Azathioprine-induced pellagra in neuromyelitis optica: a case report and review of literature
Publication date: Available online 21 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Cong Zhao, Tao Liu, Chao Ma, Hongzeng Li, Zhuyi Li, Jun GuoAbstractNeuromyelitis optica (NMO), also known as Devic's disease, is a classical autoimmune disorder of the central nervous system (CNS). The relapsing-remitting disease course contributes to application of a variety of immunosuppressants to prevent further relapses after high-dose methylprednisolone pulse therapy for acute attacks. Azathioprine is one of the most widely used immunosuppressive drugs during the remission stage of NMO due to its good efficacy an...
Source: Multiple Sclerosis and Related Disorders - July 21, 2018 Category: Neurology Source Type: research

The disease burden of Multiple Sclerosis from the individual and population perspective: which symptoms matter most?
ConclusionsWhile HRQoL at population level is most affected by balance problems, spasticity, and depression in RRMS, the biggest HRQoL losses in PMS are caused by spasticity, paralysis, weakness, and pain. Many symptoms with the largest effects in individuals substantially contribute to the population disease burden. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 21, 2018 Category: Neurology Source Type: research

Lower extremity deep venous thrombosis in a multiple sclerosis patient on Dimethyl Fumarate
Publication date: Available online 21 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Omid Mirmosayyeb, Emad Fayyazi, Vahid Shaygannejad, Nafiseh Esmaeil (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 21, 2018 Category: Neurology Source Type: research

User Testing as a method for evaluating subjects’ understanding of informed consent in clinical trials in multiple sclerosis
Publication date: Available online 20 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Michela Ponzio, Michele Messmer Uccelli, Stefano Lionetti, Dionisio Franco Barattini, Giampaolo Brichetto, Paola Zaratin, Mario Alberto Battaglia, Andrea TacchinoAbstractThe Patient Information Sheet (PIS) is an important aspect of the consent process in a clinical trial that provides potential participants the necessary information for deciding whether to take part in a specific study and for understanding their rights pertaining to participation. User Testing was originally developed to assess how written information...
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research

Pediatric-onset multiple sclerosis in Brazilian patients: clinical features, treatment response and comparison to pediatric neuromyelitis optica spectrum disorders
ConclusionsPediatric demyelinating diseases in Brazil are similar to the diseases described abroad. In patients with pMS, the EDSS score at the first appointment and the total number of relapses were associated with poor prognosis. NMOSD is more severe than MS in pediatric patients. Treatment with DMD and azathioprine was well tolerated and effective in reducing relapse rate and disability. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research

Establishing the diagnosis of multiple sclerosis in Croatian patients with clinically isolated syndrome: 2010 versus 2017 McDonald criteria
Publication date: Available online 20 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Mario Habek, Tin Pavičić, Berislav Ruška, Ivan Pavlović, Tereza Gabelić, Barbara Barun, Ivan Adamec, Luka Crnošija, Magdalena Krbot SkorićAbstractAimTo compare the sensitivity, specificity and accuracy of the 2010 and 2017 revisions of the McDonald criteria in a Croatian cohort of patients with a clinically isolated syndrome (CIS).MethodsProspectively collected data from 113 patients were retrospectively analyzed. Sensitivity, specificity and accuracy for both criteria were calculated regarding conve...
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research

Flaccid paralysis in neuromyelitis optica: an atypical presentation with possible involvement of the peripheral nervous system
ConclusionThis case suggests a manifestation of the proximal PNS in NMOSD. Thus, NMOSD should be considered as a differential diagnosis for patients presenting with signs of spinal cord disease and additional radicular involvement. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research

Oligoclonal bands in multiple sclerosis; functional significance and therapeutic implications. Does the specificity matter?
Publication date: Available online 20 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Gareth Pryce, David BakerAbstractSince their discovery, the existence of secreted oligoclonal immunoglobulin in the central nervous system in people with multiple sclerosis has been the subject of scientific investigation and debate over several decades. Although autoantibodies can be detected in some individuals, probably secondary to release of neo-antigens after damage, evidence for a major, primary involvement of damaging antibodies is still relatively lacking. However it is possible to construct a working hypothes...
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research

Gynecological adverse effects of natalizumab administration: Case report and review of the literature
ConclusionsRecurrent vaginitis should be taken into account as a possible adverse effect causing discomfort during long-term natalizumab treatment. Simple measures, such as probiotic administration and meticulous local hygiene, can provide adequate relief for such patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research

Treatment retention on fingolimod compared with injectable multiple sclerosis therapies in African-American patients: A subgroup analysis of a randomized phase 4 study
Publication date: October 2018Source: Multiple Sclerosis and Related Disorders, Volume 25Author(s): Mark Cascione, Nadia Tenenbaum, Jeanette Wendt, Xiangyi Meng, Lesley Schofield, Bruce A.C. Cree, PREFERMS investigatorsAbstractBackgroundSuboptimal persistence with injectable disease-modifying therapies (iDMTs; interferon beta-1a/b, glatiramer acetate) is common in patients with relapsing forms of multiple sclerosis (MS), reducing the effectiveness of these agents. Adherence to, and persistence with, an effective therapy is important for patient populations at increased risk of rapid disease progression. African-American in...
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research

Toxic liver injury after high-dose methylprednisolone in people with multiple sclerosis
This report describes three cases of acute liver injury following pulse corticosteroid therapy with reference to other possible causative factors. Caution should be exercised when applying high-dose methylprednisolone given the potential liver related adverse events it may cause. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research

Adult-onset Hemophagocytic Lymphohistiocytosis Type 2 Presenting as a Demyelinating Disease
Publication date: Available online 19 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Hussein Algahtani, Ahmed Absi, Wafaa Bassuni, Bader ShirahAbstractFamilial hemophagocytic lymphohistiocytosis (HLH) is a rare autosomal recessive life-threatening multisystem inflammatory disorder. It is characterized by excessive production of cytokines and uncontrolled activation of lymphocytes and macrophages leading to widespread organ infiltration and tissue destruction. Central nervous system involvement is common occurring in approximately 75% of patients. The neurological symptoms often develop during the cours...
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research

Tumefactive multiple sclerosis lesions associated with fingolimod treatment: report of 5 cases
Conclusions: Our study, along with similar reports in literature, highlights the need for close monitoring in patients who plan to switch from fingolimod to other treatments because of the risk of severe rebound. The etiopathogenic association between fingolimod and TDLs is not clear, but given the increasing reports of cases it should be taken into account for treatment selection in patients with this type of lesions. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research

Lower frequency of antibodies to MOG in Brazilian patients with demyelinating diseases: an ethnicity influence?
ConclusionThe low frequency of MOG Ab in patients from Rio de Janeiro and in other non-Caucasian populations suggests a racial/ancestral influence. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 18, 2018 Category: Neurology Source Type: research

The Prevalence, Incidence and Familial Recurrence of Multiple Sclerosis in Tehran, Iran
Publication date: Available online 17 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Sharareh Eskandarieh, Mohammad Ali Sahraian (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 18, 2018 Category: Neurology Source Type: research

An MRI evaluation of grey matter damage in African Americans with MS
Publication date: Available online 12 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Maria Petracca, Wafaa Zaaraoui, Sirio Cocozza, Roxana Vancea, Jonathan Howard, Monika M. Heinig, Lazar Fleysher, Niels Oesingmann, Jean-Philippe Ranjeva, Matilde IngleseAbstractObjectiveMultiple sclerosis (MS) is less prevalent in African Americans (AAs) than Caucasians (CAs) but in the former the disease course tends to be more severe. In order to clarify the MRI correlates of disease severity in AAs, we performed a multimodal brain MRI study to comprehensively assess the extent of grey matter (GM) damage and the degr...
Source: Multiple Sclerosis and Related Disorders - July 12, 2018 Category: Neurology Source Type: research

Myocardial infarction in a patient with multiple sclerosis after receiving natalizumab
Publication date: Available online 11 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Aala Darki, Peiman Masoumi, Abbas Soleimani, Abdorreza Naser MoghadasiAbstractNatalizumab is among the most effective drugs for controlling multiple sclerosis (MS). The most important side effect of this drug is progressive multifocal leukoencephalopathy, although some other complications are increasingly reported in literature such as meningitis and encephalitis. Here, a patient with MS who has suffered from myocardial infarction (MI) after the injection of natalizumab is introduced. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 11, 2018 Category: Neurology Source Type: research

Treatment retention on fingolimod compared with injectable multiple sclerosis therapies in African–American patients: A subgroup analysis of a randomized phase 4 study
Publication date: Available online 11 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Mark Cascione, Nadia Tenenbaum, Jeanette Wendt, Xiangyi Meng, Lesley Schofield, Bruce A.C. CreeAbstractBackground: Suboptimal persistence with injectable disease-modifying therapies (iDMTs; interferon beta-1a/b, glatiramer acetate) is common in patients with relapsing forms of multiple sclerosis (MS), reducing the effectiveness of these agents. Adherence to and persistence with an effective therapy is important for patient populations at increased risk of rapid disease progression. African–American individuals wi...
Source: Multiple Sclerosis and Related Disorders - July 11, 2018 Category: Neurology Source Type: research

Protective effects of hydro-ethanolic extract of Terminalia chebula on primary microglia cells and their polarization (M1/M2 balance)
Publication date: Available online 11 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Vafa Baradaran Rahimi, Vahid Reza Askari, Reza Shirazi-nia, Sina Soheili-Far, Nafiseh Askari, Pouria RahmanianDevin, Zahra SaneiFar, Seyed Hadi Mousavi, Razieh GhodsiAbstractTeminalia chebula (TC) has been traditionally used in the Iranian traditional medicine (ITM) and Ayurvedic medicine primarily for neurologic disorders and inflammation. Mainly, its fruits have been applied for CNS disorders. The effects of Terminalia chebula as herbal medicine with anti-inflammatory and anti-oxidant properties were aimed on lipopol...
Source: Multiple Sclerosis and Related Disorders - July 11, 2018 Category: Neurology Source Type: research

Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes
Publication date: Available online 11 June 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Magnus Spangsberg Boesen, Poul Erik Hyldgaard Jensen, Melinda Magyari, Alfred Peter Born, Peter Vilhelm Uldall, Morten Blinkenberg, Finn SellebjergAbstractBackgroundChitinase 3-like 1 (CHI3L1), neurofilament light chain (NFL) and oligoclonal bands (OCB) in cerebrospinal fluid are associated with central nervous system demyelination in adults. CHI3L1 and OCB are markers of central nervous system inflammation, whereas NFL is a marker of white-matter axonal injury. The aim was to examine whether CHI3L1 and NFL in cerebros...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Coping strategies and quality of life in Mexican Multiple Sclerosis patients: physical, psychological and social factors relationship
CONCLUSIONThe use of positive coping strategies in conjunction with a suitable psycho-social environment and good physical health result in a better perception of QoL in Mexican patients living with MS. Still, the negative factors are ineffectively diagnosed and hence generally under treated in medical MS monitoring. An interdisciplinary evaluation will provide the adequate tools to confront the diagnosis and the uncertainty of multiple sclerosis evolution, benefiting the QoL of Mexican patients with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Timed instrumental activities of daily living in multiple sclerosis: The test of everyday cognitive ability (TECA)
ConclusionsThe TECA is a TIADLs assessment appropriate for use in those with MS as it includes a broad range of task difficulties, requires minimum motor involvement, and is sensitive to MS-related cognitive impairment. The TECA is a brief and repeatable test of TIADLs and its ease of administration makes it suitable for both clinical practice and research settings. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Transient impairment of olfactory threshold in acute multiple sclerosis relapse
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Gabriel Bsteh, Harald Hegen, Felix Ladstätter, Klaus Berek, Matthias Amprosi, Sebastian Wurth, Michael Auer, Franziska Di Pauli, Florian Deisenhammer, Andreas Lutterotti, Thomas BergerAbstractBackgroundImpairment of olfactory threshold is a feature of early and active relapsing remitting multiple sclerosis (RRMS). It predicts inflammatory disease activity and was reported to be transient. However, the timing of onset and resolve of olfactory threshold impairment remains unclear.ObjectiveTo prospectively assess the developm...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Vaccines and the association with relapses in patients with neuromyelitis optica spectrum disorder
ConclusionThe evidence suggests that there may be a risk of vaccination-associated relapses among untreated neuromyelitis optica spectrum disorder patients, however immunosuppressive therapy at time of vaccine may abort the risk; this suggests that the patients who are treated with preventive immune suppression and receive routine vaccinations for common infections may fare better. Further prospective studies are necessary to verify these findings. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Does focal inflammation have an impact on cognition in multiple sclerosis? An MRI study
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Giuseppe Fenu, Mauro Arru, Lorena Lorefice, Jessica Frau, Giancarlo Coghe, Marzia Fronza, Luciano Loi, Maria Antonietta Barracciu, Maria Giovanna Marrosu, Eleonora CoccoAbstractObjectiveCognitive impairment concerns a significant percentage of patients with multiple sclerosis (MS). A transient impairment of cognition with a simultaneous presence of non-symptomatic gadolinium (Gd)-enhancing lesions in patients with MS was previously described. Our study aimed to evaluate modifications in cognitive function before and after the o...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Autonomic dysreflexia following acute myelitis due to neuromyelitis optica
ConclusionsThis case report illustrates a clinically relevant, but still under-recognized cardiovascular autonomic complication of severe, cervical or high-thoracic spinal cord impairment due to NMO. In addition to low baseline blood pressure and orthostatic hypotension, the patient developed episodes of autonomic dysreflexia during the acute stage after tetraplegia. Autonomic dysreflexia requires early diagnosis and proper treatment in order to prevent severe complications or death. Greater awareness of this potentially life-threatening cardiovascular emergency of spinal cord impairment is needed among patients, caregiver...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Severe aseptic temporal lobe encephalitis on fingolimod
We report the case of an MS patient with aseptic temporal lobe encephalitis while on treatment with fingolimod. This 49-year-old woman developed headache and decreasing level of consciousness after 3.5 years of fingolimod therapy. Imaging, CSF studies, and rapid clinical response to acyclovir suggested a viral etiology, although CSF cultures and viral PCR were negative. This case illustrates the potential for severe manifestations of infectious illnesses on fingolimod, which may have a predilection for the CNS and also include herpes virus infections, cryptococcus, and PML. Efforts to prevent these secondary infections are...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Trident sign trumps Aquaporin-4-IgG ELISA in diagnostic value in a case of longitudinally extensive transverse myelitis
We report a case in which the patient was initially diagnosed with neuromyelitis optical spectrum disorder, but where the “trident” sign ultimately led to the correct diagnosis of spinal cord sarcoidosis. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Neutropenia with fatal outcome in a multiple sclerosis patient 23 days after alemtuzumab infusion
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Konstantina G Yiannopoulou, Dimitra Papadimitriou, Aikaterini I Anastasiou, Marina SiakantarisABSTRACTA 47-year-old Caucasian female with relapsing- remitting Multiple Sclerosis, received alemtuzumab after a serious relapse. She had ceased receiving any treatment during the previous year. 23 days after alemtuzumab infusion she developed severe early neutropenia, which resulted in septic shock by Staphylococcus aureus and death. This is the first report of alemtuzumab infusion-related death due to early neutropenia in non-immuno...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

HPV-related papillary squamous cell carcinoma of the tonsil during treatment with fingolimod
We describe the case of a 50-year old man on fingolimod since 2011 who presented, in April 2017, with a voluminous swelling of the left tonsil. A left tonsillectomy was performed, and histological exam disclosed a papillary squamous cell carcinoma of the palatine tonsil, with an in situ hybridization positive for human papillomavirus (HPV)-16 DNA. Neither lymph nodes involvement nor other metastases were detected. Fingolimod was stopped as a precautionary measure in May 2017, and the patient currently continues his follow up at our Department. Immunocompromised patients are at risk for developing HPV-related malignancies p...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Cauda equina involvement following dengue fever
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Beuy Joob, Viroj Wiwanitkit (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Dimethyl fumarate downregulates the immune response through the HCA2/GPR109A pathway: Implications for the treatment of multiple sclerosis
ConclusionAlthough the DMF/MMF mechanism of action remains unclear, evidence suggests that the activation of HCA2/GPR109A pathway downregulates the immune response and may activate anti-inflammatory response in the intestinal mucosa, possibly leading to reduction in CNS tissue damage in MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

The efficacy of vitamin D in multiple sclerosis: A meta-analysis
ConclusionOur findings suggest that vitamin D appeared to have no therapeutic effect on EDSS score or ARR in the patients with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Peripheral blood memory B cell frequency predicts conversion from clinically isolated syndrome to multiple sclerosis
ConclusionOur results suggest that conversion from CIS to MS occurs due to the inability of the immune system to suppress effector B cell production. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Phase sensitive reconstruction of T1-weighted inversion recovery in the evaluation of the cervical cord lesions in multiple Sclerosis; is it similarly eligible in 1.5 T magnet fields?
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): A. Shayganfar, A.H. Sarrami, S. Fathi, V. Shaygannejad, S. ShamsianAbstractBackgroundIn primary studies with 3 T Magnets, phase sensitive reconstruction of T1-weighted inversion recovery (PSIR) have showed ability to depict the cervical multiple sclerosis (MS) lesions some of which may not be detected by short tau inversion recovery (STIR). Regarding to more availability of 1.5 T MRI, this study was designed to evaluate the eligibility of PSIR in 1.5 T for detection of spinal cord MS lesions.MethodIn a study betw...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Expiratory and phonation times as measures of disease severity in patients with Multiple Sclerosis. A case-control study
ConclusionsAs the expiratory times were significantly correlated with the EDSS scores, they could be used to measure the severity of MS and to monitor its progression. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Kathryn C. Fitzgerald, Diane Vizthum, Bobbie Henry-Barron, Amy Schweitzer, Sandra D. Cassard, Eric Kossoff, Adam L. Hartman, Dimitrios Kapogiannis, Patrick Sullivan, David J. Baer, Mark P. Mattson, Lawrence J. Appel, Ellen M. MowryAbstractAn intermittent fasting or calorie restriction diet has favorable effects in the mouse forms of multiple sclerosis (MS) and may provide additional anti-inflammatory and neuroprotective advantages beyond benefits obtained from weight loss alone. We conducted a pilot randomized controlled feedin...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Small-scale geographical variation in multiple sclerosis: A case-control study using Danish register data 1971–2013
ConclusionsSmall-scale geographical variation in the risk of MS suggests that local environmental risk factors could be at play and may be related to life style factors. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Yawning and cortisol levels in multiple sclerosis: Potential new diagnostic tool
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Simon B.N. Thompson, Alister Coleman, Nicola WilliamsAbstractYawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18–69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Reliability and validity of the DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis (Greek version) and proposed modification
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Athanasia Printza, Maria Kalaitzi, Christos Bakirtzis, Ioannis Nikolaidis, Hariklia Proios, Nikolaos GrigoriadisAbstractBackgroundRecent research confirmed that at least a third of people with multiple sclerosis (MS) are suffering from swallowing difficulties. Dysphagia is associated with significant morbidity and mortality, and has profound impact on physical ability and quality of life. Dysphagia related complications can be prevented through an effective screening protocol. The Dysphagia in Multiple Sclerosis (DYMUS) questio...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

The long-term impact of multiple sclerosis on the risk of divorce
Conclusions: We show that MS is associated with an increased risk of divorce among men, but not women. Our result should be helpful to inform health policy and clinical interventions, such as relationship counselling programs, and highlight the socio-economic burden of the disease. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Health utilities of patients with multiple sclerosis and neuromyelitis optica spectrum disorders IN thailand
ConclusionOur findings clearly demonstrated the negative impact of MS and NMOSD on patients’ health-related quality of life. Effective interventions that target pain, mobility, and anxiety/depression should be provided to improve quality of life of these patients. Health utility estimates from this study can be used as an important input for economic evaluations of treatments for MS and NMOSD to inform resource-allocation decisions. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Hypothesis: Multiple Sclerosis is caused by three-hits, strictly in order, in genetically susceptible persons
Publication date: Available online 4 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Patrick K A Kearns, Helen A Casey, John Paul LeachAbstractMultiple Sclerosis is a chronic, progressive and debilitating neurological disease which, despite extensive study for over 100 years, remains of enigmatic aetiology. Drawn from the epidemiological evidence, there exists a consensus that there are environmental (possibly infectious) factors that contribute to disease pathogenesis that have not yet been fully elucidated. Here we propose a three-tiered hypothesis: 1) a clinic-epidemiological model of multiple sclero...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Shortening the Washout to 4 Weeks when Switching from Natalizumab to Fingolimod and Risk of Disease Reactivation in Multiple Sclerosis
CONCLUSIONSOur study suggests that switching from natalizumab to fingolimod with a shorter washout of 4 weeks might reduce the risk of disease reactivation after switching. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Influences of pregnancy on neuromyelitis optica spectrum disorders and multiple sclerosis
ConclusionsBoth NMOSD and MS presented increased onset and relapses after delivery/abortion. Significant differences were observed in ARRs at different stages between them. Both delivery and abortion exerted detrimental effects on disease courses in NMOSD and MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Epidemiology of Multiple Sclerosis in Northeast of Iran during 1985-2016; Conversion of a Rare Disease to a Middle-high Prevalence Disease
Publication date: Available online 7 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Vahid Kazemi Moghaddam, Mohammad Sarmadi, Maryam Tatari, Fereshteh Najafi, Amir Esmaeili, Mostafa HadeiAbstractMany researchers believed that the risk of multiple sclerosis (MS) is associated with latitude gradient. Due to the increasing prevalence of MS in some areas around the equator such as Iran, this theory has been criticized in recent years. Since the distribution of multiple sclerosis in Iran is not uniform, this study was designed to describe the prevalence and incidence of MS in Northeastern area of Iran.The p...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Increased CCL18 plasma levels are associated with neurodegenerative MRI outcomes in multiple sclerosis patients
Publication date: Available online 7 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Nicole Ziliotto, Francesco Bernardi, Dejan Jakimovski, Marcello Baroni, Niels Bergsland, Deepa P. Ramasamy, Bianca Weinstock-Guttman, Paolo Zamboni, Giovanna Marchetti, Robert Zivadinov, Murali RamanathanABSTRACTBackground: Chemokine ligands and co-stimulatory factors are involved in macrophage activation and differentiation processes that could contribute to multiple sclerosis (MS) pathogenesis.Objective: To investigate associations of C-C motif Ligand 18 (CCL18), C-C motif ligand 5 (CCL5) and soluble Cluster of Differ...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Measures of Adiposity Differentially Correlate with C-Reactive Protein Among Persons with Multiple Sclerosis
Publication date: Available online 7 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Tracy Baynard, Thessa I.M. Hilgenkamp, Elizabeth C. Schroeder, Robert W. Motl, Bo FernhallAbstractBackgroundWhile MS is considered, in part, an inflammatory disease, the relationship between measures of adiposity and MS have not been well studied. This is important considering the strength of the association between adiposity and inflammation reported in the general population, and the resultant increased risk for cardiovascular and metabolic disease. Evidence demonstrates MS is associated with higher prevalence rates o...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Use of the new oral disease-modifying therapies for multiple sclerosis in British Columbia, Canada: the first five-years
Conclusion: The uptake and use of the oral DMTs increased substantially over the first 2 to 5 years after their introduction. These recent changes highlight the importance of monitoring the risks and benefits in the real world. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Cardiovascular conditions in persons with multiple sclerosis, neuromyelitis optica and transverse myelitis
ConclusionCardiovascular conditions are as common in those with demyelinating diseases compared to unaffected individuals, with hypertension being more common among those with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research