Multiple Sclerosis and Fabry Disease, two sides of the coin? The case of an Italian family
ConclusionsDifferential diagnosis between FD and MS may be challenging, especially in early clinical stages when only extensive clinical evaluation and correct MRI interpretation may reduce the risk of misdiagnosis. Moreover this report allows speculating on potential etiological and pathogenic mechanisms, common both to FD and MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 20, 2018 Category: Neurology Source Type: research

Health, Honesty and Happiness: Authenticity and Anonymity in Social media participation of Individuals with Multiple Sclerosis
ConclusionOur study implies that anonymity may not improve happiness of individuals with MS. We need to address structural barriers to enable their in-person interactions. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 20, 2018 Category: Neurology Source Type: research

Multiple Sclerosis Relapse Presenting as an Acute Cardiomyopathy
We report on two cases of Takotsubo cardiomyopathy with medullary demyelination secondary to multiple sclerosis. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 20, 2018 Category: Neurology Source Type: research

Reply to correspondence “Cauda equina involvement following dengue fever”
Publication date: November 2018Source: Multiple Sclerosis and Related Disorders, Volume 26Author(s): Marco Lana-Peixoto, Denison Pedrosa, Natalia Talim, Juliana Amaral, Pamela Lacerda, Rodrigo Kleinpaul (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 19, 2018 Category: Neurology Source Type: research

The dilemma of benign multiple sclerosis: Can we predict the risk of losing the “benign status”? A 12-year follow-up study
Publication date: November 2018Source: Multiple Sclerosis and Related Disorders, Volume 26Author(s): Lorenzo Razzolini, Emilio Portaccio, Maria Laura Stromillo, Benedetta Goretti, Claudia Niccolai, Luisa Pastò, Isabella Righini, Elio Prestipino, Marco Battaglini, Antonio Giorgio, Nicola De Stefano, Maria Pia AmatoAbstractBackgroundDefinition of benign multiple sclerosis (BMS) remains controversial. Moreover, a sizeable proportion of classically defined BMS patients may be no longer benign (NLB) when re-assessed in the long-term. In a previous work, we found that after a five-year follow-up, a clinical score was able...
Source: Multiple Sclerosis and Related Disorders - September 17, 2018 Category: Neurology Source Type: research

How Does Cognition Relate to Employment in Multiple Sclerosis? A Systematic Review.
ConclusionDifficulties with employment and/or reduced work hours were associated with cognitive impairment MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 15, 2018 Category: Neurology Source Type: research

Patient-reported outcomes in patients with relapsing forms of MS switching to teriflunomide from other disease-modifying therapies: Results from the global Phase 4 Teri-PRO study in routine clinical practice
Publication date: Available online 15 September 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Patricia K. Coyle, Bhupendra Khatri, Keith R. Edwards, José E. Meca-Lallana, Steve Cavalier, Pascal Rufi, Myriam Benamor, Karthinathan Thangavelu, Miqun Robinson, Ralf GoldAbstractBackgroundPatient-reported outcomes (PROs) can assist clinicians in understanding the impact of disease-modifying therapy (DMT) on the daily lives of patients with multiple sclerosis (MS). With an increased number of DMTs becoming available, patients are now switching treatments more frequently in clinical practice. The effects of...
Source: Multiple Sclerosis and Related Disorders - September 15, 2018 Category: Neurology Source Type: research

Photophobia in multiple sclerosis
ConclusionFurther studies to investigate the pathophysiological mechanisms underlying photophobia in MS are needed. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 15, 2018 Category: Neurology Source Type: research

The Bayesian Risk Estimate at Onset (BREMSO) correlates with cognitive and physical disability in patients with early Multiple Sclerosis
Publication date: Available online 13 September 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Marianne Said, Nabil K. El Ayoubi, Salem Hannoun, Ribal Haddad, Leslie Saba, Youmna Jalkh, Bassem I Yamout, Samia J KhouryAbstractBackgroundPrevention of long-term disability is the goal of therapeutic intervention in Relapsing Remitting MS (RRMS). The Bayesian Risk Estimate for MS at Onset (BREMSO) gives an individual risk score predicting disease evolution into Secondary Progressive MS (SPMS). We investigated whether BREMSO correlates with physical disability, cognitive dysfunction, and regional brain atrophy ea...
Source: Multiple Sclerosis and Related Disorders - September 14, 2018 Category: Neurology Source Type: research

Extreme Delta Brush and Distinctive Imaging in a Pediatric Patient with Autoimmune GFAP Astrocytopathy
We report a case of autoimmune GFAP astrocytopathy in a pediatric patient with extreme delta brush pattern on EEG, negative anti-NMDA-R antibodies, and distinctive MRI findings. The findings reported herein should prompt clinicians to consider the diagnosis of autoimmune GFAP astrocytopathy in patients with suspected autoimmune encephalitis. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 14, 2018 Category: Neurology Source Type: research

Pilot Investigation of the Relationship between Hippocampal Volume and Pattern Separation Deficits in Multiple Sclerosis
Publication date: Available online 13 September 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Mark D. Zuppichini, Joshua SandryAbstractMemory impairment and hippocampal atrophy are common in multiple sclerosis (MS). In the present pilot study, we investigate whether the mnemonic process of pattern separation is impaired and a predictor of hippocampal volume in relapsing remitting MS. MS participants and healthy controls completed the Mnemonic Similarities Task (MST) along with traditional neurocognitive assessments of memory. 3T structural magnetic resonance imaging was used to estimate whole hippocampal v...
Source: Multiple Sclerosis and Related Disorders - September 14, 2018 Category: Neurology Source Type: research

Primary progressive multiple sclerosis in Iran: A consensus recommendation for diagnosis and management.
Publication date: Available online 12 September 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Mohammad Ali Sahraiana, Seyed Mohammad Baghbanian, Hamidreza Ghalyanchi Langroodi, Roya Abolfazlie, Shekoofeh Alaie, Nasrin Asgari, Fereshteh Ashtari, Hormoz Ayromlou, Nahid Beladi Moghadam, Mohsen Foroughipour, Nastaran Majdinasab, Seyed Ehsan Mohammadianinejad, Alireza Nickseresht, Abbas Nourian, Sareh Shahmohammadi, Vahid Shaygannejad, Hamid Reza Torabi (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 13, 2018 Category: Neurology Source Type: research

Considerations for using Natalizumab treatment in patients with a history of choroidal melanoma
Publication date: Available online 12 September 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Abigail E. Kaye, Elizabeth D. Hawkes, Irina I. Gout, Ahmed N. El-Amir, James E. NeffendorfAbstractNatalizumab is a monoclonal antibody licensed for the treatment of relapsing-remitting multiple sclerosis (RRMS). It is known to increase the potential risk of developing progressive multifocal leukoencephalopathy (PML). There is current debate in the literature regarding its association with malignant melanoma. Herein, we report a case of a 55-year old lady with RRMS for whom natalizumab therapy was being considered ...
Source: Multiple Sclerosis and Related Disorders - September 13, 2018 Category: Neurology Source Type: research

Reply to correspondence "Cauda equina involvement following dengue fever"
Publication date: Available online 13 September 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Marco Lana-Peixoto, Denison Pedrosa, Natalia Talim, Juliana Amaral, Pamela Lacerda, Rodrigo Kleinpaul (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 13, 2018 Category: Neurology Source Type: research

Herpes simplex virus encephalitis temporally associated with dimethyl fumarate-induced lymphopenia in a multiple sclerosis patient
ConclusionOur case of HSE in a lymphopenic DMF-treated RRMS patient, points out the necessity of further studies on DMF-related lymphopenia, especially whether it implies an impaired immunity against viruses. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 13, 2018 Category: Neurology Source Type: research

Adverse Psychiatric Effects of Disease-Modifying Therapies in Multiple Sclerosis: A Systematic Review
ConclusionThe DMTs reviewed were not associated with an increased risk of adverse psychiatric effect in MS, and some may reduce the incidence of depressive symptoms. This may reflect either a positive direct effect (e.g. immune modulation) or an indirect effect arising due to a positive impact on disease activity or course. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 13, 2018 Category: Neurology Source Type: research

Severe disease exacerbation in a patient with neuromyelitis optica spectrum disorder during treatment with dimethyl fumarate
ConclusionThe case described here suggests that dimethyl fumarate is unsuitable for NMOSD treatment as it may cause disease exacerbations. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 13, 2018 Category: Neurology Source Type: research

Recurrent Disseminated Encephalomyelitis: A Case Report and Literature Review
ConclusionRecurrent disseminated encephalomyelitis is a distinct clinical entity that has features which overlap with multiple sclerosis, making it imperative to distinguish the two. Our case presentation and accompanying literature review highlights the limited scope of data available on recurrent DEM and the need for further study. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 11, 2018 Category: Neurology Source Type: research

Serum Sickness (Like Reaction) in a patient treated with alemtuzumab for multiple sclerosis: a case report
ConclusionSS/SSLR should be considered in patients treated with alemtuzumab developing delayed fever, rash and arthralgia and differentiated with Infusion Associated Reactions (IARs) and infections. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 11, 2018 Category: Neurology Source Type: research

Clinical utility of anti-MOG antibody testing in a Danish cohort
ConclusionA broad range of clinical and radiological features of anti-MOG associated disorder was observed in a single centre. MOG-Ab testing should be considered in patients with an NMOSD phenotype and in MS patients presenting atypical features. The potential use of infliximab therapy for MOG-Ab disease should be further investigated. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 11, 2018 Category: Neurology Source Type: research

Retrospective analysis of children with myelin oligodendrocyte glycoprotein antibody-related disorders
ConclusionMOG autoimmunity in children has a wide clinical spectrum, tendency to relapse, and a favourable outcome compared with other relapsing demyelinating diseases. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 11, 2018 Category: Neurology Source Type: research

Static postural control disturbances among the different Multiple Sclerosis phenotypes: a Neurocom Balance Manager® evaluation study
Conclusionour study revealed significant differences among HCs, CIS and MS. MS, especially PMS, exhibit the worst balance performances especially in EC trials. The higher correlation between balance parameters, especially sway area, and BBS score confirmed the reliability and sensibility of mCTSIB assessment in evaluating static postural control in MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 9, 2018 Category: Neurology Source Type: research

Pilot Randomized Controlled Trial of Functional Electrical Stimulation Cycling Exercise in People with Multiple Sclerosis with Mobility Disability
ConclusionsWe provide evidence that FES cycling exercise is feasible for individuals with MS with severe mobility impairment, and might have positive effects on mobility and physiological decondition. These results will inform the design of future efficacy trials of FES cycling exercise for persons with MS with mobility disability. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 9, 2018 Category: Neurology Source Type: research

“Photophobia in Multiple Sclerosis”
ConclusionFurther studies to investigate the pathophysiological mechanisms underlying photophobia in MS are needed. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 9, 2018 Category: Neurology Source Type: research

Mitochondrial DNA G15927A and G15928A variations in patients with multiple sclerosis
ConclusionNeither mtDNA variation, G15927A or G15928A, was associated with MS in the studied Iranian population. There was a non-significant association of the G15927A and the G15928A variations separately with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 8, 2018 Category: Neurology Source Type: research

Relapse prevalence, symptoms, and health care engagement: patient insights from the Multiple Sclerosis in America 2017 survey
ConclusionMS relapse remains particularly challenging for certain patients; some experience>2 relapses in 1 year, relapse durations ≥1 month, and relapse symptoms that interfere with daily functioning (e.g. walking/balance by 68.8%). However, approximately 25% of patients reported rarely or never engaging their HCP during relapse. Common reasons for not engaging, like HCP helpfulness and treatment effectiveness/tolerance, warrant further exploration. Results indicating the benefits of timely touchpoints on both the part of the patient and HCP during relapse include the relationship between higher frequency of engagem...
Source: Multiple Sclerosis and Related Disorders - September 7, 2018 Category: Neurology Source Type: research

Recurrent Schilder's disease
Publication date: Available online 5 September 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Anastasie M Dunn-Pirio, Christopher EcksteinAbstractSchilder's disease is a rare and aggressive central nervous system demyelinating disorder that is typically monophasic and steroid responsive. Here, we present an unusual case of a teenager with Schilder's disease who was treated with corticosteroids and had a clinical and radiographic recurrence nearly one year after the initial presentation. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 6, 2018 Category: Neurology Source Type: research

B-cell composition in the blood and cerebrospinal fluid of multiple sclerosis patients treated with dimethyl fumarate
ConclusionThe results of this exploratory study support a B-cell mediated mechanism of action for DMF in both blood and CSF. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 6, 2018 Category: Neurology Source Type: research

Editors’ Welcome
Publication date: August 2018Source: Multiple Sclerosis and Related Disorders, Volume 24Author(s): Chris H. Hawkes, Gavin Giovannoni, Michael Levy, Emmanuelle Waubant (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 5, 2018 Category: Neurology Source Type: research

Alemtuzumab-containing reduced intensity conditioning allogenic hematopoietic stem cell transplantation in a case of primary progressive multiple sclerosis
We present a 42 years old male with aplastic anemia who underwent allogenic HSCT for severe aplastic anemia. This patient was diagnosed with primary progressive multiple sclerosis (PPMS) one-year post transplant and had to undergo a second HSCT due to his hematological disorder. His second HSCT was conditioned with an alemtuzumab containing regimen, after which his MRI and expanded disability status scale (EDSS) remained to be stable for 18 months. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 2, 2018 Category: Neurology Source Type: research

Low Vitamin D-25(OH) Level in Indonesian Multiple Sclerosis and Neuromyelitis Optic Patients
ConclusionVitamin D deficiency is commonly found in Indonesian MS and NMO patients, but not associated with EDSS and annual relapse rate. Despite living in a country with adequate sunshine exposure, the physician should anticipate low serum vitamin D level, especially in MS or NMO patients who received corticosteroid. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 2, 2018 Category: Neurology Source Type: research

NMOSD with anti-MOG antibodies following anti-TNFα therapy: A case report
We report and discuss a case of neuromyelitis optica spectrum disorder (NMOSD) with positive myelin oligodendrocyte glycoprotein antibodies (MOG-IgG1) following anti-TNFα therapy for a pustular psoriasis. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 2, 2018 Category: Neurology Source Type: research

Modified Functional Walking Categories and Participation in People with Multiple Sclerosis
Publication date: Available online 31 August 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Rita Bertoni, Johanna Jonsdottir, Peter Feys, Ilse Lamers, Davide CattaneoAbstractBackgroundGait velocity influences the ability of a person to move in different outdoor or indoor contexts and has accordingly been classified through the Modified Functional Walking Categories (MFWC). Community ambulation in persons with multiple sclerosis (PwMS) may give information on their social and productive participation, as well as independence in household activities.Objectivesto investigate factors associated with walking and...
Source: Multiple Sclerosis and Related Disorders - September 2, 2018 Category: Neurology Source Type: research

Multiple Sclerosis: kFLC Index values related to gender
Conclusions: This study reinforces the importance that kFLC Index could have as a diagnostic aid to detect MS. Our data highlight a difference in the cut-off of the kFLC Index calculated by gender; male patients with a kFLC Index value greater than 11 are at higher risk to develop MS respect females having the same result. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 31, 2018 Category: Neurology Source Type: research

Efficacy and safety of monoclonal antibody therapies for relapsing remitting multiple sclerosis: a network meta-analysis
ConclusionThis network meta-analysis provided a comprehensive summary of efficacy and safety of monoclonal antibodies for RRMS, which might provide a reference for treatment. More direct comparison studies are warranted. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 30, 2018 Category: Neurology Source Type: research

Is there an effect of dietary intake on MS-related fatigue? – A systematic literature review
ConclusionDietary intake holds the potential to lower MS-related fatigue, but solid conclusions are not possible based on the existing evidence. Sparse evidence points towards an effect of adequate magnesium and folate intake and a trend for decreased fatigue. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 30, 2018 Category: Neurology Source Type: research

Metabolomic profile of insulin resistance in patients with multiple sclerosis is associated to the severity of the disease
ConclusionInsulin resistance is frequent in patients with multiple sclerosis and might contribute to metabolic complications and general disability. Early markers of dysglycemia should be sought for in these patients to avoid additional deterioration of their quality of life. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 26, 2018 Category: Neurology Source Type: research

Proton magnetic resonance spectroscopy differentiates tumefactive demyelinating lesions from gliomas
Publication date: Available online 24 August 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Ryotaro Ikeguchi, Yuko Shimizu, Kayoko Abe, Satoru Shimizu, Takashi Maruyama, Masayuki Nitta, Koichiro Abe, Takakazu Kawamata, Kazuo KitagawaAbstractBackgroundIt is often difficult to accurately differentiate tumefactive demyelinating lesions (TDLs) from gliomas using MRI.ObjectiveTo investigate the utility of proton magnetic resonance spectroscopy (MRS) in differentiating TDLs from gliomas.MethodsCohort 1 included 6 patients with TDLs and 5 with gliomas (3 high-grade), as assessed using a 1.5T MR unit. Cohort 2 incl...
Source: Multiple Sclerosis and Related Disorders - August 25, 2018 Category: Neurology Source Type: research

No association between socioeconomic status and risk of multiple sclerosis: A population-based incident case-control study in a developing country
ConclusionWe did not identify an association between household SES during adolescence, parental education levels, and a subsequent risk of developing MS in an Iranian population. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 24, 2018 Category: Neurology Source Type: research

Exploring the role of physical activity and exercise for managing vascular comorbidities in people with multiple sclerosis: A scoping review
ConclusionsEvidence points to a potential relationship between PA and exercise and risk factors related to vascular comorbidities in people with MS. PA and exercise training interventions may represent an effective therapeutic strategy for managing vascular comorbidities in people with MS, justifying further investigation. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 24, 2018 Category: Neurology Source Type: research

Resilience and depression/anxiety symptoms in multiple sclerosis and neuromyelitis optica spectrum disorder
ConclusionThese results suggest that resilience may serve to prevent or reduce depression/anxiety symptoms and maintain the QOL regardless of the physical disability level. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 24, 2018 Category: Neurology Source Type: research

Co-ocurrence of neurosarcoidosis and intrathecal reactivation of epstein-barr virus
Publication date: Available online 24 August 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Richard Salazar, Tiara Hypolite, Eric Bixby, Alex Nguyen (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 24, 2018 Category: Neurology Source Type: research

Is there an effect of dietary intake on MS-related fatigue? — A systematic literature review
ConclusionDietary intake holds the potential to lower MS-related fatigue, but solid conclusions are not possible based on the existing evidence. Sparse evidence points towards an effect of adequate magnesium and folate intake and a trend for decreased fatigue. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 21, 2018 Category: Neurology Source Type: research

The dilemma of benign multiple sclerosis: can we predict the risk of losing the "benign status"? A 12-year follow-up study
Publication date: Available online 18 August 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Lorenzo Razzolini, Emilio Portaccio, Maria Laura Stromillo, Benedetta Goretti, Claudia Niccolai, Luisa Pastò, Isabella Righini, Elio Prestipino, Marco Battaglini, Antonio Giorgio, Nicola De Stefano, Maria Pia AmatoAbstractBackgroundDefinition of benign multiple sclerosis (BMS) remains controversial. Moreover, a sizeable proportion of classically defined BMS patients may be no longer benign (NLB) when re-assessed in the long-term. In a previous work we found that after a five –year follow-up, a clinical s...
Source: Multiple Sclerosis and Related Disorders - August 19, 2018 Category: Neurology Source Type: research

Obstetric Outcomes in a Mexican Cohort of Patients with AQP4-antibody-seropositive Neuromyelitis Optica.
Conclusions: Close to half of the patients with previous pregnancies reported at least one pregnancy loss, most of these occurred ≥3 years before the diagnosis. This percentage is higher than expected for their age group in our country. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 17, 2018 Category: Neurology Source Type: research

Effects of cigarette smoking on respiratory problems and functional levels in multiple sclerosis patients
Publication date: Available online 17 August 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Ridvan Aktan, Sevgi Ozalevli, Serkan OzakbasAbstractObjectiveThe aim of the study was to investigate the effects of smoking on respiratory symptoms and functional levels by questioning use of cigarette in Multiple Sclerosis (MS) patients.MethodsA questionnaire was sent via e-mail to the 135 MS patients, who clinically diagnosed with MS and EDSS score was determined.Perceived dyspnea was assessed by the mMRC scale.The severity of dyspnea and fatigue perceived during rest and effort was assessed by the mBORG scale.Func...
Source: Multiple Sclerosis and Related Disorders - August 17, 2018 Category: Neurology Source Type: research

Identifying optic neuritis and transverse myelitis using administrative data
ConclusionAdministrative data can be used to identify individuals with incident ON and TM, and to distinguish those with monophasic syndromes from those with an incident presentation of MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 13, 2018 Category: Neurology Source Type: research

Peginterferon beta-1a for the treatment of relapsing multiple sclerosis: a case series
Publication date: Available online 13 August 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Barry A. HendinAbstractInterferon beta therapies have been effective in the treatment of relapsing forms of multiple sclerosis for over 2 decades. These therapies have varying routes and schedules of administration but broadly similar clinical and radiologic efficacy. The most commonly reported adverse effects are flu-like symptoms and injection site reactions. The most recent addition to the class is peginterferon beta-1a, which is administered subcutaneously every 2 weeks. Although clinically stable patients with m...
Source: Multiple Sclerosis and Related Disorders - August 13, 2018 Category: Neurology Source Type: research

Intrathecal K free light chain synthesis in multiple sclerosis at clinical onset associates with local IgG production and improves the diagnostic value of cerebrospinal fluid examination
Publication date: Available online 10 August 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): M. Puthenparampil, S. Altinier, E. Stropparo, S. Zywicki, D. Poggiali, C. Cazzola, E. Toffanin, S. Ruggero, F. Grassivaro, M. Zaninotto, M. Plebani, P. GalloAbstractBackground. The pathological significance and the diagnostic usefulness of intrathecal κ and λ free light chain (FLC) synthesis in Multiple Sclerosis (MS) are debated. Methods. Paired cerebrospinal fluid (CSF) and serum specimens from 70 relapsing remitting MS (RRMS), 40 with and 30 without CSF restricted IgG Oligoclonal Band (IgGOB), and 37 ...
Source: Multiple Sclerosis and Related Disorders - August 10, 2018 Category: Neurology Source Type: research

Promising effect of rapamycin on multiple sclerosis
In this study eight patients with RRMS were chosen and included in the trial. Patients received rapamycin (Rapacan, Biocon, India) for six months. Magnetic resonance imaging (MRI) of the patients’ brain was taken before and after the therapy. Patients’ expanded disability status scale (EDSS), and FoxP3 and GARP gene expression, and Treg cell proliferation were also been evaluated. All the patients had some degrees of significant reduction in mean plaque area size (P=0.012, Z=-2.520), and minimum and maximum size of the plaques (P=0.012, Z=-2.521). EDSS of 50% of patients was decreased after the treatment, yet i...
Source: Multiple Sclerosis and Related Disorders - August 10, 2018 Category: Neurology Source Type: research