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Specialty: Neurology
Condition: Multiple Sclerosis

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Total 440 results found since Jan 2013.

Isolated Tongue Hemi-Atrophy from Hypoglossal-Vertebral Entrapment Syndrome (P3.377)
Conclusion: Hypoglossal vertebral entrapment syndrome from a structural vascular anomaly or anomalous vascular course is an extremely rare cause of isolated hypoglossal nerve palsy. Only a few cases have been reported in the literature. Imaging studies and careful exclusion of other potential etiologies is essential to establish the diagnosis.Disclosure: Dr. Roy has nothing to disclose. Dr. Bakradze has nothing to disclose. Dr. Ollenschleger has nothing to disclose. Dr. Felice has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Roy, B., Bakradze, E., Ollenschleger, M., Felice, K. Tags: General Neurology Source Type: research

Natalizumab Versus Placebo in Patients with Acute Ischemic Stroke (AIS): Results from ACTION, a Multicenter, Double-Blind, Placebo-Controlled, Randomized Phase 2 Clinical Trial (S7.005)
CONCLUSIONS: A single dose of natalizumab administered up to 9 hours after stroke onset did not reduce focal infarct volume growth, but natalizumab appeared to be associated with important functional outcome improvements sustained over 90 days. Further natalizumab studies for AIS are warranted. Support: Biogen.Disclosure: Dr. Elkins holds stock and/or stock options in Biogen, which sponsored research in which Dr. Elkins was involved as a researcher. Dr. Elkind has received personal compensation in and editorial capacity for serving as an Associate Editor of the journal Neurology. Dr. Veltkamp has received research support ...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Elkins, J., Elkind, M., Veltkamp, R., Montaner, J., Johnston, S., Singhal, A., Becker, K., Lansberg, M., Chang, I., Tang, W., Gheuens, S., Mehta, L. Tags: Stroke Clinical Trials Source Type: research

Parakinesia Brachialis Oscitans after an Acute Internal Capsule Infarct (P1.014)
Conclusions:Involuntary stereotyped movements of an otherwise plegic arm while yawning was first observed in 1844 and coined "parakinesia brachialis oscitans" in 2010. The term parakinesia was used to differentiate the movements from synkinesia. The causes are diverse and include ischemic or hemorrhagic strokes, pontine tuberculoma, and amyotrophic lateral sclerosis. Ischemic strokes are most often implicated and typically involve a lenticulostriate branch of the middle cerebral artery. Lesions affecting the pyramidal tracts are the common denominator. The phenomenon may be observed acutely when the limb is flaccid or mont...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Koo, B., Wang, E. Tags: Movement Disorders ePoster Session Source Type: research

Non-Medical Explanations of Neurological Illnesses among Healthcare Professionals (P1.282)
Conclusion: Supernatural explanations of neurological symptoms are indeed prevalent among healthcare professionals. This requires further study as to how this affects patient careDisclosure: Dr. Khayat has nothing to disclose. Dr. Milyani has nothing to disclose. Dr. Tayeb has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Khayat, A., Milyani, H., Tayeb, H. Tags: Global Health: Infectious Disease, Capacity Building, and Other Source Type: research

Reserve, Resilience and Recovery in Stroke: A Meta-Narrative Review (P3.199)
Conclusion: There is an urgent need to individualize outcomes in stroke systematically by implementing well validated concepts from various related fields to improve patient centered decision-making in acute stroke care.Disclosure: Dr. Dangayach has nothing to disclose. Dr. Grewal has nothing to disclose. Dr. Gordon has nothing to disclose. Dr. Mayer has received research support from Non-Invasive Medical Systems, Inc. and General Electric.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Dangayach, N., Grewal, H., Gordon, E., Mayer, S. Tags: Neurocritical Care: Clinical Science Source Type: research

A Survey of Functional Movement Disorders at the National Institutes of Health (P1.073)
OBJECTIVE: To better characterize the clinical presentation of functional movement disorders. BACKGROUND: Functional (psychogenic) movement disorders are receiving greater attention as valid and treatable neurologic disorders. Unfortunately, the often long list of complaints with variable presentations may hamper timely diagnosis and treatment. METHODS: We reviewed 113 charts retrospectively of patients presenting to the National Institutes of Health. Patients were referred from 44 states and the District of Columbia, with the majority presenting from the local Washington D.C. metropolitan area. Most patients were diagnose...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Ahmad, O., Maurer, C., Villegas, M. A. F., Lungu, C., Hallett, M. Tags: Movement Disorders: Miscellaneous Source Type: research

Baseline Demographics and Clinical Characteristics of Patients Treated for Spasticity in the Adult Spasticity International Registry (ASPIRE Study) (P3.296)
Conclusions: Global epidemiological data for spasticity is lacking. ASPIRE represents the largest existing international database prospectively evaluating demographics and clinical characteristics of spasticity across multiple etiologies. Further baseline analyses will describe onabotulinumtoxinA utilization patterns, treatment satisfaction, individual/caregiver burden, and characterize the healthcare provider population treating spasticity.Disclosure: Dr. Franciso has received personal compensation for activities with Allergan as a consultant. Dr. Bandari has received personal compensation for activities with Accorda, All...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Francisco, G., Bandari, D., Bavikatte, G., Jost, W., Manack Adams, A., Largent, J., Esquenazi, A. Tags: Neurorehabilitation Source Type: research

Stroke Subtypes and Risk Factors in Saudi Arabia (P1.124)
CONCLUSION: Non-cardioembolic disease was the overwhelming stroke mechanism in this middle-eastern cohort with only 4[percnt] of patients have cardioembolic stroke, in comparison to roughly 20[percnt] reported in Western cohorts. In part, these differences may be explained by deficient prolonged cardiac monitoring. However the high prevalence of atherothrombotic risk factors and overrepresentation of non-cardioembolic stroke suggests a need to optimize atherothrombotic stroke risk factor management within our populationDisclosure: Dr. Al Harbi has nothing to disclose. Dr. Shoamanesh has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Al Harbi, A., Shoamanesh, A. Tags: Cerebrovascular Disease: Epidemiology Source Type: research

Combining High-Resolution FLAIR and T2 to Improve Multiple Sclerosis Lesion Conspicuity (P4.155)
Conclusions: FLAIR² achieves CSF suppression with improved CNR compared to conventional scans, suggesting it may replace DIR. Lesions in the entire brain are captured, including infratentorial regions and most of the cervical cord. The improved detection of WM hyperintensities will also benefit research and diagnosis in Alzheimer's disease, neurotrauma, stroke and other applications.Disclosure: Dr. Wiggermann has nothing to disclose. Dr. Hernandez-Torres has nothing to disclose. Dr. Traboulsee has received personal compensation for activities with Genzyme and Roche. Dr. Traboulsee has received research support from Ge...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Wiggermann, V., Hernandez-Torres, E., Traboulsee, A., Li, D., Rauscher, A. Tags: MS and CNS Inflammatory Disease: Neuroimaging Source Type: research

PRISM II: Effectiveness of Dextromethorphan 20 mg/Quinidine 10 mg (NUEDEXTA(R)) for Treatment of Pseudobulbar Affect Secondary to Dementia, Stroke, or Traumatic Brain Injury: Combined Results of a Multicenter Open-Label Study (P2.225)
Conclusion: The open-label PRISM II study supports DM/Q effectiveness for PBA irrespective of underlying etiology. Study supported by: Avanir Pharmaceuticals, Inc.Disclosure: Dr. Siffert has nothing to disclose. Dr. Hammond has nothing to disclose. Dr. Alexander has nothing to disclose. Dr. Cutler has received personal compensation for activities with Abbott, AstraZeneca, Bristol-Myers Squibb, Forest, GlaxoSmithKline, Lilly, Merck, Novartis, Ortho-McNeil-Janssen, Otsuka, Pamlab, Pfizer, Shire, and Sunovion. Dr. D'Amico has received personal compensation for activities with Avanir Pharmaceuticals, Inc. Dr. Doody has receive...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Siffert, J., Hammond, F., Alexander, D., Cutler, A., D'Amico, S., Doody, R., Sauve, W., Zorowitz, R., Davis, C., Shin, P., Ledon, F., Yonan, C., Formella, A. Tags: Aging and Dementia: Therapeutics Source Type: research

Is it ever lupus? A single centre retrospective review of the rheumatologic work-up in patients with clinically isolated syndrome (P6.113)
Conclusions: In our single centre review of patients with CIS who underwent rheumatologic testing, ANA was weakly/moderately positive in 64[percnt] and did not aid in predicting diagnosis of MS versus an autoimmune rheumatologic disease. More specific rheumatologic markers, including ds-DNA, ENA, low C3/C4 and antiphospholipid antibodies were rarely positive, and no CIS was attributed to a newly diagnosed rheumatologic disease.Disclosure: Dr. Budhram has nothing to disclose. Dr. Yuen has nothing to disclose. Dr. Yan has nothing to disclose. Dr. Kremenchutzky has received research support from Bayer, Biogen Idec, Genzyme, N...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Budhram, A., Yuen, J., Yan, H., Kremenchutzky, M. Tags: MS and CNS Inflammatory Disease: CNS Inflammatory Diseases and Differential Diagnosis Source Type: research

Ice Pick Headache
Abstract Ice pick headache, also called idiopathic or primary stabbing headache, is a unique headache type associated with ultra-brief stabs of pain, most commonly in the frontal or temporal area. It occurs predominantly in women and is estimated to affect 2–35 % of the population. Unlike other headache types of short duration, such as short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT), ice pick headache is not associated with any cranial autonomic symptoms but has been known to occur with nausea, vomiting, photophobia, and dizziness. It exists in two forms: primary ...
Source: Current Pain and Headache Reports - April 1, 2016 Category: Neurology Source Type: research

Immunosenescence of microglia and macrophages: impact on the ageing central nervous system
This article will propose the following: (i) infiltrating macrophages age differently from central nervous system-intrinsic microglia; (ii) several mechanisms underlie the differential ageing process of these two distinct cell types; and (iii) therapeutic strategies that selectively target these diverse mechanisms may rejuvenate macrophages and microglia for repair in the ageing central nervous system. Most responses of macrophages are diminished with senescence, but activated microglia increase their expression of pro-inflammatory cytokines while diminishing chemotactic and phagocytic activities. The senescence of macroph...
Source: Brain - February 25, 2016 Category: Neurology Authors: Rawji, K. S., Mishra, M. K., Michaels, N. J., Rivest, S., Stys, P. K., Yong, V. W. Tags: Neurodegeneration - Cellular & Molecular Updates Source Type: research

Botulinum Toxin Treatment of Spasticity in Adults and Children
Semin Neurol 2016; 36: 064-072DOI: 10.1055/s-0036-1571847Spasticity is a frequent symptom in stroke, multiple sclerosis, cerebral or spinal trauma, and cerebral palsy that affects and disables a large number of adults and children. In this review, we discuss the pathophysiology and nonpharmacologic and pharmacologic treatments of spasticity with emphasis on the role of botulinum neurotoxins (BoNTs). The world literature is reviewed on double-blind and placebo-controlled clinical trials reporting safety and efficacy of BoNT treatment in adult spasticity and spasticity of children with cerebral palsy. The evidence for effica...
Source: Seminars in Neurology - February 11, 2016 Category: Neurology Authors: Moeini-Naghani, ImanHashemi-Zonouz, TaranehJabbari, Bahman Source Type: research

Anodal transcranial direct current stimulation of motor cortex does not ameliorate spasticity in multiple sclerosis.
CONCLUSIONS: Five-daily sessions of anodal tDCS to the primary motor cortex does do not improve lower limb spasticity in MS patients. PMID: 26409407 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research