Clinically significant differences: what to choose?
Abstract A unique association joins Guillaume Apollinaire, Blaise Cendrars and Louis Ferdinand C éline. Besides being great exponents of French literature, they were all neurologically wounded during the First World War. Apollinaire had a traumatic brain injury, Cendrars developed phantom limb neuropathic pain and Céline presented radial nerve paralysis. There is quite an evidence that suppor ts that their artistic output was also influenced by acquired neurological conditions during the war. The examples of these three French authors reveal the surprising intimacy Neurology can share with art and history.Res...
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

Bilateral trochlear nerve palsy due to cerebral vasculitis related to COVID-19 infection
Abstract A unique association joins Guillaume Apollinaire, Blaise Cendrars and Louis Ferdinand C éline. Besides being great exponents of French literature, they were all neurologically wounded during the First World War. Apollinaire had a traumatic brain injury, Cendrars developed phantom limb neuropathic pain and Céline presented radial nerve paralysis. There is quite an evidence that suppor ts that their artistic output was also influenced by acquired neurological conditions during the war. The examples of these three French authors reveal the surprising intimacy Neurology can share with art and history.Res...
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

Hippocampal sclerosis in paracoccidioidomycosis
Abstract A unique association joins Guillaume Apollinaire, Blaise Cendrars and Louis Ferdinand C éline. Besides being great exponents of French literature, they were all neurologically wounded during the First World War. Apollinaire had a traumatic brain injury, Cendrars developed phantom limb neuropathic pain and Céline presented radial nerve paralysis. There is quite an evidence that suppor ts that their artistic output was also influenced by acquired neurological conditions during the war. The examples of these three French authors reveal the surprising intimacy Neurology can share with art and history.Res...
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

Aniridia as a clue for the diagnosis of Gillespie syndrome
Abstract A unique association joins Guillaume Apollinaire, Blaise Cendrars and Louis Ferdinand C éline. Besides being great exponents of French literature, they were all neurologically wounded during the First World War. Apollinaire had a traumatic brain injury, Cendrars developed phantom limb neuropathic pain and Céline presented radial nerve paralysis. There is quite an evidence that suppor ts that their artistic output was also influenced by acquired neurological conditions during the war. The examples of these three French authors reveal the surprising intimacy Neurology can share with art and history.Res...
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

The neurology behind three wounded French artists during the great world war
Abstract A unique association joins Guillaume Apollinaire, Blaise Cendrars and Louis Ferdinand C éline. Besides being great exponents of French literature, they were all neurologically wounded during the First World War. Apollinaire had a traumatic brain injury, Cendrars developed phantom limb neuropathic pain and Céline presented radial nerve paralysis. There is quite an evidence that suppor ts that their artistic output was also influenced by acquired neurological conditions during the war. The examples of these three French authors reveal the surprising intimacy Neurology can share with art and history.Res...
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

Neuroimaging investigation of memory changes in migraine: a systematic review
Conclusions: Migraine is associated to global dysfunction of multisensory integration and memory processing. This condition changes the activity of structures in various regions related to memory of pain, prospective memory, as well as in short- and long-term verbal and visuospatial memories. However, it is necessary to perform studies with larger samples in association with cognitive tests, and without the interference of medications to verify possible alterations and to draw more concrete conclusions.RESUMO Introdu ção: Indivíduos com enxaqueca geralmente se queixam de menor desempenho de memó...
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

The Xbox/Kinect use in poststroke rehabilitation settings: a systematic review
Conclusion: The greater use of Xbox/Kinect in treating patients after stroke is in recovery of balance and motor function, and the evidence support its application. These findings enable the use of virtual reality technology through Xbox/Kinect in rehabilitation programs, focusing on postural balance and motor skills. However, conclusive results are still not possible. Therefore, caution in the use of this technology is required.RESUMO Introdu ção: Jogos ativos baseados em realidade virtual têm sido amplamente utilizados na reabilitação de muitas condições clínicas. No...
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

Presence of generalized periodic discharges and hospital mortality
ABSTRACT Background: Generalized periodic discharges (GPDs) are rare patterns that can be found in long-term electroencephalographic monitoring in critical patients. These patterns have been correlated with non-seizure crisis and non-convulsive status epilepticus, associated with poor prognosis. Objective: To compare the outcome between patients who developed GPDs and patients with other abnormalities in long-term electroencephalographic monitoring. Methods: A retrospective study was performed by analyzing the medical records of 112 patients over 18 years who developed GPDs during long-term electroencephalographic monitori...
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

Decompressive craniectomy versus conservative treatment: limits and possibilities in malignant stroke
Conclusion: In absolute values, superiority in the effectiveness of DC over CT was perceived, showing that the reduction in mortality was at the expense of increased disability.RESUMO Introdu ção: O infarto maligno da artéria cerebral média (ACM) ocorre em um subgrupo de pacientes com acidente vascular cerebral (AVC) isquêmico e a craniectomia descompressiva (CD) precoce é um de seus tratamentos. Objetivo: Investigar o desfecho funcional de pacientes com acidente vascular cerebr al isquêmico maligno submetidos à craniectomia descompressiva em um centro de emergênc...
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

Cognitive assessment in patients with Hepatitis C submitted to treatment with Sofosbuvir and Simeprevir or Daclatasvir
Conclusion: The treatment of the hepatitis C virus improved cognitive performance, especially in relation to memory.RESUMO Introdu ção: A hepatite C pode ser definida como uma doença infecciosa, que se desenvolve por uma atividade inflamatória, que pode gerar um comprometimento no Sistema Nervoso Central, podendo ocasionar prejuízos cognitivos e sintomas de depressão. Objetivo: O objetivo deste estudo foi verificar o d esempenho cognitivo de pacientes com hepatite C crônica antes e após o tratamento com simeprevir, sofosbuvir e daclatasvir. Métodos: Foi realizad...
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

Cystatin C as a potential biomarker to evaluate migraine
Conclusion: Our findings demonstrate that high serum Cys C levels are independently associated to migraine without aura. To the best of our knowledge, this is the first study to determine the serum levels of Cys C in patients with migraine. Thus, serum Cys C may be a potential biomarker of migraine.RESUMO Introdu ção: A enxaqueca é uma síndrome neurovascular multifatorial e está intimamente associada à inflamação. A cistatina C (Cys C) é um polipeptídeo neuroendócrino que também desempenha papel importante na inflamação. Objet...
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

Rehabilitation for motor functional neurological disorder: a follow-up study of 185 patients
Conclusion: Participation in rehabilitation is beneficial for patients with mFND. Symptoms lasting for less than 30 days and aged less than 18 years had better outcomes (p
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

The Orofacial Pain Clinic Questionnaire (EDOF-HC) in the evaluation and diagnosis of orofacial pain
Conclusions: The EDOF-HC is a clinical supportive tool for the assessment of orofacial pain. The instrument may be used to support data collection from anamnesis and examination of patients according to the diagnostic criteria of most common orofacial conditions. It is also useful in the investigation of local and systemic abnormalities and contributes for the diagnosis of conditions that depend on exclusion criteria.RESUMO Introdu ção: Instrumentos diagnósticos são necessários para a anamnese e exame da dor orofacial, auxiliando na identificação das causas potenciais de dor...
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

Can we offer more for cognitive impairment in patients with chronic hepatitis C?
(Source: Arquivos de Neuro-Psiquiatria)
Source: Arquivos de Neuro-Psiquiatria - June 26, 2020 Category: Neurology Source Type: research

In memoriam Dr. Ângelo Machado
Abstract Professor Andrew John Lees, from the National Hospital for Neurology and Neurosurgery, a neurological hospital in Queen Square, London, UK, has contributed in a stupendous way to the development of the field of movement disorders in Brazil, with a constant and intense participation in numerous congresses and scientific meetings of this specialty since 1983.Resumo O professor Andrew Lees, do National Hospital for Neurology and Neurosurgery, Queen Square, Londres, Reino Unido, tem contribu ído de maneira estupenda para o desenvolvimento da área dos distúrbios do movimento no Brasil, com uma part...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Reply
Abstract Professor Andrew John Lees, from the National Hospital for Neurology and Neurosurgery, a neurological hospital in Queen Square, London, UK, has contributed in a stupendous way to the development of the field of movement disorders in Brazil, with a constant and intense participation in numerous congresses and scientific meetings of this specialty since 1983.Resumo O professor Andrew Lees, do National Hospital for Neurology and Neurosurgery, Queen Square, Londres, Reino Unido, tem contribu ído de maneira estupenda para o desenvolvimento da área dos distúrbios do movimento no Brasil, com uma part...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Duchenne muscular dystrophy requires treatment also of cardiac, respiratory, cerebral, and orthopedic compromise
Abstract Professor Andrew John Lees, from the National Hospital for Neurology and Neurosurgery, a neurological hospital in Queen Square, London, UK, has contributed in a stupendous way to the development of the field of movement disorders in Brazil, with a constant and intense participation in numerous congresses and scientific meetings of this specialty since 1983.Resumo O professor Andrew Lees, do National Hospital for Neurology and Neurosurgery, Queen Square, Londres, Reino Unido, tem contribu ído de maneira estupenda para o desenvolvimento da área dos distúrbios do movimento no Brasil, com uma part...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Metronidazole neurotoxicity in late liver transplantation
Abstract Professor Andrew John Lees, from the National Hospital for Neurology and Neurosurgery, a neurological hospital in Queen Square, London, UK, has contributed in a stupendous way to the development of the field of movement disorders in Brazil, with a constant and intense participation in numerous congresses and scientific meetings of this specialty since 1983.Resumo O professor Andrew Lees, do National Hospital for Neurology and Neurosurgery, Queen Square, Londres, Reino Unido, tem contribu ído de maneira estupenda para o desenvolvimento da área dos distúrbios do movimento no Brasil, com uma part...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Tribute to Professor Andrew J. Lees
Abstract Professor Andrew John Lees, from the National Hospital for Neurology and Neurosurgery, a neurological hospital in Queen Square, London, UK, has contributed in a stupendous way to the development of the field of movement disorders in Brazil, with a constant and intense participation in numerous congresses and scientific meetings of this specialty since 1983.Resumo O professor Andrew Lees, do National Hospital for Neurology and Neurosurgery, Queen Square, Londres, Reino Unido, tem contribu ído de maneira estupenda para o desenvolvimento da área dos distúrbios do movimento no Brasil, com uma part...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Transaxonal degenerations of cerebellar connections: the value of anatomical knowledge
Conclusion: Neurologists and radiologists need to become familiar with the diagnosis of these conditions since their presentations are peculiar and often subtle, and can easily be misdiagnosed as ischemic events, degenerative disease, demyelinating disease or even tumors.RESUMO Degenera ções transaxonais resultam da morte neuronal ou da interrupção de conexões sinápticas entre estruturas neurais. Essas degenerações não são comuns, mas podem ser reconhecidas por imagens de ressonância magnética convencional. Objetivo: Os objetivos de aprendiz...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Neurological complications in patients with SARS-CoV-2 infection: a systematic review
Conclusion: Recognition of neurological manifestations of SARS-CoV-2 should be emphasized despite the obvious challenges faced by clinicians caring for critical patients who are often sedated and presenting other concurrent systemic complications.RESUMO Introdu ção: À medida que a pandemia da COVID-19 se desenvolve em todo o mundo, diferentes tipos de publicações descreveram suas manifestações neurológicas. Objetivo: Revisar a literatura sobre complicações neurológicas da infecção por SARS-CoV-2. Métodos: A pesquisa bibliogr&a...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Neurological diseases in Peru: a systematic analysis of the global burden disease study
Conclusion: The burden of disease (BD) increased by 1.6% from 1990 to 2015. The main causes were migraine, CVD, and NE. ADD and NSC doubled the DALY in this period. These diseases represent a significant cause of disability attributable to the increase in the life expectancy of our population among other factors. Priority actions should be taken to prevent and treat these causes.RESUMEN Introducci ón: Los indicadores de carga de la enfermedad evalúan el impacto que producen las enfermedades en una población. Integran la mortalidad y discapacidad en un solo indicador. Esto permite fijar prioridades para...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Cerebral amyloid angiopathy: a cross-sectional study in a single center in Northeastern Brazil
Conclusion: The prevalence of CAA in our study was like those of medical literature, with a pro gressive age-related increase.RESUMO Introdu ção: A angiopatia amiloide cerebral (AAC) é uma desordem vascular causada pela deposição progressiva de peptídeos β -amiloides nas paredes de pequenos e m édios vasos corticais e leptomeníngeos. Até a presente data, a epidemiologia da AAC é desconhecida em nossa região. Objetivos: Avaliar a prevalência da AAC em uma população específica de pacientes idosos de um hospital terci&...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Hardy-Weinberg Equilibrium in different mitochondrial haplogroups of four genes associated with neuroprotection and neurodegeneration
Conclusions: HWE deviation of particular variants in relation to global populational HWE, could be, at least in part, associated with the differential susceptibility of specific populations and ethnicities to neurodegenerative diseases. Our data might contribute to the epidemiology and diagnostic/prognostic methods for neurodegenerative diseases.RESUMO Introdu ção: Mitocôndrias defeituosas ou danificadas resultam em alterações do metabolismo energético, equilíbrio redox e dinâmica celular e são, portanto, identificadas como o ponto central da patogênese em ...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Clinical and molecular correlates of the ASPECTS in the acute phase of stroke
Conclusion: Plasma levels of adiponectin are associated with the ASPECTS scores.RESUMO Introdu ção: A Alberta Stroke Early Score (ASPECTS) foi desenvolvida para monitorização de alterações isquêmicas precoces na tomografia computadorizada de crânio, estando associada a desfechos clínicos. A ASPECTS também pode se associar aos biomarcadores periféricos que refletem a resposta fisio patológica do cérebro ao AVC isquêmico. Objetivo: Investigar à associação entre os parâmetros periféricos com a Alber...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Increased serum interleukin-9 and interleukin-1β are associated with depression in type 2 diabetes patients
Conclusion: This study showed positive association between depression and IL-1 β , IL-9 in T2DM patients. Additionally, the diabetic patients have poorer quality of life, which is further worsened by the presence of depression. Thus, routine assessment for the presence of depression is suggested in T2DM patients.RESUMO Introdu ção: O diabetes e a depressão comórbidas são condições crônicas prevalentes que afetam negativamente a qualidade de vida (QdV). A inflamação tem sido considerada como um mecanismo integral em pacientes com diabetes e depress&at...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Seizures in patients with respiratory disease - a retrospective single center study
Conclusions: Blood gas changes such as hypoxemia and respiratory acidosis were among the factors statistically associated with the development of symptomatic seizures in patients with respiratory diseases. Additionally, hypoxemia, hypercapnia, and respiratory acidosis were correlated with mortality in patients hospitalized for respiratory system diseases who requested consultations for seizures.RESUMO Objetivo: Convuls ões são uma condição neurológica comumente vivenciada durante o período de acompanhamento após distúrbios sistêmicos ou metabólicos. O obj...
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Biomarkers and aspects in acute stroke
(Source: Arquivos de Neuro-Psiquiatria)
Source: Arquivos de Neuro-Psiquiatria - June 2, 2020 Category: Neurology Source Type: research

Erratum
ABSTRACT Central alveolar hypoventilation syndrome has been known for decades as Ondine ’ s curse. It was named as such after a German myth. Although most of the stories resemble one another, word of mouth has led to misinterpretation of this tale among the medical community. The present paper reviews the original narrative, its characters, and how it is linked to the most relevant aspects of the disease.RESUMEN El s índrome de hipoventilación alveolar central (por sus siglas en inglés) se conoce desde hace décadas como la maldición de Ondine. Fue nombrado como tal por un antiguo mi...
Source: Arquivos de Neuro-Psiquiatria - May 1, 2020 Category: Neurology Source Type: research

Adding pieces to the Alice in wonderland syndrome puzzle: a comment to the paper by Brooks and colleagues
ABSTRACT Central alveolar hypoventilation syndrome has been known for decades as Ondine ’ s curse. It was named as such after a German myth. Although most of the stories resemble one another, word of mouth has led to misinterpretation of this tale among the medical community. The present paper reviews the original narrative, its characters, and how it is linked to the most relevant aspects of the disease.RESUMEN El s índrome de hipoventilación alveolar central (por sus siglas en inglés) se conoce desde hace décadas como la maldición de Ondine. Fue nombrado como tal por un antiguo mi...
Source: Arquivos de Neuro-Psiquiatria - May 1, 2020 Category: Neurology Source Type: research

Posterior cortical ribboning in the Heidenhain variant of Creutzfeldt-Jakob Disease
ABSTRACT Central alveolar hypoventilation syndrome has been known for decades as Ondine ’ s curse. It was named as such after a German myth. Although most of the stories resemble one another, word of mouth has led to misinterpretation of this tale among the medical community. The present paper reviews the original narrative, its characters, and how it is linked to the most relevant aspects of the disease.RESUMEN El s índrome de hipoventilación alveolar central (por sus siglas en inglés) se conoce desde hace décadas como la maldición de Ondine. Fue nombrado como tal por un antiguo mi...
Source: Arquivos de Neuro-Psiquiatria - May 1, 2020 Category: Neurology Source Type: research

Ondine’s curse: the origin of the myth
ABSTRACT Central alveolar hypoventilation syndrome has been known for decades as Ondine ’ s curse. It was named as such after a German myth. Although most of the stories resemble one another, word of mouth has led to misinterpretation of this tale among the medical community. The present paper reviews the original narrative, its characters, and how it is linked to the most relevant aspects of the disease.RESUMEN El s índrome de hipoventilación alveolar central (por sus siglas en inglés) se conoce desde hace décadas como la maldición de Ondine. Fue nombrado como tal por un antiguo mi...
Source: Arquivos de Neuro-Psiquiatria - May 1, 2020 Category: Neurology Source Type: research

Medical management after subthalamic stimulation in Parkinson’s disease: a phenotype perspective
In this study, we review the literature data on acute medical management after STN DBS in PD and propose a clinical algorithm on medical management focused on the patient ’ s phenotypic profile at the perioperative period. Overall, across the trials, the levodopa equivalent daily dose is reduced by 30 to 50% one year after surgery. In patients taking high doses of dopaminergic drugs or with high risk of impulse control disorders, an initial reduction in dopamine agonists after STN DBS is recommended to avoid the hyperdopaminergic syndrome, particularly hypomania. On the other hand, a rapid reduction of dopaminergic a...
Source: Arquivos de Neuro-Psiquiatria - May 1, 2020 Category: Neurology Source Type: research

Electrophysiological evaluation of carpal tunnel syndrome female patients after vitamin D replacement
Abstract Objective: The effects of vitamin D on the central and peripheral nervous system continue to be investigated today. In the present study, we aimed to evaluate pain and electrophysiologic response in patients with carpal tunnel syndrome (CTS) who have undergone replacement therapy due to vitamin D deficiency. Methods: Fifty female patients diagnosed with mild and moderate CTS and accompanied by vitamin D deficiency were included in this study. Nerve conduction study (NCS) was performed before and after vitamin D replacement, and the patient ’ s pain was evaluated with Visual Analogue Scale (VAS). Results: Whe...
Source: Arquivos de Neuro-Psiquiatria - May 1, 2020 Category: Neurology Source Type: research

Evaluation of upper endoscopic findings in patients with restless legs syndrome and gastric complaints
Conclusions: The detection of increased severity of intestinal metaplasia, mucosal atrophy, and gastric inflammation in RLS/WED patients with dyspeptic complaints may entail the close gastrointestinal system evaluation of these patients. However, larger randomized and controlled trials are required on this subject where patients are evaluated by upper GIS endoscopic biopsy.Resumo Introdu ção: Os efeitos das doenças do sistema digestório sobre a Síndrome das Pernas Inquietas/doença de Willis-Ekbom (SPI/DWE) foram demonstrados previamente por testes sorológicos. No entanto, at...
Source: Arquivos de Neuro-Psiquiatria - May 1, 2020 Category: Neurology Source Type: research

Diagnostic prediction model for levodopa-induced dyskinesia in Parkinson’s disease
Conclusion: Predicted probability of LID can be estimated with reasonable accuracy using a diagnostic clinical prediction model which combines age of PD onset, disease duration, initial motor symptom and use of dopaminergic agonists.Resumo Introdu ção: No momento, não há métodos para se predizer o desenvolvimento de discinesias induzidas por levodopa (DIL), uma frequente complicação do tratamento da doença de Parkinson (DP). Preditores clínicos e polimorfismos de nucleotídeo único (SNP) têm sido associados às DIL na DP. Objetiv o: Inv...
Source: Arquivos de Neuro-Psiquiatria - May 1, 2020 Category: Neurology Source Type: research

Dopaminergic drugs alter beta coherence during motor imagery and motor execution in healthy adults
Conclusion: The administration of methylphenidate and risperidone was able to produce electrocortical changes of the cortical central regions, even when featuring antagonistic effects on the dopaminergic pathways. Moreover, the execution task allowed beta-band modulation increase.Resumo Introdu ção: A imagética motora (IM) representa o componente cognitivo do movimento e recruta os sistemas dopaminérgicos. Objetivo: Investigar o papel do sistema dopaminérgico por meio da ação do metilfenidato e da risperidona sobre a coerência em beta durante a execução, ...
Source: Arquivos de Neuro-Psiquiatria - May 1, 2020 Category: Neurology Source Type: research

Combining neuropsychological tests to improve the assessment of arithmetic difficulties in children with ADHD
Conclusions: The present study detected arithmetic difficulties in Brazilian children with ADHD and the effects of methylphenidate. Given this improvement in sensitivity, combining tests could be a promising alternative when working with limited samples.Resumo Objetivo: Comparar as formas de avaliar as habilidades aritm éticas em crianças brasileiras com TDAH, combinando três testes neuropsicológicos validados, e verificar se são sensíveis ao tratamento com metilfenidato. Métodos: Quarenta e duas crianças (9 ‒ 12 anos) participaram deste estudo: 20 eram crian ç...
Source: Arquivos de Neuro-Psiquiatria - May 1, 2020 Category: Neurology Source Type: research

Post-dural puncture headache incidence after cerebrospinal fluid aspiration. A prospective observational study
Abstract Background: Post-dural puncture headache (PDPH) is an iatrogenic condition following lumbar puncture (LP). Incidence is variable and often associated with young females. Technical features of the procedure (i.e. needle gauge) have been investigated; however there is no investigation on the method of cerebrospinal fluid (CSF) collection. Objective: To investigate whether mild CSF aspiration is associated with increased PDPH in selected patients. Methods: 336 subjects were eligible to the study. Data on 237 patients from a tertiary neurology hospital who underwent diagnostic LP from February 2010 to December 2012 we...
Source: Arquivos de Neuro-Psiquiatria - May 1, 2020 Category: Neurology Source Type: research

Predicting levodopa-induced dyskinesia
(Source: Arquivos de Neuro-Psiquiatria)
Source: Arquivos de Neuro-Psiquiatria - May 1, 2020 Category: Neurology Source Type: research

Erratum
Abstract Currently, pyridostigmine bromide is an indispensable anticholinesterase agent used worldwide to treat patients with Myasthenia Gravis (MG). However, pyridostigmine bromide was unsuccessful in its “ pioneering trials ” to treat a series of MG patients. There are important historical landmarks before pyridostigmine bromide becomes useful, safe and indispensable for MG therapy. After 70 years of these “ pioneering trials ” , this article reviews some historical aspects related to them, as well as other preliminary trials using pyridostigmine bromide as therapy for MG patients.Resumo Atualment...
Source: Arquivos de Neuro-Psiquiatria - April 27, 2020 Category: Neurology Source Type: research

Reverse crossed cerebellar diaschisis in status epilepticus: case report
Abstract Currently, pyridostigmine bromide is an indispensable anticholinesterase agent used worldwide to treat patients with Myasthenia Gravis (MG). However, pyridostigmine bromide was unsuccessful in its “ pioneering trials ” to treat a series of MG patients. There are important historical landmarks before pyridostigmine bromide becomes useful, safe and indispensable for MG therapy. After 70 years of these “ pioneering trials ” , this article reviews some historical aspects related to them, as well as other preliminary trials using pyridostigmine bromide as therapy for MG patients.Resumo Atualment...
Source: Arquivos de Neuro-Psiquiatria - April 27, 2020 Category: Neurology Source Type: research

Celebrating the 70 years of pyridostigmine on therapy of Myasthenia Gravis: historical aspects of the preliminary trials
Abstract Currently, pyridostigmine bromide is an indispensable anticholinesterase agent used worldwide to treat patients with Myasthenia Gravis (MG). However, pyridostigmine bromide was unsuccessful in its “ pioneering trials ” to treat a series of MG patients. There are important historical landmarks before pyridostigmine bromide becomes useful, safe and indispensable for MG therapy. After 70 years of these “ pioneering trials ” , this article reviews some historical aspects related to them, as well as other preliminary trials using pyridostigmine bromide as therapy for MG patients.Resumo Atualment...
Source: Arquivos de Neuro-Psiquiatria - April 27, 2020 Category: Neurology Source Type: research

Pioneers in the cisterna magna puncture
Abstract At the beginning of the 20th century, cerebrospinal fluid (CSF) collection and analysis emerged as a promising aid in the diagnosis of diseases of the central nervous system. It was obtained through the established procedure of lumbar puncture, described by Heinrich Quinke in 1891. The search for an alternative way to gather the CSF emerged in animal research, highlighting the cisterna magna as a promising source, with relative safety when performed by someone trained. Described initially and in detail by James Ayer in 1920, the procedure was widely adopted by neurologists and psychiatrists at the time, featuring ...
Source: Arquivos de Neuro-Psiquiatria - April 27, 2020 Category: Neurology Source Type: research

Neurology, psychiatry and the chess game: a narrative review
Abstract The chess game comprises different domains of cognitive function, demands great concentration and attention and is present in many cultures as an instrument of literacy, learning and entertainment. Over the years, many effects of the game on the brain have been studied. Seen that, we reviewed the current literature to analyze the influence of chess on cognitive performance, decision-making process, linking to historical neurological and psychiatric disorders as we describe different diseases related to renowned chess players throughout history, discussing the influences of chess on the brain and behavior.Resumo O ...
Source: Arquivos de Neuro-Psiquiatria - April 27, 2020 Category: Neurology Source Type: research

Cerebrospinal fluid challenges for the diagnosis of herpes simplex infection in the central nervous system
Conclusions: We demonstrated the importance to adapt serological anti-HSV IgG EIA test for CSF assays to increase the accuracy of the analysis, considering the low concentration of specific antibodies in CSF.Resumo O v írus herpes simples (HSV) é um dos agentes causadores de uma doença grave no sistema nervoso central (SNC) em humanos. A detecção de anticorpos específicos no líquido cefalorraquidiano (LCR) pode contribuir para o diagnóstico neurológico retrospectivo. Entretanto, os testes imunológicos co merciais são para uso em amostras de soro. ...
Source: Arquivos de Neuro-Psiquiatria - April 27, 2020 Category: Neurology Source Type: research

Association between statin use and mortality risks during the acute phase of ischemic stroke in patients admitted to an intensive care unit
Conclusion: Statins and angiotensin converting enzyme inhibitors use during hospitalization were independently associated to a lower rate of all-cause mortality in the first 7 days of intensive care unit admission.Resumo O acidente vascular cerebral (AVC) isqu êmico é uma causa comum de morte. O papel das estatinas na prevenção secundária da fase crônica do AVC isquêmico foi estabelecido. No entanto, as evidências sobre a sua eficácia na fase aguda do AVC isquêmico são limitadas e contraditórias. Objetivo: Avaliar a associação entr...
Source: Arquivos de Neuro-Psiquiatria - April 27, 2020 Category: Neurology Source Type: research

The effect of home exercise on the posture and mobility of people with HAM/TSP: a randomized clinical trial
Abstract Background: Physical therapy has positive results in people with tropical spastic paraparesis (TSP). However, mobility and distance from rehabilitation centers limit the participation in outpatient programs. Objective: To evaluate the impact of a home exercise program on the posture and functional mobility of people with TSP. Methods: A randomized controlled trial comparing three groups of people who performed guided exercises from a guidebook for six months: supervised (SG), unsupervised (WG), and control (CG). Primary outcomes: postural angles (SAPO ®) and functional mobility (TUG). Secondary outcomes: gait ...
Source: Arquivos de Neuro-Psiquiatria - April 27, 2020 Category: Neurology Source Type: research

Functional performance and muscular strength in symptomatic female carriers of Duchenne muscular dystrophy
Conclusion: Clinical manifestation of asymmetrical muscle weakness and compensatory movements, or both can be found in female carriers of DMD mutations, which can adversely affect posture and functional performance of these patients.Resumo A distrofia muscular de Duchenne (DMD) geralmente afeta indiv íduos do sexo masculino. No entanto, mulheres também são acometidas em casos raros. Aproximadamente 8% das portadoras de DMD têm fraqueza muscular ou cardiomiopatia. A identificação precoce das alterações funcionais e motoras pode alterar a tomada de decisão cl&iacu...
Source: Arquivos de Neuro-Psiquiatria - April 27, 2020 Category: Neurology Source Type: research

Creating cartoons to represent habitual leg movements
Conclusion: In this study we developed an instrument that allows us to oppose and distinguish a pathological condition (RLS) from a behavioral phenomenon. This state of behavioral leg fidgeting needs to be better characterized and may eventually be recognized as a clinical entity per se.Resumo Muitas pessoas t êm o hábito de movimentar as pernas e acreditam que esse comportamento decorre da Síndrome das Pernas Inquietas (SPI), uma condição neurológica altamente prevalente com grande impacto na qualidade de vida dos indivíduos acometidos. Esse padrão de comportamento, c...
Source: Arquivos de Neuro-Psiquiatria - April 27, 2020 Category: Neurology Source Type: research