Early predictors of neurodevelopment after perinatal arterial ischemic stroke: a systematic review and meta-analysis

CONCLUSION: Corticospinal tract assessment on MRI and standardized motor assessments are best to predict cerebral palsy after PAIS. Future research should be focused on improving outcome prediction for non-motor outcomes.IMPACT: We present a systematic review of early predictors for various long-term outcome categories after perinatal arterial ischemic stroke (PAIS), including a meta-analysis for the outcome unilateral spastic cerebral palsy. Corticospinal tract assessment on MRI and standardized motor assessments are best to predict cerebral palsy after PAIS, while bedside techniques such as (a)EEG and NIRS might improve cognitive outcome prediction. Future research should be focused on improving outcome prediction for non-motor outcomes.PMID:36575364 | DOI:10.1038/s41390-022-02433-w

Source: Pediatric Research - December 27, 2022 Category: Pediatrics Authors: Lisanne M Baak Niek E van der Aa Annemijn A E Verhagen Jeroen Dudink Floris Groenendaal Cora H A Nijboer Manon J N L Benders Nienke Wagenaar Source Type: research