Filtered By:
Condition: Epilepsy

This page shows you your search results in order of date. This is page number 19.

Order by Relevance | Date

Total 2623 results found since Jan 2013.

Epilepsy Surgery in Adult Stroke Survivors with New-Onset Drug-Resistant Epilepsy
CONCLUSIONS: Patients with stroke-related drug-resistant epilepsy are infrequently considered for epilepsy surgery that could reduce morbidity and mortality.PMID:36373342 | DOI:10.1017/cjn.2022.300
Source: The Canadian Journal of Neurological Sciences - November 14, 2022 Category: Neurology Authors: Tresah C Antaya Britney N Le Lucie Richard Amna Qureshi Salimah Z Shariff Luciano A Sposato Jorge G Burneo Source Type: research

One-year recurrence of stroke and death in Lebanese survivors of first-ever stroke: Time-to-Event analysis
ConclusionHigher rates of stroke recurrence and death were observed in the first year following a stroke in Lebanon. Various factors were identified as significant determinants. Thus, health care providers and officials in Lebanon can use these findings to implement effective preventive strategies to best address the management of these factors to reduce the stroke burden and improve the short and long-term prognosis of stroke survivors.
Source: Frontiers in Neurology - November 14, 2022 Category: Neurology Source Type: research

Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex and Parkinson's disease ‐related changes
AbstractTransfer RNA fragments (tRFs) have recently been shown to be an important family of small regulatory RNAs with diverse functions. Recent reports have revealed modified tRF blood levels in a number of nervous system conditions including epilepsy, ischemic stroke and neurodegenerative diseases, but little is known about tRF levels in the cerebrospinal fluid (CSF). To address this issue, we studied age, sex and Parkinson's disease (PD) effects on the distributions of tRFs in the CSF and blood data of healthy controls and PD patients from the NIH and the Parkinson's Progression Markers Initiative (PPMI) small RNA-seq d...
Source: Journal of Neurochemistry - November 11, 2022 Category: Neuroscience Authors: Iddo Paldor, Nimrod Madrer, Shani Vaknine Treidel, Dana Shulman, David S. Greenberg, Hermona Soreq Tags: ORIGINAL ARTICLE Source Type: research

Predictive factors for the development of epilepsy after ischemic stroke
In Argentina, each year approximately 50,000 people suffer an ischemic or hemorrhagic stroke1 and 340,000 people over 40 years old live with a history of stroke.2 The advent of therapies such as thrombolysis and thrombectomy achieved a substantial reduction in morbidity and mortality.3 In addition, stroke survivors have an increased risk of spontaneous seizures and the number of people who have survived a stroke but have motor, visual or cognitive sequelae is high.4 Post-stroke epilepsy (PSE) is a condition where seizures occur more than 7 days after stroke, with a high risk of recurrent unprovoked seizures over the subsequent 10-years.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2022 Category: Neurology Authors: Mat ías Alet, Fernando Márquez, Abril Marone, Maximiliano Darakdjian, Federico Sosa, Lucas Bonamico, Sebastián F. Ameriso Source Type: research

Periodic electroencephalographic discharges and epileptic spasms involve cortico-striatal-thalamic loops on Arterial Spin Labeling Magnetic Resonance Imaging
Brain Commun. 2022 Oct 6;4(5):fcac250. doi: 10.1093/braincomms/fcac250. eCollection 2022.ABSTRACTPeriodic discharges are a rare peculiar electroencephalogram pattern, occasionally associated with motor or other clinical manifestations, usually observed in critically ill patients. Their underlying pathophysiology remains poorly understood. Epileptic spasms in clusters and periodic discharges with motor manifestations share similar electroencephalogram pattern and some aetiologies of unfavourable prognosis such as subacute sclerosing panencephalitis or herpes encephalitis. Arterial spin labelling magnetic resonance imaging i...
Source: Herpes - November 3, 2022 Category: Infectious Diseases Authors: Monika Eisermann Ludovic Fillon Ana Saitovitch Jennifer Boisgontier Alice Vin çon-Leite Volodia Dangouloff-Ros Thomas Blauwblomme Marie Bourgeois Marie-Th érèse Dangles Delphine Coste-Zeitoun Patricia Vignolo-Diard M élodie Aubart Manoelle Kossorotoff Source Type: research

HMGB1 in nervous system diseases: A common biomarker and potential therapeutic target
High-mobility group box-1 (HMGB1) is a nuclear protein associated with early inflammatory changes upon extracellular secretion expressed in various cells, including neurons and microglia. With the progress of research, neuroinflammation is believed to be involved in the pathogenesis of neurological diseases such as Parkinson's, epilepsy, and autism. As a key promoter of neuroinflammation, HMGB1 is thought to be involved in the pathogenesis of Parkinson's disease, stroke, traumatic brain injury, epilepsy, autism, depression, multiple sclerosis, and amyotrophic lateral sclerosis. However, in the clinic, HMGB1 has not been de...
Source: Frontiers in Neurology - October 31, 2022 Category: Neurology Source Type: research

Factors Associated With the Development of Tinnitus and With the Degree of Annoyance Caused by Newly Developed Tinnitus
Objectives: Tinnitus is highly prevalent, but only a few risk factors for developing tinnitus are known and little is known about factors associated with the degree of annoyance of new-onset tinnitus. Longitudinal analysis can reveal risk factors associated with the development of tinnitus and might lead to targeted prevention. The aim of this study is twofold. (1) To identify risk factors that are longitudinally associated with the odds of developing tinnitus 5 years later. (2) To identify factors that are cross-sectionally associated with tinnitus annoyance in adults with new-onset tinnitus. Methods: Baseline,...
Source: Ear and Hearing - October 28, 2022 Category: Audiology Tags: Research Article Source Type: research

A Chinese female patient with LGI1 and mGluR5 antibodies: A case report
We present a case of AE with dual seropositive antibodies of LGI1 and mGluR5 in a 65-year-old woman who presented with sudden onset left faciobrachial dystonic seizures and unresponsive for 5 hours. Diagnosis: The patient was diagnosed with anti-LGI1 AE and anti-mGluR5 AE mainly based on the clinical symptoms and further test of the antibody in serum and cerebral spinal fluid (CSF). Interventions and outcomes: The patient was treated with glucocorticoid intravenous drip. We also gave her the therapy of immunoglobulin (25 g q.d) for 5 days and anti-epileptic therapy. She had no more convulsions on the left s...
Source: Medicine - October 28, 2022 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Anti-Epileptic Drug Target Perturbation and Intracranial Aneurysm Risk: Mendelian Randomization and Colocalization Study
CONCLUSIONS: CNNM2 is a driver of the pleiotropy between IA and anti-epileptic drug targets. Administration of the anti-epileptic drugs phenytoin, valproic acid, or carbamazepine may be expected to decrease CNNM2 levels and therefore subsequently decrease IA risk. CNNM2 is therefore an important target to investigate further for its role in the pathogenesis of IA.PMID:36300369 | DOI:10.1161/STROKEAHA.122.040598
Source: Atherosclerosis - October 27, 2022 Category: Cardiology Authors: Mark K Bakker Tijmen van Straten Michael Chong Guillaume Par é Dipender Gill Ynte M Ruigrok Source Type: research

Monogenic Stroke —Can We Overcome Nature With Nurture?
Although genetic underpinnings of several neurological disorders like epilepsy have been described as early as fourth century bce in the Corpus Hippocraticum, discoveries in stroke have been more recent. One of the first reports demonstrating the importance of heredity in stroke pathogenesis occurred in 1974 with the generation of the stroke-prone spontaneously hypertensive rat. This strain was created using selective breeding and has endured as a valuable asset in contemporary stroke research. Nonetheless, half a century later, the precise genetic determinants even in this single, highly specific rodent stroke phenotype h...
Source: JAMA Neurology - October 27, 2022 Category: Neurology Source Type: research

Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin
Toxins (Basel). 2022 Oct 11;14(10):696. doi: 10.3390/toxins14100696.ABSTRACTThe importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders such as stroke, epilepsy, and cancer. The immune response within the brain involves the presence of CNS resident cells; mainly glial cells, such as microglia, the CNS resident macrophages. We evaluated the peptide Ca-MAP1 bioinspired on the C. albicans immature cytolytic toxin candidalysin to develop ...
Source: Cancer Control - October 26, 2022 Category: Cancer & Oncology Authors: Pedro Henrique de Oliveira Cardoso Ana Paula de Ara újo Boleti Patr ícia Souza E Silva Lincoln Takashi Hota Mukoyama Alexya Sandim Guindo Luiz Filipe Ramalho Nunes de Moraes Caio Fernando Ramalho de Oliveira Maria Ligia Rodrigues Macedo Cristiano Marcel Source Type: research

A subtle connection between crossed cerebellar diaschisis and supratentorial collateral circulation in subacute and chronic ischemic stroke
Crossed cerebellar diaschisis (CCD) is a common phenomenon comprising hypoperfusion and hypometabolism of the contralateral cerebellar hemisphere caused by dysfunction of the supratentorial area, which occurs in many situations, such as supratentorial tumors, epilepsy, cerebral trauma, moyamoya disease, and cerebral infarction.1 –4 The most common mechanism of CCD has been suggested to involve disruption of the cortico-ponto-cerebellar (CPC) tract;5 Additionally, other tracts, including the spinocerebellar6and the dentatorubrothalamic tract,7 have been proposed to be involved in CCD pathogenesis.
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2022 Category: Neurology Authors: Chenghua Wu, Baoguo Jiang, Lingling Sun, Tianxiang Hu, Zhaogang Zhang, Xi Lu Source Type: research

Molecules, Vol. 27, Pages 7174: Repurposing SGLT2 Inhibitors for Neurological Disorders: A Focus on the Autism Spectrum Disorder
l Akour Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a substantially increasing incidence rate. It is characterized by repetitive behavior, learning difficulties, deficits in social communication, and interactions. Numerous medications, dietary supplements, and behavioral treatments have been recommended for the management of this condition, however, there is no cure yet. Recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental diseases, based on their proved anti-inflammatory effects, such as downregulating the express...
Source: Molecules - October 23, 2022 Category: Chemistry Authors: Mohammed Moutaz Nakhal Salahdein Aburuz Bassem Sadek Amal Akour Tags: Review Source Type: research

Pharmacological modulation of phosphodiesterase-7 as a novel strategy for neurodegenerative disorders
AbstractNeurodegenerative illness develops as a result of genetic defects that cause changes at numerous levels, including genomic products and biological processes. It entails the degradation of cyclic nucleotides, cyclic adenosine monophosphate (cAMP), and cyclic guanosine monophosphate (cGMP). PDE7 modulates intracellular cAMP signalling, which is involved in numerous essential physiological and pathological processes. For the therapy of neurodegenerative illnesses, the normalization of cyclic nucleotide signalling through PDE inhibition remains intriguing. In this article, we shall examine the role of PDEs in neurodege...
Source: Inflammopharmacology - October 22, 2022 Category: Drugs & Pharmacology Source Type: research