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Specialty: Neurology
Condition: Multiple Sclerosis
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Total 440 results found since Jan 2013.
Sleepiness in neurological disorders
Rev Neurol (Paris). 2023 Aug 17:S0035-3787(23)00986-4. doi: 10.1016/j.neurol.2023.07.005. Online ahead of print.ABSTRACTSleepiness is a frequent and underrecognized symptom in neurological disorders, that impacts functional outcomes and quality of life. Multiple and potentially additive factors might contribute to sleepiness in neurological disorders, including sleep quality alterations, circadian rhythm disorders, drugs, and sleep disorders including sleep apnea or central disorders of hypersomnolence. Physician awareness of the possible symptoms of hypersomnolence, and associated causes is of crucial importance to allow ...
Source: Revue Neurologique - August 19, 2023 Category: Neurology Authors: A-L Dubessy I Arnulf Source Type: research
Multiple sclerosis lesions that impair memory map to a connected memory circuit
ConclusionsLesion locations associated with memory dysfunction in MS map onto a specific brain circuit centered on the hippocampus. Lesion damage to this circuit fully mediated associations between lesion volume and memory. A circuit-based approach to mapping MS symptoms based on lesions visible on standard structural imaging may prove useful for localization and prognosis of higher order deficits in MS.
Source: Journal of Neurology - August 2, 2023 Category: Neurology Source Type: research
Associations between multiple sclerosis and in-hospital outcomes of patients with hemorrhagic stroke
To determine the influence of multiple sclerosis (MS) on in-hospital outcomes of patients with hemorrhagic strokes using a large, nationally representative database.
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2023 Category: Neurology Authors: Weiguang Xu, Dajun Yan, Zeqian Ning Source Type: research
Telephone assistance for neurological diseases: a systematic review
CONCLUSIONS: Dementias are the diseases with more bibliographic references on their telephone assistance despite not being the most prevalent. The telephone is frequently used to administer diagnostic scales or support caregivers and is particularly useful in diseases that limit mobility and attending a medical practice.PMID:37466132 | DOI:10.33588/rn.7703.2022284
Source: Revista de Neurologia - July 19, 2023 Category: Neurology Authors: J M Trejo-Gabriel-Gal án E Cubo-Delgado Source Type: research
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL): A challenging diagnosis and a rare multiple sclerosis mimic
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is an extremely rare hereditary cerebral small vessel disease caused by homozygous or compound heterozygous mutations in the gene coding for high-temperature requirement A serine peptidase 1 (HtrA1). Given the rare nature of the disease, delays in diagnosis and misdiagnosis are not uncommon. In this article, we reported the first case of CARASIL from Saudi Arabia with a novel homozygous variant c.1156C>T in exon 7 of the HTRA1 gene.
Source: Journal of Stroke and Cerebrovascular Diseases - June 20, 2023 Category: Neurology Authors: Bader Shirah, Hussein Algahtani, Raghad Algahtani, Ahmed Alfares, Ahmed Hassan Tags: Case Report Source Type: research
Validity, reliability and minimal detectable change of Mini-BESTest Turkish version in neurological disorders
ConclusionsMini-BESTestTR showed significant correlations with other balance assessment measures, and concurrent and convergent validity of Mini-BESTestTR was demonstrated when administered to a sample of patients with chronic stroke, Parkinson ’s disease and multiple sclerosis.
Source: Acta Neurologica Belgica - June 16, 2023 Category: Neurology Source Type: research
Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion
AbstractRepulsive guidance molecule A (RGMa) is an inhibitor of neuronal growth and survival which is upregulated in the damaged central nervous system following acute spinal cord injury (SCI), traumatic brain injury, acute ischemic stroke (AIS), and other neuropathological conditions. Neutralization of RGMa is neuroprotective and promotes neuroplasticity in several preclinical models of neurodegeneration and injury including multiple sclerosis, AIS, and SCI. Given the limitations of current treatments for AIS due to narrow time windows to intervention (TTI), and restrictive patient selection criteria, there is significant...
Source: Translational Stroke Research - June 16, 2023 Category: Neurology Source Type: research
Validity, reliability and minimal detectable change of Mini-BESTest Turkish version in neurological disorders
ConclusionsMini-BESTestTR showed significant correlations with other balance assessment measures, and concurrent and convergent validity of Mini-BESTestTR was demonstrated when administered to a sample of patients with chronic stroke, Parkinson ’s disease and multiple sclerosis.
Source: Acta Neurologica Belgica - June 16, 2023 Category: Neurology Source Type: research
Neuro-Ophthalmic Visual Impairment in the Setting of COVID-19
We describe and elaborate on mechanisms of disease, including para-infectious inflammation, hypercoagulability, endothelial damage, and direct neurotropic viral invasion. Despite global vaccination programs, new variants of COVID-19 continue to pose an international threat, and patients with rare neuro-ophthalmic complications are likely to continue to present for care.Afferent complications from COVID-19 include homonymous visual field loss, with or without higher cortical visual syndromes, resulting from stroke, intracerebral hemorrhage, or posterior reversible leukoencephalopathy. Optic neuritis has frequently been repo...
Source: Seminars in Neurology - June 13, 2023 Category: Neurology Authors: Dinkin, Marc Sathi, Swetha Tags: Review Article Source Type: research
Inhibition of ACSL4 Alleviates Parkinsonism Phenotypes by Reduction of Lipid Reactive Oxygen Species
AbstractFerroptosis is a programmed cell death pathway that is recently linked to Parkinson ’s disease (PD), where the key genes and molecules involved are still yet to be defined. Acyl-CoA synthetase long-chain family member 4 (ACSL4) esterifies polyunsaturated fatty acids (PUFAs) which is essential to trigger ferroptosis, and is suggested as a key gene in the pathogenesis of several ne urological diseases including ischemic stroke and multiple sclerosis. Here, we report that ACSL4 expression in the substantia nigra (SN) was increased in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated model of PD and in do...
Source: Neurotherapeutics - May 3, 2023 Category: Neurology Source Type: research
