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Condition: Epilepsy
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Total 2623 results found since Jan 2013.
Molecules, Vol. 28, Pages 2598: Gastrodin and Gastrodigenin Improve Energy Metabolism Disorders and Mitochondrial Dysfunction to Antagonize Vascular Dementia
This study explored the effects of Gas and HBA on cognitive dysfunction in VD and their possible molecular mechanisms. The VD model was established by bilateral common carotid artery ligation (2-vessel occlusion, 2-VO) combined with an intraperitoneal injection of sodium nitroprusside solution. One week after modeling, Gas (25 and 50 mg/kg, i.g.) and HBA (25 and 50 mg/kg, i.g.) were administered orally for four weeks, and the efficacy was evaluated. A Morris water maze test and passive avoidance test were used to observe their cognitive function, and H&E staining and Nissl staining were used to observe the neur...
Source: Molecules - March 13, 2023 Category: Chemistry Authors: Sha Wu Rong Huang Ruiqin Zhang Chuang Xiao Lueli Wang Min Luo Na Song Jie Zhang Fang Yang Xuan Liu Weimin Yang Tags: Article Source Type: research
Epileptiform activity in the acute phase of stroke predicts the outcomes in patients without seizures
ConclusionsAbnormalities in EEG without clinical manifestation are present in 40% of patients with acute stroke. Changes in EEG in acute stroke are associated with a poor neurological status in the first days and poor functional status in the chronic period of stroke.
Source: Frontiers in Neurology - March 13, 2023 Category: Neurology Source Type: research
Genetic Aberration Analysis of Mitochondrial Respiratory Complex I Implications in the Development of Neurological Disorders and Their Clinical Significance
Ageing Res Rev. 2023 Mar 9:101906. doi: 10.1016/j.arr.2023.101906. Online ahead of print.ABSTRACTGrowing neurological diseases pose difficult challenges for modern medicine to diagnose and manage them effectively. Many neurological disorders mainly occur due to genetic alteration in genes encoding mitochondrial proteins. Moreover, mitochondrial genes exhibit a higher rate of mutation due to the generation of Reactive oxygen species (ROS) during oxidative phosphorylation operating in their vicinity. Among the different complexes of Electron transport chain (ETC), NADH: Ubiquinone oxidoreductase (Mitochondrial complex I) is ...
Source: Ageing Research Reviews - March 11, 2023 Category: Genetics & Stem Cells Authors: Ghulam Mehdi Dar Ejaj Ahmad Asgar Ali Bhawna Mahajan Ghulam Md Ashraf Sundeep Singh Saluja Source Type: research
Prevalence, electroclinical spectrum and effect on the outcome of non-convulsive status epilepticus in critically ill patients; the utility of routine electroencephalogram
Epilepsy Behav. 2023 Feb 28;141:109144. doi: 10.1016/j.yebeh.2023.109144. Online ahead of print.ABSTRACTOBJECTIVES: To highlight the importance of routine electroencephalogram (rEEG) in detecting non-convulsive status epilepticus (NCSE), describing the electroclinical spectrum and effect on outcome in critically ill patients with altered mental status (CIPAMS).METHODS: This retrospective study was conducted at King Fahd University Hospital. Clinical data and EEG recordings of CIPAMS to rule out NCSE were reviewed. All patients had at least 30 minutes of EEG recording. The Salzburg Consensus criteria (SCC) were applied to d...
Source: Epilepsy and Behaviour - March 2, 2023 Category: Neurology Authors: Azra Zafar Source Type: research
Interference of New Antiseizure Agents with Hospital Transfer of Stroke Patients in Japan: A Retrospective Cohort Study
Biol Pharm Bull. 2023;46(3):440-445. doi: 10.1248/bpb.b22-00787.ABSTRACTPatients in Japan often have difficulty in screening and selecting chronic-care and rehabilitation hospitals for transfer because of the high cost and unavailability of new antiseizure medications, such as perampanel and lacosamide. To investigate whether the requirement for perampanel and lacosamide interfered with patients' hospital transfer by comparing the number of days required for hospital transfer. Data were obtained from patients 1) who were diagnosed with intracerebral hemorrhage or cerebral infarction, 2) who were treated with antiseizure me...
Source: Biological and Pharmaceutical Bulletin - March 1, 2023 Category: Drugs & Pharmacology Authors: Satoru Matsunuma Shigeki Sunaga Koichi Yoshimoto Hiroyuki Jimbo Source Type: research
Dietary energy restriction in neurological diseases: what’s new?
AbstractEnergy-restricted diet is a specific dietary regimen, including the continuous energy-restricted diet and the intermittent energy-restricted diet. It has been proven effective not only to reduce weight and extend the lifespan in animal models, but also to regulate the development and progression of various neurological diseases such as epilepsy, cerebrovascular diseases (stroke), neurodegenerative disorders (Alzheimer's disease and Parkinson's disease) and autoimmune diseases (multiple sclerosis). However, the mechanism in this field is still not clear and a systematic neurological summary is still missing. In this...
Source: European Journal of Nutrition - February 26, 2023 Category: Nutrition Source Type: research
Neighborhood Type Tied to Post-Stroke Mortality Risk Neighborhood Type Tied to Post-Stroke Mortality Risk
Living in a disadvantaged neighborhood may hike mortality risk after discharge from the hospital for stroke, epilepsy, or other neurologic conditions, new research suggests.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - February 22, 2023 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Impact of acute symptomatic seizures and their management on patient-reported outcomes after stroke
The objective of our study is to evaluate the association between PROMs and ASyS and ASMs following stroke.METHODS: We performed a retrospective cohort study of all stroke patients who underwent inpatient continuous EEG (cEEG) monitoring performed due to suspected ASyS, including the ones with observed convulsive ASyS, from 04/01/2012 to 03/31/2018, who completed PROMs within 6 months of hospital discharge. Patient-reported outcome measures, including one Neuro-QoL and six PROMIS v1.0 domain scales, were completed by patients as the standard of care in ambulatory stroke clinics. Since ASMs are sometimes used without clearl...
Source: Epilepsy and Behaviour - February 22, 2023 Category: Neurology Authors: Vineet Punia Yadi Li Brittany Lapin Pradeep Chandan Christopher Newey Stephen Hantus Monika Dhakar Clio Rubinos Sahar Zafar Adithya Sivaraju Irene L Katzan for Post-Acute Symptomatic Seizure Investigation and Outcomes Network (PASSION) investigators Source Type: research
Alternative medicine therapies in neurological disorders: Prevalence, reasons and associated factors. A systematic review
CONCLUSIONS: The prevalence of CAM use in neurological diseases is highly variable (16%-100%); the most used type of CAM was biological therapies and the associated factors were female sex, age between 40 and 50 years old and high socioeconomic level.PMID:36805318 | DOI:10.1016/j.ctim.2023.102932
Source: Complementary Therapies in Medicine - February 22, 2023 Category: Complementary Medicine Authors: Mar ía Soto-Lara Melissa Silva-Loredo Jos é Rodrigo Monroy-Córdoba Paola Flores-Ordo ñez Nelly G Cervera-Delgadillo Paul Carrillo-Mora Source Type: research
