Filtered By:
Specialty: Neurology
Condition: Multiple Sclerosis

This page shows you your search results in order of date. This is page number 19.

Order by Relevance | Date

Total 440 results found since Jan 2013.

Hemiplegic Migraine Presenting with Prolonged Somnolence: A Case Report
We present the case of a young 24-year-old male patient, who since the age of 4 years had been having multiple episodes of migraine associated with hemiparesis, paraesthesia, prolonged somnolence, aphasia and confusion. We review the literature and discuss important diagnostic findings in hemiplegic migraine to help establishing a prompt diagnosis.Case Rep Neurol 2016;8:204 –210
Source: Case Reports in Neurology - October 3, 2016 Category: Neurology Source Type: research

Inflammation at the blood-brain barrier: The role of liver X receptors.
Abstract The blood-brain barrier (BBB) is indispensable for the maintenance of brain homeostasis and proper neuronal functioning. Dysfunction of the BBB significantly contributes to the pathogenesis of neuroinflammatory and neurodegenerative diseases like stroke, multiple sclerosis (MS), and Alzheimer's disease (AD). The neuroinflammatory environment that characterizes these disorders propagates chronic impaired function of the BBB, processes that will be discussed in this review. Limiting dysfunction of the BBB may be an attractive target for treatment of neurological disorders. To date, no current treatments are...
Source: Neurobiology of Disease - September 18, 2016 Category: Neurology Authors: de Wit NM, Vanmol J, Kamermans A, Hendriks J, de Vries HE Tags: Neurobiol Dis Source Type: research

Milton Alter, MD, PhD (1929-2016)
Milton Alter, MD, PhD, died on February 4, 2016. He will be remembered as an outstanding neuroepidemiologist whose areas of interest included multiple sclerosis, epilepsy, and stroke.
Source: Neurology - September 4, 2016 Category: Neurology Authors: Kelley, R. E., Azizi, S. A. Tags: IN MEMORIAM Source Type: research

Is There an Increased Risk for Ischemic Stroke in Patients with Multiple Sclerosis, and If So, Should Preventive Treatment Be Considered?
Steven Mitchell LeVine
Source: Frontiers in Neurology - August 11, 2016 Category: Neurology Source Type: research

Natalizumab: a new therapy for acute ischemic stroke?
This article reviews the main experimental studies on the blockage of CD49d and identifies the potential underlying causes for their inconclusive results. Despite these divergences and the difficulties in translation of experimental studies, a phase II clinical trial has recently been conducted to evaluate the efficacy of Natalizumab in stroke patients (ACTION trial). Preliminary results of the trial are also discussed here, together with a general overview of the emerged importance of the neuroprotective strategies based on the mitigation of post-stroke neuroinflammation. Expert commentary: Despite Natalizumab showing pos...
Source: Expert Review of Neurotherapeutics - August 2, 2016 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Neurology of Pregnancy
The anatomic and physiologic changes that occur during pregnancy are unique. A neurologist needs to be aware of normal pregnancy-induced physiologic changes in the cardiovascular, renal, hematologic, and autoimmune systems, and the local anatomic changes, which include alteration of body habitus and pelvic ligaments. These changes are clearly advantageous, but in certain circumstances may predispose to pathology. In addition, pregnancy effects treatment of chronic neurologic conditions as regards medication safety and metabolism. This case-oriented review discusses the important aspects of pregnancy physiology and an appro...
Source: Neurologic Clinics - July 31, 2016 Category: Neurology Authors: Mary Angela O ’Neal Source Type: research

Cortical relapses in multiple sclerosis
Conclusions: Cortical relapses may occur in MS. MRI examination in MS should include sequences, such as double inversion recovery (DIR) or phase sensitive inversion recovery (PSIR), that are aimed at visualizing cortical lesions, especially in the presence of symptoms of cortical dysfunction. Our observation further stresses and extends the clinical relevance of cortical pathology in MS.
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Puthenparampil, M., Poggiali, D., Causin, F., Rolma, G., Rinaldi, F., Perini, P., Gallo, P. Tags: July 2016 22 (8) Original Research Papers Source Type: research

Neurology of Pregnancy
The anatomic and physiologic changes that occur during pregnancy are unique. A neurologist needs to be aware of normal pregnancy-induced physiologic changes in the cardiovascular, renal, hematologic, and autoimmune systems, and the local anatomic changes, which include alteration of body habitus and pelvic ligaments. These changes are clearly advantageous, but in certain circumstances may predispose to pathology. In addition, pregnancy effects treatment of chronic neurologic conditions as regards medication safety and metabolism. This case-oriented review discusses the important aspects of pregnancy physiology and an appro...
Source: Neurologic Clinics - July 19, 2016 Category: Neurology Authors: Mary Angela O’Neal Source Type: research

Chapter 56 Diffusion tensor imaging and functional MRI
Publication date: 2016 Source:Handbook of Clinical Neurology, Volume 136 Author(s): Massimo Filippi, Federica Agosta The advances in diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), and functional magnetic resonance imaging (fMRI) over the last 20 years have vastly contributed to improving the understanding of the brain structure and function in patients with many diseases of the central nervous system (CNS). DWI is commonly used, for instance, in the diagnostic workup of stroke, CNS neoplasia, and rapidly progressive dementia cases. The new DTI methods provide more specific information about the most ...
Source: Handbook of Clinical Neurology - July 16, 2016 Category: Neurology Source Type: research

Proinflammatory cytokines and matrix metalloproteinases in CSF of patients with VZV vasculopathy
Conclusions: CSF of patients with VZV vasculopathy revealed a unique profile of elevated proinflammatory cytokines, IL-8 and IL-6, along with elevated MMP-2. The relevance of these cytokines to the pathogenesis of VZV vasculopathy requires further study.
Source: Neurology Neuroimmunology and Neuroinflammation - June 12, 2016 Category: Neurology Authors: Jones, D., Alvarez, E., Selva, S., Gilden, D., Nagel, M. A. Tags: Vasculitis, Viral infections, All Cerebrovascular disease/Stroke Article Source Type: research

PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury
Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). The ...
Source: BMC Neurology - June 9, 2016 Category: Neurology Authors: Flora M. Hammond, David N. Alexander, Andrew J. Cutler, Stephen D’Amico, Rachelle S. Doody, William Sauve, Richard D. Zorowitz, Charles S. Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E. Formella and Joao Siffert Source Type: research

Regional disparities in botulinum toxin A (BoNT‐A) therapy for spasticity in Sweden: budgetary consequences of closing the estimated treatment gap
ConclusionsThe study revealed apparent regional disparities of BoNT‐A treatment for spasticity in Sweden. The results further suggest that the incremental cost of eliminating the treatment gap has a high probability of being offset by savings in direct costs, even at a low proportion of the patients reaching clinical improvement.
Source: Acta Neurologica Scandinavica - May 25, 2016 Category: Neurology Authors: P. Ertzgaard, M. Anhammer, A. Forsmark Tags: Original Article Source Type: research

Regional disparities in botulinum toxin A (BoNT ‐A) therapy for spasticity in Sweden: budgetary consequences of closing the estimated treatment gap
ConclusionsThe study revealed apparent regional disparities of BoNT‐A treatment for spasticity in Sweden. The results further suggest that the incremental cost of eliminating the treatment gap has a high probability of being offset by savings in direct costs, even at a low proportion of the patients reaching clinical improvement.
Source: Acta Neurologica Scandinavica - May 23, 2016 Category: Neurology Authors: P. Ertzgaard, M. Anhammer, A. Forsmark Tags: Original Article Source Type: research

Neurocognitive Deficits and Neurocognitive Rehabilitation in Adult Brain Tumors
Opinion statement Neurocognitive deficits are common with brain tumors. If assessed at presentation using detailed neurocognitive tests, problems are detected in 80 % of cases. Neurocognition may be affected by the tumor, its treatment, associated medication, mood, fatigue, and insomnia. Interpretation of neurocognitive problems should be considered in the context of these factors. Early post-operative neurocognitive rehabilitation for brain tumor patients will produce rehabilitation outcomes (e.g., quality of life, improved physical function, subjective neurocognition) equivalent to stroke, multiple sclerosis, ...
Source: Current Treatment Options in Neurology - April 4, 2016 Category: Neurology Source Type: research

Restless legs syndrome associated with major diseases: A systematic review and new concept
Recent publications on both the genetics and environmental factors of restless legs syndrome (RLS) defined as a clinical disorder suggest that overlapping genetic risk factors may play a role in primary (idiopathic) and secondary (symptomatic) RLS. Following a systematic literature search of RLS associated with comorbidities, we identified an increased prevalence of RLS only in iron deficiency and kidney disease. In cardiovascular disease, arterial hypertension, diabetes, migraine, and Parkinson disease, the methodology of studies was poor, but an association might be possible. There is insufficient evidence for conditions...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Trenkwalder, C., Allen, R., Hogl, B., Paulus, W., Winkelmann, J. Tags: Clinical trials Systematic review/meta analysis, Restless legs syndrome VIEWS & amp;amp; REVIEWS Source Type: research