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Condition: Epilepsy
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Total 2623 results found since Jan 2013.
Scientists Are Just Beginning to Understand COVID-19 ’ s Effect On the Brain
Early in the COVID-19 pandemic, doctors started to notice something striking. For what was originally described as a respiratory virus, SARS-CoV-2 seemed to have a strong effect on the brain, causing everything from loss of taste and smell and brain fog to, in serious cases, stroke.
NYU Langone Health, a New York city research hospital, started collating those anecdotes in hopes of better understanding how the virus affects the brain and nervous system. Years later, the project has morphed from focusing solely on acute symptoms to also tracking the long-term neurologic issues that some people with Long COVID experience, sa...
Source: TIME: Health - July 17, 2023 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news
Lifelong cerebrovascular disease burden among CADASIL patients: analysis from a global health research network
DiscussionEarly screening and targeted treatment strategies are warranted to help CADASIL patients with symptom management and risk mitigation.
Source: Frontiers in Neurology - July 14, 2023 Category: Neurology Source Type: research
External validation and comparison of clinical scores for predicting late seizures after intracerebral hemorrhage in Chinese patients
CONCLUSION: Our study showed that the CAVE, CAVS and LANE scores had similar AUCs for the occurrence of late seizures, but the LANE score had a relatively high PPV at the optimal cutoff score. Due to low evidence for using prophylactic antiseizure medications (ASM) in patients with ICH and poor availability of specialist stroke care in China, the LANE score with a cutoff score of 3 could be an applicable prediction tool in Chinese patients with ICH.PMID:37441984 | DOI:10.1016/j.yebeh.2023.109349
Source: Epilepsy and Behaviour - July 13, 2023 Category: Neurology Authors: Jiahe Lin Xianxian Li Jiahe Ye Guo Li Shanshan Huang Suiqiang Zhu Source Type: research
Case report: “Proust phenomenon” after right posterior cerebral artery occlusion
In this study, we provide the inaugural description of aversive odor-evoked autobiographical memories after stroke in the right hippocampal, parahippocampal, and thalamic nuclei. As potential underlying neural signatures of the phenomenon, we discuss the disinhibition of limbic circuits and impaired communication between the major networks, such as saliency, central executive, and default mode network.
Source: Frontiers in Neurology - July 13, 2023 Category: Neurology Source Type: research
Mitochondrial encephalopathy with lactic-acidosis and stroke-like episodes syndrome presenting as progressive supranuclear palsy
Clinical manifestations of MELAS are broad and include stroke-like episodes, myopathy, cardiomyopathy, headaches, hearing impairment, dementia, epilepsy, lactic acidemia, cyclic vomiting, diabetes, and short stature. Most cases of MELAS present early in childhood, with only 1 –6% presenting after the age of 40 [1]. Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which can be mimicked by a variety of conditions, such as CADASIL, cerebrovascular disease, and autoimmune encephalitis [2].
Source: Parkinsonism and Related Disorders - July 7, 2023 Category: Neurology Authors: Reece M. Hass, Jennifer L. Whitwell, Elizabeth Y. Coon, Keith A. Josephs, Farwa Ali Tags: Correspondence Source Type: research
Multiscale effects of excitatory-inhibitory homeostasis in lesioned cortical networks: A computational study
We present a large-scale model of the neocortex, with synaptic scaling of local inhibition, showing how E-I homeostasis can drive the post-lesion restoration of FC and linking it to changes in excitability. We show that functional networks could reorganize to recover disrupted modularity and small-worldness, but not network dynamics, suggesting the need to consider forms of plasticity beyond synaptic scaling of inhibition. On average, we observed widespread increases in excitability, with the emergence of complex lesion-dependent patterns related to biomarkers of relevant side effects of stroke, such as epilepsy, depressio...
Source: PLoS Computational Biology - July 7, 2023 Category: Biology Authors: Francisco P áscoa dos Santos Source Type: research
Sleep-related rhythmic movement disorder in adults - A systematic review with a case report
J Sleep Res. 2023 Jul 6:e13985. doi: 10.1111/jsr.13985. Online ahead of print.ABSTRACTSleep-related rhythmic movement disorder is characterised by stereotyped and repetitive rhythmic movements involving large muscle groups during sleep with frequencies between 0.5 and 2 Hz. Most of the published studies on sleep-related rhythmic movement disorder have focussed on children. Therefore, we performed a systematic review on this topic focussing on the adult population. The review is followed by a case report. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 ...
Source: Journal of Sleep Research - July 6, 2023 Category: Sleep Medicine Authors: Monika Michalek-Zrabkowska Mieszko Wieckiewicz Adam Wichniak Andrej Jenca Janka Jencova Weronika Frosztega Tomasz Wieczorek Justyna Chojdak-Lukasiewicz Monika Sluzewska-Niedzwiedz Anna Wojakowska Rafal Poreba Grzegorz Mazur Helena Martynowicz Source Type: research
The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy
Glutamate is the brain’s main excitatory neurotransmitter. Glutamatergic neurons primarily compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and inhibitory activities may result in epilepsy or other neurological and psychiatric conditions. Among glutamate receptors, AMPA receptors are the predominant mediator of glutamate-induced excitatory neurotransmission and dictate synaptic efficiency and plasticity by their numbers and/or properties. Therefore, they appear to be a major drug target for modulating several brain functions. Perampanel (PER) is a highly selective, noncompetitive AMPA...
Source: Frontiers in Neurology - July 6, 2023 Category: Neurology Source Type: research
Histopathological characterization of cerebral small vessel disease in epilepsy patients with temporal lobe epilepsy submitted to surgery - a case-control study
CONCLUSION: The present study provided evidence supporting the increased burden of cSVD in the neuropathological samples of patients with chronic epilepsy.PMID:37402214 | DOI:10.1111/ene.15963
Source: Atherosclerosis - July 4, 2023 Category: Cardiology Authors: Pedro Coelho Jo ão Madureira Ana Franco Ana Rita Peralta Carla Bentes Alexandre Rainha Campos Jasper Anink Eleonora Aronica Rafael Roque Jos é Pimentel Source Type: research
Reframing Lesional Epilepsy as a Network Disease
The question why some brain lesions cause epilepsy whereas other do not has remained unanswered for the past century. Lesions are the leading identifiable cause of epilepsy in adults, especially in individuals older than 55 years. But, only 6% of those with stroke, 9% of those with intracerebral hemorrhage, and approximately 40% of those with brain tumors have lesional epilepsy. Why do some develop epilepsy whereas others do not?
Source: JAMA Neurology - July 3, 2023 Category: Neurology Source Type: research
Genetics and SUDEP: Challenges and Future Directions
Sudden unexpected death in epilepsy (SUDEP) is an important cause of premature mortality in persons living with epilepsy (PWE) [1 –2]. The incidence of SUDEP in children and adults is equal, approximately 1.2 per 1000-person years [3–5]. SUDEP is the leading cause of epilepsy-related deaths in children and adults with epilepsy [1–2]. Furthermore, next to stroke, SUDEP is the second leading cause of total years of potenti al life lost [6–7]. Although inroads have been made in our understanding of SUDEP, its pathophysiology remains unknown.
Source: Seizure: European Journal of Epilepsy - July 2, 2023 Category: Neurology Authors: Robyn Whitney, Suvasini Sharma, Kevin C. Jones, Rajesh RamachandranNair Tags: Review Source Type: research
