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Specialty: Neurology
Condition: Multiple Sclerosis

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Total 440 results found since Jan 2013.

Effects of the Menstrual Cycle on Neurological Disorders
Curr Neurol Neurosci Rep. 2021 May 10;21(7):34. doi: 10.1007/s11910-021-01115-0.ABSTRACTPURPOSE OF REVIEW: The menstrual cycle involves recurrent fluctuations in hormone levels and temperature via neuroendocrine feedback loops. This paper reviews the impact of the menstrual cycle on several common neurological conditions, including migraine, seizures, multiple sclerosis, stroke, and Parkinson's disease.RECENT FINDINGS: The ovarian steroid hormones, estrogen and progesterone, have protean effects on central nervous system functioning that can impact the likelihood, severity, and presentation of many neurological diseases. H...
Source: Epilepsy Curr - May 10, 2021 Category: Neurology Authors: Hannah J Roeder Enrique C Leira Source Type: research

The Role of ASIC1a in Epilepsy: A Potential Therapeutic Target
CONCLUSION: This review is intended to provide an overview of the structure, trafficking, and molecular mechanisms of ASIC1a in order to further elucidate the role of ASIC1a in epilepsy.PMID:33797385 | DOI:10.2174/1570159X19666210402102232
Source: Epilepsy Curr - April 2, 2021 Category: Neurology Authors: Yu Cheng Wuqiong Zhang Yue Li Ting Jiang Buhajar Mamat Yunhai Zhang Famin Wang Hongmei Meng Source Type: research

Neurological Disorders Associated With COVID-19 Hospital Admissions: Experience of a Single Tertiary Healthcare Center
Conclusion: Although the exact prevalence and etiology remain unclear, new onset of neurological disorders, in addition to anosmia, is non-sporadic during the acute COVID-19-infection. Longitudinal follow-up of these patients is required to determine the clinical and functional outcome, treatment response and long-term effects of the SARS-CoV-2 infection.
Source: Frontiers in Neurology - February 19, 2021 Category: Neurology Source Type: research

A Neurodisparity Index of Nationwide Access to Neurological Health Care in Northern Ireland
Nationwide disparities in managing neurological patients have rarely been reported. We compared neurological health care between the population who reside in a Health and Social Care Trust with a tertiary neuroscience center and those living in the four non-tertiary center Trusts in Northern Ireland. Using the tertiary center Trust population as reference, neurodisparity indices (NDIs) defined as the number of treated patients resident in each Trust per 100,000 residents compared to the same ratio in the tertiary center Trust for a fixed time period. NDIs were calculated for four neurological pathways—intravenous thrombo...
Source: Frontiers in Neurology - February 12, 2021 Category: Neurology Source Type: research

The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia
The role of the immune system in stroke is well-recognised. Fingolimod, an immunomodulatory agent licensed for the management of relapsing-remitting multiple sclerosis, has been shown to provide benefit in rod...
Source: Journal of Neuroinflammation - January 30, 2021 Category: Neurology Authors: Kyle Malone, Andrea C. Diaz Diaz, Jennifer A. Shearer, Anne C. Moore and Christian Waeber Tags: Research Source Type: research

Effect of Dimethyl Fumarate on the Motor Function and Spatial Arrangement of Primary Motor Cortical Neurons in the Sub-Acute Phase of Stroke in a Rat Model
The therapeutic effects of dimethyl fumarate (DMF) in patients with multiple sclerosis and animal models of neurologic disease were reported. The density and the distribution pattern of motor neurons are important in transmitting the signal and controlling the movement-related functions. The present study evaluated the effects of DMF treatment on the neurological functions, infarct volume, and spatial distribution of the neurons in the primary motor cortex after cerebral ischemia.
Source: Journal of Stroke and Cerebrovascular Diseases - January 23, 2021 Category: Neurology Authors: Maryam Owjfard, Mohammad Reza Bigdeli, Anahid Safari, Masoud Haghani, Mohammad Reza Namavar Source Type: research

Another ‘BEE’? – Brain-Eye-Ear (BEE) Disease Secondary to HbSC Disease Masquerading as Multiple Sclerosis
We describe a man with hearing loss, visual signs and symptoms, and an accumulating burden of brain lesions, who was treated for a clinical diagnosis of MS for nearly two decades. Genetic testing revealed a unifying diagnosis.
Source: Journal of Stroke and Cerebrovascular Diseases - January 20, 2021 Category: Neurology Authors: Asya Izraelit Wallach, Maria J. Borja, Duan Chen, Rachel Eisenberg, Yasha S. Modi, Cen Zhang, Timothy M. Shepherd, Avindra Nath, Bryan Smith, Jose U. Scher, Catherine Cho, Ilya Kister Tags: Case Report Source Type: research

A Multidimensional Virtual Reality Neurorehabilitation Approach to Improve Functional Memory: Who Is the Ideal Candidate?
Discussion: The HEAD program is a rehabilitation with effects on multiple domains, including ecological memory. Residual level of cognitive and/or motor functioning is a significant predictor of the treatment success. These findings confirm the intrinsic relationship subsisting between motor and cognitive functions and suggest the beneficial effects of physical activity on cognitive functions and vice versa.
Source: Frontiers in Neurology - January 14, 2021 Category: Neurology Source Type: research

Safinamide in neurological disorders and beyond: evidence from preclinical and clinical studies.
Abstract The discovery and development of safinamide, an alpha-aminoamide, has been a valuable addition to the existing clinical management of Parkinson's disease (PD). The journey of safinamide dates back to the year 1983, when an alpha-aminoamide called milacemide showed a weak anticonvulsant activity. Milacemide was then structurally modified to give rise to safinamide, which in turn produced robust anticonvulsant activity. The underlying mechanism behind this action of safinamide is attributed to the inhibition of voltage gated calcium and sodium channels. Moreover, owing to the importance of ion channels in m...
Source: Brain Research Bulletin - December 30, 2020 Category: Neurology Authors: Wasan H, Singh D, Kh R Tags: Brain Res Bull Source Type: research

Telemedicine in neurology: current evidence
Conclusion: Current evidence supports that teleneurology can be a tool to increase care for patients suffering from neurological diseases.RESUMO Introdu ção: A telemedicina surge pela primeira vez na neurologia como uma ferramenta para facilitar o acesso ao tratamento do acidente vascular cerebral (AVC) Agudo. Mais recentemente, inúmeras evidências têm surgido acerca da eficácia e da segurança do uso da telemedicina em várias outras áreas d a neurologia. Com o advento da pandemia de COVID-19 e a necessidade de isolamento social, as autoridades brasileiras flexibilizaram a regulamentação da telemedicina, permitin...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

RANK/RANKL/OPG Signaling in the Brain: A Systematic Review of the Literature
Together with its dominant immunological and bone remodeling involvement, RRO axis, comprising of receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL), and osteoprotegerin (OPG) signaling, is as well-implicated in CNS functioning and corresponding pathologies. The CNS aspects of RANKL/RANK/OPG (RRO) axis were systematically reviewed. With search 10 databases, and 7 additional resources from first article publication to July 2019, resulted in total 2,222 hits, from which 33 relevant articles were selected. The elements of RRO axis in CNS include cells involved in neuroinflammation, predominantly in microglia...
Source: Frontiers in Neurology - November 19, 2020 Category: Neurology Source Type: research