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Condition: Epilepsy
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Total 2623 results found since Jan 2013.
Development of microRNA-based therapeutics for central nervous system diseases
Eur J Pharmacol. 2023 Aug 2;956:175956. doi: 10.1016/j.ejphar.2023.175956. Online ahead of print.ABSTRACTMicroRNA (miRNA)-mediated gene silencing is a method of RNA interference in which a miRNA binds to messenger RNA sequences and regulates target gene expression. MiRNA-based therapeutics have shown promise in treating a variety of central nervous system diseases, as verified by results from diverse preclinical model organisms. Over the last decade, several miRNA-based therapeutics have entered clinical trials for various kinds of diseases, such as tumors, infections, and inherited diseases. However, such clinical trials ...
Source: European Journal of Pharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Siqi Xia Chaoran Xu Fuyi Liu Gao Chen Source Type: research
Molecules, Vol. 28, Pages 5824: Neurological Applications of Celery (Apium graveolens): A Scoping Review
In conclusion, the safety of A. graveolens extract and NBP can be further investigated clinically on different neurological disorders based on their potential role in different targeted pathways.
Source: Molecules - August 2, 2023 Category: Chemistry Authors: Terence Yew Chin Tan Xin Yi Lim Nor Azrina Norahmad Hemahwathy Chanthira Kumar Bee Ping Teh Nai Ming Lai Ami Fazlin Syed Mohamed Tags: Review Source Type: research
New UArizona study links brain waves directly to memory
The findings could lay foundations for cognitive impairment therapy and help improve memory.
Niranjana Rajalakshmi
Today
University CommunicationsOscillations feature.jpgHealthCollege of ScienceExpertsResearch
Media contact(s)Niranjana Rajalakshmi
Science Writer, University Communicationsniranjanar@arizona.edu917-415-3497
Researcher contact(s)Arne Ekstrom
Department of Psychologyadekstrom@email.arizona.edu520-621-4594Neurons produce rhythmic patterns of electrical activity in the brain. One of the unsettled questions in the field of neuroscience is what primarily drives these rhythmic signals, called oscillations. U...
Source: The University of Arizona: Health - July 31, 2023 Category: Universities & Medical Training Authors: niranjanar Source Type: research
Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Neurochem Res. 2023 Jul 26. doi: 10.1007/s11064-023-03983-z. Online ahead of print.ABSTRACTHot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8-methyl N-vanillyl-6-noneamide) is the main pungent principle of hot green and red peppers. By acting on the capsaicin receptor or transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1), capsaicin selectively stimulates and in high doses defunctionalizes capsaicin-sensitive chemonociceptors with C and Aδ afferent fibers. This channe...
Source: Neurochemical Research - July 26, 2023 Category: Neuroscience Authors: Omar M E Abdel-Salam Gyula M ózsik Source Type: research
Telephone assistance for neurological diseases: a systematic review
CONCLUSIONS: Dementias are the diseases with more bibliographic references on their telephone assistance despite not being the most prevalent. The telephone is frequently used to administer diagnostic scales or support caregivers and is particularly useful in diseases that limit mobility and attending a medical practice.PMID:37466132 | DOI:10.33588/rn.7703.2022284
Source: Revista de Neurologia - July 19, 2023 Category: Neurology Authors: J M Trejo-Gabriel-Gal án E Cubo-Delgado Source Type: research
Preventing development of post-stroke hyperexcitability by optogenetic or pharmacological stimulation of cortical excitatory activity
Neurobiol Dis. 2023 Jul 17;184:106233. doi: 10.1016/j.nbd.2023.106233. Online ahead of print.ABSTRACTStroke is the most common cause of acquired epilepsy, but treatment for preventing the development of post-stroke epilepsy is still unavailable. Since stroke results in neuronal damage and death as well as initial loss of activity in the affected brain region, homeostatic plasticity may be trigged and contribute to an increase in network hyperexcitability that underlies epileptogenesis. Correspondingly, enhancing brain activity may inhibit hyperexcitability from enhanced homeostatic plasticity and prevent post-stroke epilep...
Source: Neurobiology of Disease - July 19, 2023 Category: Neurology Authors: Yadav Adhikari Cun-Gen Ma Zhi Chai Xiaoming Jin Source Type: research
Telephone assistance for neurological diseases: a systematic review
CONCLUSIONS: Dementias are the diseases with more bibliographic references on their telephone assistance despite not being the most prevalent. The telephone is frequently used to administer diagnostic scales or support caregivers and is particularly useful in diseases that limit mobility and attending a medical practice.PMID:37466132 | DOI:10.33588/rn.7703.2022284
Source: Revista de Neurologia - July 19, 2023 Category: Neurology Authors: J M Trejo-Gabriel-Gal án E Cubo-Delgado Source Type: research
Trends in volume-regulated anion channel (VRAC) research: visualization and bibliometric analysis from 2014 to 2022
Conclusion: The aim of this bibliometric analysis is to provide an overall perspective for research on VRAC. VRAC has become a topic of increasing interest, and our analysis shows that it continues to be a prominent area. This study offers insights into the investigation of VRAC channel and may guide researchers in identifying new directions for future research.
Source: Frontiers in Pharmacology - July 19, 2023 Category: Drugs & Pharmacology Source Type: research
TRPC Channels Activated by G Protein-Coupled Receptors Drive Ca < sup > 2+ < /sup > Dysregulation Leading to Secondary Brain Injury in the Mouse Model
Transl Stroke Res. 2023 Jul 18. doi: 10.1007/s12975-023-01173-1. Online ahead of print.ABSTRACTCanonical transient receptor potential (TRPC) non-selective cation channels, particularly those assembled with TRPC3, TRPC6, and TRPC7 subunits, are coupled to Gαq-type G protein-coupled receptors for the major classes of excitatory neurotransmitters. Sustained activation of this TRPC channel-based pathophysiological signaling hub in neurons and glia likely contributes to prodigious excitotoxicity-driven secondary brain injury expansion. This was investigated in mouse models with selective Trpc gene knockout (KO). In adult cereb...
Source: Biomed Res - July 18, 2023 Category: Research Authors: Jasneet Parmar Georg von Jonquieres Nagarajesh Gorlamandala Brandon Chung Amanda J Craig Jeremy L Pinyon Lutz Birnbaumer Matthias Klugmann Andrew J Moorhouse John M Power Gary D Housley Source Type: research
TRPC Channels Activated by G Protein-Coupled Receptors Drive Ca2+ Dysregulation Leading to Secondary Brain Injury in the Mouse Model
AbstractCanonical transient receptor potential (TRPC) non-selective cation channels, particularly those assembled with TRPC3, TRPC6, and TRPC7 subunits, are coupled to Gαq-type G protein-coupled receptors for the major classes of excitatory neurotransmitters. Sustained activation of this TRPC channel-based pathophysiological signaling hub in neurons and glia likely contributes to prodigious excitotoxicity-driven secondary brain injury expansion. This was investigated in mouse models with selectiveTrpc gene knockout (KO). In adult cerebellar brain slices, application of glutamate and the class I metabotropic glutamate rece...
Source: Translational Stroke Research - July 18, 2023 Category: Neurology Source Type: research
