Illegal cannabis use is common among Danes with multiple sclerosis
ConclusionThis study shows that illegal cannabis use is common among Danes with MS as only 21% of the current cannabis users received prescribed cannabis-based medicine. Current cannabis users reported high efficacy in relieving pain, spasticity and sleep disturbances. In addition, only mild to moderate severity of adverse effects were reported. To the best of our knowledge, this is the most comprehensive survey of cannabis use among MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 17, 2019 Category: Neurology Source Type: research

THE ARGENTINEAN MULTIPLE SCLEROSIS REGISTRY (RelevarEM): METHODOLOGICAL ASPECTS AND DIRECTIONS
ConclusionRelevarEM is the first MS nationwide registry in Argentina, as well as in LATAM, with the objective of providing reliable real-world data of MS in the country. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 16, 2019 Category: Neurology Source Type: research

The 20-Year History: Change of Multiple Sclerosis Patient Profile over 20 Years
This study was conducted retrospectively examining the patient records of our MS Clinic. The patient records in 1996 were compared to those in 2016.MethodsDemographic data, duration of disease, time to diagnosis, course of the disease, EDSS scores, and whether or not patients used DMTs were recorded in both 1996 and 2016.ResultsThe mean frequency of visits were significantly higher in 1996 compared to 2016 (p=0.003). There were significantly more number of patients with CIS (p=0.004) and SPMS (p=0.001) in 1996; however, significantly less number of patients with RRMS (p
Source: Multiple Sclerosis and Related Disorders - May 16, 2019 Category: Neurology Source Type: research

The clinical spectrum of Anti-MOG associated acquired demyelinating disorders: three case-reports
ConclusionsSince anti-MOG+ patients can have a multiphasic disease course and accumulate disability over time, high degree of suspicion and early diagnosis are of critical importance for treatment decision-making in clinical practice.AimThe aim of this case report is to enhance focus on an emerging disease spectrum among acquired CNS demyelinating disorders. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 16, 2019 Category: Neurology Source Type: research

Response to: Kobayashi et al.: “Erythroblast appearance associated with natalizumab” Multiple Sclerosis and Related Disorders 2019
Publication date: July 2019Source: Multiple Sclerosis and Related Disorders, Volume 32Author(s): Katja Akgün, Martin Bornhäuser, Tjalf Ziemssen (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 16, 2019 Category: Neurology Source Type: research

Response to: Kobayashi et al.: “Erythroblast appearance associated with natalizumab” Multiple Sclerosis and Related Disorders 2019
Publication date: Available online 13 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Katja Akgün, Martin Bornhäuser, Tjalf Ziemssen (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 14, 2019 Category: Neurology Source Type: research

Higher satisfaction and adherence with glatiramer acetate 40 mg/mL TIW vs 20 mg/mL QD in RRMS
Publication date: Available online 9 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Gary Cutter, Antonella Veneziano, Augusto Grinspan, Mahir Al-Banna, Alexey Boyko, Maria Zakharova, Eva Maida, Marija Bosnjak Pasic, Sanjay K. Gandhi, Robin Everts, Cinzia Cordioli, Silvia RossiAbstractBackgroundPatients who perceive their medication to be ineffective or inconvenient are less likely to be adherent to treatment, with potentially significant consequences on long-term clinical outcomes. Many patients with multiple sclerosis (MS) are nonadherent to treatment despite demonstrated efficacy of disease-modifying ...
Source: Multiple Sclerosis and Related Disorders - May 10, 2019 Category: Neurology Source Type: research

Corrigendum to ‘Pilates for people with multiple sclerosis: A systematic review and meta-analysis’ Multiple Sclerosis and Related Disorders 28 (2019)199–212
Publication date: Available online 6 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Miguel A. Sánchez-Lastra, Daniel Martínez-Aldao, Antonio J. Molina, Carlos Ayán (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 7, 2019 Category: Neurology Source Type: research

Comparison of Telemedicine Versus In-Person Visits for Persons with Multiple Sclerosis: A Randomized Crossover Study of Feasibility, Cost, and Satisfaction
ConclusionsVHCs were found to be feasible, cost-effective, and appealing to persons with MS and physicians, supporting their utility as a care delivery method for MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 7, 2019 Category: Neurology Source Type: research

Longitudinal assessment of hand function in individuals with multiple sclerosis
ConclusionsHand function is commonly impaired in individuals with MS. Assessing hand dysfunction with dynamometry and the 9HPT could help improve the precision of detecting changes in hand function over time in MS, and may be more sensitive in detecting changes in PMS. These quantitative tests may be useful as outcome measures in clinical trials using neuroprotective or reparative therapies and rehabilitative interventions. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 6, 2019 Category: Neurology Source Type: research

Neuromyelitis optica spectrum disorder in three generations of a Chinese family
We report here three subjects meeting diagnostic criteria for NMOSD in one family: a father and son, and the maternal aunt of the father. Anticipation, of 27 years, was apparent in transmission from father to son. Aquaporin-4 antibodies were observed in the aunt but not the father and son, nor in other family members. A putative pathogenic mutation in the NECL2 gene was not found in this pedigree. This first report of NMOSD in three generations of one family underlines the heterogeneity of familial NMOSD. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 5, 2019 Category: Neurology Source Type: research

Neuromyelitis optica spectrum disorder with lung adenocarcinoma and intraductal papillary mucinous neoplasm
Publication date: July 2019Source: Multiple Sclerosis and Related Disorders, Volume 32Author(s): Wei Fang, Yang Zheng, Meng-Ting Cai, Yin-Xi ZhangAbstractFew cases reported the coexistence of tumors and neuromyelitis optica spectrum disorder (NMOSD), which is generally considered idiopathic. Here we describe a 61-year-old woman who developed anti-aquaporin-4 IgG positive myelitis with a pathologically-diagnosed lung adenocarcinoma and a radiologically-diagnosed intraductal papillary mucinous neoplasm. With corticosteroids and immunoglobulin in the acute phase and surgical resection of the lung adenocarcinoma, the patient r...
Source: Multiple Sclerosis and Related Disorders - May 5, 2019 Category: Neurology Source Type: research

Matrix metalloproteases 9 rs3918242 gene polymorphism and serum vit D in MS Egyptian patients
In this study, we evaluated the role of MMP9 genotypes of rs3918242 (−1562 C/T) in MS susceptibility and disability among patients using PCR-RFLP. Vitamin D assessment using ELISA, as an indirect indicator of MMP activity and proinflammatory status, was also measured to find out its relation to this polymorphism.Results: CT, CT+TT genotypes and T allele carriers were found most among MS patients as compared to healthy controls with a P value of 0.009 CI (1.216- 4.346), suggesting higher susceptibility risk for the disease. Also a significant decrease of Vitamin D in MS group (P 
Source: Multiple Sclerosis and Related Disorders - May 3, 2019 Category: Neurology Source Type: research

Biotinidase deficiency: A treatable cause of opticospinal syndrome in young adults✰
We present the case of 19-year old male with progressive optic atrophy and in a second phase spinal cord syndrome unresponsive to immunosuppressive therapies. After diagnosis of profound biotinidase deficiency, oral biotin substitution was started with partial visual improvement and normalization of gait. This case highlights the possibility of late-onset biotinidase deficiency and its treatable character. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 3, 2019 Category: Neurology Source Type: research

Perceived fatigue and cognitive performance change in multiple sclerosis: Uncovering predictors beyond baseline fatigue
ConclusionFatigue in MS is a multifactorial construct, with perceived fatigue and cognitive performance fatigability largely influenced by indirect psychological and cognitive factors. Future studies need to take these influences into account when developing fatigue assessment tools. Further, targeting influential fatigue drivers such as psychological variables may improve the burden of fatigue and quality of life of people with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 3, 2019 Category: Neurology Source Type: research

Whole body vibration improves core muscle strength and endurance in ambulant Individuals with multiple sclerosis: a randomized clinical trial
Publication date: Available online 30 April 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Maryam Abbasi, Amin Kordi Yoosefinejad, Maryam Poursadeghfard, Farnaz Parsaei Jahromi, Alireza Motealleh, Sobhan SobhaniAbstractBackgroundPeople with Multiple sclerosis (MS) have been found to impair strength and endurance of core muscles compared with healthy people. Whole body vibration (WBV) is a relatively new method of neuromuscular training which can induce positive effects on mobility and postural control of MS patients.ObjectiveTo evaluate the effects of a 6-week WBV training program on the strength and endura...
Source: Multiple Sclerosis and Related Disorders - May 2, 2019 Category: Neurology Source Type: research

Corrigendum to “Editors’ Welcome” [Mult. Scler. Relat. Disord., 29 (2019) A1–A2]
Publication date: Available online 1 May 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Prof. Michael Levy (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - May 2, 2019 Category: Neurology Source Type: research

One size doesn't fit all
Publication date: Available online 30 April 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): E. Waubant (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 30, 2019 Category: Neurology Source Type: research

Latitudinal variation in MS incidence in Scotland
ConclusionsWe found an increasing incidence of MS with latitude without any relationship to population in Scotland. The reasons for this are likely to be multifactorial. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 30, 2019 Category: Neurology Source Type: research

The Prevalence of Multiple Sclerosis continues to increase in Kuwait
ConclusionThe prevalence of MS in Kuwaiti nationals continued to increase reflecting a better case ascertainment and improved awareness and referrals across the country. However, the incidence has stabilized in the last 5 years which was mostly driven a slight decline in newly diagnosed cases in women compared to men despite the increase in the overall female to male ratio. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 29, 2019 Category: Neurology Source Type: research

Assessing cognitive performance in radiologically isolated syndrome
ConclusionsCognitive performance in RIS subjects was below average for age- and education- matched norms. Information processing speed was the most impaired cognitive test. Cognitive performance of RIS subjects should be followed closely in order to identify any changes that may indicate conversion to MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 29, 2019 Category: Neurology Source Type: research

Primary progressive multiple sclerosis and neurofibromatosis type 1
ConclusionCo-occurrence of PPMS and NF1 may be a consequence of genetic changes. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 26, 2019 Category: Neurology Source Type: research

Biotinidase deficiency: a treatable cause of opticospinal syndrome in young adults
We present the case of 19-year old male with progressive optic atrophy and in a second phase spinal cord syndrome unresponsive to immunosuppressive therapies. After diagnosis of profound biotinidase deficiency, oral biotin substitution was started with partial visual improvement and normalization of gait. This case highlights the possibility of late-onset biotinidase deficiency and its treatable character. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 24, 2019 Category: Neurology Source Type: research

Recurrent atrial fibrillation after pulse corticosteroid treatment for a relapse of multiple sclerosis
Publication date: Available online 23 April 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Tin Pavičić, Berislav Ruška, Ivan Adamec, Mario HabekAbstractStandard therapy for a relapse of multiple sclerosis is a high dose pulse corticosteroid therapy. Cardiovascular adverse events ranging from palpitations to serious arrhythmias like atrial fibrillation and ventricular tachycardia have been associated with this treatment. The underlying mechanism behind the development of atrial fibrillation and treatment of multiple sclerosis relapse with steroids is still unclear. In this case, a 27-year-old male w...
Source: Multiple Sclerosis and Related Disorders - April 23, 2019 Category: Neurology Source Type: research

The Relationship between Cognitive Function and Body Mass Index in Multiple Sclerosis Patients
ConclusionWe have shown that, BMI is associated with poor cognitive performance in some tests which, MACFIMS battery was included. This could suggest that obesity might be an important factor, which have effect on the cognitive performance. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 22, 2019 Category: Neurology Source Type: research

Neuromyelitis optica spectrum disorder occurred after interferon alpha therapy in malignant melanoma
ConclusionsA unique case of NMOSD with positive anti-AQP-4 antibody after IFN-α treatment in malignant melanoma was reported. Type I IFNs may be pro-inflammatory in NMOSD and this possible consequence of IFNs use should be cautioned in future practice. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 22, 2019 Category: Neurology Source Type: research

Successful intravenous immunoglobulin treatment in relapsing mog-antibody-associated disease
Publication date: Available online 15 April 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Elena Tsantes, Erica Curti, Ernesto Siena, Franco GranellaAbstractTreatment of MOG Ab-associated disease is poorly standardized: several drugs have been employed, with variable results. A 50-year-old Caucasian male was admitted to hospital in 2009, with severe acute transverse myelitis. A brain and spinal cord MRI showed multiple demyelinating lesions and cerebrospinal fluid analysis revealed no oligoclonal bands (OCBs). A diagnosis of multiple sclerosis (MS) was made. He was treated with interferon-beta 1a, then with...
Source: Multiple Sclerosis and Related Disorders - April 17, 2019 Category: Neurology Source Type: research

Callosal lesions on magnetic resonance imaging with multiple sclerosis, neuromyelitis optica spectrum disorder and acute disseminated encephalomyelitis
Publication date: Available online 16 April 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Meng-Ting Cai, Yin-Xi Zhang, Yang Zheng, Wei Fang, Mei-Ping DingAbstractObjective: To clarify the features of callosal lesions on magnetic resonance imaging (MRI) in Multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and acute disseminated encephalomyelitis (ADEM).Methods: Chinese patients diagnosed with MS (n=33), NMOSD (n=31), and ADEM (n=18) were enrolled. Characteristics of lesions in corpus callosum were evaluated with 1.5 Tesla MRI scanners. Chi-squared test (Fisher's exact test) was used ...
Source: Multiple Sclerosis and Related Disorders - April 17, 2019 Category: Neurology Source Type: research

Longitudinally extensive transverse myelitis in a patient infected with west nile virus
We report a 39-year old man with WNV infection and LETM. In neurological examination, there was a left periscapular hypotrophy, moderate weakness of left arm, decreased left brachioradialis reflex, tandem instability and gait ataxia. Cervical spine MRI showed enhancing intramedullary lesion extending from C3-C7 level. According to the neurological, EMG and MRI findings, a diagnosis of LETM, with affection of anterior horn cells of the cervical spinal cord, induced by WNV infection was established. The patient was treated with antibiotics, acyclovir and high dose-steroids, methylprednisolone (MP) 1g/daily in intravenous inf...
Source: Multiple Sclerosis and Related Disorders - April 17, 2019 Category: Neurology Source Type: research

Engaging across dimensions of diversity: a cross-national perspective on mHealth tools for managing relapsing remitting and progressive multiple sclerosis
ConclusionsWe took a cross-national perspective and found many similarities between three European countries across people with RRMS and PMS. Future provision should accommodate the key requirements identified to engage people with MS in scalable mHealth interventions. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 17, 2019 Category: Neurology Source Type: research

Perceived Fatigue Change and Cognitive Performance Change in Multiple Sclerosis: Uncovering Predictors Beyond Baseline Fatigue
ConclusionFatigue in MS is a multifactorial construct, with perceived fatigue and cognitive performance fatigability largely influenced by indirect psychological and cognitive factors. Future studies need to take these influences into account when developing fatigue assessment tools. Further, targeting influential fatigue drivers such as psychological variables may improve the burden of fatigue and quality of life of people with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 17, 2019 Category: Neurology Source Type: research

Tumefactive multiple sclerosis which initially presented with brainstem encephalitis with a long-term follow-up
Publication date: Available online 17 April 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Akihiko Mitsutake, Tatsuya Sato, Junko Katsumata, Fumiko Kusunoki Nakamoto, Tomonari Seki, Risa Maekawa, Takuto Hideyama, Jun Shimizu, Yasushi ShiioAbstractTumefactive demyelinating lesions (TDLs) are rare in multiple sclerosis (MS). We herein report a case of tumefactive MS which initially presented with brainstem encephalitis with a long-term follow-up. The patient had experienced relapse mostly in the brainstem in the first twenty years, and then in the periventricular white matter afterwards. The patient responded...
Source: Multiple Sclerosis and Related Disorders - April 17, 2019 Category: Neurology Source Type: research

Worsening of disability caused by relapses in multiple sclerosis: a different approach
Publication date: Available online 15 April 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Nils Koch-Henriksen, Lau Caspar Thygesen, Per Soelberg Sørensen, Melinda MagyariAbstractBackgroundIn multiple sclerosis (MS) the quantitative role of relapses in Expanded Disability Status Scale (EDSS) worsening beyond the recovery phase is not well known. Most studies have examined the predictive role of early relapses in more distant endpoints. Relapses and worsening may be associated because they could be independent effects of the same underlying disease characteristics without causal relationship. With the...
Source: Multiple Sclerosis and Related Disorders - April 16, 2019 Category: Neurology Source Type: research

Capturing fatigue parameters: The impact of vagal processing in multiple sclerosis related cognitive fatigue
Conclusion: Cognitive fatigue in MS is related to parasympathetic activity and reduced responsiveness, supporting our model representing fatigue as inflammatory processes in the brain. Standardized subjective and objective autonomous dysfunction measures might be considered as additional assessments in MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 15, 2019 Category: Neurology Source Type: research

Familial multiple sclerosis patients have a shorter delay in diagnosis than sporadic cases
Conclusion: The 2nd and 3rd family members in MS families tend do get diagnosed faster than sporadic cases. This has implications in the diagnostic process of familial MS cases. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 15, 2019 Category: Neurology Source Type: research

The Association of Fatigue and Social Participation in Multiple Sclerosis as Assessed using two Different Instruments
ConclusionA high proportion of respondents experience some level of fatigue and it is independently associated with reduced social participation. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 14, 2019 Category: Neurology Source Type: research

A SCA7 premutation may be a novel Mendelian modifier of MS course: a case report
Publication date: Available online 13 April 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Christina Sundal, Markus Axelsson, Leif Wiklund, Christopher Lindberg, Oluf AndersenAbstractA proportion of patients with the phenotype of complex genetic disorders carry dominantly inherited Mendelian traits, exemplified by hereditary spastic paraparesis influencing pyramidal symptoms in some MS cases. We here describe a mutable ATXN7 gene, a SCA7 premutation, in a patient fulfilling contemporary definitions of primary progressive MS. His onset age, and onset with a severely progressive cerebellar ataxia syndrome, wa...
Source: Multiple Sclerosis and Related Disorders - April 14, 2019 Category: Neurology Source Type: research

Evaluation of a Web-Based Fall Prevention Program among People with Multiple Sclerosis
ConclusionThis study supports the viability of online delivery of self-management strategies in MS, suggests that FFFO may help prevent falls in people with MS, and provides the preliminary data needed to verify the findings of this pilot study of FFFO with a fully powered randomized controlled trial in people with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 14, 2019 Category: Neurology Source Type: research

Three suggestions to decrease the financial burden of MS treatments
Publication date: May 2019Source: Multiple Sclerosis and Related Disorders, Volume 30Author(s): Emmanuelle Waubant, Gavin Giovannoni, Chris Hawkes, Jeanette Lechner-Scott, Michael Levy (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 14, 2019 Category: Neurology Source Type: research

Comparison of Sleep complaints and quality of life between patients with Neuromyelitis Optica spectrum disorder (NMOSD) and healthy controls
ConclusionCompared to HCs, individuals with NMOSD reported poorer quality of life and higher levels of depression and anxiety. Further, among individuals with NMOSD, sleep characteristics are predicted by a complex variety of illness-related factors. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 12, 2019 Category: Neurology Source Type: research

Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society
Conclusion: Physicians and patients should be aware of the updated recommendations for immunizations of patients with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 11, 2019 Category: Neurology Source Type: research

The association between dietary sugar intake and neuromyelitis optica spectrum disorder: A case–control study
ConclusionThe present study proposes a possible direct association between high intake of various sugar types and odds of suffering from NMOSD. More investigations are needed to prove this results. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 11, 2019 Category: Neurology Source Type: research

Management strategies for female patients of reproductive potential with multiple sclerosis: an evidence-based review
Publication date: Available online 5 April 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Patricia K Coyle, Jiwon Oh, Melinda Magyari, Celia Oreja-Guevara, Maria HoutchensAbstractMultiple sclerosis (MS) is an inflammatory, demyelinating, neurodegenerative, immune-mediated disease primarily diagnosed in early adulthood. Multiple sclerosis mostly impacts women of reproductive potential, with pregnancy and birth outcomes being major concerns for many patients. While there is ample evidence that the disease itself has no impact on pregnancy, many women living with MS still question their ability to have childre...
Source: Multiple Sclerosis and Related Disorders - April 6, 2019 Category: Neurology Source Type: research

Neuromyelitis Optica Spectrum Disorder in a Tertiary Hospital in the Philippines: A Case Series
Publication date: Available online 6 April 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Adrian I. Espiritu, Bryan Vincent Q. Mesina, Athena Angellie DL. Puerto, Nikolai Gil D. Reyes, Ludwig F. Damian, Jose Leonard R. Pascual VAbstractNeuromyelitis optica spectrum disorder (NMOSD) is a rare disease that commonly presents with optic nerve and spinal cord inflammation, and it is associated with the presence of aquaporin-4 immunoglobulin G antibody (AQP4-IgG). Information on the clinical profile and occurrence of NMOSD among Filipino patients, however, is not sufficiently documented. In this series, we presen...
Source: Multiple Sclerosis and Related Disorders - April 6, 2019 Category: Neurology Source Type: research

Cerebral cortex impairment in neuromyelitis optica spectrum disorder: A case report and literature review
ConclusionsCortical impairment with leptomeningeal enhancement can be considered an imaging performance component of NMOSD. Serious damage to the blood–brain barrier and Aquaporin-4 antibody (AQP4) may be involved in the process of cortical and leptomeningeal damage. We identified the frontal lobes as being the most susceptible area, especially the cortex adjacent to the cerebral falx. NMOSD cortical lesions may be reversed by methylprednisolone and immunosuppressant treatment. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 6, 2019 Category: Neurology Source Type: research

The association between Dietary sugar intake and Neuromyelitis optica spectrum disorder: a case- control study
ConclusionThe present study proposes a possible direct association between high intake of various sugar types and odds of suffering from NMOSD. More investigations are needed to prove this results. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 6, 2019 Category: Neurology Source Type: research

Racial differences in Retinal Neurodegeneration as a Surrogate Marker for Cortical Atrophy in Multiple Sclerosis.
ConclusionGCIPL might be a sensitive biomarker predicting GM atrophy and disability in CAMS, but not in AAMS. Larger studies are needed to investigate reliable biomarkers across races. Inclusion of AAMS in research studies is necessary to shed more light on the pathobiology of MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 4, 2019 Category: Neurology Source Type: research

Cervical spondylotic myelopathy mimicking transverse myelitis
ConclusionSpondylotic myelopathy is an important consideration in the differential of inflammatory myelopathy, especially since misdiagnosis may result in serious consequences as was seen in the cases presented, including exposure to unnecessary costly treatments and irreversible neurological disability from delayed appropriate surgical intervention. Intramedullary spinal cord enhancement can occur with spondylotic myelopathies, albeit rare, and may persistently enhance for an extended period of time even after decompressive surgery. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 4, 2019 Category: Neurology Source Type: research

Whole-Body Vibration Impedes the Deterioration of Postural Control in Patients with Multiple Sclerosis
ConclusionsAfter CON, MS patients experienced substantial deteriorations in postural control which have previously been associated with greater postural instability. No further disease-associated deteriorations were observed following the intervention. Thus, WBV might alleviate neurodegeneration of postural control in people with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - April 4, 2019 Category: Neurology Source Type: research

CSF oligoclonal bands and normal appearing white matter periventricular damage in patients with clinically isolated syndrome suggestive of MS
Publication date: Available online 2 April 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Matteo Pardini, Lorenzo Gualco, Giulia Bommarito, Luca Roccatagliata, Simona Schiavi, Claudio Solaro, Gianluigi Mancardi, Antonio Uccelli, Elisabetta Capello, Matilde IngleseAbstractBackgroundA periventricular gradient of normal appearing white matter (NAWM) damage has been described in multiple sclerosis (MS), including subjects with clinically isolated syndrome (CIS). The pathological mechanisms underlying this gradient is not currently understood.Methods34 CIS subjects were enrolled and underwent cerebrospinal fluid...
Source: Multiple Sclerosis and Related Disorders - April 3, 2019 Category: Neurology Source Type: research