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Condition: Epilepsy
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Total 2623 results found since Jan 2013.
Cytochrome P450-derived eicosanoids in brain: From basic discovery to clinical translation
Adv Pharmacol. 2023;97:283-326. doi: 10.1016/bs.apha.2022.11.002. Epub 2023 Jan 11.ABSTRACTCytochrome P450 metabolism of arachidonic acid produces epoxyeicosatrienoates (EETs) and hydroxyeicosatetraenoates (HETEs). Both classes of eicosanoids play important and opposing roles in brain function and disease. EETs promote vasodilation and exhibit antiinflammatory and cytoprotective properties; their biological action is blunted by metabolism to less active diols by the enzyme soluble epoxide hydrolase (sEH). EETs levels are dysregulated in disease states, primarily due to increased activity of sEH. Inhibition of sEH is a prom...
Source: Advances in Pharmacology - May 26, 2023 Category: Drugs & Pharmacology Authors: Catherine M Davis Aseel H Ibrahim Nabil J Alkayed Source Type: research
Case report: Young-onset large vessel ischemic stroke due to hyperhomocysteinemia associated with the C677T polymorphism on 5,10-methylenetetrahydrofolate reductase and multi-vitamin deficiency
Hyperhomocysteinemia is an important risk factor for cerebral infarction. Herein, we report on a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. Magnetic resonance imaging showed a fronto-temporal ischemic lesion due to occlusion of the left middle cerebral artery. Clinical testing and imaging demonstrated that he had hyperhomocysteinemia induced by multiple factors including the C677T polymorphism on 5.10-methylenetetrahydrofolate reductase (MTHFR), and multiple vitamin deficiencies. The C677T polymorphism on MTHFR is closely related to hyperhomocysteinemia and fol...
Source: Frontiers in Neurology - May 18, 2023 Category: Neurology Source Type: research
Risk assessment of mechanic thrombectomy on post-stroke seizures: a systematical review and meta-analysis
Acute ischemic stroke is a leading cause of disability, with over a third of survivors developing new post-stroke disabilities around the world.1 Many post-stroke patients have a significant higher risk of developing post-stroke seizures of which the incidence has also been increasing over the past decades.2 Cerebrovascular disease is the leading cause of seizures in adults over 60-year-old, which has been shown to account for nearly 50% of newly diagnosed epilepsy in this age group.3
Source: Journal of Stroke and Cerebrovascular Diseases - May 10, 2023 Category: Neurology Authors: Wen Jiang, Xiaoyan Zhu, Chunyan Lei, Guoliang Jiang, Linming Zhang, Song Mei, Lianmei Zhong Source Type: research
Microfluidic 'brain-on chip' systems to supplement neurological practice: development, applications and considerations
Regen Med. 2023 Apr 26. doi: 10.2217/rme-2022-0212. Online ahead of print.ABSTRACTAmong the greatest general challenges in bioengineering is to mimic human physiology. Advanced efforts in tissue engineering have led to sophisticated 'brain-on-chip' (BoC) microfluidic devices that can mimic structural and functional aspects of brain tissue. BoC may be used to understand the biochemical pathways of neurolgical pathologies and assess promising therapeutic agents for facilitating regenerative medicine. We evaluated the potential of microfluidic BoC devices in various neurological pathologies, such as Alzheimer's, glioblastoma,...
Source: Regenerative Medicine - May 1, 2023 Category: Genetics & Stem Cells Authors: Ryan Jarrah Karim Rizwan Nathani Shaan Bhandarkar Chibuze S Ezeudu Ryan T Nguyen Abrham Amare Usama A Aljameey Sabrina I Jarrah Archis R Bhandarkar Brian Fiani Source Type: research
