Temporal evolution of acute multiple sclerosis lesions on serial sodium (23Na) MRI
Conclusions: In lesions with a reduction of the ADC sodium levels are near normal and precede signs of BBB breakdown. These findings suggest a relatively preserved tissue structure in this early phase of lesion evolution (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 17, 2019 Category: Neurology Source Type: research

Pachymeningitis with optic neuropathy associated with extrapulmonary tuberculosis and secondary antiphospholipid syndrome
Publication date: Available online 15 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Pia De Stefano, Agustina M. Lascano, Manuel Schibler, Aikaterini Fitsiori, Jean-Paul Janssens, Patrice H. Lalive, Markus Gschwind (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 15, 2019 Category: Neurology Source Type: research

Variants in NLRP3 and NLRC4 inflammasome associate with susceptibility and severity of Multiple Sclerosis
Publication date: Available online 11 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Jaine LS SOARES, Enedina ML OLIVEIRA, Alessandra PONTILLOAbstractBackgroundMultiple sclerosis (MS) is a neurodegenerative disease of central nervous system (CNS) with autoimmune and inflammatory characteristics, and a still uncertain pathogenesis. Early events as well as evolution of MS are heterogeneous (three main clinical forms) and multifactorial. Genome-wide association studies indicates that MS pathogenesis shares features with both autoimmune and inflammatory diseases. Innate immunity has been recently proved...
Source: Multiple Sclerosis and Related Disorders - January 12, 2019 Category: Neurology Source Type: research

A cross-sectional study on the relationship between cardiorespiratory fitness, disease severity and walking speed in persons with Multiple Sclerosis
Publication date: Available online 11 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Laurits T. Madsen, Ulrik Dalgas, Lars G. Hvid, Jens BansiAbstractBackground: In persons with Multiple Sclerosis (PwMS) cardiorespiratory fitness has been associated with disease severity, walking capacity and comorbidities. However, current evidence is of moderate quality and a large-scale single-center study is needed to further elucidate these relationshipsObjective: The purpose of the study was 1) to examine the relationship between cardiorespiratory fitness and disease severity in PwMS; 2) to investigate the rel...
Source: Multiple Sclerosis and Related Disorders - January 12, 2019 Category: Neurology Source Type: research

Radiological characteristics of Myelin Oligodendrocyte Glycoprotein antibody disease
ConclusionsThis is a dedicated radiological study aiming to characterize the features of MOG antibody disease which might aid in the proper investigation of cases presenting with acquired demyelinating disorders. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 11, 2019 Category: Neurology Source Type: research

The neuromyelitis optica presentation in HIV seropositive patients
Publication date: Available online 6 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ahmed I Bhigjee (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 10, 2019 Category: Neurology Source Type: research

Commentary on the manuscript "the neuromyelitis optica presentation in HIV seropositive patients"
Publication date: Available online 6 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Thomas Mathew, Amrutha Avati (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 10, 2019 Category: Neurology Source Type: research

Pilates for people with multiple sclerosis: A systematic review and meta-analysis
ConclusionsPilates is a feasible therapy for people with MS that can lead to improvements on their physical function, and it might be helpful for reducing self-perceived fatigue. The potential beneficial effects of Pilates are not significantly greater than those derived from the performance of other physical therapies. Further high-quality RCTs are needed to consolidate the existing scientific evidence regarding the impact of Pilates on this population. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 10, 2019 Category: Neurology Source Type: research

Benefit evaluation in multiple sclerosis relapse treatment from the patients’ perspective – Development and validation of a new questionnaire
The objective of this study was to develop and validate a new method for monitoring recovery from MS relapses and patient-relevant treatment benefits.MethodsA 27-item questionnaire was developed using a multi-step approach comprising open item collection, multidisciplinary expert panel and cognitive debriefing. It was evaluated regarding psychometric properties and feasibility in a longitudinal validation study with 100 patients with MS undergoing relapse treatment. Construct validity was tested by correlations with patient and physician global impressions of change as well as disease-specific and generic health-related qu...
Source: Multiple Sclerosis and Related Disorders - January 10, 2019 Category: Neurology Source Type: research

Letter to the editor on “Multiple sclerosis registries in Europe – An updated mapping survey” published in Multiple Sclerosis and Related Disorder 27 (2019) 171–178
Publication date: February 2019Source: Multiple Sclerosis and Related Disorders, Volume 28Author(s): Braune Stefan, Bergmann Arnfin (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 10, 2019 Category: Neurology Source Type: research

Unusual cortical involvement in aquaporin-4 antibody-positive patients: an analysis with double inversion recovery and phase-sensitive inversion recovery imaging
Conclusion: Although rare, cortical involvement may exist in aquaporin-4 antibody-positive patients. DIR and PSIR MRI can help to determine the exact location of the lesion. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 8, 2019 Category: Neurology Source Type: research

Factors associated with receiving bone mineral density screening among people with multiple sclerosis
ConclusionFactors known to be associated with low BMD were associated with BMD screening in people with MS, but overall BMD screening rates are relatively low suggesting that a clinically meaningful proportion of individuals with MS who have low bone mass may be missed. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 8, 2019 Category: Neurology Source Type: research

Frequency, type, distribution of pain and related factors in persons with multiple sclerosis,
Publication date: February 2019Source: Multiple Sclerosis and Related Disorders, Volume 28Author(s): Turhan Kahraman, Asiye Tuba Özdoğar, Özge Ertekin, Serkan ÖzakbaşAbstractBackgroundAlthough there is accumulating evidence on neuropathic pain in persons with multiple sclerosis (pwMS), little is known about musculoskeletal pain. The aim was to examine the frequency, type, distribution of pain and related factors in pwMS.MethodsThis cross-sectional study included 223 pwMS. The Nordic Musculoskeletal Questionnaire and painDETECT Questionnaire were used to assess pain. Depression, fatigue, sleepiness, and hea...
Source: Multiple Sclerosis and Related Disorders - January 8, 2019 Category: Neurology Source Type: research

Letter to the editor on “Multiple sclerosis registries in Europe - an updated mapping survey” published in Multiple Sclerosis and Related Disorder 27 (2019) 171-178
Publication date: Available online 6 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Braune Stefan, Arnfin Bergmann (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 6, 2019 Category: Neurology Source Type: research

LETTER TO THE EDITOR: The Neuromyelitis Optica presentation in HIV seropositive patients.
Publication date: Available online 6 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ahmed I Bhigjee (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 6, 2019 Category: Neurology Source Type: research

Commentary on the manuscript "The Neuromyelitis Optica presentation in HIV seropositive patients."
Publication date: Available online 6 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Dr. Thomas Mathew, Dr. Amrutha Avati (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 6, 2019 Category: Neurology Source Type: research

Interferon Alpha Might Be An Alternative Therapeutic Choice for Refractory Neuro-Behçet's Disease
Publication date: Available online 6 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ertugrul Cagri Bolek, Alper Sari, Levent Kilic, Omer Karadag (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 6, 2019 Category: Neurology Source Type: research

Single-Arm Study to Assess Comprehensive Infusion Guidance for the Prevention and Management of the Infusion Associated Reactions (IARs) in Relapsing-Remitting Multiple Sclerosis (RRMS) Patients Treated With Alemtuzumab (EMERALD)
ConclusionAlthough most alemtuzumab-treated patients experienced IARs as in previous controlled clinical studies, there was an improvement in the frequency and distribution of alemtuzumab-associated rash, which may have been associated with this study's prophylaxis regimen. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 6, 2019 Category: Neurology Source Type: research

Pulmonary Arterial Hypertension associated with Interferon-beta treatment for Multiple Sclerosis. Case Report and Literature Review.
We report a patient with Multiple Sclerosis treated with IFN-β who diagnosed with PAH and her course of disease under specific PAH drug therapy. A review of the literature in IFN-β-induced PAH is provided. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 6, 2019 Category: Neurology Source Type: research

Frequency and relevance of IgM, and IgA antibodies against MOG in MOG-IgG-associated disease
Conclusion: Coexisting IgM and IgA antibodies occurs in 19% of children and adult patients with MOG-IgG-associated disease. The presence of these antibodies does not seem to play a relevant clinical role in the disorder. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 4, 2019 Category: Neurology Source Type: research

Body composition and disability in people with multiple sclerosis: A dual-energy x-ray absorptiometry study
Publication date: Available online 3 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Lara A. Pilutti, Robert W. MotlABSTRACTIntroductionBody composition refers to the relative distribution of different tissue types within the body, including fat, lean, and bone tissues. There is evidence for associations between body composition and the development of multiple sclerosis (MS). The relationship between body composition and disease progression and disability accumulation, however, is unclear.ObjectivesTo examine: a) differences in overall and regional body composition by disability status in persons wit...
Source: Multiple Sclerosis and Related Disorders - January 4, 2019 Category: Neurology Source Type: research

Incidence of pregnancy and disease-modifying therapy exposure trends in women with multiple sclerosis: a contemporary cohort study
CONCLUSIONSWe report low pregnancy incidence rates, with increasing number of pregnancies conceived on DMT over the past 12-years. The median duration of DMT exposure in pregnancy was relatively short at one month. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 4, 2019 Category: Neurology Source Type: research

A single nucleotide polymorphism in the metabotropic glutamate receptor 7 gene is associated with multiple sclerosis in Iranian population
Publication date: Available online 3 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mehrdokht Mazdeh, Rezvan Noroozi, Alireza Komaki, Iman Azari, Soudeh Ghafouri-Fard, Mohammad TaheriAbstractGlutamate excitotoxicity has been previously associated with development of multiple sclerosis (MS). The metabotropic glutamate receptor 7 (GRM7) gene is a G protein-coupled receptor that suppresses the cyclic AMP cascade after activation by glutamate. Single nucleotide polymorphisms (SNPs) within this gene have been reported to be associated with neuropsychiatric disorders. In the present study, we assessed ass...
Source: Multiple Sclerosis and Related Disorders - January 4, 2019 Category: Neurology Source Type: research

Prevalence of fatigue and its association with clinical features in progressive and non-progressive forms of Multiple Sclerosis
Publication date: Available online 3 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Scott Rooney, Les Wood, Fiona Moffat, Lorna PaulAbstractBackgroundFatigue is a complex and disabling symptom of Multiple Sclerosis (MS); however, there is conflicting evidence of the relationship between fatigue and clinical features of MS. Furthermore, few studies have considered these relationships specifically in a progressive MS population.Aims(1) estimate the prevalence of self-reported fatigue in people with MS; (2) evaluate the relationship between fatigue severity/impact and clinical features of MS; (3) compa...
Source: Multiple Sclerosis and Related Disorders - January 4, 2019 Category: Neurology Source Type: research

2017 McDonald criteria for multiple sclerosis: earlier diagnosis with reduced specificity?
CONCLUSION2017 McDonald criteria appear to have higher sensitivity but reduced specificity compared to 2010 McDonald criteria (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 4, 2019 Category: Neurology Source Type: research

Otolaryngological symptoms and Multiple Sclerosis: a forgotten and underestimated relationship
Publication date: Available online 3 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): A. Di Stadio, E. Bernitsas (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 4, 2019 Category: Neurology Source Type: research

Core temperature is not elevated at rest in people with relapsing-remitting multiple sclerosis
ConclusionContrary to recent reports, resting core temperature is not elevated in relapsing-remitting MS patients compared to healthy controls when measured using precision thermometry. Furthermore, no association was observed between resting Tre and any subjective measures of fatigue in a subset of participants with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 4, 2019 Category: Neurology Source Type: research

Systematic review and network meta-analysis comparing ocrelizumab with other treatments for relapsing multiple sclerosis
Conclusions: Results suggest that ocrelizumab has an efficacy superior to or comparable with all other currently approved DMTs across all endpoints analyzed, and a similar safety profile, indicating it offers a valuable package for the treatment of patients with RMS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research

Therapeutic lag in reducing disability progression in relapsing-remitting multiple sclerosis: 8-year follow-up of two randomized add-on trials with atorvastatin
DiscussionThese data suggest that a delayed treatment effect maybe seen with atorvastatin added to interferon-beta, eight years after entering the clinical trials. Long-term follow-up of trial cohorts should be mandated. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research

In vivo conversion of astrocytes to oligodendrocyte lineage cells in adult mice demyelinated brains by Sox2
This study provides a new strategy for endogenous production of myelinating cells. After optimizing the experimental conditions for safety and feasibility, this approach may contribute into future cell based therapies in patients with white matter insults as like as those with multiple sclerosis. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research

Anti-HSV-2 Antibody in patients with MS and NMO
Publication date: Available online 2 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Masoud Etemadifar, Arefeh Izadi, Fatemeh Sabeti, Pegah NoorsharghAbstractBackground: Multiple sclerosis (MS) and neuromyelitis optica(NMO) are demyelinating disorders of the central nervous system. There is growing evidence that viruses may play a causal role in these diseases. Human herpes viruses have been of special attention since their DNA have been detected in many of MS patients' samples. Human herpes simplex virus 2(HSV-2) is a member of this family which has not been investigated thoroughly in MS and NMO.Met...
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research

Autonomic symptom burden can predict disease activity in early multiple sclerosis
Publication date: Available online 3 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Magdalena Krbot Skorić, Luka Crnošija, Tereza Gabelić, Barbara Barun, Ivan Adamec, Anamari Junaković, Tin Pavičić, Berislav Ruška, Mario HabekAbstractBackgroundWe aimed to evaluate the role of autonomic nervous system (ANS) abnormalities on disease activity (relapses and new MRI lesions) and disease progression in people with clinically isolated syndrome (pwCIS).MethodsOut of 121 consecutive pwCIS, data on disease activity and progression after 2.9 (1.4-4.1) years of follow-up, was available for 94...
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research

Lyme myelopathy: Case report and literature review of a rare but treatable disorder
We describe a rare case of a 56-year-old previously healthy male who presented with thoracic paresthesias and hyperesthesias involving the T6-11 dermatomes several weeks after a febrile illness. A thoracic MRI demonstrated a T7-10 transverse myelitis and an exhaustive evaluation revealed neuroborreliosis. His symptoms improved significantly after an initial steroid course and 21 day course of ceftriaxone. We review neuroborreliosis and summarize the features of 23 previously reported cases of Lyme myelopathy. Although Lyme myelopathy is rare, including Lyme in the differential diagnosis of an acute transverse myelitis work...
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research

Geographic variations of multiple sclerosis in Iran: A population based study
ConclusionIt seems that the incidence rate of MS and its ratio in females and males are more or less comparable with the dominant patterns in developed countries, although its variation within the country is very considerable. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research

Inequalities in access to health and social care among adults with multiple sclerosis: a scoping review of the literature
Publication date: Available online 3 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Hazel Roddam, David Rog, Jessie Janssen, Neil Wilson, Lucy Cross, Olufemi Olajide, Paola DeyAbstractVariations in access to health care are known to contribute to differences in life expectancy, morbidity and health-related quality-of-life across population subgroups. We undertook a scoping review to identify what is known about in-country variations in access to services for adults with multiple sclerosis and to identify gaps in the literature to inform future research and national policies. We searched MEDLINE, CIN...
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research

Clinical Course, Treatment Responses and Outcomes in Chinese Paediatric Neuromyelitis Optica Spectrum Disorder
Publication date: Available online 3 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Yifan Zhou, Xiaonan Zhong, Yaqing Shu, Chunping Cui, Jingqi Wang, Yuge Wang, Xiaojing Li, Zhuanggui Chen, Lisheng Peng, Allan Kermode, Wei QiuAbstractBackgroundFew data exists on paediatric neuromyelitis optica spectrum disorder (NMOSD). Here, we investigated the clinical presentation, treatment responses and long-term prognoses in a large cohort of patients with NMOSD and compared between children and adults with aquaporin-4 antibody (AQP4-IgG).MethodsA retrospective chart review of patients followed in multiple cen...
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research

Pilates for people with multiple sclerosis: A systematic review and meta-analysis.
ConclusionsPilates is a feasible therapy for people with MS that can lead to improvements on their physical function, and it might be helpful for reducing self-perceived fatigue. The potential beneficial effects of Pilates are not significantly greater than those derived from the performance of other physical therapies. Further high-quality RCTs are needed to consolidate the existing scientific evidence regarding the impact of Pilates on this population. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research

Frequency, type, distribution of pain and related factors in persons with multiple sclerosis
Publication date: Available online 3 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Turhan Kahraman, Asiye Tuba Özdoğar, Ertekin Özge, Serkan ÖzakbaşAbstractBackgroundAlthough there is accumulating evidence on neuropathic pain in persons with multiple sclerosis (pwMS), little is known about musculoskeletal pain. The aim was to examine the frequency, type, distribution of pain and related factors in pwMS.MethodsThis cross-sectional study included 223 pwMS. The Nordic Musculoskeletal Questionnaire and painDETECT Questionnaire were used to assess pain. Depression, fatigue, sleepiness, ...
Source: Multiple Sclerosis and Related Disorders - January 3, 2019 Category: Neurology Source Type: research

Risk of Obstructive Sleep Apnea in Multiple Sclerosis: Frequency, Clinical and Radiological Correlates
Publication date: Available online 31 December 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Osama A. Abdel Salam, Nesma A.M. Ghonimi, Mohamed H. IsmailAbstractBackgroundPrimary sleep disorder, especially, obstructive sleep apnea(OSA), are noted to occur in MS patients at higher frequency than the general population.ObjectivesOur objectives are: (1) To assess the frequency of OSA risk among MS patients. (2) To evaluate the relationship between OSA risk and self-reported fatigue and sleepiness. (3) To evaluate the relationship between OSA risk and clinical disability, radiological findings and treatment sta...
Source: Multiple Sclerosis and Related Disorders - January 1, 2019 Category: Neurology Source Type: research

Autoimmune inflammatory meningoencephalitis in a patient negative for glial fibrillary acidic protein-specific immunoglobulin G
ConclusionWe describe a case of subacute corticosteroid-responsive nonvasculitic autoimmune inflammatory meningoencephalitis in the absence of GFAP-IgG. The pathological features were distinct from those of patients with GFAP-IgG-positive meningoencephalitis, suggesting that nonvasculitic autoimmune inflammatory meningoencephalitis is a heterogeneous neurological syndrome. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - January 1, 2019 Category: Neurology Source Type: research

Clinical significance of assaying anti-MOG antibody in cerebrospinal fluid in MOG-antibody-associated diseases: A case report
We report the case of a 59-year-old woman with a history of 12 recurrent central nervous system lesions in the optic nerve, cerebrum, and spinal cord. The woman's condition improved by each steroid therapy. She tested seronegative for MOG-Ab, yet CSF-positive, leading to a diagnosis of MOG-Ab-associated encephalomyelitis. Our experience suggests measuring MOG-Ab in CSF and serum to prevent the underdiagnosis of MOG-Ab-associated diseases. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - December 30, 2018 Category: Neurology Source Type: research

Screening for autoantibodies in inflammatory neurological syndrome using fluorescence pattern in a tissue-based assay: Cerebrospinal fluid findings from 793 patients
ConclusionsThe TBA is helpful for diagnosing autoimmune neurological syndrome, especially in patients with unknown antibodies and antigens. Presence of unidentified antibodies against neuronal or glial cells could be an interesting finding, but should be investigated in future studies which incorporate parallel serum samples at an appropriate IgG dilution. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - December 30, 2018 Category: Neurology Source Type: research

Pregnancy outcomes in Portuguese women with multiple sclerosis: the PREGNIMS study
Conclusions: In our cohort, it has been confirmed that MS has no negative effect on pregnancy or on children's perinatal health. However, the use of immunomodulatory drugs may have some impact on newborns’ somatometric features. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - December 26, 2018 Category: Neurology Source Type: research

The role of Vestibular Evoked Myogenic Potentials in multiple sclerosis-related vertigo. A systematic review of the literature
ConclusionsOur results suggest that VEMPs may detect very small lesions in the vestibular pathways of MS patients; thus, they could have a role in the diagnosis of MS-related vertigo and in the monitoring of vertigo in MS patients as a tool additional to traditional MRI.Graphical Abstract (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - December 25, 2018 Category: Neurology Source Type: research

Erythema Nodosum in A Patient With Multiple Sclerosis on Dimethyl Fumarate
Publication date: Available online 25 December 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Hussein Algahtani, Bader Shirah, Siham Marghalani, Ayed AlgarniAbstractErythema nodosum is an uncommon cutaneous hypersensitivity reaction characterized by tender round slightly raised red nodules that become bruise-like and then resolve without scarring. It may be caused by infections, pregnancy, malignancy, systemic illnesses, or idiopathic. Several drugs have been reported in association with erythema nodosum including oral contraceptive pills, penicillin, and sulphonamides. Glatiramer acetate is the only medica...
Source: Multiple Sclerosis and Related Disorders - December 25, 2018 Category: Neurology Source Type: research

MRI utilization during the diagnostic and post-diagnostic phases in multiple sclerosis
Publication date: Available online 23 December 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): José M.A. Wijnands, Okechukwu Ekuma, Elaine Kingwell, Feng Zhu, Yinshan Zhao, John D. Fisk, Charity Evans, Helen Tremlett, Ruth Ann MarrieABSTRACTBackground: Magnetic resonance imaging (MRI) plays an important role in the diagnosis and monitoring of people with multiple sclerosis (MS). MRI rates in MS populations are poorly understood. Although Canada has universal health care, socioeconomic status (SES) is associated with MRI use. It is unknown if such disparities persist for specific conditions such as MS ...
Source: Multiple Sclerosis and Related Disorders - December 25, 2018 Category: Neurology Source Type: research

Neurophysiological, radiological and neuropsychological evaluation of fatigue in multiple sclerosis
Conclusion: The neuropsychological findings suggest common underlying mechanisms as well as bi-directional relationships between fatigue and each of anxiety, depression, and alexithymia. The neurophysiological findings may reflect maladaptive neuroplasticity processes and an aberrant GABAergic transmission in the generation of fatigue. The radiological findings could be interpreted in the light of the ‘dysfunctional hypertrophy’ or ‘compensatory hypertrophy’ hypotheses. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - December 22, 2018 Category: Neurology Source Type: research

Adherence to Oral Disease-Modifying Therapy in Multiple Sclerosis Patients: A Systematic Review
Publication date: Available online 19 December 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Ee Ling Yoon, Wing Loong Cheong (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - December 20, 2018 Category: Neurology Source Type: research

Neuromyelitis optica spectrum disorder presenting with concurrent autoimmune diseases
Publication date: Available online 20 December 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Vlad C. Bibic, Tyson B. Brust, M. Burton JodieAbstractNeuromyelitis optica spectrum disorder (NMOSD) is an autoimmune syndrome characterized by optic nerve and spinal cord inflammation. In recent years, there has been increasing awareness of NMOSD presenting concurrently with other autoimmune diseases, including myasthenia gravis (MG), systemic lupus erythematosus (SLE), Sjögren's syndrome, and sarcoidosis, among others. Whether these diseases coexist in patients due to shared susceptibility to multiple autoim...
Source: Multiple Sclerosis and Related Disorders - December 20, 2018 Category: Neurology Source Type: research

Is the ‘MS Establishment’ biased; the case for addressing gender inequality in the field of MS?
Publication date: Available online 20 December 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Gavin Giovannoni (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - December 20, 2018 Category: Neurology Source Type: research