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Condition: Epilepsy
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Total 2623 results found since Jan 2013.
The microRNAs (miRs) overexpressing mesenchymal stem cells (MSCs) therapy in neurological disorders; hope or hype
AbstractAltered expression of multiple miRNAs was found to be extensively involved in the pathogenesis of different neurological disorders including Alzheimer's disease, Parkinson's disease, stroke, epilepsy, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. One of the biggest concerns within gene-based therapy is the delivery of the therapeutic microRNAs to the intended place, which is obligated to surpass the biological barriers without undergoing degradation in the bloodstream or renal excretion. Hence, the delivery of modified and unmodified miRNA molecules using excellent vehicles is require...
Source: Biotechnology Progress - September 6, 2023 Category: Biotechnology Authors: Sulieman Ibraheem Shelash Al ‐Hawary,
Anas Yahya Ali,
Yasser Fakri Mustafa,
Ria Margiana,
Shamsutdinova Maksuda Ilyasovna,
Montather F. Ramadan,
Sami G. Almalki,
Marim Alwave,
Safa Alkhayyat,
Ali Alsalamy Tags: REVIEW Source Type: research
Frequency and predictors of poststroke epilepsy after mechanical thrombectomy for large vessel occlusion stroke: results from a multicenter cohort study
ConclusionIn our study, patients with large vessel occlusion stroke receiving MT had a 9% prevalence of PSE over a median follow-up period of 6.5 years. Besides larger infarct size, presence of cerebral microbleeds on brain MRI predicted PSE occurrence.
Source: Journal of Neurology - September 2, 2023 Category: Neurology Source Type: research
The microRNAs (miRs) overexpressing mesenchymal stem cells (MSCs) therapy in neurological disorders; hope or hype
AbstractAltered expression of multiple miRNAs was found to be extensively involved in the pathogenesis of different neurological disorders including Alzheimer's disease, Parkinson's disease, stroke, epilepsy, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. One of the biggest concerns within gene-based therapy is the delivery of the therapeutic microRNAs to the intended place, which is obligated to surpass the biological barriers without undergoing degradation in the bloodstream or renal excretion. Hence, the delivery of modified and unmodified miRNA molecules using excellent vehicles is require...
Source: Biotechnology Progress - August 30, 2023 Category: Biotechnology Authors: Sulieman Ibraheem Shelash Al ‐Hawary,
Anas Yahya Ali,
Yasser Fakri Mustafa,
Ria Margiana,
Shamsutdinova Maksuda Ilyasovna,
Montather F. Ramadan,
Sami G. Almalki,
Marim Alwave,
Safa Alkhayyat,
Ali Alsalamy Tags: REVIEW Source Type: research
Flexible, Miniaturized Sensing Probes Inspired by Biofuel Cells for Monitoring Synaptically Released Glutamate in the Mouse Brain
Angew Chem Int Ed Engl. 2023 Aug 26:e202310245. doi: 10.1002/anie.202310245. Online ahead of print.ABSTRACTChemical biomarkers in the central nervous system can provide valuable quantitative measures to gain insight into the etiology and pathogenesis of neurological diseases. Glutamate, one of the most important excitatory neurotransmitters in the brain, has been found to be upregulated in various neurological disorders, such as traumatic brain injury, Alzheimer's disease, stroke, epilepsy, chronic pain, and migraines. However, quantitatively monitoring glutamate release in situ has been challenging. This work presents a n...
Source: Angewandte Chemie - August 26, 2023 Category: Chemistry Authors: Prasad Nithianandam Tzu-Li Liu Shulin Chen Yizhen Jia Yan Dong Morgan Saul Andrea Tedeschi Wenjing Sun Jinghua Li Source Type: research
Watch a person unable to speak for years ‘talk’ using a new brain implant
When it comes to talking, our brain does the heavy lifting. It subconsciously directs the complex coordination of lips, tongue, throat, and jaws we need to pronounce words. And it keeps directing, even in people with paralysis or who are unable to turn these commands into speech.
Now, scientists have harnessed this phenomenon to create brain implants that transform this neural activity into text with unprecedented speed and accuracy. In two new studies—both reported today in
Nature
—the devices enabled two people to “speak” for the first time in more than a decade. The implants produced speech from brain...
Source: ScienceNOW - August 23, 2023 Category: Science Source Type: news
Sleepiness in neurological disorders
Rev Neurol (Paris). 2023 Aug 17:S0035-3787(23)00986-4. doi: 10.1016/j.neurol.2023.07.005. Online ahead of print.ABSTRACTSleepiness is a frequent and underrecognized symptom in neurological disorders, that impacts functional outcomes and quality of life. Multiple and potentially additive factors might contribute to sleepiness in neurological disorders, including sleep quality alterations, circadian rhythm disorders, drugs, and sleep disorders including sleep apnea or central disorders of hypersomnolence. Physician awareness of the possible symptoms of hypersomnolence, and associated causes is of crucial importance to allow ...
Source: Revue Neurologique - August 19, 2023 Category: Neurology Authors: A-L Dubessy I Arnulf Source Type: research
Infraclavicular Catheter in MELAS Syndrome for Analgesic Purposes
M Onay, T Tanyel Kiremitçi, G Erdoğan Kayhan, D İlhan Algın, MS GüleçNeurology India 2023 71(4):764-766
MELAS syndrome is defined as mitochondrial myopathy accompanied by encephalopathy, lactic acidosis, myoclonus, stroke-like episodes. It has a progressive course, multi-systemic effects and severe complications. Myoclonic contractions are unresponsive to many anti-epileptic drugs; these contractions and spasms may lead to severe pain. Systemic analgesic drugs are not sufficient to control pain. Therefore, continuous brachial plexus blockage may be pr...
Source: Neurology India - August 18, 2023 Category: Neurology Authors: M Onay T Tanyel Kiremit & #231;i G Erdo & #287;an Kayhan D & #304;lhan Alg & #305;n MS G & #252;le & #231; Source Type: research
Development of microRNA-based therapeutics for central nervous system diseases
Eur J Pharmacol. 2023 Aug 2:175956. doi: 10.1016/j.ejphar.2023.175956. Online ahead of print.ABSTRACTMicroRNA (miRNA)-mediated gene silencing is a method of RNA interference in which a miRNA binds to messenger RNA sequences and regulates target gene expression. MiRNA-based therapeutics have shown promise in treating a variety of central nervous system diseases, as verified by results from diverse preclinical model organisms. Over the last decade, several miRNA-based therapeutics have entered clinical trials for various kinds of diseases, such as tumors, infections, and inherited diseases. However, such clinical trials for ...
Source: European Journal of Pharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Siqi Xia Chaoran Xu Fuyi Liu Gao Chen Source Type: research
Association of Plasma A β 42/40 Ratio and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study
DISCUSSION: A reduction in plasma Aβ42/Aβ40 is associated with an increased risk of subsequent epilepsy. Our observations provide a further validation of the link between Aβ, hyperexcitable states, and LOE.PMID:37541842 | DOI:10.1212/WNL.0000000000207635
Source: Atherosclerosis - August 4, 2023 Category: Cardiology Authors: Emily L Johnson Kevin J Sullivan Andrea Lauren Christman Schneider Jeannette Simino Tom H Mosley Anna Kucharska-Newton David S Knopman Rebecca F Gottesman Source Type: research
Trends in volume-regulated anion channel (VRAC) research: visualization and bibliometric analysis from 2014 to 2022
Conclusion: The aim of this bibliometric analysis is to provide an overall perspective for research on VRAC. VRAC has become a topic of increasing interest, and our analysis shows that it continues to be a prominent area. This study offers insights into the investigation of VRAC channel and may guide researchers in identifying new directions for future research.PMID:37538172 | PMC:PMC10394876 | DOI:10.3389/fphar.2023.1234885
Source: Atherosclerosis - August 4, 2023 Category: Cardiology Authors: Tianbao Liu Yin Li Dawei Wang Tobias Stauber Jiajun Zhao Source Type: research
