Characterizing the Penumbras of White Matter Hyperintensities and Their Associations With Cognitive Function in Patients With Subcortical Vascular Mild Cognitive Impairment

Conclusion In this study, reduced CBF and FA and increased MD in the inner NAWM layers for both PVWMH and DWMH suggested extensive WM alterations beyond the visible WM lesions commonly observed on clinical MRI of svMCI subjects. CBF penumbras cover more extensive WM at risk than DTI penumbras, suggesting the likelihood that compromised CBF precedes white matter integrity changes, and CBF penumbras may be a potential target for the prevention of further microstructural white matter damage. The imaging parameters investigated, however, did not correlate to cognition. Author Contributions YZ, QX, and XG conceived and designed the experiments. XW, XH, JD,YS, WD, and MC performed the experiments. XW, XG, and YW analyzed the data. XW, XG, and JD contributed reagents, materials, analysis tools. XW and YW wrote the paper. XW and JD figures processing. Funding This work was supported by the Shanghai Science and Technology Committee Medical Guide Project (western medicine; No. 17411964300), and the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (No. 20172013), the National Natural Science Foundation of China (No. 81571650), the Medical Engineering Cross Research Foundation of Shanghai JiaoTong University (No. YG2017QN47), and the Research Seed Fund of Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University (RJZZ18-003), the national Key Research and Development Program of China 2016YFC1300600, and the Incubating Program for Clinical Rese...
Source: Frontiers in Neurology - Category: Neurology Source Type: research