and others highlighted the detrimental role of MMP-12 in the pathogenesis of several neurological diseases. In this review, we discuss in detail the pathological role of MMP-12 and the possible underlying molecular mechanisms that contribute to disease pathogenesis in the context of central nervous system diseases such as stroke, spinal cord injury, and multiple sclero...
Source: Molecular Neurobiology - February 1, 2017 Category: Neurology Source Type: research

Inherited and Uncommon Causes of Stroke
This article is a practical guide to identifying uncommon causes of stroke and offers guidance for evaluation and management, even when large controlled trials are lacking in these rarer forms of stroke. Recent Findings: Fabry disease causes early-onset stroke, particularly of the vertebrobasilar system; enzyme replacement therapy should be considered in affected patients. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), often misdiagnosed as multiple sclerosis, causes migraines, early-onset lacunar strokes, and dementia. Moyamoya disease can cause either ischemic or he...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2017 Category: Neurology Tags: Review Articles Source Type: research

The Burden of Neurological Disease in the United States: A Summary Report and Call to Action
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - December 31, 2016 Category: Neurology Authors: Clifton L. Gooch, Etienne Pracht, Amy R. Borenstein Tags: Invited Editorial Source Type: research

Fingolimod Confers Neuroprotection through Activation of Rac1 after Experimental Germinal Matrix Hemorrhage in Rat Pups
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - December 31, 2016 Category: Neurology Authors: William B. Rolland, Paul R. Krafft, Tim Lekic, Damon Klebe, Julia LeGrand, Abby Jones Weldon, Liang Xu, John H. Zhang Tags: Original Article Source Type: research

Neurology Health Advocacy Curriculum: Needs Assessment, Curricular Content and Underlying Components.
CONCLUSION: Neurologists' and residents' responses support that NHA curriculum is needed. Four components of NHA were identified that can be used for teaching NHA as well as health advocacy in general practice. PMID: 27846918 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - November 15, 2016 Category: Neurology Authors: Abuzinadah AR, Cooke L Tags: Can J Neurol Sci Source Type: research

Neuroimmune Crosstalk in CNS Disorders: The Histamine Connection.
Abstract The neuroimmune system represents a dense network of biochemical signals associated with neurotransmitters, neuropeptides, neurohormones, cytokines, chemokines, and growth factors synthesized in neurons, glial cells and immune cells, to maintain systemic homeostasis. Endogenous and/or exogenous, noxious stimuli in any tissue are captured by sensor cells to inform the brain; likewise, signals originating at the central nervous system (CNS) level are transmitted to peripheral immune effectors which react to central stimuli. This multidirectional information system makes it possible for the CNS to respond to...
Source: Epilepsy Curr - November 1, 2016 Category: Neurology Authors: Cacabelos R, Torrellas C, Fernández-Novoa L, Aliev G Tags: Curr Pharm Des Source Type: research