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Condition: Epilepsy

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Total 2623 results found since Jan 2013.

Pattern of Neurological Disorders among Patients Evaluated in the Emergency Department; Cross-Sectional Study
CONCLUSION: In our study, neurologic emergencies accounted for 3.7% of all emergency admissions. Stroke, epileptic seizures, cerebral venous thrombosis, encephalopathies, and acute spinal cord diseases were the most common neurological disorders. The admission rate was very high following neurologic assessment by neurologists.PMID:36743701 | PMC:PMC9887228 | DOI:10.22037/aaem.v11i1.1813
Source: Accident and Emergency Nursing - February 6, 2023 Category: Emergency Medicine Authors: Mohamed Sheikh Hassan Nor Osman Sidow Alper G ökgül Bakar Ali Adam Mohamed Farah Osman Hussein Hassan Mohamed Ismail Gedi Ibrahim Ishak Ahmed Abdi Source Type: research

Neuroprotective Roles of Apelin-13 in Neurological Diseases
This study summarizes the pathophysiological roles of apelin-13 in the development and progression of neurological related diseases.PMID:36745269 | DOI:10.1007/s11064-023-03869-0
Source: Neurochemical Research - February 6, 2023 Category: Neuroscience Authors: Yang Zhang Weiwei Jiang Wenjie Sun Weiming Guo Beibei Xia Xiangru Shen Mingyuan Fu Teng Wan Mei Yuan Source Type: research

Development and validation of a novel radiomics-clinical model for predicting post-stroke epilepsy after first-ever intracerebral haemorrhage
ConclusionsThe combined radiomics-clinical model was better able to predict ICH-associated PSE compared to the clinical model. This can help clinicians better predict an individual patient ’s risk of PSE following a first-ever ICH and facilitate earlier PSE diagnosis and treatment.Key Points•Radiomics has not been used in predicting the risk of developing PSE.•Higher Rad-scores were associated with higher risk of developing PSE.•The combined model showed better performance of PSE prediction ability.
Source: European Radiology - February 3, 2023 Category: Radiology Source Type: research

Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging
This article focuses on clinical applications of arterial spin labeling (ASL) and is part of a wider effort from the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group to update and expand on the recommendations provided in the 2015 ASL consensus paper. Although the 2015 consensus paper provided general guidelines for clinical applications of ASL MRI, there was a lack of guidance on disease-specific parameters. Since that time, the clinical availability and clinical demand for ASL MRI has increased. This position paper provides guidance on using ASL in specific clinical scenarios, includ...
Source: Magnetic Resonance in Medicine - January 25, 2023 Category: Radiology Authors: Thomas Lindner Divya S Bolar Eric Achten Frederik Barkhof Ant ónio J Bastos-Leite John A Detre Xavier Golay Matthias G ünther Danny J J Wang Sven Haller Silvia Ingala Hans R J äger Geon-Ho Jahng Meher R Juttukonda Vera C Keil Hirohiko Kimura Mai-Lan Ho Source Type: research

Role of tRNA-Derived Fragments in Neurological Disorders: a Review
AbstracttRFs are small tRNA derived fragments that are emerging as novel therapeutic targets and regulatory molecules in the pathophysiology of various neurological disorders. These are derived from precursor or mature tRNA, forming different subtypes that have been reported to be involved in neurological disorders like stroke, Alzheimer ’s, epilepsy, Parkinson’s, MELAS, autism, and Huntington’s disorder. tRFs were earlier believed to be random degradation debris of tRNAs. The significant variation in the expression level of tRFs in disease conditions indicates their salient role as key players in regulation of these...
Source: Molecular Neurobiology - January 19, 2023 Category: Neurology Source Type: research

The incidence and prevalence of epilepsy in the United Kingdom 2013 –2018: A retrospective cohort study of UK primary care data
The estimated incidence (50 –80 per 100,000 person-years) and prevalence rates (5–10 per 1000 person / year) for epilepsy have been found to be relatively consistent across high income countries [1–3]. Nevertheless, changes in demographics and risk factors mean that the epidemiology of epilepsy may change over time. For instance, in countries with an aging population, the increasing prevalence of diseases of old age such as stroke or dementia could increase the prevalence of epilepsy. Conversely, improved General Practitioner (GP) and specialist training, improved guidance for clinicians, better obstetric care and mo...
Source: Seizure: European Journal of Epilepsy - January 5, 2023 Category: Neurology Authors: S Wigglesworth, A Neligan, JM Dickson, A Pullen, E Yelland, T Anjuman, M Reuber Source Type: research

The Incidence and Prevalence of Epilepsy in the United Kingdom 2013-2018: a retrospective cohort study of UK primary care data.
The estimated incidence (50-80 per 100,000 person-years) and prevalence rates (5-10 per 1000 person / year) for epilepsy have been found to be relatively consistent across high income countries [1 –3]. Nevertheless, changes in demographics and risk factors mean that the epidemiology of epilepsy may change over time. For instance, in countries with an aging population, the increasing prevalence of diseases of old age such as stroke or dementia could increase the prevalence of epilepsy. Conve rsely, improved General Practitioner (GP) and specialist training, improved guidance for clinicians, better obstetric care and more ...
Source: Seizure: European Journal of Epilepsy - January 5, 2023 Category: Neurology Authors: S Wigglesworth, A Neligan, JM Dickson, A Pullen, E Yelland, T Anjuman, M Reuber Source Type: research

Epileptic nystagmus in MELAS and non-mitochondrial disorders
We eagerly read the article by Aykac et  al. about 20 patients with horizontal epileptic nystagmus [1]. One of these patients was reported as having mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome [1]. It was found that the ictal discharge pattern was rhythmic fast activity with a mean frequency o f 15 Hz, that ictal discharges originated from the parieto-occipital, temporo-occipital, parieto-occipito-temporal, temporal, occipital, or centro-parietal areas, that the fast phase of the nystagmus was beating away from the side of ictal discharges, and that the origin of the ictal disc...
Source: Seizure: European Journal of Epilepsy - January 1, 2023 Category: Neurology Authors: Josef Finsterer Tags: Letter to the editor Source Type: research

Early predictors of neurodevelopment after perinatal arterial ischemic stroke: a systematic review and meta-analysis
CONCLUSION: Corticospinal tract assessment on MRI and standardized motor assessments are best to predict cerebral palsy after PAIS. Future research should be focused on improving outcome prediction for non-motor outcomes.IMPACT: We present a systematic review of early predictors for various long-term outcome categories after perinatal arterial ischemic stroke (PAIS), including a meta-analysis for the outcome unilateral spastic cerebral palsy. Corticospinal tract assessment on MRI and standardized motor assessments are best to predict cerebral palsy after PAIS, while bedside techniques such as (a)EEG and NIRS might improve ...
Source: Pediatric Research - December 27, 2022 Category: Pediatrics Authors: Lisanne M Baak Niek E van der Aa Annemijn A E Verhagen Jeroen Dudink Floris Groenendaal Cora H A Nijboer Manon J N L Benders Nienke Wagenaar Source Type: research

The influential factors and non-pharmacological interventions of cognitive impairment in children with ischemic stroke
ConclusionHowever, evidence regarding the efficacy of these interventions is relatively weak. In future studies, the active application of a variety of interventions to improve pediatric cognitive function will be necessary, and neuroimaging and electrophysiological measurement techniques will be of great value in this context. Larger multi-center prospective longitudinal studies are also required to offer more accurate evidence-based guidance for the treatment of patients with pediatric stroke.
Source: Frontiers in Neurology - December 15, 2022 Category: Neurology Source Type: research

Sleep Disturbances in Neurological Disease: A Target for Intervention
Semin Neurol 2022; 42: 639-657 DOI: 10.1055/a-1958-0710Sleep is a biological function required for neurological and general health, but a significant and under-recognized proportion of the population has disturbed sleep. Here, we briefly overview the biology of sleep, sleep requirements over the lifespan, and common sleep disorders. We then turn our attention to five neurological diseases that significantly contribute to global disease burden and neurology practice makeup: epilepsy, headache, ischemic stroke, Parkinson's disease, and Alzheimer's disease. For each disease, we review evidence that sleep disturbances contribu...
Source: Seminars in Neurology - December 13, 2022 Category: Neurology Authors: Khambadkone, Seva G. Benjamin, Sara E. Tags: Review Article Source Type: research

Acute Symptomatic Seizure Associated With Chronic Antiseizure Medication Use After Stroke
Discussion Chronic ASM use is highly associated with electrographic, rather than convulsive, ASyS. However, long-term ASM use is independently associated with PSE and its risk factors, including convulsive ASyS. With the ubiquity of stroke-related ASyS concerns in routine clinical practice, comparative effectiveness studies to guide ASM management are needed.
Source: Neurology Clinical Practice - December 13, 2022 Category: Neurology Authors: Byrnes, M., Chandan, P., Newey, C., Hantus, S., Punia, V. Tags: Research Article Source Type: research

One-year recurrence of stroke and death in Lebanese survivors of first-ever stroke: Time-to-Event analysis
CONCLUSION: Higher rates of stroke recurrence and death were observed in the first year following a stroke in Lebanon. Various factors were identified as significant determinants. Thus, health care providers and officials in Lebanon can use these findings to implement effective preventive strategies to best address the management of these factors to reduce the stroke burden and improve the short and long-term prognosis of stroke survivors.PMID:36452174 | PMC:PMC9702576 | DOI:10.3389/fneur.2022.973200
Source: Atherosclerosis - December 1, 2022 Category: Cardiology Authors: Celina F Boutros Walaa Khazaal Maram Taliani Najwane Said Sadier Pascale Salameh Hassan Hosseini Source Type: research