Risk Factors for External Ventricular Drainage-Related Infection: A Systematic Review and Meta-analysis
Discussion The meta-analysis of various relevant factors in the onset of EVD-related infection in patients submitted to EVD enabled us to establish a more probable profile of the patients who are more likely to develop it during the treatment. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - June 2, 2023 Category: Neurology Authors: Zhou, J., Zhong, Y., Li, X., Li, H., Wang, J., Yang, S., Chen, G. Tags: Encephalitis, Meningitis, Bacterial infections, All Clinical Neurology, Critical care Review Source Type: research
Nationwide Study of Postlegalization Marijuana Use Among Patients With Epilepsy in Canada
This study reveals a high prevalence of marijuana use among patients with epilepsy living in Canada particularly when seizures are drug resistant. A significant proportion of patients reported improvement of seizures with marijuana use, consistent with previous studies. With the increased accessibility of marijuana, it is imperative that physicians are aware of marijuana usage habits among patients with epilepsy. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - May 26, 2023 Category: Neurology Authors: Esmonde-White, C., McLachlan, R. S., Burneo, J., Arts, J., Redhead, C., Suller Marti, A. Tags: All Clinical Neurology, All clinical neurophysiology, EEG; see Epilepsy/Seizures, All Epilepsy/Seizures, Antiepileptic drugs Research Article Source Type: research
Ulotaront, a Trace Amine-Associated Receptor 1/Serotonin 5-HT1A Agonist, in Patients With Parkinson Disease Psychosis: A Pilot Study
Discussion In this exploratory pilot study, ulotaront may decrease PDP symptoms without worsening motor function, particularly in patients with cognitive impairment. Trial Registration Information ClinicalTrials.gov identifier: NCT02969369; submitted: November 17, 2016; study start date: December 31, 2016. Classification of Evidence This Class II study was an exploratory pilot study that was underpowered to detect a statistically significant difference between ulotaront and placebo in the treatment of patients with Parkinson disease psychosis without worsening motor function. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - May 25, 2023 Category: Neurology Authors: Isaacson, S. H., Goldstein, M., Pahwa, R., Singer, C., Klos, K., Pucci, M., Zhang, Y., Crandall, D., Koblan, K. S., Navia, B., for the Parkinson's Psychosis TAAR1 Study Group Tags: Class II Research Article Source Type: research
Sociodemographic and Geographic Disparities in End-of-Life Health Care Intensity Among Medicare Beneficiaries With Parkinson Disease
Discussion Most persons with PD in the US are hospitalized in the last 6 months of life, and treatment intensity varies by sex, race, ethnicity, and geographic location. These group differences emphasize the importance of exploring end-of-life care preferences, service availability, and care quality among diverse populations with PD and may inform new approaches to advance care planning. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - May 25, 2023 Category: Neurology Authors: Aamodt, W. W., Bilker, W. B., Willis, A. W., Farrar, J. T. Tags: Outcome research, Parkinson's disease/Parkinsonism, Inclusion, Diversity, Equity, Anti-racism, and Social Justice (IDEAS), Palliative care Research Article Source Type: research
Observational Study of Patients Hospitalized With Neurologic Events After SARS-CoV-2 Vaccination, December 2020-June 2021
Discussion All cases in this study were determined to have at least 1 risk factor and/or known etiology accounting for their neurologic syndromes. Our comprehensive clinical review of these cases supports the safety of mRNA COVID-19 vaccines. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - May 25, 2023 Category: Neurology Authors: Kim, C. Y., McNeill, E. N., Young, C., King, F., Clague, M., Caldwell, M., Boruah, A., Zucker, J., Thakur, K. T. Tags: Autoimmune diseases, Post-infectious, Inclusion, Diversity, Equity, Anti-racism, and Social Justice (IDEAS), COVID-19 Research Article Source Type: research
Managing Antiseizure Medications in Pregnancy: Is Earlier and More Frequent Monitoring Better?
This study demonstrates that frequency and timing of ASM level monitoring may not affect overall seizure outcomes during pregnancy in those on lamotrigine or levetiracetam. Furthermore, one can consider preemptive dose adjustments or a laboratory-based/clinical-based approach in managing lamotrigine as both seem safe and feasible. However, in those with drug-resistant epilepsy before pregnancy, earlier and closer monitoring is warranted given the risk of seizures early during pregnancy. Larger prospective studies are needed to confirm these results. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - May 22, 2023 Category: Neurology Authors: Freund, B., Chen, B., Kaplan, P. W., Johnson, E. L. Tags: Gender, All Epilepsy/Seizures, Antiepileptic drugs, Generalized seizures, Partial seizures Research Article Source Type: research
Routine EEG vs Ambulatory EEG for a First Seizure: Once Bitten, Twice Shy?
A first single unprovoked seizure (FSUS) is one of the most terrifying life events a person can experience. Beyond immediate impairment of normal activities in daily life crippling, its quality and safety risks include potential morbidity and mortality affecting physical, mental, and emotional health regardless of age, sex, ethnicity, and cultural background.1 Routine EEG (rEEG) is a well-known, established, and essential tool used to diagnose people with epilepsy.2 There is high specificity for an epilepsy diagnosis when interictal epileptiform discharges (IEDs) are identified on EEG.2-4 Six essential criteria to define I...
Source: Neurology Clinical Practice - May 12, 2023 Category: Neurology Authors: Tatum, W. O. Tags: All Epilepsy/Seizures, Antiepileptic drugs, EEG, Epilepsy monitoring, Video/ EEG use in epilepsy Editorial Source Type: research
Diagnostic Accuracy of Ambulatory EEG vs Routine EEG in Patients With First Single Unprovoked Seizure
This study provides Class I evidence supporting that, in adults with First Single Unprovoked Seizure (FSUS), 24-h ambulatory EEG has increased sensitivity when compared with routine and repeated EEG. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - May 12, 2023 Category: Neurology Authors: Hernandez-Ronquillo, L., Thorpe, L., Feng, C., Hunter, G., Dash, D., Hussein, T., Dolinsky, C., Waterhouse, K., Roy, P. L., Jette, N. Tags: EEG; see Epilepsy/Seizures, Class I Research Article Source Type: research
Intrathecal Dexamethasone in Febrile Infection-Related Epilepsy Syndrome: A Case Report
We present a child with FIRES with favorable outcome after receiving concomitant anakinra and IT-DaEX. A 9-year-old male patient presented with encephalopathy following a febrile illness. He developed seizures evolving to RSE refractory to multiple ASM, 3 CIs, steroids, IVIG, plasmapheresis, ketogenic diet (KD), and anakinra. After continued seizures and inability to wean off CI, IT-DEX was initiated. Results He received 6 doses of IT-DEX with resolution of RSE, rapid wean off CI, and improved inflammatory markers. At discharge, he was ambulating with assistance, speaking 2 languages, and ingesting food orally. Discussio...
Source: Neurology Clinical Practice - May 12, 2023 Category: Neurology Authors: Mehta, N. P., Sawdy, R., Maloney, K., Overlee, B., Johnson, R. K., Howe, C. L., Farias-Moeller, R. Tags: All Immunology, EEG; see Epilepsy/Seizures, Status epilepticus Clinical/Scientific Note Source Type: research
Conversion Rate of Essential Tremor to Essential Tremor Parkinson Disease: Data From a Prospective Longitudinal Study
Discussion The incidence of PD in an ET cohort is substantially higher than that reported in historical population-based control groups across numerous countries. Additional prospective longitudinal data are needed to further explore this association. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - May 10, 2023 Category: Neurology Authors: Louis, E. D., Berry, D., Ghanem, A., Cosentino, S. A. Tags: All Clinical Neurology, All Movement Disorders, Parkinson's disease/Parkinsonism, Tremor, Cohort studies Research Article Source Type: research
Risk of All-Cause Dementia, Alzheimer Disease, and Vascular Dementia in Breast Cancer Survivors: A Longitudinal Register-Based Study
We examined the risk of dementia among 5-year breast cancer survivors using a matched cohort study design. We included breast cancer survivors aged 50 years and older at diagnosis (n = 26,741) and cancer-free comparison participants (n = 249,540). Women eligible for inclusion in the study were those born 1935–1975 and registered in the Swedish Total Population Register between January 1, 1991, and December 31, 2015. We defined breast cancer survivors as women with an initial breast cancer diagnosis between 1991 and 2005 who survived 5 or more years after their first diagnosis. We assessed all-cause dementia, Alzheime...
Source: Neurology Clinical Practice - May 10, 2023 Category: Neurology Authors: Wennberg, A., Ding, M., Feychting, M., Modig, K. Tags: All Oncology, Alzheimer's disease, Vascular dementia, Cohort studies Research Article Source Type: research
Breast Cancer, Cognitive Impairment, and Dementia: An Opportunity For Prevention?
Lives change after a breast cancer diagnosis. When an acute personal ordeal persists for years as an emotional and financial nightmare, multiple domains of mental life, family relationships, and friendships are affected in many awful ways. Heightened fear of the unknown exacerbates symptoms and can reduce treatment efficacy. In this setting, it is unsurprising that cancer-related cognitive impairment1 (CRCI) affects a majority—perhaps 75%—during breast cancer treatment and persistent CRCI can endure among about 30% for many years. Some recent studies, but not all, suggest a link between breast cancer and progre...
Source: Neurology Clinical Practice - May 10, 2023 Category: Neurology Authors: Whalley, L. Tags: All Oncology, Alzheimer's disease, Vascular dementia Editorial Source Type: research
Neurobrucellosis Mimicking Primary CNS Vasculitis--Should We Perform CSF Metagenomics Before Brain Biopsy?: A Case Report
Discussion Brucellosis is an endemic disease in developing countries and may mimic PCNSV. Our patient fulfilled the criteria for possible PCNSV; however, brain biopsy was inconsistent with PCNSV, and CSF mNGS disclosed neurobrucellosis. This case illustrates the importance of CSF mNGS in the differential diagnosis of CNS vasculitis. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - May 9, 2023 Category: Neurology Authors: Mathias, M. B., Menezes, F. G., Fernandes, G. B. P., Paes, V. R., Silva, G. S., Braga-Neto, P., Barbosa, A. A., De Oliveira, A. C. P., Baccin, C. E., Dutra, L. A. Tags: Vasculitis Clinical/Scientific Note Source Type: research
Amount and Distribution of Intracranial Calcification in Symptomatic and Asymptomatic Primary Familial Brain Calcification
Discussion Patients with PFBC had more severe intracranial calcifications, and these calcifications were more diffusely distributed through the brain compared with controls. Symptomatic patients with PFBC might have more intracranial calcifications than asymptomatic persons. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - May 9, 2023 Category: Neurology Authors: Golüke, N. M. S., Meijer, E., van Maren, E. A., de Jonghe, A., Emmelot-Vonk, M. H., van Valen, E., de Jong, P. A., Koek, H. L. Tags: CT, Case control studies, All Genetics Research Article Source Type: research
Screening of Major Depression Disorder in Patients With Epilepsy in Indonesian National Referral Hospital
This study aims to determine the accuracy of the valid and reliable NDDI-E Indonesian version as an MDD screening tool in PWE and investigate the prevalence and risk factors for the development of MDD in PWE. Methods A diagnostic cross-sectional study was conducted at Cipto Mangunkusumo National Referral Hospital, Indonesia. Patients were PWE aged 18 years or older who visited the epilepsy outpatient clinic. The valid and reliable NDDI-E Indonesian version and Mini International Neuropsychiatric Interview (MINI) International Classification of Disease, 10th Revision (ICD-10) were used to diagnose MDD. In phase II of the s...
Source: Neurology Clinical Practice - May 3, 2023 Category: Neurology Authors: Budikayanti, A., Rahmi, I., Amalini, L., Lastri, D. N., Herqutanto, , Prihartono, J., Octaviana, F. Tags: Depression, Prevalence studies, Risk factors in epidemiology, All Epilepsy/Seizures Research Article Source Type: research