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Specialty: Neurology
Condition: Multiple Sclerosis

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Total 440 results found since Jan 2013.

Recent Insights on the Role of PPAR- β/δ in Neuroinflammation and Neurodegeneration, and Its Potential Target for Therapy
AbstractPeroxisome proliferator-activated receptor (PPAR) β/δ belongs to the family of hormone and lipid-activated nuclear receptors, which are involved in metabolism of long-chain fatty acids, cholesterol, and sphingolipids. Similar to PPAR-α and PPAR-γ, PPAR-β/δ also acts as a transcription factor activated by dietary lipids and endogenous ligands, such as long-chain saturated and polyunsaturated fatty acids, and selected lipid metabolic products, such as eicosanoids, leukotrienes, lipoxins, and hydroxyeicosatetraenoic acids. Together with other PPARs, PPAR-β/δ displays transcriptional activity through interactio...
Source: NeuroMolecular Medicine - November 18, 2020 Category: Neurology Source Type: research

Visual Mapping With Magnetoencephalography: An Update on the Current State of Clinical Research and Practice With Considerations for Clinical Practice Guidelines
Summary: Using visual evoked fields (VEFs) to differentiate healthy, normal brain function from dysfunctional cortex has been demonstrated to be both valid and reliable. Currently, VEFs are widely implemented to guide intracranial surgeries for epilepsy and brain tumors. There are several areas of possible future clinical use of VEFs, including early identification of disorders, such as multiple sclerosis, Parkinson's disease, stroke, and human immunodeficiency virus–associated neurocognitive disorders. These studies have suggested that VEFs could be used to study disease pathophysiology or as a biomarker for early i...
Source: Journal of Clinical Neurophysiology - November 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Telephone-based follow-up of children with epilepsy: comparison of accuracy between a specialty nurse and a pediatric neurology fellow
Telemedicine is the provision of health care services to a patient separated from the physician by a distance, with the help of information technologies and telecommunication[1]. In recent years, there is quick advancement of scope and usage of telemedicine in the field of neurology, also referred to as teleneurology. Beginning with acute stroke care, it is fast expanding to the care of persons with multiple sclerosis, Parkinson ’s disease, and epilepsy[2–6]. The two key factors driving the ever-increasing demand for telemedicine in Neurology are limited access to specialists (Neurologists) and difficulties faced by th...
Source: Seizure: European Journal of Epilepsy - October 4, 2020 Category: Neurology Authors: Sheffali Gulati, NM Shruthi, Prateek Kumar Panda, Indar Kumar Sharawat, Mable Josey, Ravindra M Pandey Source Type: research

Telemedicine and Virtual Reality for Cognitive Rehabilitation: A Roadmap for the COVID-19 Pandemic
The current COVID-19 pandemic presents unprecedented new challenges to public health and medical care delivery. To control viral transmission, social distancing measures have been implemented all over the world, interrupting the access to routine medical care for many individuals with neurological diseases. Cognitive disorders are common in many neurological conditions, e.g., stroke, traumatic brain injury, Alzheimer's disease, and other types of dementia, Parkinson's disease and parkinsonian syndromes, and multiple sclerosis, and should be addressed by cognitive rehabilitation interventions. To be effective, cognitive reh...
Source: Frontiers in Neurology - September 14, 2020 Category: Neurology Source Type: research

CADASIL vs. Multiple Sclerosis: Is It Misdiagnosis or Concomitant? A Case Series
Conclusion: Since CADASIL is a rare disease, it is imperative to raise awareness of its unique clinical condition as well as variation in its clinical presentations. It is crucial that the overlapping symptoms between MS and CADASIL be thoroughly examined to avoid misdiagnosis and treatment complications. The involvement of autoimmune mechanisms in CADASIL and the role of NOTCH3 gene mutations in provoking an autoimmune process should be further investigated.
Source: Frontiers in Neurology - September 3, 2020 Category: Neurology Source Type: research

Vascular disease and multiple sclerosis: a post-mortem study exploring their relationships
AbstractVascular comorbidities have a deleterious impact on multiple sclerosis clinical outcomes but it is unclear whether this is mediated by an excess of extracranial vascular disease (i.e. atherosclerosis) and/or of cerebral small vessel disease or worse multiple sclerosis pathology. To address these questions, a study using a unique post-mortem cohort wherein whole body autopsy reports and brain tissue were available for interrogation was established. Whole body autopsy reports were used to develop a global score of systemic vascular disease that included aorta and coronary artery atheroma, cardiac hypertensive disease...
Source: Brain - September 2, 2020 Category: Neurology Source Type: research

FTY720 in CNS injuries: Molecular Mechanisms and Therapeutic Potential.
Abstract Central nervous system (CNS) injuries, such as traumatic brain injury (TBI), subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH), are important causes of disability and death worldwide. FTY720, a structural sphingosine analog and sphingosine-1-phosphate receptor (S1PR) modulator, is currently used in the treatment of relapsing-remitting multiple sclerosis (RRMS). However, recent in vivo and in vitro studies suggest that FTY720 plays a key role in many neurological diseases, especially in CNS injuries. In addition, FTY720 is under clinical trial for the treatment of acute stroke and ICH. FTY72...
Source: Brain Research Bulletin - August 22, 2020 Category: Neurology Authors: Zhang L, Wang H Tags: Brain Res Bull Source Type: research

Are stroke-like lesions in Leber's hereditary optic neuropathy mistaken as MS-like cerebral lesions?
Publication date: Available online 21 June 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Josef Finsterer
Source: Multiple Sclerosis and Related Disorders - June 30, 2020 Category: Neurology Source Type: research

Can and should neurologists screen their patients for depression? Yes, and...
The boundary between neurology and psychiatry is often an artificial one. Sharing an organ system, neurologists refer to diseases of the brain and nervous system, whereas psychiatrists diagnose and treat disorders of the mind. The distinction is one more of perspective than the actual state of our respective patients. The elegant approach of neuroanatomical localization does not neatly accommodate mood and thought disorders, whereas focal neurologic diseases are considered outside the spectrum of psychiatric disease. However, the prevalence of psychiatric disease in the neurologic population is considerable. Patients suffe...
Source: Neurology Clinical Practice - June 7, 2020 Category: Neurology Authors: Ney, J. P., Satya-Murti, S. Tags: Cost effectiveness/economic, Diagnostic test assessment, All Clinical Neurology, Depression, All epidemiology Editorial Source Type: research

Validity of the Patient Health Questionnaire-9 in neurologic populations
Conclusions Despite theoretical concerns about its validity, the PHQ-9 performed well at its standard cut-point of 10. Consistent with the literature, being able to use a validated, brief tool that is available publicly should improve case finding of depression in neurologic populations. When considering clinical practicality along with the findings of this analyzed, this study confirmed that the PHQ-9 is valid in a general outpatient neurologic population.
Source: Neurology Clinical Practice - June 7, 2020 Category: Neurology Authors: Williams, K. G., Sanderson, M., Jette, N., Patten, S. B. Tags: Cost effectiveness/economic, Diagnostic test assessment, All Clinical Neurology, Depression, All epidemiology Research Source Type: research

Exergames for balance dysfunction in neurological disability: a meta-analysis with meta-regression
ConclusionsThe pooled evidence suggests that exergames improve balance dysfunction and are safe in several neurological conditions. The findings of high-frequency interventions associated with larger effect size, together with a possible sustained effect of exergaming, may guide treatment decisions and inform future research.
Source: Journal of Neurology - May 22, 2020 Category: Neurology Source Type: research

Translation into Brazilian Portuguese, cross-cultural adaptation, reliability and validation of the Functional Ambulation Classification for the categorization of ambulation following a stroke in a clinical setting.
CONCLUSION: The translation, cross-cultural adaptation and measurement properties demonstrated that the FAC is a valid, reliable clinical measure for the categorization of ambulation in the Brazilian population of stroke survivors in a clinical setting. PMID: 32390129 [PubMed - in process]
Source: Revista de Neurologia - May 13, 2020 Category: Neurology Authors: Elord C, Corrêa FI, Pereira GS, Silva SM, Corrêa JC Tags: Rev Neurol Source Type: research

COVID-19: How Neurologists Are Defining Those ‘Essential’ Visits in Migraine, Stroke, Epilepsy, and Multiple Sclerosis
No abstract available
Source: Neurology Today - May 7, 2020 Category: Neurology Tags: For Your Patients Source Type: research

Rituximab, MS, and pregnancy
Conclusion We observed no increase in adverse pregnancy outcomes compared with expected national incidence rates and remarkably little disease activity in RTX-treated women with MS, particularly when compared with periconceptional natalizumab-treated cohorts. However, larger studies are needed to fully assess the safety of RTX use before pregnancy, especially risks associated with prolonged B-cell depletion and hypogammaglobulinemia. Until these data are available, we recommend restricting RTX use before pregnancy to women who require highly effective MS treatments. Classification of evidence This study provides Class IV ...
Source: Neurology Neuroimmunology and Neuroinflammation - April 30, 2020 Category: Neurology Authors: Smith, J. B., Hellwig, K., Fink, K., Lyell, D. J., Piehl, F., Langer-Gould, A. Tags: Multiple sclerosis Article Source Type: research

2019-NCoV: What Every Neurologist Should Know ?
Nitika Mahajan, Monika Singla, Balveen Singh, Venkatesh Sajja, Parth Bansal, Birinder Paul, Parveen Goel, Rahul Midha, Rajinder Bansal, Gagandeep SinghAnnals of Indian Academy of Neurology 2020 23(7):28-32The 2019 novel Corona Virus pandemic beginning from Wuhan, China primarily affects the respiratory tract but its has impacted clinical practice across a range of specialities including neurology. We review the bearing of the 2019 NCoV infection on neurological practice. Neurological manifestations are less common than respiratory manifestations, yet conspicuous, affecting nearly over a third of hospitalized individuals. T...
Source: Annals of Indian Academy of Neurology - April 23, 2020 Category: Neurology Authors: Nitika Mahajan Monika Singla Balveen Singh Venkatesh Sajja Parth Bansal Birinder Paul Parveen Goel Rahul Midha Rajinder Bansal Gagandeep Singh Source Type: research