Characterizing the Penumbras of White Matter Hyperintensities and Their Associations With Cognitive Function in Patients With Subcortical Vascular Mild Cognitive Impairment

Conclusion In this study, reduced CBF and FA and increased MD in the inner NAWM layers for both PVWMH and DWMH suggested extensive WM alterations beyond the visible WM lesions commonly observed on clinical MRI of svMCI subjects. CBF penumbras cover more extensive WM at risk than DTI penumbras, suggesting the likelihood that compromised CBF precedes white matter integrity changes, and CBF penumbras may be a potential target for the prevention of further microstructural white matter damage. The imaging parameters investigated, however, did not correlate to cognition. Author Contributions YZ, QX, and XG conceived and designed the experiments. XW, XH, JD,YS, WD, and MC performed the experiments. XW, XG, and YW analyzed the data. XW, XG, and JD contributed reagents, materials, analysis tools. XW and YW wrote the paper. XW and JD figures processing. Funding This work was supported by the Shanghai Science and Technology Committee Medical Guide Project (western medicine; No. 17411964300), and the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (No. 20172013), the National Natural Science Foundation of China (No. 81571650), the Medical Engineering Cross Research Foundation of Shanghai JiaoTong University (No. YG2017QN47), and the Research Seed Fund of Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University (RJZZ18-003), the national Key Research and Development Program of China 2016YFC1300600, and the Incubating Program for Clinical Rese...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

Related Links:

Conclusions Fear of shame and fear of blame are the most important barriers to the improvement of patient safety in the hospitals of China. Facility characteristics contributed somewhat to hospital patient safety climate in some dimensions. The initiatives to improve hospital patient safety climate are necessary and its implementation strategies needs to be shared.
Source: Journal of Patient Safety - Category: Health Management Tags: The Health Care Manager Source Type: research
Conclusions We have developed scales measuring exposure and responses to disruptive behavior. They generate valid and reliable scores when surveying operating room clinicians, and they overcome the limitations of previous tools. These survey scales are freely available.
Source: Journal of Patient Safety - Category: Health Management Tags: Original Studies Source Type: research
Objectives Insulin charts represent a key component in the inpatient glycemic management process. The aim was to evaluate the quality of structure, documentation, and treatment of diabetic inpatient care to design a new standardized insulin chart for a large university hospital setting. Methods Historically grown blank insulin charts in use at 39 general wards were collected and evaluated for quality structure features. Documentation and treatment quality were evaluated in a consecutive snapshot audit of filled-in charts. The primary end point was the percentage of charts with any medication error. Results ...
Source: Journal of Patient Safety - Category: Health Management Tags: Original Studies Source Type: research
Conclusions Adults with cerebral palsy or spina bifida have a significantly higher prevalence of common psychological, cardiometabolic, and musculoskeletal morbidity and multimorbidity, as compared with adults without cerebral palsy or spina bifida. Efforts are needed to facilitate the development of improved clinical screening algorithms and early interventions to reduce risk of disease onset/progression in these higher risk populations. To Claim CME Credits Complete the self-assessment activity and evaluation online at http://www.physiatry.org/JournalCME CME Objectives Upon completion of this article, t...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: CME Article . 2021 Series . Number 10 Source Type: research
Conclusions In this exploratory study, motor unit number index did not demonstrate discriminatory ability between patients with lumbar spinal stenosis and was not correlated with pain and functional measures. Further study is needed to explore motor unit number index’s role in longitudinal evaluation of patients with the clinical syndrome of lumbar spinal stenosis.
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
This study evaluated Women Physiatry Facebook group members’ perceptions of the value of an online community. The authors hypothesized that members would find the group protective against burnout, and early career participants would be more likely to use the group for education and networking. This was a cross-sectional survey study of women physicians in the field of physical medicine and rehabilitation primarily in the United States. The survey consisted of 51 questions covering demographic information, work/life satisfaction, and physician burnout.
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Education & Administration Source Type: research
A 64-yr-old man with a history of previous motor vehicle collision with chronic back pain presented as a referral to an outpatient spine clinic with a 3-yr history of bilateral lower limb weakness and numbness that progressed to severe bilateral foot drop. He had been seen by another practitioner from a different hospital 2 yrs prior who performed an electromyography that was interpreted as possible primary lateral sclerosis. His clinical picture was difficult to interpret as it did not fit any of the disease patterns, such as a motor neuron disease, suggested by previous electromyography. Repeated magnetic resonance imagi...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Case Report Source Type: research
ConclusionNPH ventricles deform non-uniformly. The pattern of surface distortion may be used as an additional tool to differentiate between these hydrocephalic conditions.
Source: Neuroradiology - Category: Radiology Source Type: research
The most common method of assessing the condition may make Black patients seem less ill than they really are, some experts say. A new report calls for scrapping the formula.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Kidneys Transplants Race and Ethnicity Black People Tests (Medical) Minorities New England Journal of Medicine United States Source Type: news
Scientific advisers to the C.D.C. also recommended the coronavirus vaccine boosters for those with certain medical conditions, but excluded those at risk because of their jobs.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Vaccination and Immunization Coronavirus (2019-nCoV) Drugs (Pharmaceuticals) United States Politics and Government Washington (DC) Source Type: news
More News: Academia | Alcoholism | Alzheimer's | Atrial Fibrillation | Brain | Canada Health | Cardiology | China Health | Dementia | Depression | Diabetes | Disability | Education | Endocrinology | Grants | Greece Health | Heart | Hydrocephalus | Hypertension | Ischemic Stroke | Laboratory Medicine | Medical Ethics | Men | MRI Scan | Multiple Sclerosis | Neurology | Neuroscience | Neurosurgery | Oxford University | Parkinson's Disease | Pathology | Pediatrics | Perfusion | PET Scan | Psychiatry | Radiology | Reproduction Medicine | Science | Statistics | Stroke | Study | Toxicology | UK Health | Universities & Medical Training | USA Health