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Specialty: Neurology
Condition: Multiple Sclerosis

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Total 440 results found since Jan 2013.

C-Reactive Protein and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis
Conclusions: This meta-analysis revealed that PD is associated with an increase of CRP levels. CRP might be a risk factor for PD or PD leads to an inflammatory response. Introduction Parkinson's disease (PD) is one of the most complex neuro-degenerative disorders next to Alzheimer's disease. It is characterized by bradykinesia, tremor, rigidity, abnormal postural, and gait (1). PD has been recognized by the selective loss of dopaminergic neurons within the substantia nigra pars compacta, whereas the exact etiology remains elusive (2). Previously, multiple inferences have reviewed the environmental a...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

Mental imagery training for treatment of central neuropathic pain: a narrative review
AbstractMental imagery is a quasi-perceptual experience in the absence of external stimuli. This concept has intrigued psychologists, sportspersons, neurologists and other scientists for over a decade now. Imagery has been used in rehabilitation and the results have been promising. Researchers refer to this as healing the body through the mind. However, the challenge is lack of standardized protocols, homogeneity and consistency in application of mental imagery in different populations. The purpose of this review is to discuss and understand the role of mental imagery in the treatment of central neuropathic pain (CNP). Tre...
Source: Acta Neurologica Belgica - April 14, 2019 Category: Neurology Source Type: research

Characterizing the Penumbras of White Matter Hyperintensities and Their Associations With Cognitive Function in Patients With Subcortical Vascular Mild Cognitive Impairment
Conclusion In this study, reduced CBF and FA and increased MD in the inner NAWM layers for both PVWMH and DWMH suggested extensive WM alterations beyond the visible WM lesions commonly observed on clinical MRI of svMCI subjects. CBF penumbras cover more extensive WM at risk than DTI penumbras, suggesting the likelihood that compromised CBF precedes white matter integrity changes, and CBF penumbras may be a potential target for the prevention of further microstructural white matter damage. The imaging parameters investigated, however, did not correlate to cognition. Author Contributions YZ, QX, and XG conceived and desig...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Publication date: Available online 14 March 2019Source: The Lancet NeurologyAuthor(s): Valery L Feigin, Emma Nichols, Tahiya Alam, Marlena S Bannick, Ettore Beghi, Natacha Blake, William J Culpepper, E Ray Dorsey, Alexis Elbaz, Richard G Ellenbogen, James L Fisher, Christina Fitzmaurice, Giorgia Giussani, Linda Glennie, Spencer L James, Catherine Owens Johnson, Nicholas J Kassebaum, Giancarlo Logroscino, Benoît Marin, W Cliff Mountjoy-VenningSummaryBackgroundNeurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Inj...
Source: The Lancet Neurology - March 16, 2019 Category: Neurology Source Type: research

Corrigendum to Intracerebral Hemorrhage in Multiple Sclerosis: A Retrospective Cohort Study Journal of Stroke and Cerebrovascular Diseases Volume 28, Issue 2, February 2019, Pages 267-275
The authors regret that the author name for Enrique Leira was incorrect at the time of publishing. This is now been corrected.
Source: Journal of Stroke and Cerebrovascular Diseases - February 8, 2019 Category: Neurology Authors: Maryam Zulfiqar, Fares Qeadan, Asad Ikram, Mudassir Farooqui, Sarah P. Richardson, Christopher S. Calder, Syed A. Quadri, Puja Mathur, Corey Ford, Santiago Ortega-Gutierrez, Enrique Leira, Harry Snow, Joel N. Gonzalez, Atif Zafar Tags: Corrigendum Source Type: research

Neurological diseases in pregnancy.
Abstract PURPOSE OF REVIEW: To summarize recent research findings and current concepts related to care of neurologic diseases in pregnancy and the risks of pregnancy to the mother-infant dyad. Recent publications related to best practices for neurologic care, risks of pregnancy, rate of relapse during and after pregnancy, as well as medication safety in pregnancy and lactation for more commonly used neurologic medications are reviewed. RECENT FINDINGS: Data continues to grow that women with neurologic conditions can experience pregnancy with minimal risks. Additionally, as more data is being published on medi...
Source: Epilepsy Curr - February 5, 2019 Category: Neurology Authors: Toscano M, Thornburg LL Tags: Curr Opin Obstet Gynecol Source Type: research

Misdiagnosis of Multiple Sclerosis in a Female Heterozygote with Fabry's Disease
Publication date: Available online 30 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Joseph R. BergerAbstractFabry's disease is an X-linked disorder of enzyme alpha-galactosidase A which leads to an accumulation of the glycolipids in lysosomes in vessels and organs. The disorder is rare with an estimated incidence of 1 in 40,000 and disease occurs more rarely in women than men. Paresthesias, hearing loss, and stroke are the typical neurological manifestations. Brain magnetic resonance imaging abnormalities may mimic those seen in multiple sclerosis (MS). Reported here is one of the rarely reported c...
Source: Multiple Sclerosis and Related Disorders - January 31, 2019 Category: Neurology Source Type: research

Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death
AbstractNR4A2 is a nuclear receptor and a transcription factor, with distinctive physiological features. In the cell nuclei of the central nervous system, it is widely expressed and identified as a crucial regulator of dopaminergic (DA) neuronal differentiation, survival, and maintenance. Importantly, it has regulated different genes crucial for dopaminergic signals, and its expression has been diminished in both aged and PD post-mortem brains and reduced in PD patients. In microglia and astrocytes, the expression of NR4A2 has been found where it can be capable of inhibiting the expression of proinflammatory mediators; hen...
Source: Molecular Neurobiology - January 25, 2019 Category: Neurology Source Type: research

Experience of a neurology service during the 2016 Olympic and Paralympic Games
Conclusions As expected, many athletes with sports-related injuries were evaluated, but cases of diverse acute neurologic pathologies were observed among nonathlete members of the OF and PF. Olympic Games are large, logistically complex events involving thousands of people. Our observations suggest that a comprehensive and detailed plan for neurologic emergencies should be considered for future games.
Source: Neurology Clinical Practice - December 10, 2018 Category: Neurology Authors: da Silva, I. R. F., Gouvea, L., Bruno Nogueira, C., Cravo, V., Liberato, B. B. Tags: Medical care, All Cerebrovascular disease/Stroke, Brain trauma, Critical care Research Source Type: research

Understanding the Role of Hypoxia Inducible Factor During Neurodegeneration for New Therapeutics Opportunities.
Abstract Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated with NDG. Since other pathologies such as refractory epilepsy, brain infections, or hereditary diseases such as "neurodegeneration with brain iron accumulation", also lead to chronic brain inflammation with loss of neural cells, NDG can be said to affe...
Source: Epilepsy Curr - November 28, 2018 Category: Neurology Authors: Merelli A, Rodríguez JCG, Folch J, Regueiro MR, Camins A, Lazarowski A Tags: Curr Neuropharmacol Source Type: research

Intracerebral Hemorrhage in Multiple Sclerosis: A Retrospective Cohort Study
Background: To identify the vascular risk factors associated with the occurrence of intracerebral hemorrhage (ICH) in Multiple Sclerosis (MS) patients.
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2018 Category: Neurology Authors: Maryam Zulfiqar, Fares Qeadan, Asad Ikram, Mudassir Farooqui, Sarah P. Richardson, Christopher S. Calder, Syed A. Quadri, Puja Mathur, Corey Ford, Santiago O.Gutierrez, Enrique Liera, Harry Snow, Joel N.Gonzalez, Atif Zafar Source Type: research

Targeting pericytes for therapeutic approaches to neurological disorders
AbstractMany  central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood–brain barrier. Pericytes, an u nder-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood–brain barrier, capillary blood flow and the movement of immune cells into the brain. They also form part of the “glial” scar isolating damaged parts of the CN...
Source: Acta Neuropathologica - October 1, 2018 Category: Neurology Source Type: research

Stem cell therapy for neurological disorders: A focus on aging.
Abstract Age-related neurological disorders continue to pose a significant societal and economic burden. Aging is a complex phenomenon that affects many aspects of the human body. Specifically, aging can have detrimental effects on the progression of brain diseases and endogenous stem cells. Stem cell therapies possess promising potential to mitigate the neurological symptoms of such diseases. However, aging presents a major obstacle for maximum efficacy of these treatments. In this review, we discuss current preclinical and clinical literature to highlight the interactions between aging, stem cell therapy, and th...
Source: Neurobiology of Disease - September 13, 2018 Category: Neurology Authors: Nguyen H, Zarriello S, Coats A, Nelson C, Kingsbury C, Gorsky A, Rajani M, Neal EG, Borlongan CV Tags: Neurobiol Dis Source Type: research

Operant Up-Conditioning of the Tibialis Anterior Motor-Evoked Potential in Multiple Sclerosis: Feasibility Case Studies.
Abstract Damage to the corticospinal pathway often results in weak dorsiflexion of the ankle, thereby limiting the mobility of people with multiple sclerosis (MS). Thus, strengthening corticospinal connectivity may improve locomotion. Here, we investigated the feasibility of tibialis anterior (TA) motor-evoked potential (MEP) operant conditioning and whether it can enhance corticospinal excitability and alleviate locomotor problems in people with chronic stable MS. The protocol consisted of 6 baseline and 24 up-conditioning sessions over 10 weeks. In all sessions, TA MEPs were elicited at 10% above active threshol...
Source: Neural Plasticity - August 22, 2018 Category: Neurology Authors: Thompson AK, Favale BM, Velez J, Falivena P Tags: Neural Plast Source Type: research

Targeting pericytes for therapeutic approaches to neurological disorders
AbstractMany  central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood–brain barrier. Pericytes, an u nder-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood–brain barrier, capillary blood flow and the movement of immune cells into the brain. They also form part of the “glial” scar isolating damaged parts of the CN...
Source: Acta Neuropathologica - August 10, 2018 Category: Neurology Source Type: research