Professor Iván Antonio Izquierdo (1937-2021)
ABSTRACT Since the Greek Aellus Galenum (129 AD - c.200/c.216), vertigo was considered a problem attributed to a cerebral disorder, diagnosed as the manifestation of apoplectiform cerebral congestion. In the mid-19th century, the Frenchman Prosper Meni ère changed this concept by placing the origin of this symptom in the inner ear. The main objective of this historical note is to highlight who Menière was, his work, and some aspects of the disease that bears his name.RESUMO Desde o grego Aellus Galenum (129 d.C. - c.200/c.216), a vertigem era considerada um problema atribu ído a um distúrbio cer...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

COVID-19 as the trigger for respiratory failure in neuromuscular diseases
ABSTRACT Since the Greek Aellus Galenum (129 AD - c.200/c.216), vertigo was considered a problem attributed to a cerebral disorder, diagnosed as the manifestation of apoplectiform cerebral congestion. In the mid-19th century, the Frenchman Prosper Meni ère changed this concept by placing the origin of this symptom in the inner ear. The main objective of this historical note is to highlight who Menière was, his work, and some aspects of the disease that bears his name.RESUMO Desde o grego Aellus Galenum (129 d.C. - c.200/c.216), a vertigem era considerada um problema atribu ído a um distúrbio cer...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Atlas condemned to hold up the celestial heavens and bailout the mechanical thrombectomy failures in stroke?
ABSTRACT Since the Greek Aellus Galenum (129 AD - c.200/c.216), vertigo was considered a problem attributed to a cerebral disorder, diagnosed as the manifestation of apoplectiform cerebral congestion. In the mid-19th century, the Frenchman Prosper Meni ère changed this concept by placing the origin of this symptom in the inner ear. The main objective of this historical note is to highlight who Menière was, his work, and some aspects of the disease that bears his name.RESUMO Desde o grego Aellus Galenum (129 d.C. - c.200/c.216), a vertigem era considerada um problema atribu ído a um distúrbio cer...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Severe progressive brain involvement in a patient with TRMT10C mutation
ABSTRACT Since the Greek Aellus Galenum (129 AD - c.200/c.216), vertigo was considered a problem attributed to a cerebral disorder, diagnosed as the manifestation of apoplectiform cerebral congestion. In the mid-19th century, the Frenchman Prosper Meni ère changed this concept by placing the origin of this symptom in the inner ear. The main objective of this historical note is to highlight who Menière was, his work, and some aspects of the disease that bears his name.RESUMO Desde o grego Aellus Galenum (129 d.C. - c.200/c.216), a vertigem era considerada um problema atribu ído a um distúrbio cer...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Partial persistence of the primitive lateral basilovertebral anastomosis of Padget
ABSTRACT Since the Greek Aellus Galenum (129 AD - c.200/c.216), vertigo was considered a problem attributed to a cerebral disorder, diagnosed as the manifestation of apoplectiform cerebral congestion. In the mid-19th century, the Frenchman Prosper Meni ère changed this concept by placing the origin of this symptom in the inner ear. The main objective of this historical note is to highlight who Menière was, his work, and some aspects of the disease that bears his name.RESUMO Desde o grego Aellus Galenum (129 d.C. - c.200/c.216), a vertigem era considerada um problema atribu ído a um distúrbio cer...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Prosper Menière: the man who located vertigo in the inner ear
ABSTRACT Since the Greek Aellus Galenum (129 AD - c.200/c.216), vertigo was considered a problem attributed to a cerebral disorder, diagnosed as the manifestation of apoplectiform cerebral congestion. In the mid-19th century, the Frenchman Prosper Meni ère changed this concept by placing the origin of this symptom in the inner ear. The main objective of this historical note is to highlight who Menière was, his work, and some aspects of the disease that bears his name.RESUMO Desde o grego Aellus Galenum (129 d.C. - c.200/c.216), a vertigem era considerada um problema atribu ído a um distúrbio cer...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Post-stroke aphasia in famous writers: when Neurology left geniuses speechless
ABSTRACT Aphasia is a frequent and devastating stroke complication that does not spare even great writers. In these cases, not only one of the highest cognitive functions is suddenly lost but also the act of bringing beauty into the world. Herein, we discuss the case of three writers who had to abandon their art compulsorily due to a cerebrovascular disease: Charles Baudelaire, Ralph Waldo Emerson, and Stendhal. They were magnificent writers, united by excellence in literature and an inevitable destiny that restricted their art to just a few words. They are also examples of the proximity of Neurology to Art, History, and L...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

“Migrânea” and “enxaqueca”: not opposite, but complementary words
RESUMO Neste artigo de opini ão, os autores discutem aspectos históricos e etimológicos do termo “ migr ânea ” e refutam as cr íticas mais comuns à sua adoção, pela Sociedade Brasileira de Cefaleia, na tradução oficial da Classificação Internacional das Cefaleias.ABSTRACT In this opinion paper, the authors discuss historical and etymological aspects of the term “ migr ânea ” and refute the most common criticisms regarding its adoption by the Brazilian Headache Society in the official translation of the Internati...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Evaluating subjective cognitive decline: a systematic review of tools available for evaluating cognitive complaints in Portuguese
Conclusions: In summary, SCD is still underinvestigated in Portuguese-speaking countries. The MAC-Q was the most commonly used tool in Portuguese, despite its lack of formal translation and validation for the Portuguese-speaking population. Further studies are required in order to develop and validate a screening tool that includes questions for detecting SCD-plus features and affective symptoms, so as to improve its predictive value.RESUMO Introdu ção: Declínio cognitivo subjetivo (DCS) é uma percepção não objetivamente mensurada em testes de rastreio. Apesar de muitos inst...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Acute chorea: case series from the emergency room of a Brazilian tertiary-level center
Conclusion: Acute chorea is an uncommon and challenging problem at the emergency room, often associated with potentially treatable causes. We suggest that use of the acronym DANCE (Diagnosis of chorea, Acute stroke protocol, Normal glucose levels, Check neuroimaging, Exposure to drugs) could form a potential initial approach in the evaluation, in order to emphasize causes that require prompt proper management (e.g. thrombolysis).RESUMO Introdu ção: Coreia é um distúrbio do movimento caracterizado por contrações musculares caóticas, migratórias, aleatórias e inv...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Long-term safety of azathioprine for treatment of neuromyelitis optica spectrum disorders
Conclusion: Azathioprine may be considered a safe agent for long-term treatment (>10 years) of NMOSD, but continuous vigilance for infections and malignancies is required.RESUMO Introdu ção: A azatioprina é um tratamento comum de primeira linha para os transtornos do espectro neuromielite óptica (NMOSD). Objetivo: Este estudo visou determinar a segurança do tratamento a longo prazo (>10 anos) da NMOSD com a azatioprina. M étodos: Foi realizada revisão retrospectiva de todos os prontuários de pacientes que preenchiam critérios de NMOSD de acordo com o &ldq...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Who is in charge when I have a headache? Brazilian version of the Headache-Specific Locus of Control Scale
ABSTRACT Background: Headache-Specific Locus of Control (LOC) refers to individuals ’ beliefs about their control over the onset, course and consequences of headaches. LOC beliefs have been associated with depression, coping strategies, headache-related disability and treatment outcomes. Objective: To test the cross-cultural adaptation and psychometric properties of a Brazilian version of the Headache-Specific Locus of Control Scale (HSLC). Methods: One hundred and thirty-four migraine outpatients completed the HSLC and provided measurements of psychopathological symptoms, pain catastrophizing, depression, anxiety, q...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Phytohormone abscisic acid boosts pentobarbital-induced sleep through activation of GABA-A, PPARβ and PPARγ receptor signaling
Conclusions: The data showed that ABA boosts pentobarbital-induced sleep and that GABA-A, PPAR β and PPAR γ receptors are, at least in part, involved in ABA signaling.RESUMO Introdu ção: Os distúrbios do sono induzem a ansiedade e esquecimento e mudam hábitos. Os medicamentos hipnóticos químicos utilizados atualmente têm efeitos colaterais graves e, portanto, as pessoas são atraídas para o uso de compostos naturais, como agentes de cura à base de plantas. O ácido ab scísico (ABA) é produzido em uma variedade de tecidos de m...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Predisposing factors and impact of healthcare-associated infections in patients with status epilepticus
Conclusions: HCAIs are a common complication among Ecuadorian patients with SE and were related to a lower survival rate at three months. Prolonged hospital length of stay, RSE and CCI ≥ 2 were associated with the risk of developing HCAIs.RESUMEN Antecedentes: Pocos estudios han evaluado la incidencia, los factores predisponentes y el impacto de las infecciones asociadas a los cuidados de salud (IACS) en pacientes con Estatus Epil éptico (EE). Objetivo: Evaluar los factores predisponentes de IACS en pacientes con EE y su impacto evolutivo después de tres meses. Métodos: Se realizó un an&aacut...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Cognition and chronic pain: an analysis on community-dwelling elderly caregivers and non-caregivers
Conclusion: In general, it was observed that pain-free individuals presented better performance. No relationship was observed between the factors care and pain regarding cognitive performance.RESUMO Introdu ção: Nos últimos anos, observou-se crescente número de idosos que realizam o cuidado a outro idoso no mesmo domicílio. Esses idosos estão mais susceptíveis à sobrecarga e à presença de dor crônica, sendo que a dor pode influenciar negativamente as variáveis cognitivas. Objetivo: Compa rar o desempenho e o processamento cognitivo de cuidad...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Determining the utility of minimum F-wave latency alterations in the electrodiagnosis of ulnar neuropathy at the elbow
Conclusion: Our study confirmed the utility of F-min latency measurements in the electrodiagnosis of UNE. F-wave latency differences can help in making an early diagn osis to provide better treatment options.RESUMO Introdu ção: A neuropatia ulnar do cotovelo (NUC) é a segunda neuropatia por encarceramento mais comum. Existem poucas informações sobre a aplicação dos estudos da onda F para avaliação da NUC. Objetivo: O objetivo deste estudo foi avaliar o valor diagnóstico das alterações mínimas de latên cia da onda F (F-min), com...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Increased serum chemerin levels associated with carotid intima-media thickness
This study compared 40 patients with ischemic stroke and 40 healthy subjects. Measurements were made at end-diastole using color Doppler ultrasonography (CDUS) after a 5-min rest interval in a quiet and dark room. CIMT was defined as the distance between the innermost edge of the luminal echo to the innermost edge of the media/adventitia echo. CIMT was measured in the posterior wall of both common carotid arteries within 1 cm proximally to the bulbus. Three measurements were made on both sides and the average measurement was taken as the CIMT. Serum chemerin levels were determined in all patients and healthy subjects. Resu...
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Acute chorea in adults: old and new truths
(Source: Arquivos de Neuro-Psiquiatria)
Source: Arquivos de Neuro-Psiquiatria - April 19, 2021 Category: Neurology Source Type: research

Reply to the letter “Is unilateral facial palsy truly caused by SARS-COV-2?”
ABSTRACT Roberto Melaragno Filho, an associate professor of neurology at the School of Medicine of Universidade de S ão Paulo and head of the neurology service at Hospital do Servidor Público Estadual Francisco Morato Oliveira (HSPE-FMO), had a significant scientific career. He is recognized as a reference in the 20th century Brazilian neurology in addition to having a notable international career.RESUMO Roberto Melaragno Filho, professor livre-docente em neurologia pela Faculdade de Medicina da Universidade de S ão Paulo, e chefe do serviço de neurologia do Hospital do Servidor Público E...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Is unilateral facial palsy truly caused by SARS-CoV-2?
ABSTRACT Roberto Melaragno Filho, an associate professor of neurology at the School of Medicine of Universidade de S ão Paulo and head of the neurology service at Hospital do Servidor Público Estadual Francisco Morato Oliveira (HSPE-FMO), had a significant scientific career. He is recognized as a reference in the 20th century Brazilian neurology in addition to having a notable international career.RESUMO Roberto Melaragno Filho, professor livre-docente em neurologia pela Faculdade de Medicina da Universidade de S ão Paulo, e chefe do serviço de neurologia do Hospital do Servidor Público E...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Rete middle cerebral artery: a rare variant
ABSTRACT Roberto Melaragno Filho, an associate professor of neurology at the School of Medicine of Universidade de S ão Paulo and head of the neurology service at Hospital do Servidor Público Estadual Francisco Morato Oliveira (HSPE-FMO), had a significant scientific career. He is recognized as a reference in the 20th century Brazilian neurology in addition to having a notable international career.RESUMO Roberto Melaragno Filho, professor livre-docente em neurologia pela Faculdade de Medicina da Universidade de S ão Paulo, e chefe do serviço de neurologia do Hospital do Servidor Público E...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Leptomeningeal metastasis of multiple myeloma
ABSTRACT Roberto Melaragno Filho, an associate professor of neurology at the School of Medicine of Universidade de S ão Paulo and head of the neurology service at Hospital do Servidor Público Estadual Francisco Morato Oliveira (HSPE-FMO), had a significant scientific career. He is recognized as a reference in the 20th century Brazilian neurology in addition to having a notable international career.RESUMO Roberto Melaragno Filho, professor livre-docente em neurologia pela Faculdade de Medicina da Universidade de S ão Paulo, e chefe do serviço de neurologia do Hospital do Servidor Público E...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Calcified intracranial tuberculomas as sequelae of pediatric neurotuberculosis
ABSTRACT Roberto Melaragno Filho, an associate professor of neurology at the School of Medicine of Universidade de S ão Paulo and head of the neurology service at Hospital do Servidor Público Estadual Francisco Morato Oliveira (HSPE-FMO), had a significant scientific career. He is recognized as a reference in the 20th century Brazilian neurology in addition to having a notable international career.RESUMO Roberto Melaragno Filho, professor livre-docente em neurologia pela Faculdade de Medicina da Universidade de S ão Paulo, e chefe do serviço de neurologia do Hospital do Servidor Público E...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Roberto Melaragno's scientific contributions to Brazilian Neurology
ABSTRACT Roberto Melaragno Filho, an associate professor of neurology at the School of Medicine of Universidade de S ão Paulo and head of the neurology service at Hospital do Servidor Público Estadual Francisco Morato Oliveira (HSPE-FMO), had a significant scientific career. He is recognized as a reference in the 20th century Brazilian neurology in addition to having a notable international career.RESUMO Roberto Melaragno Filho, professor livre-docente em neurologia pela Faculdade de Medicina da Universidade de S ão Paulo, e chefe do serviço de neurologia do Hospital do Servidor Público E...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Jean-Martin Charcot (1825–1893) and his second thoughts about hysteria
ABSTRACT Jean-Martin Charcot's (1825 – 1893) concepts of hysteria evolved significantly over the last 20 years of his career. In the “ Le çons du Mardi à la Salpêtrière ” (Tuesday lessons), his original conception of a “ dynamic lesion ” coexists alongside a new psychological conception, sometimes in a rather contradictory way. According to the hand-written transcript of his Tuesday lesson on February 21st, 1888, Charcot stated: “ Hysteria must be taken for what it is: psychic disease par excellence ” . However, in the printed edition of the Tuesday lesso...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Approaching glioblastoma during COVID-19 pandemic: current recommendations and considerations in Brazil
Conclusion: Approaching glioblastoma during the COVID-19 pandemic will be challenging worldwide, but particularly in Brazil, where a significant inequality of healthcare exists.RESUMO Introdu ção: Pacientes com câncer, em geral, e particularmente pacientes com glioblastoma estão sob elevado risco de desenvolver síndrome respiratória aguda grave devido à infecção pelo SARS-CoV-2, e alcançar um equilíbrio entre risco de exposição à infecção e benefício clínico do tratamen to seria o ideal. O comportame...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Impact of rapid eye movement sleep behavior disorder and autonomic disorders on Parkinson's disease: a review
This article aimed at critically reviewing the literature on the controversies about the prevalence of RBD in PD, the higher incidence of PD non-motor symptoms associated with RBD, the evidence of faster motor worsening in parkinsonian patients with this parasomnia, and the main pathophysiological hypotheses that support these findings.RESUMO A doen ça de Parkinson (DP) apresenta variadas manifestações clínicas e distintos prognósticos. É caracterizada por um conjunto de sintomas motores e não motores que podem variar desde um quadro de independência até a compl...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Impact of COVID-19 pandemic on the sleep quality of medical professionals in Brazil
Conclusion: Our study found that more than 70% of the physicians assessed had impaired sleep quality, characterizing insomnia symptoms during COVID-19 outbreak. Related factors included an environment of isolation, concerns about COVID-19 outbreak and symptoms of anxiety and depression. Special interventions are needed to promote health professionals ’ mental well-being and implement changes in this scenario.RESUMO Introdu ção: A pandemia de coronavírus iniciada na China em 2019 (COVID-19) não só causou problemas de saúde pública mas também trouxe grande sofrime...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Exposure to electromagnetic field, cell phone use behaviors, SAR values, and changes in health following exposure in adolescent university students
Conclusions: Participants exhibited high levels of cell phone use and experienced biological, behavioral, and sleep problems. They also had very little knowledge about specific SAR values, an important criterion concerning cell phones.RESUMO Introdu ção: O uso de dispositivos tecnológicos está crescendo rapidamente e o uso de telefone celulares aumenta em paralelo. A dependência de dispositivos tecnológicos é um fator nesse aumento de exposição. Diversos estudos sobre o campo eletromagnético foram realizados, mas nenhuma conclusão de finitiva foi a...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Older adults with epilepsy: memory complaints and objective neuropsychological performance
Conclusions: OAE presented worse cognitive performance and greater memory complaints. Episode onset at ≥ 60 years of age was associated with complaints, but not with objective cognitive deficit. We found an association between subjective and objective cognitive performance, with aspects of epilepsy and worse QoL scores.RESUMO Introdu ção: A queixa de memória fraca é frequente em pessoas com epilepsia. Objetivo: Avaliar a ocorrência de queixas de memória em idosos com epilepsia (IE) e se há associação com variáveis clínicas, desempenho cognitivo ...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Managing intrathecal administration of nusinersen in adolescents and adults with 5q-spinal muscular atrophy and previous spinal surgery
Conclusion: In SMA patients with previous spinal surgery, the use of imaging-guided intervention is necessary for administering intrathecal nusinersen. Transforaminal technique is indicated in patients for whom the interlaminar space is not available, and injections should always be guided by either CT or fluoroscopy.RESUMO Introdu ção: A atrofia muscular espinal (AME) é uma desordem neurodegenerativa dos motoneurônios inferiores frequentemente associada à ocorrência de deformidade da coluna vertebral. Nusinersena é um oligonucleotídeo antisense que aumenta os ní...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Prevalence of multiple sclerosis in key cities of Brazil. A study in Joinville, Southern Brazil
Conclusions: Despite its latitude location and European colonization, the prevalence rate was below expectation. The intense internal migration from regions with lower MS prevalence rates to Joinville may have played a role in attenuating the increased risk of MS associated with latitude gradient and European ancestry. Prevalence studies in other cities from Southern Brazil with no significant internal migration and taking part in this broad project may clarify this issue.RESUMO Introdu ção: O Comitê Brasileiro de Tratamento e Pesquisa em Esclerose Múltipla (EM) (BCTRIMS) lançou uma inicia...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Parkinson's disease effect on autonomic modulation: an analysis using geometric indices
Conclusions: The results suggest a reduction in the parasympathetic autonomic modulation and global variability in individuals with PD compared to controls, regardless of sex, age, and bod y mass index.RESUMO Introdu ção: A doença de Parkinson (DP) produz alterações autonômicas, que indicam menor modulação parassimpática e variabilidade global, mas que devem ser investigadas quanto aos métodos geométricos. Objetivo: Investigar a modulação autonômica em indivíduos com DP, por meio de índices de v ariabilidade da fre...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Knowledge and attitudes in dementia held by general practitioners in the primary care setting of Botucatu, São Paulo, Brazil
The objective of this study was to assess the knowledge of and attitudes toward dementia held by GPs from a city in the interior of S ão Paulo State, Brazil. Methods: A non-randomized intervention study was conducted involving six lectures about dementia. Before and after the intervention, the participating physicians completed two quizzes about knowledge of and attitudes towards dementia. The study was carried out in the primar y care services of the town and a total of 34 GPs participated in the study. Results: The mean age of the sample was 33.9 (±10.2) years and the majority (76.5%) of the sample had not ...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Small vessel occlusion and syphilis in patients with first-ever ischemic stroke
ABSTRACT Background: Syphilis is an endemic disease, particularly in low- and middle-income countries, with vascular involvement in large vessels (aortitis), but no clear relationship with stroke patients, except for those who presented with meningovascular neurosyphilis. Objective: To investigate the relationship between a positive history of syphilis determined by serological testing and ischemic stroke etiology, particularly small vessel disease (SVD). Methods: In total, 269 first-ever ischemic stroke patients admitted to the stroke unit were tested for syphilis. Patients with neurosyphilis were excluded. All patients w...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

The relationship of syphilis to small vessel stroke in the absence of neurosyphilis: real or imaginary?
(Source: Arquivos de Neuro-Psiquiatria)
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Thanks to Editorial Board of Arquivos de Neuro-Psiquiatria
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Reply to the letter “Multifocal T2-/DWI-hyperintense cerebral lesions in COVID-19 not necessarily imply demyelination”
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Multifocal T2-/DWI-hyperintense cerebral lesions in COVID-19 not necessarily imply demyelination
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Solitaire stent retriever failure during thrombectomy: is there any image that can predict non-recanalization?
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Facial paralysis in the acute form of Chagas disease
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Complicated retropharyngeal abscess: an atypical cause of myelopathy
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

The controversial Third Reich history of Hans Creutzfeldt: was he a supporter or just another adept of the “hand washing policy”?
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Denny-Brown and Pennybacker: 80 years after their pioneering article on electromyography, fibrillation and fasciculation
We present a historical review, highlighting the role of Professor Derek Denny-Brown and doctor Joseph Buford Pennybacker in the development of current electromyography (EMG), of the 80 years since the publication of his original report in 1938 on fasciculation and fibrillation potentials and the subsequent studies describing most of the electrical changes necessary to perform and interpret the EMG.RESUMO Os autores apresentam uma revis ão histórica destacando o papel do Professor Derek Denny-Brown e do doutor Joseph Buford Pennybacker no desenvolvimento da eletromiografia atual, ao longo dos oitenta anos de ...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Acute hepatic porphyrias for the neurologist: current concepts and perspectives
Conclusions: This review article highlights the main biochemical, pathophysiological, clinical, and therapeutic aspects of acute hepatic porphyrias in clinical practice.RESUMO Introdu ção: As porfirias hepáticas agudas representam um grupo de doenças metabólicas hereditárias complexas em expansão, decorrentes de erros inatos do metabolismo, envolvendo a via de biossíntese do grupamento heme. Objetivo: realizar revisão dos principais aspectos clínicos e terapêuticos as sociados com as porfirias hepáticas agudas. Métodos: Os autores rea...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Blood-cerebrospinal fluid (CSF) barrier dysfunction means reduced CSF flow not barrier leakage - conclusions from CSF protein data
Conclusion: Blood-CSF and blood-brain barrier dysfunctions are an expression of reduced CSF or ISF flow rate.RESUMO Introdu ção: Concentrações aumentadas de proteínas séricas no líquido cefalorraquidiano são interpretadas como disfunção da barreira (hemato-liquórica) sanguínea do LCR. Interpretações frequentemente usadas, como vazamento de barreira (quebra ou rompimento de barreira), rompimento ou quebra, contradiz os dados de proteína do LCR, que sugerem uma taxa de fluxo reduzida do LCR como a causa. Resultados: Mesmo...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Trigeminal neuralgia recurrence: a comparison of microvascular decompression and percutaneous balloon compression: a five years follow-up study
Conclusions: MD presented with a more precocious recurrence of pain than PBC in this article. Moreover, it had a higher recurrence rate than described in the literature as well, which is possibly explained by the type of graft (muscle) that was used to separate the neurovascular structures.RESUMO Introdu ção: Cerca de 50% dos pacientes com neuralgia do trigêmeo não apresenta benefícios a longo prazo com o uso de medicação oral. Para a manutenção do tratamento, algumas opções cirúrgicas estão disponíveis, sendo a compressã...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

The impact of physical functions on depressive symptoms in people with multiple sclerosis
Conclusions: Impairment in physical functions consists in a potential predictor of depressive symptoms in people with MS. Exercise interventions aiming at the improvement of physical functions, together with the treatment of depressive symptoms and conventional medical treatment, are suggested.RESUMO Introdu ção: A esclerose múltipla (EM) é uma doença imunomediada que afeta o sistema nervoso central. O impacto da doença transcende as funções físicas e se estende a comprometimento psicológico. Aproximadamente 50% das pessoas com EM desenvolvem sintomas de...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Is restless legs syndrome in Parkinson disease patients associated with any specific factor?
Conclusion: Restless legs syndrome is a prevalent condition in patients with Parkinson disease and is associated with specific characteristics in this group of patients.RESUMO Introdu ção: A síndrome das pernas inquietas, ou doença de Willis-Ekbom, é um transtorno caracterizado por sensações de desconforto associadas à necessidade de movimentar os membros inferiores. Nos pacientes com doença de Parkinson, a síndrome das pernas inquietas está associada a uma qualidade de vida inferior e sonolência excessiva. Em relação a outros ...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Multimorbidity and associated outcomes among older adult inpatients with neurological disorders
ABSTRACT Background: Multimorbidity is common among adults and associated with socioeconomic deprivation, polypharmacy, poor quality of life, functional impairment, and mortality. Objectives: To identify the frequency of multimorbidity among older adults inpatients with neurological disorders (NDs), stratify clusters of chronic comorbidities associated with NDs in degrees, and verify whether multimorbidity was associated with demographic data, readmission, long length of hospital stay (LOS), and hospital mortality in this population. Methods: We enrolled patients aged ≥ 60 years successively admitted to a tertiary medic...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research