Thanks to Editorial Board of Arquivos de Neuro-Psiquiatria
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Reply to the letter “Multifocal T2-/DWI-hyperintense cerebral lesions in COVID-19 not necessarily imply demyelination”
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Multifocal T2-/DWI-hyperintense cerebral lesions in COVID-19 not necessarily imply demyelination
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Solitaire stent retriever failure during thrombectomy: is there any image that can predict non-recanalization?
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Facial paralysis in the acute form of Chagas disease
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Complicated retropharyngeal abscess: an atypical cause of myelopathy
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

The controversial Third Reich history of Hans Creutzfeldt: was he a supporter or just another adept of the “hand washing policy”?
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, b...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Denny-Brown and Pennybacker: 80 years after their pioneering article on electromyography, fibrillation and fasciculation
We present a historical review, highlighting the role of Professor Derek Denny-Brown and doctor Joseph Buford Pennybacker in the development of current electromyography (EMG), of the 80 years since the publication of his original report in 1938 on fasciculation and fibrillation potentials and the subsequent studies describing most of the electrical changes necessary to perform and interpret the EMG.RESUMO Os autores apresentam uma revis ão histórica destacando o papel do Professor Derek Denny-Brown e do doutor Joseph Buford Pennybacker no desenvolvimento da eletromiografia atual, ao longo dos oitenta anos de ...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Acute hepatic porphyrias for the neurologist: current concepts and perspectives
Conclusions: This review article highlights the main biochemical, pathophysiological, clinical, and therapeutic aspects of acute hepatic porphyrias in clinical practice.RESUMO Introdu ção: As porfirias hepáticas agudas representam um grupo de doenças metabólicas hereditárias complexas em expansão, decorrentes de erros inatos do metabolismo, envolvendo a via de biossíntese do grupamento heme. Objetivo: realizar revisão dos principais aspectos clínicos e terapêuticos as sociados com as porfirias hepáticas agudas. Métodos: Os autores rea...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Blood-cerebrospinal fluid (CSF) barrier dysfunction means reduced CSF flow not barrier leakage - conclusions from CSF protein data
Conclusion: Blood-CSF and blood-brain barrier dysfunctions are an expression of reduced CSF or ISF flow rate.RESUMO Introdu ção: Concentrações aumentadas de proteínas séricas no líquido cefalorraquidiano são interpretadas como disfunção da barreira (hemato-liquórica) sanguínea do LCR. Interpretações frequentemente usadas, como vazamento de barreira (quebra ou rompimento de barreira), rompimento ou quebra, contradiz os dados de proteína do LCR, que sugerem uma taxa de fluxo reduzida do LCR como a causa. Resultados: Mesmo...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Trigeminal neuralgia recurrence: a comparison of microvascular decompression and percutaneous balloon compression: a five years follow-up study
Conclusions: MD presented with a more precocious recurrence of pain than PBC in this article. Moreover, it had a higher recurrence rate than described in the literature as well, which is possibly explained by the type of graft (muscle) that was used to separate the neurovascular structures.RESUMO Introdu ção: Cerca de 50% dos pacientes com neuralgia do trigêmeo não apresenta benefícios a longo prazo com o uso de medicação oral. Para a manutenção do tratamento, algumas opções cirúrgicas estão disponíveis, sendo a compressã...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

The impact of physical functions on depressive symptoms in people with multiple sclerosis
Conclusions: Impairment in physical functions consists in a potential predictor of depressive symptoms in people with MS. Exercise interventions aiming at the improvement of physical functions, together with the treatment of depressive symptoms and conventional medical treatment, are suggested.RESUMO Introdu ção: A esclerose múltipla (EM) é uma doença imunomediada que afeta o sistema nervoso central. O impacto da doença transcende as funções físicas e se estende a comprometimento psicológico. Aproximadamente 50% das pessoas com EM desenvolvem sintomas de...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Is restless legs syndrome in Parkinson disease patients associated with any specific factor?
Conclusion: Restless legs syndrome is a prevalent condition in patients with Parkinson disease and is associated with specific characteristics in this group of patients.RESUMO Introdu ção: A síndrome das pernas inquietas, ou doença de Willis-Ekbom, é um transtorno caracterizado por sensações de desconforto associadas à necessidade de movimentar os membros inferiores. Nos pacientes com doença de Parkinson, a síndrome das pernas inquietas está associada a uma qualidade de vida inferior e sonolência excessiva. Em relação a outros ...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Multimorbidity and associated outcomes among older adult inpatients with neurological disorders
ABSTRACT Background: Multimorbidity is common among adults and associated with socioeconomic deprivation, polypharmacy, poor quality of life, functional impairment, and mortality. Objectives: To identify the frequency of multimorbidity among older adults inpatients with neurological disorders (NDs), stratify clusters of chronic comorbidities associated with NDs in degrees, and verify whether multimorbidity was associated with demographic data, readmission, long length of hospital stay (LOS), and hospital mortality in this population. Methods: We enrolled patients aged ≥ 60 years successively admitted to a tertiary medic...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Trends in prescribing patterns of antiepileptic drugs among older adult inpatients in a Brazilian tertiary center
ABSTRACT Background: Data on prescribing patterns of antiepileptic drugs (AEDs) to older adult inpatients are limited. Objective: To assess changes in prescribing patterns of AEDs to older adult inpatients with late-onset epilepsy between 2009-2010 and 2015-2019, and to interpret any unexpected patterns over the 2015-2019 period. Methods: Patients aged ≥ 60 years with late-onset epilepsy from a tertiary center were selected. Demographic data, seizure characteristics and etiology, comorbidities, and comedications were analyzed, in addition to prescription regimens of inpatients taking AEDs to treat epilepsy. AED regimens...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Simultaneous electrocardiogram during routine electroencephalogram: arrhythmia rates through the eyes of the cardiologist
Conclusions: A considerably high rate of arrhythmia cases was determined on simultaneous ECG during routine EEG after being interpreted by a cardiologist. However, the screening results of EEG reports revealed relatively low arrhythmia rates. These results suggest that the detection rates of ECG abnormalities during routine EEG may be potentially improved.RESUMO Introdu ção: A importância do registro simultâneo de eletrocardiograma (ECG) de duas derivações durante o eletroencefalograma (EEG) de rotina foi relatada várias vezes por motivos clínicos. Objetivos: Investigar...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Swallowing in behavioral variant frontotemporal dementia
ABSTRACT Background: Swallowing and feeding problems may occur with the progression of behavioral variant frontotemporal dementia (bvFTD) and can impair the anticipatory and oral preparatory phases of swallowing. Objective: To characterize swallowing problems and the feeding situation of patients with bvFTD and to correlate the swallowing problems with functionality, executive functions, cognitive and behavioral features. Methods: Consecutive outpatients with bvFTD in mild, moderate and severe dementia stages were recruited along with their caregivers. Patients and caregivers were screened with the following scales: &ldquo...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Realistic simulation is associated with healthcare professionals’ increased self-perception of confidence in providing acute stroke care: a before-after controlled study
Conclusions: This stroke realistic simulation course was associated with an improvement on trainees ’ self-perception of confidence in providing acute stroke care.RESUMO Introdu ção: Simulações são amplamente utilizadas na educação médica, mas há pouca evidência de sua eficácia no tratamento de pacientes neurocríticos. Como o acidente vascular cerebral agudo (AVC) é uma patologia que requer atendimento imediato, o uso de simulação pode ser uma ferramenta út il no treinamento do manejo desses pacientes. Objet...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

EEG-EKG, or when 1 + 1 is more than 2
(Source: Arquivos de Neuro-Psiquiatria)
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Telemedicine in neurology: current evidence
Conclusion: Current evidence supports that teleneurology can be a tool to increase care for patients suffering from neurological diseases.RESUMO Introdu ção: A telemedicina surge pela primeira vez na neurologia como uma ferramenta para facilitar o acesso ao tratamento do acidente vascular cerebral (AVC) Agudo. Mais recentemente, inúmeras evidências têm surgido acerca da eficácia e da segurança do uso da telemedicina em várias outras áreas d a neurologia. Com o advento da pandemia de COVID-19 e a necessidade de isolamento social, as autoridades brasileiras flexibi...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Neuroimaging and ophthalmologic findings in incomplete Susac syndrome
ABSTRACT The authors review the role of Jules Bernard Luys in the discovery of the subthalamic nucleus (STN) over 150 years ago. The relationships between the STN and movement disorders, particularly hemiballismus and Parkinson ’ s disease, are well known. The academic life of Jules Bernard Luys can be divided into two periods: a brilliant start as a neuroanatomist, culminating in the discovery of the STN, followed by a second period marked by a shift in his academic activity and an increased interest in topics such as hysteria, hypnotism and, eventually, esotericism.RESUMO Os autores revisam o papel de Jules Bernard...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Acute parkinsonism and bilateral basal ganglia lesions
ABSTRACT The authors review the role of Jules Bernard Luys in the discovery of the subthalamic nucleus (STN) over 150 years ago. The relationships between the STN and movement disorders, particularly hemiballismus and Parkinson ’ s disease, are well known. The academic life of Jules Bernard Luys can be divided into two periods: a brilliant start as a neuroanatomist, culminating in the discovery of the STN, followed by a second period marked by a shift in his academic activity and an increased interest in topics such as hysteria, hypnotism and, eventually, esotericism.RESUMO Os autores revisam o papel de Jules Bernard...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Malignant cerebral edema: an unusual neurological manifestation of systemic lupus erythematosus
ABSTRACT The authors review the role of Jules Bernard Luys in the discovery of the subthalamic nucleus (STN) over 150 years ago. The relationships between the STN and movement disorders, particularly hemiballismus and Parkinson ’ s disease, are well known. The academic life of Jules Bernard Luys can be divided into two periods: a brilliant start as a neuroanatomist, culminating in the discovery of the STN, followed by a second period marked by a shift in his academic activity and an increased interest in topics such as hysteria, hypnotism and, eventually, esotericism.RESUMO Os autores revisam o papel de Jules Bernard...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Jules Bernard Luys: from a description of the subthalamic nucleus to hypnotism
ABSTRACT The authors review the role of Jules Bernard Luys in the discovery of the subthalamic nucleus (STN) over 150 years ago. The relationships between the STN and movement disorders, particularly hemiballismus and Parkinson ’ s disease, are well known. The academic life of Jules Bernard Luys can be divided into two periods: a brilliant start as a neuroanatomist, culminating in the discovery of the STN, followed by a second period marked by a shift in his academic activity and an increased interest in topics such as hysteria, hypnotism and, eventually, esotericism.RESUMO Os autores revisam o papel de Jules Bernard...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Acute Disseminated Encephalomyelitis in COVID-19: presentation of two cases and review of the literature
Conclusion: A recurrent pattern of multifocal white matter lesions can occur in COVID-19 patients, possibly associated with delayed awakening. Additional studies are necessary to elucidate the role of the viral infection and of inflammatory and immune-mediated assoc iated changes in neurological manifestations of COVID-19.RESUMO Introdu ção: As manifestações neurológicas causadas pela COVID-19 ainda não estão completamente elucidadas. O comprometimento neurológico pode decorrer de um efeito viral direto em neurônios ou em células gliais, a efeito imunomed...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

A clinical approach to hypertrophic pachymeningitis
Conclusion: HP is a manifestation of several diseases, and a precise etiological diagnosis is crucial because of the difference among treatments. An extensive investigation of patients with HP helps early diagnosis and correct treatment.RESUMO Import ância: Paquimeningite hipertrófica (PH) é uma manifestação não usual de doenças reumatológicas, infecciosas e neoplásicas. O diagnóstico etiológico por vezes é um desafio, entretanto quando realizado em tempo cria uma janela de tratamento com a possibilidade de reversão total dos sintom a...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Differentiation of relapsing-remitting and secondary progressive multiple sclerosis: a magnetic resonance spectroscopy study based on machine learning
Conclusions: A combined analysis of MRS and computer-aided diagnosis may be useful as a complementary imaging technique to determine MS types.RESUMO Introdu ção: A ressonância magnética é a ferramenta mais importante para o diagnóstico e acompanhamento na EM. A transição da EM recorrente-remitente (EMRR) para a EM progressiva secundária (EMPS) é clinicamente difícil e seria importante desenvolver a proposta apresentada neste estudo a fim de contribuir com o processo. Objetivo: o objetivo deste estudo foi garantir a classificação autom...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Uric acid as a marker of severity of obstructive sleep apnoea syndrome in older patients
Conclusions: No relationship was observed between uric acid level and OSAS severity, as defined by the apnoea-hypopnea index. Further studies are needed to determine the value of uric acid as a marker of OSAS, after controlling for cardiovascular comorbidities, in older patients with this syndrome.RESUMO Objetivo: o ácido úrico mostrou estar relacionado à gravidade da síndrome da apneia obstrutiva do sono (SAOS) em adultos. Avaliamos o papel do ácido úrico na SAOS em uma coorte de pacientes idosos. Métodos: Um total de 164 pacientes com idade>65 anos, admitidos em nosso l...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Impulsivity prevalence in migraine patients without and with medication overuse
Conclusions: It was not possible to establish a clear connection between migraine and impulsive behavior. Association was higher among migraineurs without medication overuse.RESUMO Introdu ção: A enxaqueca é uma das condições mais comuns na prática clínica neurológica, enquadrando-se no grupo das cefaleias primárias. Sua prevalência é maior na faixa etária de 25 a 55 anos, coincidindo com o pico da produtividade econômica. Muitos pacientes recorrem ao uso abusivo de anal gésicos. O uso excessivo desses medicamentos é defi...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Depression is a major determinant of sleep abnormalities in patients with epilepsy
Conclusion: We concluded that depression rather than epilepsy negatively affects sleep, suggesting that all patients should be asked about their mood and sleep complaints.RESUMO Introdu ção: O objetivo deste estudo foi identificar distúrbios do sono em pacientes com epilepsia e compará-los com uma população saudável. Também foram examinadas as características dos distúrbios do sono em pacientes com epilepsia para demonstrar o efeito e os tipos de convulsões no sono. Mé todos: O estudo consistiu em 43 pacientes com epilepsia e 53 controles s...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Dementias in Brazil: increasing burden in the 2000–2016 period. Estimates from the Global Burden of Disease Study 2016
Conclusion: Population growth and aging have resulted in an increased burden of AD and other dementias in Brazil. Preventive and early diagnostic measures are essential to mitigate the burden associated with these diseases.RESUMO Introdu ção: A demência é um problema de saúde globalmente relevante, com grande carga para os pacientes e suas famílias. Este estudo teve como objetivo estimar a carga associada à doença de Alzheimer (DA) e outras demências no Brasil. Métodos: Neste estudo descritivo, foram avaliadas as estimati vas obtidas pelo estudo de Carga G...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

The use of e-ASPECTS in acute stroke care: validation of method performance compared to the performance of specialists
Conclusion: e-ASPECTS is a validated and reliable tool for determining early signs of ischemia in NCCT.RESUMO Introdu ção: A avaliação rápida da tomografia de crânio sem contraste (TCSC) em pacientes com AVC de circulação anterior economiza tempo e permite um tratamento rápido e otimizado. O e-ASPECTS é um software que calcula automaticamente os valores do ASPECTS e permite uma avaliação da imagem mais precisa e ágil. Objetivo: Determinar a habilidade do e-ASPECTS em diferenciar imagens com e sem lesão. Métodos: Cento e ...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Burden of dementia in Brazil
(Source: Arquivos de Neuro-Psiquiatria)
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Facial palsy as a neurological complication of SARS-CoV-2
ABSTRACT Epilepsy is one of the most dreaded and terrifying human afflictions. One of the many names it has received was Sacred Disease, during Greek times. Heracles served as a source of the divine connotation that epilepsy received in ancient times, as he was one of the most important demigods in Greek mythology. However, several authors have attributed Heracles ’ actions to a seizure, including Hippocrates, who described the sacred disease on his “ Corpus Hippocraticum. ” This paper reviewed some of the publications on the myth and content of the text of Hippocrates, in relation to the current knowledg...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Possible acute multifocal demyelinating lesions in a COVID-19 patient
ABSTRACT Epilepsy is one of the most dreaded and terrifying human afflictions. One of the many names it has received was Sacred Disease, during Greek times. Heracles served as a source of the divine connotation that epilepsy received in ancient times, as he was one of the most important demigods in Greek mythology. However, several authors have attributed Heracles ’ actions to a seizure, including Hippocrates, who described the sacred disease on his “ Corpus Hippocraticum. ” This paper reviewed some of the publications on the myth and content of the text of Hippocrates, in relation to the current knowledg...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Pontine hot cross bun sign in spinocerebellar ataxia type 2
ABSTRACT Epilepsy is one of the most dreaded and terrifying human afflictions. One of the many names it has received was Sacred Disease, during Greek times. Heracles served as a source of the divine connotation that epilepsy received in ancient times, as he was one of the most important demigods in Greek mythology. However, several authors have attributed Heracles ’ actions to a seizure, including Hippocrates, who described the sacred disease on his “ Corpus Hippocraticum. ” This paper reviewed some of the publications on the myth and content of the text of Hippocrates, in relation to the current knowledg...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Spinal cord compression due to extramedullary hematopoiesis in beta-thalassemia
ABSTRACT Epilepsy is one of the most dreaded and terrifying human afflictions. One of the many names it has received was Sacred Disease, during Greek times. Heracles served as a source of the divine connotation that epilepsy received in ancient times, as he was one of the most important demigods in Greek mythology. However, several authors have attributed Heracles ’ actions to a seizure, including Hippocrates, who described the sacred disease on his “ Corpus Hippocraticum. ” This paper reviewed some of the publications on the myth and content of the text of Hippocrates, in relation to the current knowledg...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Heracles and epilepsy: the sacred disease
ABSTRACT Epilepsy is one of the most dreaded and terrifying human afflictions. One of the many names it has received was Sacred Disease, during Greek times. Heracles served as a source of the divine connotation that epilepsy received in ancient times, as he was one of the most important demigods in Greek mythology. However, several authors have attributed Heracles ’ actions to a seizure, including Hippocrates, who described the sacred disease on his “ Corpus Hippocraticum. ” This paper reviewed some of the publications on the myth and content of the text of Hippocrates, in relation to the current knowledg...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Intracerebral hemorrhage: update and future directions
ABSTRACT Intracerebral hemorrhage (ICH), defined as bleeding into the brain parenchyma, is a significant public health issue. Although it accounts for only 10 to 15% of strokes, it is associated with the highest morbidity and mortality rates. Despite advances in the field of stroke and neurocritical care, the principles of acute management have fundamentally remained the same over many years. The main treatment strategies include aggressive blood pressure control, early hemostasis, reversal of coagulopathies, clot evacuation through open surgical or minimally invasive surgical techniques, and the management of raised intra...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Current uses of intracranial vessel wall imaging for clinical practice: a high-resolution MR technique recently available
ABSTRACT Intracranial vessel wall imaging plays an increasing role in diagnosing intracranial vascular diseases. With the growing demand and subsequent increased use of this technique in clinical practice, radiologists and neurologists should be aware of the choices in imaging parameters and how they affect image quality, clinical indications, methods of assessment, and limitations in the interpretation of these images. Due to the improvement of the MRI techniques, the possibility of accurate and direct evaluation of the abnormalities in the arterial vascular wall (vessel wall imaging) has evolved, adding substantial data ...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Dietary habits in a group of patients with multiple sclerosis are similar to those of healthy control subjects
Conclusion: The dietary patterns of patients with MS and healthy controls were similar in the city of Santos, S ão Paulo, Brazil, and surrounding towns, except for higher intake of carbohydrates by patients. No profile of pro-inflammatory diets was identified among the patients with MS enrolled in this study.RESUMO Introdu ção: Esclerose múltipla (EM) é uma doença crônica e autoimune do sistema nervoso central. Ao longo do tempo, pacientes com EM acumulam incapacidades neurológicas. A EM tipicamente afeta adultos jovens e se associa a um perfil inflamatório de c...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Validation of the Brazilian Portuguese version of the Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire (RBDSQ-BR)
Conclusions: RBDSQ-BR is a reliable instrument, which may be useful for RBD diagnosis of Brazilian patients with PD. The instrument is also valid and may help in a better selection of cases for a more detailed clinical evaluation or even PSG analysis.RESUMO Introdu ção: O diagnóstico do transtorno comportamental do sono REM (TCSREM) implica na realização da polissonografia (PSG), mas sua disponibilidade pode não ser suficiente. Portanto, meios clínicos para o diagnóstico podem ser úteis. Objetivo: Validar para a língua portuguesa falada no Brasil o quest...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Validation of 19-items wearing-off (WOQ-19) questionnaire to Portuguese
ABSTRACT Background: The treatment of Parkinson disease with dopaminergic therapy improves functionality and quality of life. However, as the disease progresses, the wearing-off phenomenon develops. To improve the recognition of this phenomenon, the 19-item wearing-off questionnaire (WOQ-19) was developed. Objective: To translate and validate the WOQ-19 into Portuguese. Methods: The questionnaire was translated into Portuguese and, subsequently, back-translated into English and analyzed. The final version was tested in Parkinson disease patients for reliability through the test-retest paradigm and internal consistency. Als...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Electroacupuncture alleviates inflammatory pain via adenosine suppression and its mediated substance P expression
Conclusion: Our results indicate regulation of adenosine-mediated substance P secretion. Substance P-mediated pathway may be involved in the analgesia process by electroacupuncture in rats.RESUMO Introdu ção: A acupuntura tem sido amplamente utilizada para alívio de dor. No entanto, seus mecanismos são muito pouco conhecidos. Objetivo: Investigar a relação entre o efeito analgésico da eletroacupuntura e a regulação da expressão de adenosina e de substância P. Métodos: Utilizou-se um modelo de dor inflamatória crônica em ratos po...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Analysis of YouTube as a source of information for restless leg syndrome
Conclusions: This study demonstrates that 77% of the videos uploaded on YouTube regarding RLS are in the useful category, whereas only 16 videos were providing misleading information. However, even videos in the useful category do not provide a full and complete description of the RLS.RESUMO Introdu ção: O YouTube é um dos principais recursos no mundo para vídeos relacionados à saúde. Objetivo: O objetivo deste estudo foi avaliar a qualidade das informações disponíveis no YouTube sobre a síndrome das pernas inquietas (SPI). Métodos: Realizou-se um...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Enriched environment alleviates post-stroke cognitive impairment through enhancing α7-nAChR expression in rats
Conclusions: EE markedly improves cognitive impairment and enhances neuroplasticity in PSCI rats, which may be closely related to enhancement of α 7-nAChR expression.RESUMO Introdu ção: O ambiente enriquecido (AE) é uma intervenção simples e eficaz para melhorar a função cognitiva no comprometimento cognitivo pós-AVC, em parte devido ao reequilíbrio da via de sinalização colinérgica no hipocampo. O receptor nicotínico α 7 de acetilcolina ( α 7-nAChR) é um receptor colinérgico cuja ativaçã...
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

REM Behavior Disorder diagnostic challenges
(Source: Arquivos de Neuro-Psiquiatria)
Source: Arquivos de Neuro-Psiquiatria - November 2, 2020 Category: Neurology Source Type: research

Erratum: Association between executive and food functions in the acute phase after stroke
ABSTRACT Aloysio de Castro (1881-1959) is now remembered as one of Brazil's greatest physicians and is considered the father of Brazilian neurological semiology. However, his interests went far beyond the realm of Medicine, and he became one of the most illustrious intellectuals of his time. In 1927, he gave a speech at the S ão Paulo Society of Artistic Culture on Frédéric Chopin and embarked on a journey across the composer's life and times, discussing the medical issues involving his death, as well as his lovers, his compositions, and the spiritual aspects of musical interpretation. Thus, Castro rei...
Source: Arquivos de Neuro-Psiquiatria - October 7, 2020 Category: Neurology Source Type: research

Symptomatic female carriers of mutations in the Duchenne muscular dystrophy gene
ABSTRACT Aloysio de Castro (1881-1959) is now remembered as one of Brazil's greatest physicians and is considered the father of Brazilian neurological semiology. However, his interests went far beyond the realm of Medicine, and he became one of the most illustrious intellectuals of his time. In 1927, he gave a speech at the S ão Paulo Society of Artistic Culture on Frédéric Chopin and embarked on a journey across the composer's life and times, discussing the medical issues involving his death, as well as his lovers, his compositions, and the spiritual aspects of musical interpretation. Thus, Castro rei...
Source: Arquivos de Neuro-Psiquiatria - October 7, 2020 Category: Neurology Source Type: research

Migrainous periorbital ecchymosis
ABSTRACT Aloysio de Castro (1881-1959) is now remembered as one of Brazil's greatest physicians and is considered the father of Brazilian neurological semiology. However, his interests went far beyond the realm of Medicine, and he became one of the most illustrious intellectuals of his time. In 1927, he gave a speech at the S ão Paulo Society of Artistic Culture on Frédéric Chopin and embarked on a journey across the composer's life and times, discussing the medical issues involving his death, as well as his lovers, his compositions, and the spiritual aspects of musical interpretation. Thus, Castro rei...
Source: Arquivos de Neuro-Psiquiatria - October 7, 2020 Category: Neurology Source Type: research